Sebacic acid (BioDeep_00000002588)

 

Secondary id: BioDeep_00000229702, BioDeep_00000400416, BioDeep_00000415741, BioDeep_00000860441

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


Sebacic acid, monocadmium salt

化学式: C10H18O4 (202.1205)
中文名称: 癸二酸, 皮脂酸, 葵二酸
谱图信息: 最多检出来源 Homo sapiens(blood) 14.99%

分子结构信息

SMILES: C(C(=O)O)CCCCCCCC(=O)O
InChI: InChI=1S/C10H18O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h1-8H2,(H,11,12)(H,13,14)

描述信息

Sebacic acid is a saturated, straight-chain naturally occurring dicarboxylic acid with 10 carbon atoms. Sebacic acid is a normal urinary acid. In patients with multiple acyl-CoA-dehydrogenase deficiency (MADD), also known as glutaric aciduria type II (GAII), a group of metabolic disorders due to deficiency of either electron transfer flavoprotein or electron transfer flavoprotein ubiquinone oxidoreductase, biochemical data shows an increase in urine sebacic acid excretion. Sebacic acid is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism. Sebacic acid is a white flake or powdered crystal slightly soluble in water that has been proposed as an alternative energy substrate in total parenteral nutrition. Sebacic Acid was named from the Latin sebaceus (tallow candle) or sebum (tallow) in reference to its use in the manufacture of candles. Sebacic acid and its derivatives such as azelaic acid have a variety of industrial uses as plasticizers, lubricants, hydraulic fluids, cosmetics, candles, etc. It is used in the synthesis of polyamide and alkyd resins. It is also used as an intermediate for aromatics, antiseptics and painting materials (PMID: 10556649, 1738216, 8442769, 12706375).
Sebacic acid is a saturated, straight-chain naturally occurring dicarboxylic acid with 10 carbon atoms. Sebacic acid is a normal urinary acid. In patients with multiple acyl-CoA-dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII) are a group of metabolic disorders due to deficiency of either electron transfer flavoprotein or electron transfer flavoprotein ubiquinone oxidoreductase, biochemical data shows an increase in urine sebacic acid excretion.
CONFIDENCE standard compound; INTERNAL_ID 671; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4109; ORIGINAL_PRECURSOR_SCAN_NO 4104
CONFIDENCE standard compound; INTERNAL_ID 671; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4132; ORIGINAL_PRECURSOR_SCAN_NO 4130
CONFIDENCE standard compound; INTERNAL_ID 671; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4118; ORIGINAL_PRECURSOR_SCAN_NO 4114
CONFIDENCE standard compound; INTERNAL_ID 671; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4132; ORIGINAL_PRECURSOR_SCAN_NO 4129
CONFIDENCE standard compound; INTERNAL_ID 671; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4099; ORIGINAL_PRECURSOR_SCAN_NO 4095
CONFIDENCE standard compound; INTERNAL_ID 671; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4127; ORIGINAL_PRECURSOR_SCAN_NO 4123
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID S017
Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency.
Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency.

同义名列表

29 个代谢物同义名

Sebacic acid, monocadmium salt; Sebacic acid, aluminum salt; 1,8-Octanedicarboxylic acid; Sebacic acid, sodium salt; 1,8-Octanedicarboxylate; Decanedicarboxylic acid; 4-Oxodecanedioic acid; 1,10-Decanedioic acid; Dicarboxylic acid C10; 4,7-Dioxosebacic acid; 1,8-Dicarboxyoctane; N-Decanedioic acid; 4-Oxodecanedioate; 1,10-Decanedioate; Decanedioic acid; Acide sebacique; N-Decanedioate; Sebacinsaeure; Sebacic acids; Sebacic acid; Decanedioate; Seracic acid; Sebacinsaure; Ipomic acid; Iponic acid; FA 10:1;O2; Sebacate; Sebacic acid; Sebacic acid



