Procaine (BioDeep_00000002680)
Secondary id: BioDeep_00000408953
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
Chaix et du marais brand OF procaine hydrochloride
化学式: C13H20N2O2 (236.1525)
中文名称: 普鲁卡因
谱图信息:
最多检出来源 Homo sapiens(blood) 16.87%
分子结构信息
SMILES: CCN(CC)CCOC(=O)c(c1)ccc(N)c1
InChI: InChI=1S/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3
描述信息
Procaine is only found in individuals that have used or taken this drug. It is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). [PubChem]Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, procaine is sometimes referred to generically as novocaine. It acts mainly by being a sodium channel blocker.
C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AD - Local anesthetics
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01B - Anesthetics, local > N01BA - Esters of aminobenzoic acid
S - Sensory organs > S01 - Ophthalmologicals > S01H - Local anesthetics > S01HA - Local anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
KEIO_ID P190; [MS2] KO009161
KEIO_ID P190
同义名列表
56 个代谢物同义名
Chaix et du marais brand OF procaine hydrochloride; 4-Aminobenzoic acid 2-diethylaminoethyl ester; p-Aminobenzoic acid 2-diethylaminoethyl ester; beta-(Diethylamino)ethyl 4-aminobenzoic acid; beta-(Diethylamino)ethyl p-aminobenzoic acid; Serra pamies brand OF procaine hydrochloride; Steigerwald brand OF procaine hydrochloride; Lomapharm brand OF procaine hydrochloride; Β-(diethylamino)ethyl 4-aminobenzoic acid; 4-Aminobenzoate 2-diethylaminoethyl ester; Pharmakon brand OF procaine hydrochloride; b-(Diethylamino)ethyl 4-aminobenzoic acid; Jenapharm brand OF procaine hydrochloride; b-(Diethylamino)ethyl p-aminobenzoic acid; Β-(diethylamino)ethyl p-aminobenzoic acid; p-Aminobenzoate 2-diethylaminoethyl ester; beta-(Diethylamino)ethyl p-aminobenzoate; beta-(Diethylamino)ethyl 4-aminobenzoate; Curasan brand OF procaine hydrochloride; 2-Diethylaminoethyl p-aminobenzoic acid; Aventis brand OF procaine hydrochloride; Hevert brand OF procaine hydrochloride; Abbott brand OF procaine hydrochloride; 2-(diethylamino)ethyl 4-aminobenzoate; b-(Diethylamino)ethyl p-aminobenzoate; Β-(diethylamino)ethyl 4-aminobenzoate; Braun brand OF procaine hydrochloride; Loges brand OF procaine hydrochloride; Β-(diethylamino)ethyl p-aminobenzoate; b-(Diethylamino)ethyl 4-aminobenzoate; 2-Diethylaminoethyl p-aminobenzoate; Pröcaine chlorhydrate lavoisier; Hydrochloride, procaine; Procaine hydrochloride; Solution OF novocain; Procain steigerwald; Lophakomp-procain N; Hewedolor-procain; Procain jenapharm; Procain curasan; Procaina serra; Procain rödler; Procain braun; Procain-loges; Procaine HCL; Röwo procain; Vitamin H3; Geriocaine; Novocaine; Procainum; Novocain; procaine; Procaina; Gerokit; Anuject; Procaine
数据库引用编号
27 个数据库交叉引用编号
- ChEBI: CHEBI:8430
- KEGG: C07375
- KEGGdrug: D08422
- PubChem: 4914
- HMDB: HMDB0014859
- Metlin: METLIN43314
- DrugBank: DB00721
- ChEMBL: CHEMBL569
- Wikipedia: Procaine
- MeSH: Procaine
- foodb: FDB029371
- chemspider: 4745
- CAS: 59-46-1
- MoNA: KO003919
- MoNA: KO009163
- MoNA: KO009161
- MoNA: KO003921
- MoNA: KO003918
- MoNA: KO009162
- MoNA: KO003917
- MoNA: KO003920
- MoNA: KO009164
- PMhub: MS000004464
- PubChem: 9579
- NIKKAJI: J4.603E
- RefMet: Procaine
- KNApSAcK: 8430
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Miaomiao Song, Yaping Chen. Local anaesthetic procaine derivatives protect rat against diabetic nephropathy via inhibition of DPP-4, inflammation and oxidative stress.
