Asiaticoside (BioDeep_00000002583)

Main id: BioDeep_00000400528

 

human metabolite PANOMIX_OTCML-2023 Endogenous Volatile Flavor Compounds natural product


代谢物信息卡片


6-({[3,4-dihydroxy-6-(hydroxymethyl)-5-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl 10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid

化学式: C48H78O19 (958.5137038)
中文名称: 积雪草苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CCC2(C(=O)OC3OC(COC4OC(CO)C(OC5OC(C)C(O)C(O)C5O)C(O)C4O)C(O)C(O)C3O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC43C)C2C1C
InChI: InChI=1S/C48H78O19/c1-20-10-13-48(15-14-46(6)23(29(48)21(20)2)8-9-28-44(4)16-24(51)39(60)45(5,19-50)27(44)11-12-47(28,46)7)43(61)67-42-36(58)33(55)31(53)26(65-42)18-62-40-37(59)34(56)38(25(17-49)64-40)66-41-35(57)32(54)30(52)22(3)63-41/h8,20-22,24-42,49-60H,9-19H2,1-7H3

描述信息

Constituent of Centella asiatica (Asiatic pennywort). Asiaticoside is found in herbs and spices and green vegetables.
Asiaticoside is found in green vegetables. Asiaticoside is a constituent of Centella asiatica (Asiatic pennywort)
D000890 - Anti-Infective Agents
Same as: D07576
Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties.
Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties.

同义名列表

14 个代谢物同义名

6-({[3,4-dihydroxy-6-(hydroxymethyl)-5-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl 10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid; 6-({[3,4-dihydroxy-6-(hydroxymethyl)-5-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl 10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate; 6-({[3,4-dihydroxy-6-(hydroxymethyl)-5-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl 10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,7,8,8a,10,11,12,12b,13,14b-tetradecahydro-1H-picene-4a-carboxylate; Blastoestimulina; Blastostimulina; Dermatologico; Asiaticoside; Marticassol; Asiaticosid; Madecassol; Emdecassol; Centelase; FK 1080; Asiaticoside



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

30 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhilan Hu, Ya Long, Xiangyue Li, Zhiqin Jia, Mingyan Wang, Xuemei Huang, Xiaolan Yu. Effects of asiaticoside on the model of gestational diabetes mellitus in HTR-8/svneo cells via PI3K/AKT pathway. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2024 Dec; 44(1):2350761. doi: 10.1080/01443615.2024.2350761. [PMID: 38785148]
  • Zaynab Mando, Huda Mando, Adlin Afzan, Khozirah Shaari, Zurina Hassan, Mohamad Nurul Azmi Mohamad Taib, Fauziahanim Zakaria. Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies. Behavioural brain research. 2024 May; 466(?):114976. doi: 10.1016/j.bbr.2024.114976. [PMID: 38599249]
  • Ziliang He, Yeye Hu, Ying Zhang, Jing Xie, Zhiqiang Niu, Guigui Yang, Ji Zhang, Zixuan Zhao, Shuai Wei, Haifeng Wu, Weicheng Hu. Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 May; 127(?):155494. doi: 10.1016/j.phymed.2024.155494. [PMID: 38471370]
  • Kunjian Liu, Yu Yin, Chong Shi, Chengqiu Yan, Yiwen Zhang, Li Qiu, Shuangyan He, Guofeng Li. Asiaticoside ameliorates DSS-induced colitis in mice by inhibiting inflammatory response, protecting intestinal barrier and regulating intestinal microecology. Phytotherapy research : PTR. 2024 Apr; 38(4):2023-2040. doi: 10.1002/ptr.8129. [PMID: 38384110]
  • Chennian Xu, Lin Xia, Dengyue Xu, Yang Liu, Ping Jin, Mengen Zhai, Yu Mao, Yiwei Wang, Anguo Wen, Jian Yang, Lifang Yang. Cardioprotective effects of asiaticoside against diabetic cardiomyopathy: Activation of the AMPK/Nrf2 pathway. Journal of cellular and molecular medicine. 2024 Jan; 28(2):e18055. doi: 10.1111/jcmm.18055. [PMID: 38113341]
  • Katarzyna Witkowska, Magdalena Paczkowska-Walendowska, Tomasz Plech, Daria Szymanowska, Bożena Michniak-Kohn, Judyta Cielecka-Piontek. Chitosan-Based Hydrogels for Controlled Delivery of Asiaticoside-Rich Centella asiatica Extracts with Wound Healing Potential. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417229. [PMID: 38139059]
  • Narumon Changsan, Teerapol Srichana, Apichart Atipairin, Somchai Sawatdee. Wound healing efficacy of a polymeric spray film solution containing Centella asiatica leaf extract on acute wounds. Journal of wound care. 2023 Dec; 32(Sup12):S22-S32. doi: 10.12968/jowc.2023.32.sup12.s22. [PMID: 38063299]
