quinolone (BioDeep_00000002689)

   


代谢物信息卡片


2-Hydroxyquinoline

化学式: C9H7NO (145.0527612)
中文名称: 2-羟基喹啉, 2-喹啉醇
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.33%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=CC(=O)N2
InChI: InChI=1S/C9H7NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-6H,(H,10,11)

描述信息

KEIO_ID Q001
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 52
CONFIDENCE standard compound; INTERNAL_ID 2491

同义名列表

7 个代谢物同义名

2-Hydroxyquinoline; quinolone; Quinolin-2(1H)-one; 2(1H)-Quinolinone; Quinolin-2-ol; 2-Quinolinol; 2-Quinolone



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Ane G Vogt, Guilherme T Voss, Renata L de Oliveira, Jaini J Paltian, Luis F B Duarte, Diego Alves, Cristiano R Jesse, Silvane S Roman, Juliano A Roehrs, Ethel A Wilhelm, Cristiane Luchese. Organoselenium group is critical for antioxidant activity of 7-chloro-4-phenylselenyl-quinoline. Chemico-biological interactions. 2018 Feb; 282(?):7-12. doi: 10.1016/j.cbi.2018.01.003. [PMID: 29317251]
  • Jongmin Ahn, Hee-Sung Chae, Young-Won Chin, Jinwoong Kim. Alkaloids from aerial parts of Houttuynia cordata and their anti-inflammatory activity. Bioorganic & medicinal chemistry letters. 2017 06; 27(12):2807-2811. doi: 10.1016/j.bmcl.2017.04.072. [PMID: 28499733]
  • Minori Matsumoto, Katsumi Shigemura, Toshiro Shirakawa, Yuzo Nakano, Hideaki Miyake, Kazushi Tanaka, Shohiro Kinoshita, Soichi Arakawa, Masato Kawabata, Masato Fujisawa. Mutations in the gyrA and parC genes and in vitro activities of fluoroquinolones in 114 clinical isolates of Pseudomonas aeruginosa derived from urinary tract infections and their rapid detection by denaturing high-performance liquid chromatography. International journal of antimicrobial agents. 2012 Nov; 40(5):440-4. doi: 10.1016/j.ijantimicag.2012.06.021. [PMID: 22884856]
  • Ming-Han Tsai, Sih-Ru Wu, Hao-Yuan Lee, Chyi-Liang Chen, Tzou-Yien Lin, Yhu-Chering Huang, Cheng-Hsun Chiu. Recognition of mechanisms involved in bile resistance important to halting antimicrobial resistance in nontyphoidal Salmonella. International journal of antimicrobial agents. 2012 Aug; 40(2):151-7. doi: 10.1016/j.ijantimicag.2012.04.016. [PMID: 22743016]
  • Moshe Ben-David, Mikael Elias, Jean-Jacques Filippi, Elisabet Duñach, Israel Silman, Joel L Sussman, Dan S Tawfik. Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1. Journal of molecular biology. 2012 May; 418(3-4):181-96. doi: 10.1016/j.jmb.2012.02.042. [PMID: 22387469]
  • Frederick A Sirgel, Robin M Warren, Elizabeth M Streicher, Thomas C Victor, Paul D van Helden, Erik C Böttger. gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis. The Journal of antimicrobial chemotherapy. 2012 May; 67(5):1088-93. doi: 10.1093/jac/dks033. [PMID: 22357804]
  • Bao-hua Tuo, Jia-bao Yan, Bao-an Fan, Zhong-hua Yang, Jian-zhong Liu. Biodegradation characteristics and bioaugmentation potential of a novel quinoline-degrading strain of Bacillus sp. isolated from petroleum-contaminated soil. Bioresource technology. 2012 Mar; 107(?):55-60. doi: 10.1016/j.biortech.2011.12.114. [PMID: 22243925]
  • Fangyou Yu, Chun Chen, Qiang Chen, Xiaojun Yu, Baixing Ding, Lehe Yang, Qiaoqiao Li, Zhiqiang Qin, Chris Parsons, Xueqing Zhang, Liming Zhang, Di Qu, Liangxing Wang, Jingye Pan. Identification of transferable DHA-1 type AmpC β-lactamases and two mutations in quinolone resistance-determining regions of Salmonella enterica serovar Thompson. Journal of medical microbiology. 2012 Mar; 61(Pt 3):460-462. doi: 10.1099/jmm.0.040691-0. [PMID: 22096136]
