19(S)-HETE (BioDeep_00000002523)

   

human metabolite Endogenous


代谢物信息卡片


(5Z,8Z,11Z,14Z)-(19S)-19-Hydroxyeicosa-5,8,11,14-tetraenoic acid

化学式: C20H32O3 (320.2351)
中文名称: 5,8,11,14-二十碳四烯酸，19-羟基-（5Z，8Z，11Z，14Z，19R）
谱图信息: 最多检出来源 Viridiplantae(plant) 5.99%

分子结构信息

SMILES: CC(CCCC=CCC=CCC=CCC=CCCCC(=O)O)O
InChI: InChI=1S/C20H32O3/c1-19(21)17-15-13-11-9-7-5-3-2-4-6-8-10-12-14-16-18-20(22)23/h3-6,9-12,19,21H,2,7-8,13-18H2,1H3,(H,22,23)

描述信息

19(S)-HETE is an intermediate in Arachidonic acid metabolism. 19(S)-HETE is converted from Arachidonic acid via the enzyme CYP2U and Unspecific. Monooxygenase. (EC:1.14.14.1).
19(S)-HETE is an intermediate in Arachidonic acid metabolism. 19(S)-HETE is converted from Arachidonic acid via the enzyme CYP2U and Unspecific

同义名列表

29 个代谢物同义名

(5Z,8Z,11Z,14Z)-(19S)-19-Hydroxyeicosa-5,8,11,14-tetraenoic acid; (5Z,8Z,11Z,14Z,19S)-19-Hydroxyeicosa-5,8,11,14-tetraenoic acid; (19S,5Z,8Z,11Z,14Z)-19-Hydroxy-5,8,11,14-eicosatetraenoic acid; (5Z,8Z,11Z,14Z,19S)-19-Hydroxyicosa-5,8,11,14-tetraenoic acid; (5Z,8Z,11Z,14Z)-(19S)-19-Hydroxyeicosa-5,8,11,14-tetraenoate; (19S,5Z,8Z,11Z,14Z)-19-Hydroxy-5,8,11,14-eicosatetraenoate; (5Z,8Z,11Z,14Z,19S)-19-Hydroxyeicosa-5,8,11,14-tetraenoate; (5Z,8Z,11Z,14Z,19S)-19-Hydroxyicosa-5,8,11,14-tetraenoate; 19(S)-Hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid; 19(S)-Hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoate; 19(S)-Hydroxy-all-cis-5,8,11,14-eicosatetraenoic acid; 19(S)-Hydroxy-all-cis-5,8,11,14-eicosatetraenoate; 19S-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid; 19R-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid; 19-Hydroxy-5,8,11,14-eicosatetraenoic acid; (19S)-Hydroxyeicosatetraenoic acid; 19(S)-Hydroxyeicosatetraenoic acid; (19S)-Hydroxyicosatetraenoic acid; (19S)-Hydroxy arachidonic acid; (19S)-Hydroxyeicosatetraenoate; (19S)-Hydroxyicosatetraenoate; (19S)-Hydroxy arachidonate; 19(R)-HETE; 19(S)-HETE; 19S-HETE; 19-HETE; 19(S)-HETE; 5,8,11,14-Eicosatetraenoic acid, 19-hydroxy-, (5Z,8Z,11Z,14Z,19R)-; (S,5Z,8Z,11Z,14Z)-19-Hydroxyicosa-5,8,11,14-tetraenoic acid