  • Temitope Akinwumi Ajani, Kenechukwu Obikeze, Zandisiwe E Magwebu, Samuel Egieyeh, Chesa G Chauke. In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme. BMC pharmacology & toxicology. 2023 11; 24(1):67. doi: 10.1186/s40360-023-00701-x. [PMID: 38007481]
  • Jinyi Sun, Lei Tang, Yun Shan, Manshu Yu, Li Sheng, Liyan Huang, Huimin Cao, Huibo Dai, Funing Wang, Juan Zhao, Meixiao Sheng. TMT quantitative proteomics and network pharmacology reveal the mechanism by which asiaticoside regulates the JAK2/STAT3 signaling pathway to inhibit peritoneal fibrosis. Journal of ethnopharmacology. 2023 Jun; 309(?):116343. doi: 10.1016/j.jep.2023.116343. [PMID: 36906159]
  • Ziliang He, Yeye Hu, Zhiqiang Niu, Kang Zhong, Tingwu Liu, Meng Yang, Lilian Ji, Weicheng Hu. A review of pharmacokinetic and pharmacological properties of asiaticoside, a major active constituent of Centella asiatica (L.) Urb. Journal of ethnopharmacology. 2023 Feb; 302(Pt A):115865. doi: 10.1016/j.jep.2022.115865. [PMID: 36306932]
  • Shinjini Bandopadhyay, Sujata Mandal, Mimosa Ghorai, Niraj Kumar Jha, Manoj Kumar, Radha, Arabinda Ghosh, Jarosław Proćków, José M Pérez de la Lastra, Abhijit Dey. Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review. Journal of cellular and molecular medicine. 2023 Feb; ?(?):. doi: 10.1111/jcmm.17635. [PMID: 36756687]
  • Sujata Mandal, Tuyelee Das, Samapika Nandy, Mimosa Ghorai, Suchismita Chatterjee Saha, Abilash Valsala Gopalakrishnan, Manoj Kumar, Radha, Arabinda Ghosh, Nobendu Mukerjee, Mahipal S Shekhawat, Devendra Kumar Pandey, Abhijit Dey. Biotechnological and endophytic-mediated production of centellosides in Centella asiatica. Applied microbiology and biotechnology. 2023 Feb; 107(2-3):473-489. doi: 10.1007/s00253-022-12316-z. [PMID: 36481800]
  • Xushan Chen, Huimin Zhang, Yuyan Liang, Yao Lu, Xiaofen Xie, Jin Tu, Li Ba, Xuanyue Zhang, Hanjiao Liu. Inflammation-modulating antibacterial hydrogel sustained release asiaticoside for infection wound healing. Biomaterials advances. 2023 Jan; 147(?):213302. doi: 10.1016/j.bioadv.2023.213302. [PMID: 36841110]
  • Xuemei Huang, Zhiqin Jia, Xiangyue Li, Zhilan Hu, Xiaolan Yu, Jiyi Xia. Asiaticoside hampers epithelial-mesenchymal transition by promoting PPARG expression and suppressing P2RX7-mediated TGF-β/Smad signaling in triple-negative breast cancer. Phytotherapy research : PTR. 2022 Nov; ?(?):. doi: 10.1002/ptr.7692. [PMID: 36444395]
  • Shengjie Tang, Xiangcheng Xie, Ming Wang, Lili Yang, Wei Wei. Protective effects of asiaticoside on renal ischemia reperfusion injury in vivo and in vitro. Bioengineered. 2022 04; 13(4):10235-10243. doi: 10.1080/21655979.2022.2061302. [PMID: 35435108]
  • Tussapon Boonyarattanasoonthorn, Anusak Kijtawornrat, Phanit Songvut, Nitra Nuengchamnong, Visarut Buranasudja, Phisit Khemawoot. Increase water solubility of Centella asiatica extract by indigenous bioenhancers could improve oral bioavailability and disposition kinetics of triterpenoid glycosides in beagle dogs. Scientific reports. 2022 02; 12(1):2909. doi: 10.1038/s41598-022-06967-1. [PMID: 35190633]
  • Min Zhang, Shuhuan Liu, Liming Fang, Gang Wang, Liping Yin. Asiaticoside inhibits renal fibrosis development by regulating the miR-142-5p/ACTN4 axis. Biotechnology and applied biochemistry. 2022 Feb; 69(1):313-322. doi: 10.1002/bab.2110. [PMID: 33444480]
  • Amit Jaisi, Prema, Siribhorn Madla, Yuan-E Lee, Abdi Septama, Hiroyuki Morita. Investigation of HIV-1 Viral Protein R Inhibitory Activities of Twelve Thai Medicinal Plants and Their Commercially Available Major Constituents. Chemistry & biodiversity. 2021 Dec; 18(12):e2100540. doi: 10.1002/cbdv.202100540. [PMID: 34599555]
  • Shruthi Vasanth, Regina Sumitha Mohanraj, Jharna Mandal. In-vitro study of the effect of Centella asiatica on cholera toxin production and the gene expression level of ctxA gene in Vibrio cholerae isolates. Journal of ethnopharmacology. 2021 Oct; 279(?):113930. doi: 10.1016/j.jep.2021.113930. [PMID: 33596471]
