methylselenocysteine (BioDeep_00000268010)

Main id: BioDeep_00000000633

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3-(Methylseleno)alanine

化学式: C4H9NO2Se (182.97984639999999)
中文名称: 3-(甲基硒)丙氨酸, Se-(甲基)硒基-L-半胱氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C[Se]CC(C(=O)O)N
InChI: InChI=1S/C4H9NO2Se/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)

描述信息

D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
D000970 - Antineoplastic Agents
Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis[1][2].
Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis[1][2].

同义名列表

4 个代谢物同义名

3-(Methylseleno)alanine; methylselenocysteine; Se-Methylselenocysteine; Se-Methylseleno-L-cysteine



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yongli Xie, Xiaoshan Ke, Zhencong Ye, Xuexia Li, Zetao Chen, Jiantao Liu, Ziyi Wu, Qiong Liu, Xiubo Du. Se-methylselenocysteine ameliorates mitochondrial function by targeting both mitophagy and autophagy in the mouse model of Alzheimer's disease. Food & function. 2024 Apr; 15(8):4310-4322. doi: 10.1039/d4fo00520a. [PMID: 38529619]
  • Yuxiang Fei, Tao Li, Ruoyu Wu, Xuejiao Xu, Sheng Hu, Ya Yang, Chenchen Jin, Wenlian Tang, Xu Zhang, Qianming Du, Chao Liu. Se-(Methyl)-selenocysteine ameliorates blood-brain barrier disruption of focal cerebral ischemia mice via ferroptosis inhibition and tight junction upregulation in an Akt/GSK3β-dependent manner. Psychopharmacology. 2024 Feb; 241(2):379-399. doi: 10.1007/s00213-023-06495-4. [PMID: 38019326]
  • Xichen Bai, Hong Zhou, Dan Luo, Dan Chen, Jianyuan Fan, Xiaoting Shao, Jun Zhou, Wei Liu. A Rational Combination of Cyclocarya paliurus Triterpene Acid Complex (TAC) and Se-Methylselenocysteine (MSC) Improves Glucose and Lipid Metabolism via the PI3K/Akt/GSK3β Pathway. Molecules (Basel, Switzerland). 2023 Jul; 28(14):. doi: 10.3390/molecules28145499. [PMID: 37513373]
  • Valentina N Mal'tseva, Michael V Goltyaev, Egor A Turovsky, Elena G Varlamova. Immunomodulatory and Anti-Inflammatory Properties of Selenium-Containing Agents: Their Role in the Regulation of Defense Mechanisms against COVID-19. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042360. [PMID: 35216476]
  • Jin Wang, Jiayu Zhang, Yuting Zhong, Liqiang Qin, Jianxiang Li. Sex-dimorphic distribution and anti-oxidative effects of selenomethionine and Se-methylselenocysteine supplementation. Journal of food science. 2021 Dec; 86(12):5424-5438. doi: 10.1111/1750-3841.15970. [PMID: 34796490]
  • Jia Ma, Jing Huang, Jinli Sun, Yanfeng Zhou, Xiaoyuan Ji, Daoxia Guo, Chang Liu, Jiyu Li, Jiye Zhang, Haiyun Song. L-Se-methylselenocysteine sensitizes lung carcinoma to chemotherapy. Cell proliferation. 2021 May; 54(5):e13038. doi: 10.1111/cpr.13038. [PMID: 33793020]
  • Romina López, Roberto D'Amato, Massimo Trabalza-Marinucci, Luca Regni, Primo Proetti, Ariel Maratta, Soledad Cerutti, Pablo Pacheco. Green and simple extraction of free seleno-amino acids from powdered and lyophilized milk samples with natural deep eutectic solvents. Food chemistry. 2020 Oct; 326(?):126965. doi: 10.1016/j.foodchem.2020.126965. [PMID: 32413755]
  • Maggie-Anne Harvey, Peter D Erskine, Hugh H Harris, Gillian K Brown, Elizabeth A H Pilon-Smits, Lachlan W Casey, Guillaume Echevarria, Antony van der Ent. Distribution and chemical form of selenium in Neptunia amplexicaulis from Central Queensland, Australia. Metallomics : integrated biometal science. 2020 04; 12(4):514-527. doi: 10.1039/c9mt00244h. [PMID: 32055807]