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  • Abdolkarim Mahrooz, Mohammad-Reza Rashidi, Mohammad Nouri. Naringenin is an inhibitor of human serum paraoxonase (PON1): an in vitro study. Journal of clinical laboratory analysis. 2011 Nov; 25(6):395-401. doi: 10.1002/jcla.20490. [PMID: 22086792]
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  • Manojkumar Valiyaveettil, Yonas Alamneh, Lionel Biggemann, Iswarduth Soojhawon, Heba A Farag, Prashasthi Agrawal, Bhupendra P Doctor, Madhusoodana P Nambiar. In vitro efficacy of paraoxonase 1 from multiple sources against various organophosphates. Toxicology in vitro : an international journal published in association with BIBRA. 2011 Jun; 25(4):905-13. doi: 10.1016/j.tiv.2011.02.012. [PMID: 21382471]
  • Kyu Seop Kim, Hyung Seo Park, Il Soon Jung, Jae-Hyeong Park, Kye Taek Ahn, Seon-Ah Jin, Yong Kyu Park, Jun Hyung Kim, Jae-Hwan Lee, Si Wan Choi, Jin-Ok Jeong, In-Whan Seong. Endothelial dysfunction in the smokers can be improved with oral cilostazol treatment. Journal of cardiovascular ultrasound. 2011 Mar; 19(1):21-5. doi: 10.4250/jcu.2011.19.1.21. [PMID: 21519488]
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  • Nafiseh Darandeh, Ebrahim Hadavi. Effect of Pre-Harvest Foliar Application of Citric Acid and Malic Acid on Chlorophyll Content and Post-Harvest Vase Life of Lilium cv. Brunello. Frontiers in plant science. 2011; 2(?):106. doi: 10.3389/fpls.2011.00106. [PMID: 22639626]
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  • Gwendoline Van Goietsenoven, Jenna Hutton, Jean-Paul Becker, Benjamin Lallemand, Francis Robert, Florence Lefranc, Christine Pirker, Guy Vandenbussche, Pierre Van Antwerpen, Antonio Evidente, Walter Berger, Martine Prévost, Jerry Pelletier, Robert Kiss, Terri Goss Kinzy, Alexander Kornienko, Véronique Mathieu. Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 Nov; 24(11):4575-84. doi: 10.1096/fj.10-162263. [PMID: 20643906]
  • Inderjit, Devika Bajpai, M S Rajeswari. Interaction of 8-hydroxyquinoline with soil environment mediates its ecological function. PloS one. 2010 Sep; 5(9):e12852. doi: 10.1371/journal.pone.0012852. [PMID: 20877629]
  • Yaohui Bai, Qinghua Sun, Cui Zhao, Donghui Wen, Xiaoyan Tang. Quinoline biodegradation and its nitrogen transformation pathway by a Pseudomonas sp. strain. Biodegradation. 2010 Jun; 21(3):335-44. doi: 10.1007/s10532-009-9304-9. [PMID: 19856115]
  • Frédérique Renault, Tiffany Carus, Cécile Cléry-Barraud, Mikael Elias, Eric Chabrière, Patrick Masson, Daniel Rochu. Integrative analytical approach by capillary electrophoresis and kinetics under high pressure optimized for deciphering intrinsic and extrinsic cofactors that modulate activity and stability of human paraoxonase (PON1). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 May; 878(17-18):1346-55. doi: 10.1016/j.jchromb.2009.11.027. [PMID: 19945920]
  • Syed Ahmad, Jade J Carter, John E Scott. A homogeneous cell-based assay for measurement of endogenous paraoxonase 1 activity. Analytical biochemistry. 2010 May; 400(1):1-9. doi: 10.1016/j.ab.2010.01.023. [PMID: 20096260]