  • Supannikar Tawinwung, Dhirarin Junsaeng, Supanut Utthiya, Phisit Khemawoot. Immunomodulatory effect of standardized C. asiatica extract on a promotion of regulatory T cells in rats. BMC complementary medicine and therapies. 2021 Sep; 21(1):220. doi: 10.1186/s12906-021-03394-z. [PMID: 34479568]
  • Min Guo, Jianmeng Xu, Shiwei Wang, Baohua Dong. Asiaticoside reduces autophagy and improves memory in a rat model of dementia through mTOR signaling pathway regulation. Molecular medicine reports. 2021 Sep; 24(3):. doi: 10.3892/mmr.2021.12284. [PMID: 34278477]
  • Ahmed Alafnan, Talib Hussain, Syed Mohd Danish Rizvi, Afrasim Moin, Abdulwahab Alamri. Prostate Apoptotic Induction and NFκB Suppression by Dammarolic Acid: Mechanistic Insight into Onco-Therapeutic Action of an Aglycone Asiaticoside. Current issues in molecular biology. 2021 Aug; 43(2):932-940. doi: 10.3390/cimb43020066. [PMID: 34449548]
  • Nur Aziah Hanapi, Ahmad Saifuddin Mohamad Arshad, Jafri Malin Abdullah, Tengku Sifzizul Tengku Muhammad, Siti R Yusof. Blood-Brain Barrier Permeability of Asiaticoside, Madecassoside and Asiatic Acid in Porcine Brain Endothelial Cell Model. Journal of pharmaceutical sciences. 2021 02; 110(2):698-706. doi: 10.1016/j.xphs.2020.09.015. [PMID: 32949562]
  • Ninie Nadia Zulkipli, Rahimah Zakaria, Idris Long, Siti Fadilah Abdullah, Erma Fatiha Muhammad, Habibah A Wahab, Teguh Haryo Sasongko. In Silico Analyses and Cytotoxicity Study of Asiaticoside and Asiatic Acid from Malaysian Plant as Potential mTOR Inhibitors. Molecules (Basel, Switzerland). 2020 Sep; 25(17):. doi: 10.3390/molecules25173991. [PMID: 32887218]
  • Rasyidah Ryta Ayumi, Wan Mastura Shaik Mossadeq, Zainul Amiruddin Zakaria, Muhammad Taher Bakhtiar, Nadhirah Kamarudin, Nadia Hisamuddin, Madihah Talib, Aina Mardhiah Sabar. Antinociceptive Activity of Asiaticoside in Mouse Models of Induced Nociception. Planta medica. 2020 May; 86(8):548-555. doi: 10.1055/a-1144-3663. [PMID: 32294786]
  • Saowanee Wannasarit, Sirima Mahattanadul, Ousanee Issarachot, Panupong Puttarak, Ruedeekorn Wiwattanapatapee. Raft-forming gastro-retentive formulations based on Centella asiatica extract-solid dispersions for gastric ulcer treatment. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2020 Feb; 143(?):105204. doi: 10.1016/j.ejps.2019.105204. [PMID: 31870812]
  • Xuqiang Nie, Han Zhang, Xiujun Shi, Jiufeng Zhao, Yu Chen, Faming Wu, Jianwen Yang, Xiaohui Li. Asiaticoside nitric oxide gel accelerates diabetic cutaneous ulcers healing by activating Wnt/β-catenin signaling pathway. International immunopharmacology. 2020 Feb; 79(?):106109. doi: 10.1016/j.intimp.2019.106109. [PMID: 31865242]
  • Chunhui Zhang, Suyan Chen, Zhenxiang Zhang, Hui Xu, Weihong Zhang, Dongqing Xu, Beilei Lin, Yongxia Mei. Asiaticoside Alleviates Cerebral Ischemia-Reperfusion Injury via NOD2/Mitogen-Activated Protein Kinase (MAPK)/Nuclear Factor kappa B (NF-κB) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. 2020 Feb; 26(?):e920325. doi: 10.12659/msm.920325. [PMID: 32006420]
  • Lang-Jun Mai, Xue-Xing Fu, Gang He, Er-Nong Zhao, Ming Xue. [Effect of asiaticoside on hyperoxia-induced bronchopulmonary dysplasia in neonatal rats and related mechanism]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 2020 Jan; 22(1):71-76. doi: . [PMID: 31948528]
  • Nur Nadia Mohd Razali, Chin Theng Ng, Lai Yen Fong. Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review. Planta medica. 2019 Nov; 85(16):1203-1215. doi: 10.1055/a-1008-6138. [PMID: 31539918]
  • Lisa J Patel, Manan A Raval, Samir G Patel, Archita J Patel. Development and Validation of Stability Indicating High-Performance Thin-Layer Chromatographic (HPTLC) Method for Quantification of Asiaticoside from Centella asiatica L. and its Marketed Formulation. Journal of AOAC International. 2019 Jul; 102(4):1014-1020. doi: 10.5740/jaoacint.18-0381. [PMID: 30572980]
  • Yingrak Boondam, Phanit Songvut, Mayuree H Tantisira, Sompol Tapechum, Kanokwan Tilokskulchai, Narawut Pakaprot. Inverted U-shaped response of a standardized extract of Centella asiatica (ECa 233) on memory enhancement. Scientific reports. 2019 06; 9(1):8404. doi: 10.1038/s41598-019-44867-z. [PMID: 31182820]