  • Stephen O Evans, Gregory M Jacobson, Hugh J B Goodman, Steve Bird, Michael B Jameson. Comparative Safety and Pharmacokinetic Evaluation of Three Oral Selenium Compounds in Cancer Patients. Biological trace element research. 2019 Jun; 189(2):395-404. doi: 10.1007/s12011-018-1501-0. [PMID: 30187284]
  • Isabelle Rohn, Nina Kroepfl, Julia Bornhorst, Doris Kuehnelt, Tanja Schwerdtle. Side-Directed Transfer and Presystemic Metabolism of Selenoneine in a Human Intestinal Barrier Model. Molecular nutrition & food research. 2019 06; 63(12):e1900080. doi: 10.1002/mnfr.201900080. [PMID: 30939220]
  • Youcef M Rustum, Sreenivasulu Chintala, Farukh A Durrani, Arup Bhattacharya. Non-Coding Micro RNAs and Hypoxia-Inducible Factors Are Selenium Targets for Development of a Mechanism-Based Combination Strategy in Clear-Cell Renal Cell Carcinoma-Bench-to-Bedside Therapy. International journal of molecular sciences. 2018 Oct; 19(11):. doi: 10.3390/ijms19113378. [PMID: 30380599]
  • Kazuaki Takahashi, Noriyuki Suzuki, Yasumitsu Ogra. Effect of administration route and dose on metabolism of nine bioselenocompounds. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2018 Sep; 49(?):113-118. doi: 10.1016/j.jtemb.2018.05.007. [PMID: 29895359]
  • Sabier Torres, Raul Gil, María Fernanda Silva, Pablo Pacheco. Determination of seleno-amino acids bound to proteins in extra virgin olive oils. Food chemistry. 2016 Apr; 197(Pt A):400-5. doi: 10.1016/j.foodchem.2015.10.008. [PMID: 26616967]
  • Mingzhu Fang, Wei-Ren Guo, Youngil Park, Hwan-Goo Kang, Helmut Zarbl. Enhancement of NAD⁺-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells. Oncotarget. 2015 Dec; 6(40):42879-91. doi: 10.18632/oncotarget.6002. [PMID: 26544624]
  • Yanbo Liu, Xichun Liu, Yaxiong Guo, Zuowen Liang, Yong Tian, Lili Lu, Xiaohui Zhao, Ying Sun, Xuejian Zhao, Haitao Zhang, Yan Dong. Methylselenocysteine preventing castration-resistant progression of prostate cancer. The Prostate. 2015 Jun; 75(9):1001-8. doi: 10.1002/pros.22987. [PMID: 25754033]
  • Gang Huang, Bi-cheng Yong, Ming-hong Xu, Jing-chun Li, Hai-hua Guo, Jing-nan Shen. Analysis of Selenium Levels in Osteosarcoma Patients and the Effects of Se-Methylselenocysteine on Osteosarcoma Cells In Vitro. Nutrition and cancer. 2015; 67(5):847-56. doi: 10.1080/01635581.2015.1042548. [PMID: 26121331]
  • Zhao Yao, Yunlong Zhang, Hongyan Li, Zeyuan Deng, Xiaoping Zhang. Synergistic effect of Se-methylselenocysteine and vitamin E in ameliorating the acute ethanol-induced oxidative damage in rat. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2015 Jan; 29(?):182-7. doi: 10.1016/j.jtemb.2014.08.004. [PMID: 25213679]
  • Kristýna Šindelářová, Jiřina Száková, Jana Tremlová, Oto Mestek, Lukáš Praus, Antonín Kaňa, Jana Najmanová, Pavel Tlustoš. The response of broccoli (Brassica oleracea convar. italica) varieties on foliar application of selenium: uptake, translocation, and speciation. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2015; 32(12):2027-38. doi: 10.1080/19440049.2015.1099744. [PMID: 26414440]
  • Fabricio William Avila, Yong Yang, Valdemar Faquin, Silvio Junio Ramos, Luiz Roberto G Guilherme, Theodore W Thannhauser, Li Li. Impact of selenium supply on Se-methylselenocysteine and glucosinolate accumulation in selenium-biofortified Brassica sprouts. Food chemistry. 2014 Dec; 165(?):578-86. doi: 10.1016/j.foodchem.2014.05.134. [PMID: 25038715]