  • Lorenzo Drago, Lucia Nicola, Roberto Mattina, Elena De Vecchi. In vitro selection of resistance in Escherichia coli and Klebsiella spp. at in vivo fluoroquinolone concentrations. BMC microbiology. 2010 Apr; 10(?):119. doi: 10.1186/1471-2180-10-119. [PMID: 20409341]
  • Yusuke Kakizaki, Roger S Seymour, Kikukatsu Ito. A novel functional element in the N-terminal region of Arum concinnatum alternative oxidase is indispensable for catalytic activity of the enzyme in HeLa cells. Biochimica et biophysica acta. 2010 Jan; 1797(1):20-8. doi: 10.1016/j.bbabio.2009.07.006. [PMID: 19643077]
  • Teresa L Micotto, Adrienne S Brown, James N Wilson. Fluorescent mimics of 5-hydroxytryptamine based on N-alkylated derivatives of 6-hydroxycarbostyril. Chemical communications (Cambridge, England). 2009 Dec; ?(48):7548-50. doi: 10.1039/b917578d. [PMID: 20024275]
  • Giovanna Farruggia, Stefano Iotti, Luca Prodi, Nelsi Zaccheroni, Marco Montalti, Paul B Savage, Giulia Andreani, Valentina Trapani, Federica I Wolf. A simple spectrofluorometric assay to measure total intracellular magnesium by a hydroxyquinoline derivative. Journal of fluorescence. 2009 Jan; 19(1):11-9. doi: 10.1007/s10895-008-0374-6. [PMID: 18528748]
  • Yao-hui Bai, Cui Zhao, Ya-na Xiao, Dong-hui Wen, Xiao-yan Tang. [Isolation, identification, and biodegradation characteristics of a quinoline-degrading bacterium]. Huan jing ke xue= Huanjing kexue. 2008 Dec; 29(12):3546-53. doi: . [PMID: 19256399]
  • Tiffany L Graves, John E Scott. A high throughput serum paraoxonase assay for discovery of small molecule modulators of PON1 activity. Current chemical genomics. 2008 Nov; 2(?):51-61. doi: 10.2174/1875397300802010051. [PMID: 20161844]
  • Christian Radauer, Peter Lackner, Heimo Breiteneder. The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands. BMC evolutionary biology. 2008 Oct; 8(?):286. doi: 10.1186/1471-2148-8-286. [PMID: 18922149]
  • Carmen Antonia Sanches Ito, Ana Cristina Gales, Maria Cristina B Tognim, Patrícia Munerato, Libera Maria Dalla Costa. Quinolone-resistant Escherichia coli. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. 2008 Feb; 12(1):5-9. doi: 10.1590/s1413-86702008000100003. [PMID: 18553006]
  • Shun-ni Zhu, Dong-qi Liu, Li Fan, Jin-ren Ni. [Isolation, identification and degradation characteristics of a quinoline-degrading bacterium Rhodococcus sp QL2]. Huan jing ke xue= Huanjing kexue. 2008 Feb; 29(2):488-93. doi: ". [PMID: 18613525]
  • Mario Thevis, Maxie Kohler, Nils Schlörer, Gregor Fusshöller, Wilhelm Schänzer. Screening for two selective androgen receptor modulators using gas chromatography-mass spectrometry in doping control analysis. European journal of mass spectrometry (Chichester, England). 2008; 14(3):153-61. doi: 10.1255/ejms.917. [PMID: 18708695]
  • Toshinobu Horii, Mai Osaki, Hideaki Muramatsu. Fluoroquinolone resistance in clinical isolates of Klebsiella oxytoca. Chemotherapy. 2008; 54(4):323-7. doi: 10.1159/000151266. [PMID: 18698136]
  • Qianxue Li, Xingming Bi, Youjiang Diao, Xuming Deng. Mutant-prevention concentrations of enrofloxacin for Escherichia coli isolates from chickens. American journal of veterinary research. 2007 Aug; 68(8):812-5. doi: 10.2460/ajvr.68.8.812. [PMID: 17669019]
  • Hoi-Seon Lee. Acaricidal effects of quinone and its congeners and color alteration of Dermatophagoides spp. with quinone. Journal of microbiology and biotechnology. 2007 Aug; 17(8):1394-8. doi: ". [PMID: 18051611]
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