  • Mamangam Subaraja, Arambakkam Janardhanam Vanisree. The novel phytocomponent asiaticoside-D isolated from Centella asiatica exhibits monoamine oxidase-B inhibiting potential in the rotenone degenerated cerebral ganglions of Lumbricus terrestris. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 May; 58(?):152833. doi: 10.1016/j.phymed.2019.152833. [PMID: 30903943]
  • Lilei He, Guoju Hong, Lin Zhou, Jianguo Zhang, Jian Fang, Wei He, Jennifer Tickner, Xiaorui Han, Lilian Zhao, Jiake Xu. Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-κB signaling pathways. Journal of cellular physiology. 2019 04; 234(4):4267-4276. doi: 10.1002/jcp.27195. [PMID: 30146787]
  • Li Yingchun, Wang Huihan, Zhang Rong, Zhang Guojun, Yang Ying, Liu Zhuogang. Antitumor Activity of Asiaticoside Against Multiple Myeloma Drug-Resistant Cancer Cells Is Mediated by Autophagy Induction, Activation of Effector Caspases, and Inhibition of Cell Migration, Invasion, and STAT-3 Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. 2019 Feb; 25(?):1355-1361. doi: 10.12659/msm.913397. [PMID: 30785126]
  • Mamangam Subaraja, A Kulandaisamy, N R Siva Shanmugam, Arambakkam Janardhanam Vanisree. Homology modeling identified for purported drug targets to the neuroprotective effects of levodopa and asiaticoside-D in degenerated cerebral ganglions of Lumbricus terrestris. Indian journal of pharmacology. 2019 Jan; 51(1):31-39. doi: 10.4103/ijp.ijp_600_18. [PMID: 31031465]
  • Renu Arora, Ritesh Kumar, Amit Agarwal, K H Reeta, Y K Gupta. Comparison of three different extracts of Centella asiatica for anti-amnesic, antioxidant and anticholinergic activities: in vitro and in vivo study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Sep; 105(?):1344-1352. doi: 10.1016/j.biopha.2018.05.156. [PMID: 30021372]
  • Shubhpriya Gupta, Pankaj Bhatt, Preeti Chaturvedi. Determination and quantification of asiaticoside in endophytic fungus from Centella asiatica (L.) Urban. World journal of microbiology & biotechnology. 2018 Jul; 34(8):111. doi: 10.1007/s11274-018-2493-9. [PMID: 29980864]
  • Ok Tae Kim, Yurry Um, Mei Lan Jin, Jang Uk Kim, Daniela Hegebarth, Lucas Busta, Radu C Racovita, Reinhard Jetter. A Novel Multifunctional C-23 Oxidase, CYP714E19, is Involved in Asiaticoside Biosynthesis. Plant & cell physiology. 2018 Jun; 59(6):1200-1213. doi: 10.1093/pcp/pcy055. [PMID: 29579306]
  • S Jisha, P R Gouri, K N Anith, K K Sabu. Piriformospora indica cell wall extract as the best elicitor for asiaticoside production in Centella asiatica (L.) Urban, evidenced by morphological, physiological and molecular analyses. Plant physiology and biochemistry : PPB. 2018 Apr; 125(?):106-115. doi: 10.1016/j.plaphy.2018.01.021. [PMID: 29438895]
  • Xiaobing Wang, Xueli Cai, Wu Wang, Yi Jin, Mayun Chen, Xiaoying Huang, Xiaochun Zhu, Liangxing Wang. Effect of asiaticoside on endothelial cells in hypoxia‑induced pulmonary hypertension. Molecular medicine reports. 2018 Feb; 17(2):2893-2900. doi: 10.3892/mmr.2017.8254. [PMID: 29257311]
  • Patcharaporn Hengjumrut, Tosapol Anukunwithaya, Mayuree H Tantisira, Boonyong Tantisira, Phisit Khemawoot. Comparative pharmacokinetics between madecassoside and asiaticoside presented in a standardised extract of Centella asiatica, ECa 233 and their respective pure compound given separately in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2018 Jan; 48(1):18-27. doi: 10.1080/00498254.2016.1273562. [PMID: 28001462]
  • Ok Tae Kim, Mei Lan Jin, Dae Young Lee, Reinhard Jetter. Characterization of the Asiatic Acid Glucosyltransferase, UGT73AH1, Involved in Asiaticoside Biosynthesis in Centella asiatica (L.) Urban. International journal of molecular sciences. 2017 Dec; 18(12):. doi: 10.3390/ijms18122630. [PMID: 29210992]
  • Priscila Bianca Rodrigues da Rocha, Bruno Dos Santos Souza, Lígia Marquez Andrade, Ricardo Neves Marreto, Eliana Martins Lima, Stephânia Fleury Taveira. Development of a High-Performance Liquid Chromatographic Method for Asiaticoside Quantification in Different Skin Layers after Topical Application of a Centella asiatica Extract. Planta medica. 2017 Dec; 83(18):1431-1437. doi: 10.1055/s-0043-113325. [PMID: 28651288]