  • María Sánchez-Martínez, Teresa Pérez-Corona, Cristina Martínez-Villaluenga, Juana Frías, Elena Peñas, Jesús M Porres, Gloria Urbano, Carmen Cámara, Yolanda Madrid. Synthesis of [(77)Se]-methylselenocysteine when preparing sauerkraut in the presence of [(77)Se]-selenite. Metabolic transformation of [ (77)Se]-methylselenocysteine in Wistar rats determined by LC-IDA-ICP-MS. Analytical and bioanalytical chemistry. 2014 Dec; 406(30):7949-58. doi: 10.1007/s00216-014-8224-7. [PMID: 25311192]
  • Susie Shih-Yin Huang, Silas S O Hung, Hing Man Chan. Maintaining tissue selenium species distribution as a potential defense mechanism against methylmercury toxicity in juvenile white sturgeon (Acipenser transmontanus). Aquatic toxicology (Amsterdam, Netherlands). 2014 Nov; 156(?):88-95. doi: 10.1016/j.aquatox.2014.08.004. [PMID: 25170596]
  • Sabier Torres, Soledad Cerutti, Julio Raba, Pablo Pacheco, María Fernanda Silva. Preconcentration of seleno-amino acids on a XAD resin and determination in regional olive oils by SPE UPLC-ESI-MS/MS. Food chemistry. 2014 Sep; 159(?):407-13. doi: 10.1016/j.foodchem.2014.03.045. [PMID: 24767074]
  • M Michalska-Kacymirow, E Kurek, A Smolis, M Wierzbicka, E Bulska. Biological and chemical investigation of Allium cepa L. response to selenium inorganic compounds. Analytical and bioanalytical chemistry. 2014 Jun; 406(15):3717-22. doi: 10.1007/s00216-014-7742-7. [PMID: 24652154]
  • S Cao, F A Durrani, K Tóth, Y M Rustum. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. British journal of cancer. 2014 Apr; 110(7):1733-43. doi: 10.1038/bjc.2014.85. [PMID: 24619073]
  • Michael T Stallings, Brandon R Cardon, Jeremy M Hardman, Tyler A Bliss, Scott E Brunson, Chris M Hart, Maria D Swiss, Squire D Hepworth, Merrill J Christensen, Chad R Hancock. A high isoflavone diet decreases 5' adenosine monophosphate-activated protein kinase activation and does not correct selenium-induced elevations in fasting blood glucose in mice. Nutrition research (New York, N.Y.). 2014 Apr; 34(4):308-17. doi: 10.1016/j.nutres.2014.03.003. [PMID: 24774067]
  • Witphon Thosaikham, Kritsana Jitmanee, Rossukon Sittipout, Sarunya Maneetong, Anut Chantiratikul, Piyanete Chantiratikul. Evaluation of selenium species in selenium-enriched pakchoi (Brassica chinensis Jusl var parachinensis (Bailey) Tsen & Lee) using mixed ion-pair reversed phase HPLC-ICP-MS. Food chemistry. 2014 Feb; 145(?):736-42. doi: 10.1016/j.foodchem.2013.08.116. [PMID: 24128538]
  • T Z Davis, B L Stegelmeier, B T Green, K D Welch, J O Hall. Evaluation of the respiratory elimination kinetics of selenate and Se-methylselenocysteine after oral administration in lambs. Research in veterinary science. 2013 Dec; 95(3):1163-8. doi: 10.1016/j.rvsc.2013.09.015. [PMID: 24210249]
  • Kristen R Hladun, Osman Kaftanoglu, David R Parker, Khoa D Tran, John T Trumble. Effects of selenium on development, survival, and accumulation in the honeybee (Apis mellifera L.). Environmental toxicology and chemistry. 2013 Nov; 32(11):2584-92. doi: 10.1002/etc.2357. [PMID: 24115124]
  • T Z Davis, B L Stegelmeier, K D Welch, J A Pfister, K E Panter, J O Hall. Comparative oral dose toxicokinetics of selenium compounds commonly found in selenium accumulator plants. Journal of animal science. 2013 Sep; 91(9):4501-9. doi: 10.2527/jas.2012-6101. [PMID: 23825349]