Chemical biology & drug design.
2023 Apr; ?(?):. doi:
10.1111/cbdd.14252. [PMID: 37076428] - David Vinyes, Montserrat Muñoz-Sellart, Teresa García Caballero. Local anesthetics as a therapeutic tool for post COVID-19 patients: A case report.
Medicine.
2022 Jul; 101(28):e29358. doi:
10.1097/md.0000000000029358. [PMID: 35839020] - Juan P Ortiz Fragola, Gabriel Cao, Mariano Tumarkin, Marisa Moriondo, Angélica Muller, Martin Sangiorgio, Francisco Azzato, Giuseppe Ambrosio, José Milei. Bretschneider Solution and Two Antianginal Drugs Protect Peripheral Tissue in an Animal Model of Hemorrhagic Shock.
Journal of cardiovascular pharmacology.
2022 Jun; 79(6):896-903. doi:
10.1097/fjc.0000000000001253. [PMID: 35249963] - Elsbeth J Wesselink, Seppe J Koopman, Rien van der Vegt, Peter M van de Ven, Jan P van der Aa, Carlijne Stapper, Friso Wesdorp, Laura de Kok, Yiyi Zhang, Eric J Franssen, Eleonora L Swart, Christa Boer, Marcel A de Leeuw. ED90 of spinal 2-chloroprocaine 1\% in ambulatory knee arthroscopy up to 45 min: a randomized biased-coin- up-and-down sequential allocation trial.
Regional anesthesia and pain medicine.
2022 04; 47(4):212-216. doi:
10.1136/rapm-2021-103089. [PMID: 35027477] - Allison Lee, Ben Shatil, Ruth Landau, Prahlad Menon, Richard Smiley. Intrathecal 2-Chloroprocaine 3\% Versus Hyperbaric Bupivacaine 0.75\% for Cervical Cerclage: A Double-Blind Randomized Controlled Trial.
Anesthesia and analgesia.
2022 03; 134(3):624-632. doi:
10.1213/ane.0000000000005653. [PMID: 34153006] - Augustinas Bausys, Juste Maneikyte, Bettina Leber, Jennifer Weber, Nicole Feldbacher, Kestutis Strupas, Thomas Bernd Dschietzig, Peter Schemmer, Philipp Stiegler. Custodiol® Supplemented with Synthetic Human Relaxin Decreases Ischemia-Reperfusion Injury after Porcine Kidney Transplantation.
International journal of molecular sciences.
2021 Oct; 22(21):. doi:
10.3390/ijms222111417. [PMID: 34768845] - Charlotte von Horn, Benjamin Wilde, Ursula Rauen, Andreas Paul, Thomas Minor. Use of the new preservation solution Custodiol-MP for ex vivo reconditioning of kidney grafts.
Artificial organs.
2021 Sep; 45(9):1117-1123. doi:
10.1111/aor.13951. [PMID: 33683761] - Immanuel I Turner, Mark Ruzmetov, Jianli Niu, Steven Bibevski, Frank G Scholl. Scavenging right atrial Bretschneider histidine-tryptophan-ketoglutarate cardioplegia: Impact on hyponatremia and seizures in pediatric cardiac surgery patients.
The Journal of thoracic and cardiovascular surgery.
2021 Jul; 162(1):228-237. doi:
10.1016/j.jtcvs.2020.08.098. [PMID: 33036746] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
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2021 Apr; 16(1):94. doi:
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BMC anesthesiology.
2021 02; 21(1):58. doi:
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International journal of molecular sciences.
2020 Sep; 21(18):. doi:
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International journal of molecular sciences.
2020 Sep; 21(18):. doi:
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Transplantation proceedings.
2020 Sep; 52(7):2050-2054. doi:
10.1016/j.transproceed.2020.01.101. [PMID: 32278582] - Jiani Huang, Fang Wen, Wenjie Huang, Yingfeng Bai, Xiaona Lu, Peng Shu. Identification of hub genes and discovery of promising compounds in gastric cancer based on bioinformatics analysis.