  • Tosapol Anukunwithaya, Mayuree H Tantisira, Boonyong Tantisira, Phisit Khemawoot. Pharmacokinetics of a Standardized Extract of Centella asiatica ECa 233 in Rats. Planta medica. 2017 May; 83(8):710-717. doi: 10.1055/s-0042-122344. [PMID: 27992940]
  • Chun-Hsu Yao, Jen-Yu Yeh, Yueh-Sheng Chen, Ming-Hsien Li, Chiung-Hua Huang. Wound-healing effect of electrospun gelatin nanofibres containing Centella asiatica extract in a rat model. Journal of tissue engineering and regenerative medicine. 2017 03; 11(3):905-915. doi: 10.1002/term.1992. [PMID: 25711743]
  • Qing-Qing Fang, Chun-Ye Chen, Min-Xia Zhang, Chun-Lan Huang, Xiao-Wei Wang, Ji-Hua Xu, Li-Hong Wu, Li-Yun Zhang, Wei-Qiang Tan. The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management. Current pharmaceutical design. 2017; 23(15):2268-2275. doi: 10.2174/1381612822666161025144434. [PMID: 27784253]
  • Amit Kar, Subrata Pandit, Kakali Mukherjee, Shiv Bahadur, Pulok K Mukherjee. Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study. Journal of the science of food and agriculture. 2017 Jan; 97(1):333-340. doi: 10.1002/jsfa.7739. [PMID: 27030208]
  • Chen-Zhen Zhang, Jie Niu, Yee-Song Chong, Yan-Fen Huang, Yang Chu, Sheng-Yang Xie, Zhi-Hong Jiang, Li-Hua Peng. Porous microspheres as promising vehicles for the topical delivery of poorly soluble asiaticoside accelerate wound healing and inhibit scar formation in vitro &in vivo. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2016 Dec; 109(?):1-13. doi: 10.1016/j.ejpb.2016.09.005. [PMID: 27614186]
  • Robert Azerad. Chemical structures, production and enzymatic transformations of sapogenins and saponins from Centella asiatica (L.) Urban. Fitoterapia. 2016 Oct; 114(?):168-187. doi: 10.1016/j.fitote.2016.07.011. [PMID: 27491750]
  • Jiayu Wang, Changhua Ma, Chengjie Guo, Ruijuan Yuan, Xueyan Zhan. CTG-loaded liposomes as an approach for improving the intestinal absorption of asiaticoside in Centella Total Glucosides. International journal of pharmaceutics. 2016 Jul; 509(1-2):296-304. doi: 10.1016/j.ijpharm.2016.05.044. [PMID: 27251012]
  • Cláudio Rodrigues Rezende Costa, Bruna Rabelo Amorim, Pérola de Magalhães, Graziela De Luca Canto, Ana Carolina Acevedo, Eliete Neves Silva Guerra. Effects of Plants on Osteogenic Differentiation and Mineralization of Periodontal Ligament Cells: A Systematic Review. Phytotherapy research : PTR. 2016 Apr; 30(4):519-31. doi: 10.1002/ptr.5568. [PMID: 26822584]
  • Tao Sun, Bin Liu, Peng Li. Nerve Protective Effect of Asiaticoside against Ischemia-Hypoxia in Cultured Rat Cortex Neurons. Medical science monitor : international medical journal of experimental and clinical research. 2015 Oct; 21(?):3036-41. doi: 10.12659/msm.894024. [PMID: 26447863]
  • Lai Yen Fong, Chin Theng Ng, Zainul Amiruddin Zakaria, Mohamad Taufik Hidayat Baharuldin, Abdul Kadir Arifah, Muhammad Nazrul Hakim, Ahmad Zuraini. Asiaticoside Inhibits TNF-α-Induced Endothelial Hyperpermeability of Human Aortic Endothelial Cells. Phytotherapy research : PTR. 2015 Oct; 29(10):1501-8. doi: 10.1002/ptr.5404. [PMID: 26171791]
  • Zhujun Yin, Haiyang Yu, She Chen, Chunhua Ma, Xiao Ma, Lixing Xu, Zhanqiang Ma, Rong Qu, Shiping Ma. Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway. Behavioural brain research. 2015 Oct; 292(?):288-99. doi: 10.1016/j.bbr.2015.06.024. [PMID: 26097002]
  • Xiao-Bing Wang, Wu Wang, Xiao-Chun Zhu, Wen-Jing Ye, Hui Cai, Pei-Liang Wu, Xiao-Ying Huang, Liang-Xing Wang. The potential of asiaticoside for TGF-β1/Smad signaling inhibition in prevention and progression of hypoxia-induced pulmonary hypertension. Life sciences. 2015 Sep; 137(?):56-64. doi: 10.1016/j.lfs.2015.07.016. [PMID: 26209140]
  • Shahdat Hossain, Michio Hashimoto, Masanori Katakura, Abdullah Al Mamun, Osamu Shido. Medicinal value of asiaticoside for Alzheimer's disease as assessed using single-molecule-detection fluorescence correlation spectroscopy, laser-scanning microscopy, transmission electron microscopy, and in silico docking. BMC complementary and alternative medicine. 2015 Apr; 15(?):118. doi: 10.1186/s12906-015-0620-9. [PMID: 25880304]