  • Fabricio William Ávila, Valdemar Faquin, Yong Yang, Silvio Junio Ramos, Luiz Roberto G Guilherme, Theodore W Thannhauser, Li Li. Assessment of the anticancer compounds Se-methylselenocysteine and glucosinolates in Se-biofortified broccoli (Brassica oleracea L. var. italica) sprouts and florets. Journal of agricultural and food chemistry. 2013 Jul; 61(26):6216-23. doi: 10.1021/jf4016834. [PMID: 23763668]
  • Ignacio Sepúlveda, Herna Barrientos, Andrea Mahn, Alejandra Moenne. Changes in SeMSC, glucosinolates and sulforaphane levels, and in proteome profile in broccoli (Brassica oleracea var. Italica) fertilized with sodium selenate. Molecules (Basel, Switzerland). 2013 May; 18(5):5221-34. doi: 10.3390/molecules18055221. [PMID: 23652991]
  • Yasumitsu Ogra, Ayane Katayama, Yurie Ogihara, Ayako Yawata, Yasumi Anan. Analysis of animal and plant selenometabolites in roots of a selenium accumulator, Brassica rapa var. peruviridis, by speciation. Metallomics : integrated biometal science. 2013 May; 5(5):429-36. doi: 10.1039/c2mt20187a. [PMID: 23348393]
  • Ho-Sang Shin, Woo-Jung Yang, Eun-Mi Choi. The preventive effect of Se-methylselenocysteine on γ-radiation-induced oxidative stress in rat lungs. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2013 Apr; 27(2):154-9. doi: 10.1016/j.jtemb.2012.09.003. [PMID: 23176811]
  • Emanuela Gionfriddo, Attilio Naccarato, Giovanni Sindona, Antonio Tagarelli. A reliable solid phase microextraction-gas chromatography-triple quadrupole mass spectrometry method for the assay of selenomethionine and selenomethylselenocysteine in aqueous extracts: difference between selenized and not-enriched selenium potatoes. Analytica chimica acta. 2012 Oct; 747(?):58-66. doi: 10.1016/j.aca.2012.08.016. [PMID: 22986136]
  • Huawei Zeng, Matthew I Jackson, Wen-Hsing Cheng, Gerald F Combs. Chemical form of selenium affects its uptake, transport, and glutathione peroxidase activity in the human intestinal Caco-2 cell model. Biological trace element research. 2011 Nov; 143(2):1209-18. doi: 10.1007/s12011-010-8935-3. [PMID: 21181292]
  • David A Brummell, Lyn M Watson, Ranjith Pathirana, Nigel I Joyce, Phillip J West, Donald A Hunter, Marian J McKenzie. Biofortification of tomato (Solanum lycopersicum) fruit with the anticancer compound methylselenocysteine using a selenocysteine methyltransferase from a selenium hyperaccumulator. Journal of agricultural and food chemistry. 2011 Oct; 59(20):10987-94. doi: 10.1021/jf202583f. [PMID: 21942920]
  • Eric Uthus, Adrienne Begaye, Sharon Ross, Huawei Zeng. The von Hippel-Lindau (VHL) tumor-suppressor gene is down-regulated by selenium deficiency in Caco-2 cells and rat colon mucosa. Biological trace element research. 2011 Aug; 142(2):223-31. doi: 10.1007/s12011-010-8764-4. [PMID: 20632125]
  • B Santhosh Kumar, Amit Kunwar, Beena G Singh, Adeel Ahmad, K Indira Priyadarsini. Anti-hemolytic and peroxyl radical scavenging activity of organoselenium compounds: an in vitro study. Biological trace element research. 2011 May; 140(2):127-38. doi: 10.1007/s12011-010-8692-3. [PMID: 20424929]
  • Valeria Mapelli, Peter R Hillestrøm, Emese Kápolna, Erik H Larsen, Lisbeth Olsson. Metabolic and bioprocess engineering for production of selenized yeast with increased content of seleno-methylselenocysteine. Metabolic engineering. 2011 May; 13(3):282-93. doi: 10.1016/j.ymben.2011.03.001. [PMID: 21397033]