数据库引用编号

41 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

38 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ALB, APOE, BGLAP, PCK1, PEG3, PVALB
Peripheral membrane protein 1 AP1S2
Nucleus 3 ALB, APOE, PEG3
autophagosome 1 PEG3
cytosol 5 ALB, AP1S2, LIPE, PCK1, SLC2A4
dendrite 3 APOE, BGLAP, RCVRN
trans-Golgi network 1 SLC2A4
centrosome 1 ALB
Cell membrane 5 CD80, CD86, LIPE, SLC2A4, TNF
Lipid-anchor 1 RCVRN
Cytoplasmic side 2 AP1S2, RCVRN
Multi-pass membrane protein 2 RHO, SLC2A4
Synapse 1 PVALB
cell surface 5 BMP2, CD40, CD80, CD86, TNF
glutamatergic synapse 1 APOE
Golgi apparatus 4 ALB, AP1S2, APOE, RHO
Golgi membrane 3 AP1S2, INS, RHO
lysosomal membrane 1 AP1S2
neuronal cell body 3 APOE, CD40, TNF
sarcolemma 1 SLC2A4
Cytoplasm, cytosol 2 LIPE, PCK1
Presynapse 1 SLC2A4
plasma membrane 8 APOE, BMP2, CD40, CD80, CD86, RHO, SLC2A4, TNF
Membrane 8 APOE, CD40, CD80, CD86, LIPE, RCVRN, RHO, SLC2A4
axon 1 PVALB
caveola 1 LIPE
extracellular exosome 8 ALB, APOE, BMP3, CD40, CD86, LYZ, PCK1, SLC2A4
endoplasmic reticulum 3 ALB, APOE, PCK1
extracellular space 10 ALB, APOE, BGLAP, BMP2, BMP3, CD40, IL10, INS, LYZ, TNF
perinuclear region of cytoplasm 1 SLC2A4
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 3 AP1S2, BMP2, CD40
Single-pass type I membrane protein 3 CD40, CD80, CD86
Secreted 7 ALB, APOE, BGLAP, BMP2, BMP3, IL10, INS
extracellular region 9 ALB, APOE, BGLAP, BMP2, BMP3, IL10, INS, LYZ, TNF
anchoring junction 1 ALB
centriolar satellite 1 CD86
ciliary membrane 1 RHO
photoreceptor inner segment 2 RCVRN, RHO
photoreceptor outer segment 2 RCVRN, RHO
CD40 receptor complex 1 CD40
external side of plasma membrane 5 CD40, CD80, CD86, SLC2A4, TNF
varicosity 1 CD40
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 2 APOE, SLC2A4
very-low-density lipoprotein particle 1 APOE
T-tubule 1 SLC2A4
perikaryon 2 BGLAP, RCVRN
Early endosome 2 AP1S2, APOE
Membrane, clathrin-coated pit 1 AP1S2
cell-cell junction 1 RHO
clathrin-coated pit 2 AP1S2, SLC2A4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 BGLAP
Cytoplasm, perinuclear region 1 SLC2A4
Membrane raft 2 SLC2A4, TNF
extracellular matrix 1 APOE
sarcoplasmic reticulum 1 SLC2A4
collagen-containing extracellular matrix 1 APOE
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
Cell projection, cilium, photoreceptor outer segment 2 RCVRN, RHO
Secreted, extracellular space 1 APOE
spindle pole 1 ALB
blood microparticle 2 ALB, APOE
sperm midpiece 1 RHO
Endomembrane system 2 AP1S2, SLC2A4
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Cytoplasmic vesicle membrane 2 AP1S2, SLC2A4
Melanosome 1 APOE
Golgi-associated vesicle membrane 1 RHO
clathrin-coated vesicle 1 SLC2A4
trans-Golgi network membrane 1 AP1S2
trans-Golgi network transport vesicle 1 SLC2A4
secretory granule lumen 1 INS
Golgi lumen 2 BGLAP, INS
endoplasmic reticulum lumen 4 ALB, APOE, BGLAP, INS
platelet alpha granule lumen 1 ALB
Photoreceptor inner segment membrane 1 RHO
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 INS
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
vesicle membrane 1 SLC2A4
clathrin-coated endocytic vesicle membrane 1 APOE
synaptic cleft 1 APOE
AP-type membrane coat adaptor complex 1 AP1S2
membrane coat 1 AP1S2
photoreceptor outer segment membrane 2 RCVRN, RHO
sperm head plasma membrane 1 RHO
AP-1 adaptor complex 1 AP1S2
discoidal high-density lipoprotein particle 1 APOE
photoreceptor disc membrane 1 RHO
endocytic vesicle lumen 1 APOE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
rod photoreceptor outer segment 1 RHO
protein complex involved in cell adhesion 1 CD80
BMP receptor complex 1 BMP2
insulin-responsive compartment 1 SLC2A4
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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