  • Vijeta Bobade, Subhash L Bodhankar, Urmila Aswar, Mohan Vishwaraman, Prasad Thakurdesai. Prophylactic effects of asiaticoside-based standardized extract of Centella asiatica (L.) Urban leaves on experimental migraine: Involvement of 5HT1A/1B receptors. Chinese journal of natural medicines. 2015 Apr; 13(4):274-82. doi: 10.1016/s1875-5364(15)30014-5. [PMID: 25908624]
  • Yuejuan Zheng, Xin Jiang, Feng Gao, Junxiang Song, Jinxia Sun, Lixin Wang, Xiaoxia Sun, Zhenhui Lu, Huiyong Zhang. Identification of plant-derived natural products as potential inhibitors of the Mycobacterium tuberculosis proteasome. BMC complementary and alternative medicine. 2014 Oct; 14(?):400. doi: 10.1186/1472-6882-14-400. [PMID: 25315519]
  • Arun Rasheed, Madam Teja Sri, Kotappadath Pillanayil Mohammed-Haneefa, Raveendran Pillai Arun-Kumar, Abdul Kharim Azeem. Formulation, standardization and pharmacological studies of Saraswataristam: a polyhedral preparation. Pakistan journal of pharmaceutical sciences. 2014 Sep; 27(5):1163-9. doi: ". [PMID: 25176373]
  • Wiesława Bylka, Paulina Znajdek-Awiżeń, Elżbieta Studzińska-Sroka, Aleksandra Dańczak-Pazdrowska, Małgorzata Brzezińska. Centella asiatica in dermatology: an overview. Phytotherapy research : PTR. 2014 Aug; 28(8):1117-24. doi: 10.1002/ptr.5110. [PMID: 24399761]
  • Shi-Qiang Hou, Ming Fang, Sha-Sha Chen, Xin-Peng Cong, Da-Dong Zhang, Xin-Ming Li. [Biochemical regulatory mechanism of asiaticoside in preventing and treating stent restenosis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 Apr; 39(8):1479-84. doi: . [PMID: 25039186]
  • Fatma J Al-Saeedi. Study of the cytotoxicity of asiaticoside on rats and tumour cells. BMC cancer. 2014 Mar; 14(?):220. doi: 10.1186/1471-2407-14-220. [PMID: 24667059]
  • Qian Shen, Lu-shan Yu, Hui Zhou, Su Zeng. [Simultaneous determination of madecassoside, asiaticoside and their aglycones in Centella asiatica (L.) urban extracts by RP-HPLC]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2014 03; 43(2):135-40. doi: 10.3785/j.issn.1008-9292.2014.03.002. [PMID: 24782366]
  • Agung Endro Nugroho, Novena Yety Lindawati, Kyky Herlyanti, Lina Widyastuti, Suwidjiyo Pramono. Anti-diabetic effect of a combination of andrographolide-enriched extract of Andrographis paniculata (Burm f.) Nees and asiaticoside-enriched extract of Centella asiatica L. in high fructose-fat fed rats. Indian journal of experimental biology. 2013 Dec; 51(12):1101-8. doi: ". [PMID: 24579376]
  • Quanfang Huang, Shijun Zhang, Renbin Huang, Ling Wei, Yongxing Chen, Shujuan Lv, Chunhong Liang, Shimei Tan, Shuang Liang, Lang Zhuo, Xing Lin. Isolation and identification of an anti-hepatitis B virus compound from Hydrocotyle sibthorpioides Lam. Journal of ethnopharmacology. 2013 Nov; 150(2):568-75. doi: 10.1016/j.jep.2013.09.009. [PMID: 24051027]
  • Yan Ren, Xing-Dong He, Bei-Cheng Shang, Xiu-Kun Bao, Yan-Fang Wang, Ji-Sheng Ma. [Analysis on preparation and characterization of asiaticoside-loaded flexible nanoliposomes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Oct; 38(19):3282-6. doi: ". [PMID: 24422392]
  • Nguyen Hoang Loc, Nguyen Thi Duy Nhat. Production of asiaticoside from centella (Centella asiatica L. Urban) cells in bioreactor. Asian Pacific journal of tropical biomedicine. 2013 Oct; 3(10):806-10. doi: 10.1016/s2221-1691(13)60159-8. [PMID: 24075346]
  • Zhu Wang, Juntian Liu, Wansen Sun. Effects of asiaticoside on levels of podocyte cytoskeletal proteins and renal slit diaphragm proteins in adriamycin-induced rat nephropathy. Life sciences. 2013 Sep; 93(8):352-8. doi: 10.1016/j.lfs.2013.07.010. [PMID: 23871990]
  • Neelesh Kumar Nema, Niladri Maity, Birendra Kumar Sarkar, Pulok Kumar Mukherjee. Matrix metalloproteinase, hyaluronidase and elastase inhibitory potential of standardized extract of Centella asiatica. Pharmaceutical biology. 2013 Sep; 51(9):1182-7. doi: 10.3109/13880209.2013.782505. [PMID: 23763301]
  • JingYuan Wan, Xia Gong, Rong Jiang, Zhuo Zhang, Li Zhang. Antipyretic and anti-inflammatory effects of asiaticoside in lipopolysaccharide-treated rat through up-regulation of heme oxygenase-1. Phytotherapy research : PTR. 2013 Aug; 27(8):1136-42. doi: 10.1002/ptr.4838. [PMID: 22972613]