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2020 08; 14(12):1069-1084. doi:
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Transplantation proceedings.
2020 Jun; 52(5):1262-1264. doi:
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Journal of medicinal chemistry.
2020 02; 63(4):1763-1774. doi:
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Annals of vascular surgery.
2020 Feb; 63(?):459.e5-459.e8. doi:
10.1016/j.avsg.2019.08.105. [PMID: 31622767] - Daniela Kniepeiss, Philipp Houben, Philipp Stiegler, Andrea Berghold, Regina Riedl, Judith Kahn, Peter Schemmer. A prospective, randomized, single-blind, multicentre, phase III study on organ preservation with Custodiol-N solution compared with Custodiol® solution in organ transplantation (kidney, liver and pancreas).
Trials.
2020 Jan; 21(1):62. doi:
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Oxidative medicine and cellular longevity.
2020; 2020(?):3580934. doi:
10.1155/2020/3580934. [PMID: 32685092] - Mohammed I El-Gamal, Hanan S Anbar, Hamadeh Tarazi, Chang-Hyun Oh. Discovery of a potent p38α/MAPK14 kinase inhibitor: Synthesis, in vitro/in vivo biological evaluation, and docking studies.
European journal of medicinal chemistry.
2019 Dec; 183(?):111684. doi:
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Scientific reports.
2019 09; 9(1):13897. doi:
10.1038/s41598-019-50101-7. [PMID: 31554887] - Pia Weiler, Marwan Hamiko, Fritz Mellert, Wilhelm Roell, Martina Roell, Cecilia Welz, Georg Daniel Duerr. Impact of Crystalloid or Albumin Priming of the Heart-Lung Machine on Inhospital Outcome after Coronary Artery Bypass Surgery.
The Thoracic and cardiovascular surgeon.
2019 Sep; 67(6):475-483. doi:
10.1055/s-0038-1667328. [PMID: 30049018] - Isabell Kemker, Christian Schnepel, David C Schröder, Antoine Marion, Norbert Sewald. Cyclization of RGD Peptides by Suzuki-Miyaura Cross-Coupling.
Journal of medicinal chemistry.
2019 08; 62(16):7417-7430. doi:
10.1021/acs.jmedchem.9b00360. [PMID: 31306009] - Jan Weis, Håkan Ahlström, Olle Korsgren. Proton MR spectroscopy of human pancreas allografts.
Magma (New York, N.Y.).
2019 Aug; 32(4):511-517. doi:
10.1007/s10334-019-00740-8. [PMID: 30937576] - Mehmet Haberal, Mahir Kirnap, S Remzi Erdem, B Handan Ozdemir, K Michael Lux, Didem Bacanli. Evaluation of New Baskent University Preservation Solution for Kidney Graft During Cold Ischemia: Preliminary Experimental Animal Study.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2019 06; 17(3):287-297. doi:
10.6002/ect.bups2019. [PMID: 31145052] - Katharina Hofmann, Anna Rauh, Jürgen Harlizius, Christine Weiß, Tobias Scholz, Theodor Schulze-Horsel, Damián Escribano, Mathias Ritzmann, Susanne Zöls. [Pain and distress responses of suckling piglets to injection and castration under local anaesthesia with procaine and lidocaine - Part 1: Cortisol, chromogranin A, wound healing, weights, losses].
Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere.
2019 Apr; 47(2):87-96. doi:
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Reproduction in domestic animals = Zuchthygiene.
2019 Feb; 54(2):184-194. doi:
10.1111/rda.13328. [PMID: 30179285] - Cheng-Chia Lee, Ya-Ju Hsieh, Shao-Wei Chen, Shu-Hsuan Fu, Chia-Wei Hsu, Chih-Ching Wu, Wei Han, Yunong Li, Tao Huan, Yu-Sun Chang, Jau-Song Yu, Liang Li, Chih-Hsiang Chang, Yi-Ting Chen. Bretschneider solution-induced alterations in the urine metabolome in cardiac surgery patients.
Scientific reports.