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

46 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AHR, CYP1A1, CYP2E1, CYP4A11, FST, NCAPG, NOS3, PTGS1, PTGS2, VASP
Peripheral membrane protein 5 CYP1A1, CYP2E1, CYP4A11, PTGS1, PTGS2
Endoplasmic reticulum membrane 6 CYP1A1, CYP1A2, CYP2E1, CYP4A11, PTGS1, PTGS2
Nucleus 5 AHR, FST, LCORL, NCAPG, NOS3
cytosol 5 AHR, NCAPG, NOS3, PTGIR, VASP
nucleoplasm 2 AHR, NOS3
Cell membrane 3 GPRC5A, PTGIR, TBXA2R
lamellipodium 1 VASP
Multi-pass membrane protein 4 GPRC5A, PTGIR, SLC45A2, TBXA2R
glutamatergic synapse 1 VASP
Golgi apparatus 2 NOS3, PTGS1
Golgi membrane 1 NOS3
lysosomal membrane 1 EGF
mitochondrial inner membrane 2 CYP1A1, CYP2E1
postsynapse 1 VASP
acrosomal vesicle 1 TBXA2R
plasma membrane 7 EGF, F2, GPRC5A, NOS3, PTGIR, TBXA2R, VASP
Membrane 5 CYP4A11, EGF, NCAPG, PTGIR, SLC45A2
apical plasma membrane 1 CYP4A11
caveola 2 NOS3, PTGS2
extracellular exosome 5 EGF, F2, GPRC5A, PTGS1, VASP
endoplasmic reticulum 1 PTGS2
extracellular space 5 CXCL8, EGF, F13A1, F2, FST
perinuclear region of cytoplasm 1 NOS3
Cell junction, tight junction 1 VASP
bicellular tight junction 1 VASP
mitochondrion 1 CYP1A1
protein-containing complex 2 AHR, PTGS2
intracellular membrane-bounded organelle 6 CYP1A1, CYP1A2, CYP2E1, CYP4A11, GPRC5A, PTGS1
Microsome membrane 6 CYP1A1, CYP1A2, CYP2E1, CYP4A11, PTGS1, PTGS2
filopodium 1 VASP
Secreted 3 CXCL8, F13A1, F2
extracellular region 5 CXCL8, EGF, F13A1, F2, FST
transcription regulator complex 1 AHR
photoreceptor outer segment 1 PTGS1
actin cytoskeleton 1 VASP
nucleolus 1 GPRC5A
Melanosome membrane 1 SLC45A2
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
vesicle 1 GPRC5A
Cell projection, lamellipodium 1 VASP
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
Cytoplasm, cytoskeleton 1 VASP
focal adhesion 1 VASP
collagen-containing extracellular matrix 2 F13A1, F2
nuclear speck 1 TBXA2R
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 GPRC5A
neuron projection 2 PTGS1, PTGS2
chromatin 1 AHR
cell projection 1 VASP
Chromosome 1 NCAPG
cytoskeleton 2 NOS3, VASP
condensed chromosome, centromeric region 1 NCAPG
blood microparticle 2 F13A1, F2
Endomembrane system 1 PTGS1
aryl hydrocarbon receptor complex 1 AHR
Cytoplasmic vesicle membrane 1 GPRC5A
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
filopodium membrane 1 VASP
Golgi lumen 1 F2
endoplasmic reticulum lumen 2 F2, PTGS2
platelet alpha granule lumen 2 EGF, F13A1
endocytic vesicle membrane 1 NOS3
condensed nuclear chromosome 1 NCAPG
clathrin-coated endocytic vesicle membrane 1 EGF
condensed chromosome 1 NCAPG
transferase complex 1 F13A1
condensin complex 1 NCAPG
lamellipodium membrane 1 VASP
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR


文献列表

  • Inge Van Bogaert, Guodong Zhang, Jun Yang, Jun-Yan Liu, Yonghao Ye, Wim Soetaert, Bruce D Hammock. Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola. Journal of lipid research. 2013 Nov; 54(11):3215-9. doi: 10.1194/jlr.d042226. [PMID: 23966667]
  • Aurore Devos, Christian Lacks Lino Cardenas, François Glowacki, Anne Engels, Jean-Marc Lo-Guidice, Dany Chevalier, Delphine Allorge, Franck Broly, Christelle Cauffiez. Genetic polymorphism of CYP2U1, a cytochrome P450 involved in fatty acids hydroxylation. Prostaglandins, leukotrienes, and essential fatty acids. 2010 Aug; 83(2):105-10. doi: 10.1016/j.plefa.2010.06.005. [PMID: 20630735]
  • Yoshihiro Konno, Hiroki Kamino, Rick Moore, Fred Lih, Kenneth B Tomer, Darryl C Zeldin, Joyce A Goldstein, Masahiko Negishi. The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver. Drug metabolism and disposition: the biological fate of chemicals. 2010 Jul; 38(7):1177-82. doi: 10.1124/dmd.110.032334. [PMID: 20371638]
  • N Rimmerman, H B Bradshaw, A Basnet, B Tan, Theodore S Widlanski, J M Walker. Microsomal omega-hydroxylated metabolites of N-arachidonoyl dopamine are active at recombinant human TRPV1 receptors. Prostaglandins & other lipid mediators. 2009 Jan; 88(1-2):10-7. doi: 10.1016/j.prostaglandins.2008.08.004. [PMID: 18812233]
  • Igor Ivanov, Jan Saam, Hartmut Kuhn, Hermann-Georg Holzhütter. Dual role of oxygen during lipoxygenase reactions. The FEBS journal. 2005 May; 272(10):2523-35. doi: 10.1111/j.1742-4658.2005.04673.x. [PMID: 15885101]
  • Ingrid Fleming. Cytochrome P-450 under pressure: more evidence for a link between 20-hydroxyeicosatetraenoic acid and hypertension. Circulation. 2005 Jan; 111(1):5-7. doi: 10.1161/01.cir.0000152695.11867.d8. [PMID: 15630035]
  • Samuel M Poloyac, Michael A Tortorici, Danielle I Przychodzin, Robert B Reynolds, Wen Xie, Reginald F Frye, Michael A Zemaitis. The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney. Drug metabolism and disposition: the biological fate of chemicals. 2004 Jul; 32(7):727-33. doi: 10.1124/dmd.32.7.727. [PMID: 15205388]
  • R Quigley, M Baum, K M Reddy, J C Griener, J R Falck. Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport. American journal of physiology. Renal physiology. 2000 Jun; 278(6):F949-53. doi: 10.1152/ajprenal.2000.278.6.f949. [PMID: 10836982]
  • K Mao, K K Reddy, J R Falck, J C McGiff, M Balazy. New group of lipid mediators containing omega-hydroxyarachadonic acid (20-HETE). Advances in experimental medicine and biology. 1997; 433(?):55-9. doi: 10.1007/978-1-4899-1810-9_10. [PMID: 9561103]