  • F Moreno, T García-Barrera, J L Gómez-Ariza. Simultaneous analysis of mercury and selenium species including chiral forms of selenomethionine in human urine and serum by HPLC column-switching coupled to ICP-MS. The Analyst. 2010 Oct; 135(10):2700-5. doi: 10.1039/c0an00090f. [PMID: 20725669]
  • Colin F Quinn, John L Freeman, Ray J B Reynolds, Jennifer J Cappa, Sirine C Fakra, Matthew A Marcus, Stormy D Lindblom, Erin K Quinn, Lindsay E Bennett, Elizabeth A H Pilon-Smits. Selenium hyperaccumulation offers protection from cell disruptor herbivores. BMC ecology. 2010 Aug; 10(?):19. doi: 10.1186/1472-6785-10-19. [PMID: 20799959]
  • B Santhosh Kumar, Amit Kunwar, A Ahmad, L B Kumbhare, V K Jain, K I Priyadarsini. In vitro radioprotection studies of organoselenium compounds: differences between mono- and diselenides. Radiation and environmental biophysics. 2009 Nov; 48(4):379-84. doi: 10.1007/s00411-009-0240-1. [PMID: 19756688]
  • Yuki Ohta, Yayoi Kobayashi, Sakae Konishi, Seishiro Hirano. Speciation analysis of selenium metabolites in urine and breath by HPLC- and GC-inductively coupled plasma-MS after administration of selenomethionine and methylselenocysteine to rats. Chemical research in toxicology. 2009 Nov; 22(11):1795-801. doi: 10.1021/tx900202m. [PMID: 19715347]
  • Prince O Amoako, Peter C Uden, Julian F Tyson. Speciation of selenium dietary supplements; formation of S-(methylseleno)cysteine and other selenium compounds. Analytica chimica acta. 2009 Oct; 652(1-2):315-23. doi: 10.1016/j.aca.2009.08.013. [PMID: 19786198]
  • Andrea V Mahn, Hector M Toledo, Manuel Ruz. Dietary supplementation with selenomethylselenocysteine produces a differential proteomic response. The Journal of nutritional biochemistry. 2009 Oct; 20(10):791-9. doi: 10.1016/j.jnutbio.2008.07.008. [PMID: 18926683]
  • Marian J McKenzie, Donald A Hunter, Ranjith Pathirana, Lyn M Watson, Nigel I Joyce, Adam J Matich, Daryl D Rowan, David A Brummell. Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators. Transgenic research. 2009 Jun; 18(3):407-24. doi: 10.1007/s11248-008-9233-0. [PMID: 19051051]
  • Jung Tae Lee, Tae-Jin Lee, Jong-Wook Park, Taeg Kyu Kwon. Se-methylselenocysteine sensitized TRAIL-mediated apoptosis via down-regulation of Bcl-2 expression. International journal of oncology. 2009 May; 34(5):1455-60. doi: . [PMID: 19360359]
  • Jiankun Duan, Bin Hu. Separation and determination of seleno amino acids using gas chromatography hyphenated with inductively coupled plasma mass spectrometry after hollow fiber liquid phase microextraction. Journal of mass spectrometry : JMS. 2009 May; 44(5):605-12. doi: 10.1002/jms.1533. [PMID: 19053158]
  • Lei Wang, Melissa J L Bonorden, Guang-xun Li, Hyo-Jeong Lee, Hongbo Hu, Yong Zhang, Joshua D Liao, Margot P Cleary, Junxuan Lü. Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit. Cancer prevention research (Philadelphia, Pa.). 2009 May; 2(5):484-95. doi: 10.1158/1940-6207.capr-08-0173. [PMID: 19401524]
  • Yoshiro Tsuji, Noriyuki Suzuki, Kazuo T Suzuki, Yasumitsu Ogra. Selenium metabolism in rats with long-term ingestion of Se-methylselenocysteine using enriched stable isotopes. The Journal of toxicological sciences. 2009 Apr; 34(2):191-200. doi: 10.2131/jts.34.191. [PMID: 19336976]