  • Xing Lin, Renbin Huang, Shijun Zhang, Ling Wei, Lang Zhuo, Xiaoyan Wu, Aicun Tang, Quanfang Huang. Beneficial effects of asiaticoside on cognitive deficits in senescence-accelerated mice. Fitoterapia. 2013 Jun; 87(?):69-77. doi: 10.1016/j.fitote.2013.03.023. [PMID: 23562630]
  • Jacinda T James, Fidele Tugizimana, Paul A Steenkamp, Ian A Dubery. Metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb Centella asiatica (L.) urban. Molecules (Basel, Switzerland). 2013 Apr; 18(4):4267-81. doi: 10.3390/molecules18044267. [PMID: 23579994]
  • P Puttarak, P Panichayupakaranant. Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials. Pharmaceutical biology. 2012 Dec; 50(12):1508-12. doi: 10.3109/13880209.2012.685946. [PMID: 22966846]
  • Jeong-Hyun Lee, Hye-Lee Kim, Mi Hee Lee, Kyung Eun You, Byeong-Ju Kwon, Hyok Jin Seo, Jong-Chul Park. Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Oct; 19(13):1223-7. doi: 10.1016/j.phymed.2012.08.002. [PMID: 22939261]
  • Donatella Paolino, Donato Cosco, Felisa Cilurzo, Elena Trapasso, Valeria M Morittu, Christian Celia, Massimo Fresta. Improved in vitro and in vivo collagen biosynthesis by asiaticoside-loaded ultradeformable vesicles. Journal of controlled release : official journal of the Controlled Release Society. 2012 Aug; 162(1):143-51. doi: 10.1016/j.jconrel.2012.05.050. [PMID: 22698941]
  • Jisha Satheesan, Anith K Narayanan, Manjula Sakunthala. Induction of root colonization by Piriformospora indica leads to enhanced asiaticoside production in Centella asiatica. Mycorrhiza. 2012 Apr; 22(3):195-202. doi: 10.1007/s00572-011-0394-y. [PMID: 21688071]
  • Archana Prasad, Archana Mathur, Manju Singh, Madan M Gupta, Girish C Uniyal, Raj K Lal, Ajay K Mathur. Growth and asiaticoside production in multiple shoot cultures of a medicinal herb, Centella asiatica (L.) Urban, under the influence of nutrient manipulations. Journal of natural medicines. 2012 Apr; 66(2):383-7. doi: 10.1007/s11418-011-0588-9. [PMID: 21947691]
  • Boonchoo Sritularak, Thaweesak Juengwatanatrakul, Waraporn Putalun, Hiroyuki Tanaka, Satoshi Morimoto. A rapid one-step immunochromatographic assay for the detection of asiaticoside. Journal of natural medicines. 2012 Apr; 66(2):279-83. doi: 10.1007/s11418-011-0582-2. [PMID: 21874622]
  • Chang-Liang Xu, Qi-Zhi Wang, Ling-Mei Sun, Xiu-Min Li, Ji-Min Deng, Lu-Fan Li, Jin Zhang, Rong Xu, Shi-Ping Ma. Asiaticoside: attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax. Pharmacology, biochemistry, and behavior. 2012 Jan; 100(3):413-8. doi: 10.1016/j.pbb.2011.09.014. [PMID: 22001429]
  • Zeliha Akdemir, Ciğdem Kahraman, I Irem Tatlı, Esra Küpeli Akkol, Ipek Süntar, Hikmet Keles. Bioassay-guided isolation of anti-inflammatory, antinociceptive and wound healer glycosides from the flowers of Verbascum mucronatum Lam. Journal of ethnopharmacology. 2011 Jul; 136(3):436-43. doi: 10.1016/j.jep.2010.05.059. [PMID: 20621642]
  • Ipek Süntar, Esra Küpeli Akkol, Fatma Sezer Senol, Hikmet Keles, Ilkay Erdogan Orhan. Investigating wound healing, tyrosinase inhibitory and antioxidant activities of the ethanol extracts of Salvia cryptantha and Salvia cyanescens using in vivo and in vitro experimental models. Journal of ethnopharmacology. 2011 Apr; 135(1):71-7. doi: 10.1016/j.jep.2011.02.022. [PMID: 21354290]
  • Ipek Süntar, Ayşe Baldemir, Maksut Coşkun, Hikmet Keleş, Esra Küpeli Akkol. Wound healing acceleration effect of endemic Ononis species growing in Turkey. Journal of ethnopharmacology. 2011 Apr; 135(1):63-70. doi: 10.1016/j.jep.2011.02.023. [PMID: 21354296]
  • Thaweesak Juengwatanatrakul, Boonchoo Sritularak, Paveena Amornnopparattanakul, Patcharin Tassanawat, Waraporn Putalun, Hiroyuki Tanaka, Satoshi Morimoto. Preparation of a specific monoclonal antibody to asiaticoside for the development of an enzyme-linked immunosorbent assay. The Analyst. 2011 Mar; 136(5):1013-7. doi: 10.1039/c0an00868k. [PMID: 21180694]