2018 12; 8(1):17774. doi:
10.1038/s41598-018-35631-w. [PMID: 30538262] - Soma Sengupta, Paramita Paul, Biswajit Mukherjee, Raghuvir H Gaonkar, Mita Chatterjee Debnath, Rhitabrita Chakraborty, Nobila Khatun, Somdatta Roy. Peripheral nerve targeting by procaine-conjugated ribavirin-loaded dual drug nanovesicle.
Nanomedicine (London, England).
2018 12; 13(23):3009-3023. doi:
10.2217/nnm-2018-0192. [PMID: 30507340] - A Ostróżka-Cieślik, B Dolińska, K Czyż. Analysis of Interactions Between Components of Selected Solution for Organ Perfusion and Preservation.
Transplantation proceedings.
2018 Sep; 50(7):1967-1970. doi:
10.1016/j.transproceed.2018.02.166. [PMID: 30177089] - B Szulc-Musioł, B Dolińska, K Jasik, F Ryszka. Effect of Prolactin on Biochemical and Morphological Parameters of Rabbit Liver in Warm Ischemia.
Transplantation proceedings.
2018 Sep; 50(7):2229-2234. doi:
10.1016/j.transproceed.2018.02.135. [PMID: 30177141] - Junhong Lin. Platelet-rich plasma injection in the treatment of frozen shoulder: A randomized controlled trial with 6-month follow-up
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International journal of clinical pharmacology and therapeutics.
2018 Aug; 56(8):366-371. doi:
10.5414/cp203262. [PMID: 29932415] - Fan Wu, Jintao Wang, Jianming Sun, Liman Shen, Meijuan Liu, Erjun Zhao. Procaine stimulates aquaporin‑5 expression in human salivary gland ductal cells via the suppression of DNA methyltransferase‑1.
Molecular medicine reports.
2018 Jun; 17(6):7996-8002. doi:
10.3892/mmr.2018.8821. [PMID: 29620185] - J K Teloh, L Ansorge, M Petersen, E Demircioglu, I N Waack, S Brauckmann, H Jakob, D-S Dohle. Histidine metabolism after Bretschneider cardioplegia in cardiac surgical patients.
Physiological research.
2018 05; 67(2):209-216. doi:
10.33549/physiolres.933691. [PMID: 29303608] - Jindong Li, Yanhong Wu, Xudong Tian, Jiantang Wang, Mingfeng Dong, Anbiao Wang, Shengjun Ma. Protective effect of HTK solution on postoperative pulmonary function in infants with CHD and PAH.
Bioscience reports.
2017 Dec; 37(6):. doi:
10.1042/bsr20170984. [PMID: 29089468] - W-Y Fan, D-P Wang, Q Wen, T-J Fan. The cytotoxic effect of oxybuprocaine on human corneal epithelial cells by inducing cell cycle arrest and mitochondria-dependent apoptosis.
Human & experimental toxicology.
2017 Aug; 36(8):765-775. doi:
10.1177/0960327116665676. [PMID: 27590991] - Giorgio Veneziano, Joseph D Tobias. Chloroprocaine for epidural anesthesia in infants and children.
Paediatric anaesthesia.
2017 Jun; 27(6):581-590. doi:
10.1111/pan.13134. [PMID: 28321983] - J Moritz Kaths, Juan Echeverri, Yi Min Chun, Jun Yu Cen, Nicolas Goldaracena, Ivan Linares, Luke S Dingwell, Paul M Yip, Rohan John, Darius Bagli, Istvan Mucsi, Anand Ghanekar, David R Grant, Lisa A Robinson, Markus Selzner. Continuous Normothermic Ex Vivo Kidney Perfusion Improves Graft Function in Donation After Circulatory Death Pig Kidney Transplantation.
Transplantation.
2017 Apr; 101(4):754-763. doi:
10.1097/tp.0000000000001343. [PMID: 27467537] - Mohammad Golriz, Hamidreza Fonouni, Gani Kuttymuratov, Majid Esmaeilzadeh, Morva Tahmasbi Rad, Parvin Jarahian, Thomas Longerich, Alireza Faridar, Sepehr Abbasi, Arianeb Mehrabi, Marta M Gebhard. Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model.
Asian journal of surgery.
2017 Apr; 40(2):106-115. doi:
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Perfusion.