  • A Nickel, G Kottra, G Schmidt, J Danier, T Hofmann, H Daniel. Characteristics of transport of selenoamino acids by epithelial amino acid transporters. Chemico-biological interactions. 2009 Feb; 177(3):234-41. doi: 10.1016/j.cbi.2008.09.008. [PMID: 18845132]
  • Anna Kiersztan, Anna Baranska, Michal Hapka, Magdalena Lebiedzinska, Katarzyna Winiarska, Marta Dudziak, Jadwiga Bryla. Differential action of methylselenocysteine in control and alloxan-diabetic rabbits. Chemico-biological interactions. 2009 Jan; 177(2):161-71. doi: 10.1016/j.cbi.2008.10.022. [PMID: 19010315]
  • Andrea V Mahn, Héctor M Toledo, Manuel H Ruz. Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats. Biological research. 2009; 42(2):163-73. doi: /s0716-97602009000200004. [PMID: 19746261]
  • Kazuo T Suzuki, Yoshiro Tsuji, Yuki Ohta, Noriyuki Suzuki. Preferential organ distribution of methylselenol source Se-methylselenocysteine relative to methylseleninic acid. Toxicology and applied pharmacology. 2008 Feb; 227(1):76-83. doi: 10.1016/j.taap.2007.10.001. [PMID: 18035386]
  • Susana Cuello, Sonia Ramos, Raquel Mateos, M Angeles Martín, Yolanda Madrid, Carmen Cámara, Laura Bravo, Luis Goya. Selenium methylselenocysteine protects human hepatoma HepG2 cells against oxidative stress induced by tert-butyl hydroperoxide. Analytical and bioanalytical chemistry. 2007 Dec; 389(7-8):2167-78. doi: 10.1007/s00216-007-1626-z. [PMID: 17952420]
  • Rami G Azrak, Shousong Cao, Lakshmi Pendyala, Farukh A Durrani, Marwan Fakih, Gerald F Combs, Joshua Prey, Patrick F Smith, Youcef M Rustum. Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent. Biochemical pharmacology. 2007 May; 73(9):1280-7. doi: 10.1016/j.bcp.2006.12.020. [PMID: 17239826]
  • John L Freeman, Stormy Dawn Lindblom, Colin F Quinn, Sirine Fakra, Matthew A Marcus, Elizabeth A H Pilon-Smits. Selenium accumulation protects plants from herbivory by Orthoptera via toxicity and deterrence. The New phytologist. 2007; 175(3):490-500. doi: 10.1111/j.1469-8137.2007.02119.x. [PMID: 17635224]
  • Jan-Ying Yeh, Bor-Rung Ou, Yu-Chuan Liang, Joel Burchfiel, Judy A Butler, Neil E Forsberg, Philip D Whanger. Mechanism for proliferation inhibition by various selenium compounds and selenium-enriched broccoli extract in rat glial cells. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2006 Dec; 19(6):611-21. doi: 10.1007/s10534-006-0007-y. [PMID: 16951906]
  • Kazuo T Suzuki, Chiaki Doi, Noriyuki Suzuki. Metabolism of 76Se-methylselenocysteine compared with that of 77Se-selenomethionine and 82Se-selenite. Toxicology and applied pharmacology. 2006 Dec; 217(2):185-95. doi: 10.1016/j.taap.2006.09.006. [PMID: 17056079]
  • John L Freeman, Colin F Quinn, Matthew A Marcus, Sirine Fakra, Elizabeth A H Pilon-Smits. Selenium-tolerant diamondback moth disarms hyperaccumulator plant defense. Current biology : CB. 2006 Nov; 16(22):2181-92. doi: 10.1016/j.cub.2006.09.015. [PMID: 17113382]
  • Soo Ok Lee, Jae Yeon Chun, Nagalakshmi Nadiminty, Donald L Trump, Clement Ip, Yan Dong, Allen C Gao. Monomethylated selenium inhibits growth of LNCaP human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA). The Prostate. 2006 Jul; 66(10):1070-5. doi: 10.1002/pros.20329. [PMID: 16637076]
  • Dong-ping Tian, Min Su, Xian-ying Wu, Ge Zhang. [Effects of selenium and B-27 supplements on viability and differentiation of neural stem cell in newborn rat]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2005 Sep; 39(5):324-7. doi: NULL. [PMID: 16266543]