  • Ipek Süntar, I Irem Tatlı, Esra Küpeli Akkol, Hikmet Keleş, Çiğdem Kahraman, Zeliha Akdemir. An ethnopharmacological study on Verbascum species: from conventional wound healing use to scientific verification. Journal of ethnopharmacology. 2010 Nov; 132(2):408-13. doi: 10.1016/j.jep.2010.08.004. [PMID: 20709167]
  • Orawan Suwantong, Uracha Ruktanonchai, Pitt Supaphol. In vitro biological evaluation of electrospun cellulose acetate fiber mats containing asiaticoside or curcumin. Journal of biomedical materials research. Part A. 2010 Sep; 94(4):1216-25. doi: 10.1002/jbm.a.32797. [PMID: 20694988]
  • Xiao Song Liu, Yan Gao, Li Wu Zheng, Hong Hua. New alternative therapy for orofacial localized scleroderma. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2010 Sep; 110(3):e15-9. doi: 10.1016/j.tripleo.2010.04.004. [PMID: 20634110]
  • Li Zhang, Hong-Zhong Li, Xia Gong, Fu-Ling Luo, Bin Wang, Ning Hu, Chang-Dong Wang, Zhuo Zhang, Jing-Yuan Wan. Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Aug; 17(10):811-9. doi: 10.1016/j.phymed.2010.01.008. [PMID: 20171071]
  • Yan Pan, Badrul Amini Abd-Rashid, Zakiah Ismail, Rusli Ismail, Joon Wah Mak, Peter C K Pook, Hui Meng Er, Chin Eng Ong. In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica. Journal of ethnopharmacology. 2010 Jul; 130(2):275-83. doi: 10.1016/j.jep.2010.05.002. [PMID: 20457244]
  • Jiajia Zheng, Li'na Zhang, Mengjiao Wu, Xiaohui Li, Li Zhang, Jingyuan Wan. [Protective effects of asiaticoside on sepsis-induced acute kidney injury in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Jun; 35(11):1482-5. doi: . [PMID: 20822026]
  • Ipek Peşin Süntar, Esra Küpeli Akkol, Funda Nuray Yalçin, Ufuk Koca, Hikmet Keleş, Erdem Yesilada. Wound healing potential of Sambucus ebulus L. leaves and isolation of an active component, quercetin 3-O-glucoside. Journal of ethnopharmacology. 2010 May; 129(1):106-14. doi: 10.1016/j.jep.2010.01.051. [PMID: 20132876]
  • Zouhir Djerrou, Z Maameri, Y Hamdi-Pacha, M Serakta, F Riachi, H Djaalab, A Boukeloua. Effect of virgin fatty oil of Pistacia lentiscus on experimental burn wound's healing in rabbits. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2010 Apr; 7(3):258-63. doi: 10.4314/ajtcam.v7i3.54788. [PMID: 21461154]
  • Ok Tae Kim, Sun Hee Kim, Kiyoshi Ohyama, Toshiya Muranaka, Yong Eui Choi, Hyeon Yong Lee, Min Young Kim, Baik Hwang. Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase. Plant cell reports. 2010 Apr; 29(4):403-11. doi: 10.1007/s00299-010-0831-y. [PMID: 20195611]
  • Esra Küpeli Akkol, Ufuk Koca, Ipek Peşin, Demet Yilmazer, Gülnur Toker, Erdem Yeşilada. Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in vivo models. Journal of ethnopharmacology. 2009 Jul; 124(1):137-41. doi: 10.1016/j.jep.2009.03.019. [PMID: 19500923]
  • Mingzhe Gao, Xiaoyan Yuan, Hongbin Xiao. [Preparation of asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb using preparative high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2008 May; 26(3):362-5. doi: ". [PMID: 18724677]
  • Yoshiyuki Kimura, Maho Sumiyoshi, Kei-Ichi Samukawa, Noriko Satake, Masahiro Sakanaka. Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism. European journal of pharmacology. 2008 Apr; 584(2-3):415-23. doi: 10.1016/j.ejphar.2008.02.036. [PMID: 18353310]
  • Feng-Lun Zhang, Ying-Jie Wei, Jia Zhu, Zhu-Nan Gong. Simultaneous quantitation of three major triterpenoid glycosides in Centella asiatica extracts by high performance liquid chromatography with evaporative light scattering detection. Biomedical chromatography : BMC. 2008 Feb; 22(2):119-24. doi: 10.1002/bmc.901. [PMID: 17703474]
  • Ok-Tae Kim, Kyong-Hwan Bang, Yu-Su Shin, Min-Jeong Lee, Su-Jin Jung, Dong-Yun Hyun, Young-Chang Kim, Nak-Sul Seong, Seon-Woo Cha, Baik Hwang. Enhanced production of asiaticoside from hairy root cultures of Centella asiatica (L.) Urban elicited by methyl jasmonate. Plant cell reports. 2007 Nov; 26(11):1941-9. doi: 10.1007/s00299-007-0400-1. [PMID: 17632725]
  • Hong-zhong Li, Jing-yuan Wan, Li Zhang, Qi-xin Zhou, Fu-ling Luo, Zhuo Zhang. [Inhibitiory action of asiaiticoside on collagen-induced arthritis in mice]. Yao xue xue bao = Acta pharmaceutica Sinica. 2007 Jul; 42(7):698-703. doi: . [PMID: 17882951]