2017 Apr; 32(3):245-252. doi:
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European biophysics journal : EBJ.
2017 Apr; 46(3):265-282. doi:
10.1007/s00249-016-1164-8. [PMID: 27557558] - Xu-Jiao Yu, Wei Zhao, Yu-Jie Li, Feng-Xian Li, Zhong-Jie Liu, Hua-Li Xu, Lu-Ying Lai, Rui Xu, Shi-Yuan Xu. Neurotoxicity Comparison of Two Types of Local Anaesthetics: Amide-Bupivacaine versus Ester-Procaine.
Scientific reports.
2017 03; 7(?):45316. doi:
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Luminescence : the journal of biological and chemical luminescence.
2017 Feb; 32(1):4-10. doi:
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European journal of medicinal chemistry.
2017 Jan; 125(?):87-100. doi:
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Transplantation.
2016 Sep; 100(9):1862-70. doi:
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Amino acids.
2016 06; 48(6):1423-32. doi:
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Asian journal of surgery.
2016 Apr; 39(2):66-73. doi:
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Transplantation proceedings.
2016 Jan; 48(1):191-8. doi:
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European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.
2016; 57(1-2):10-21. doi:
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Paediatric anaesthesia.
2016 Jan; 26(1):84-91. doi:
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Electrophoresis.
2015 Dec; 36(23):2961-7. doi:
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Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
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Xenotransplantation.
2015 Jul; 22(4):284-94. doi:
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Transplantation proceedings.
2015 May; 47(4):888-93. doi:
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2015 Apr; 20(?):233-42. doi:
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Interactive cardiovascular and thoracic surgery.
2015 Mar; 20(3):387-94. doi:
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European journal of anaesthesiology.
2014 Nov; 31(11):575-85. doi:
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2014 Sep; 53(?):200-205. doi:
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Georgian medical news.
2014 Jul; ?(232-233):103-7. doi:
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Current opinion in organ transplantation.
2014 Apr; 19(2):100-7. doi:
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Journal of vascular surgery.
2014 Mar; 59(3):623-33. doi:
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Progress in transplantation (Aliso Viejo, Calif.).
2013 Dec; 23(4):383-91. doi:
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Luminescence : the journal of biological and chemical luminescence.
2013 Sep; 28(5):673-8. doi:
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Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2013 Jun; 15(6):453-7. doi:
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Transplantation proceedings.
2013 Jun; 45(5):1720-2. doi:
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Transplantation.
2013 Apr; 95(8):1064-9. doi:
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Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury.
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Reproduction, fertility, and development.
2013; 25(7):1036-50. doi:
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2012 Dec; 1818(12):3010-8. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
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The Journal of surgical research.
2012 Dec; 178(2):959-67. doi:
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The Journal of pharmacology and experimental therapeutics.
2012 Aug; 342(2):376-88. doi:
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Berliner und Munchener tierarztliche Wochenschrift.
2012 Jul; 125(7-8):315-25. doi:
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Journal of cardiothoracic surgery.
2012 Jun; 7(?):52. doi:
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Alternative medicine review : a journal of clinical therapeutic.
2012 Mar; 17(1):57-68. doi:
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2012 Feb; 18(2):219-25. doi:
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Journal of Korean medical science.
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Molecular neurodegeneration.
2012 Jan; 7(?):2. doi:
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Acta biochimica Polonica.
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PloS one.
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Anesthesiology research and practice.
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Current genomics.
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Transplantation proceedings.
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Molecular pain.
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Foodborne pathogens and disease.
2011 Aug; 8(8):861-7. doi:
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Biology of reproduction.
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Plant, cell & environment.
2011 Aug; 34(8):1258-66. doi:
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Cell death and differentiation.
2011 Aug; 18(8):1356-65. doi:
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The Journal of surgical research.
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Langenbeck's archives of surgery.
2011 Jun; 396(5):677-83. doi:
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Acta veterinaria Scandinavica.
2011 May; 53(?):34. doi:
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Journal of tissue viability.
2011 May; 20(2):67-72. doi:
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The Annals of thoracic surgery.
2011 Mar; 91(3):755-63. doi:
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