  • Rami G Azrak, Jinsheng Yu, Lakshmi Pendyala, Patrick F Smith, Shousong Cao, Xia Li, William D Shannon, Farukh A Durrani, Howard L McLeod, Youcef M Rustum. Irinotecan pharmacokinetic and pharmacogenomic alterations induced by methylselenocysteine in human head and neck xenograft tumors. Molecular cancer therapeutics. 2005 May; 4(5):843-54. doi: 10.1158/1535-7163.mct-04-0315. [PMID: 15897249]
  • Rizky Abdulah, Kaori Miyazaki, Minato Nakazawa, Hiroshi Koyama. Chemical forms of selenium for cancer prevention. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2005; 19(2-3):141-50. doi: 10.1016/j.jtemb.2005.09.003. [PMID: 16325529]
  • Eric Block, Richard S Glass, Neil E Jacobsen, Sherida Johnson, Chethaka Kahakachchi, Rafal Kamiński, Alexandra Skowrońska, Harriet Totoe Boakye, Julian F Tyson, Peter C Uden. Identification and synthesis of a novel selenium-sulfur amino acid found in selenized yeast: Rapid indirect detection NMR methods for characterizing low-level organoselenium compounds in complex matrices. Journal of agricultural and food chemistry. 2004 Jun; 52(12):3761-71. doi: 10.1021/jf049887z. [PMID: 15186094]
  • Danika L LeDuc, Alice S Tarun, Maria Montes-Bayon, Juris Meija, Michele F Malit, Carol P Wu, Manal AbdelSamie, Chih-Yuan Chiang, Abderrhamane Tagmount, Mark deSouza, Bernhard Neuhierl, August Böck, Joseph Caruso, Norman Terry. Overexpression of selenocysteine methyltransferase in Arabidopsis and Indian mustard increases selenium tolerance and accumulation. Plant physiology. 2004 May; 135(1):377-83. doi: 10.1104/pp.103.026989. [PMID: 14671009]
  • Danielle R Ellis, Thomas G Sors, Dennis G Brunk, Carrie Albrecht, Cindy Orser, Brett Lahner, Karl V Wood, Hugh H Harris, Ingrid J Pickering, David E Salt. Production of Se-methylselenocysteine in transgenic plants expressing selenocysteine methyltransferase. BMC plant biology. 2004 Jan; 4(?):1. doi: 10.1186/1471-2229-4-1. [PMID: 15005814]
  • Y Dong, D Lisk, E Block, C Ip. Characterization of the biological activity of gamma-glutamyl-Se-methylselenocysteine: a novel, naturally occurring anticancer agent from garlic. Cancer research. 2001 Apr; 61(7):2923-8. doi: . [PMID: 11306469]
  • J N Commandeur, M Rooseboom, N P Vermeulen. Chemistry and biological activity of novel selenium-containing compounds. Advances in experimental medicine and biology. 2001; 500(?):105-12. doi: 10.1007/978-1-4615-0667-6_11. [PMID: 11764919]
  • Y Wang, A Böck, B Neuhierl. Acquisition of selenium tolerance by a selenium non-accumulating Astragalus species via selection. BioFactors (Oxford, England). 1999; 9(1):3-10. doi: 10.1002/biof.5520090102. [PMID: 10221152]
  • X Guo, L Wu. Distribution of free seleno-amino acids in plant tissue of Melilotus indica L. grown in selenium-laden soils. Ecotoxicology and environmental safety. 1998 Mar; 39(3):207-14. doi: 10.1006/eesa.1997.1628. [PMID: 9570912]
  • M Berggren, A Gallegos, J Gasdaska, G Powis. Cellular thioredoxin reductase activity is regulated by selenium. Anticancer research. 1997 Sep; 17(5A):3377-80. doi: NULL. [PMID: 9413175]
  • J Lu, H Pei, C Ip, D J Lisk, H Ganther, H J Thompson. Effect on an aqueous extract of selenium-enriched garlic on in vitro markers and in vivo efficacy in cancer prevention. Carcinogenesis. 1996 Sep; 17(9):1903-7. doi: 10.1093/carcin/17.9.1903. [PMID: 8824512]
  • . . . . doi: . [PMID: 15863700]