Thromboxane B2 (BioDeep_00000002514)

 

Secondary id: BioDeep_00000629602, BioDeep_00001870902

human metabolite Endogenous blood metabolite natural product


代谢物信息卡片


(5Z)-7-[(2R,3S,4S)-4,6-dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]oxan-3-yl]hept-5-enoic acid

化学式: C20H34O6 (370.2355)
中文名称: 凝血氧烷 B2
谱图信息: 最多检出来源 Homo sapiens(blood) 19.84%

分子结构信息

SMILES: CCCCCC(C=CC1C(C(CC(O1)O)O)CC=CCCCC(=O)O)O
InChI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20-/m0/s1

描述信息

Thromboxanes. A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin). -- Pubchem. Thromboxanes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways.
Thromboxanes

同义名列表

9 个代谢物同义名

(5Z)-7-[(2R,3S,4S)-4,6-dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]oxan-3-yl]hept-5-enoic acid; (Z)-7-[(2R,3S,4S,6S)-4,6-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]oxan-3-yl]hept-5-enoic acid; 9S,11,15S-trihydroxy-thromboxa-5Z,13E-dien-1-oic acid; TXB2 (Thromboxane B2); b2, Thromboxane; Thromboxane B2; TXB2; PhD; Thromboxane B2



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

59 个相关的代谢反应过程信息。

Reactome(5)

BioCyc(0)

WikiPathways(8)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ALB, ALOX5, EDN1, PF4, PLA2G12A, PTGS1, PTGS2
Peripheral membrane protein 4 ALOX5, AP1S2, PTGS1, PTGS2
Endoplasmic reticulum membrane 2 PTGS1, PTGS2
Nucleus 1 ALB
cytosol 4 ALB, ALOX5, AP1S2, PRKCQ
centrosome 1 ALB
nucleoplasm 1 ALOX5
Cell membrane 3 CYSLTR2, TBXA2R, TNF
Cytoplasmic side 1 AP1S2
Multi-pass membrane protein 2 CYSLTR2, TBXA2R
cell surface 2 C3, TNF
Golgi apparatus 3 ALB, AP1S2, PTGS1
Golgi membrane 2 AP1S2, INS
lysosomal membrane 1 AP1S2
neuronal cell body 1 TNF
Cytoplasm, cytosol 1 ALOX5
acrosomal vesicle 1 TBXA2R
plasma membrane 7 C3, CYSLTR2, F2, PRKCQ, SERPINC1, TBXA2R, TNF
caveola 1 PTGS2
extracellular exosome 5 ALB, C3, F2, PTGS1, SERPINC1
endoplasmic reticulum 2 ALB, PTGS2
extracellular space 13 ALB, ALOX5, C3, CCL2, EDN1, F2, IL10, IL6, INS, PF4, PPBP, SERPINC1, TNF
perinuclear region of cytoplasm 1 ALOX5
protein-containing complex 3 ALB, C3, PTGS2
intracellular membrane-bounded organelle 2 AP1S2, PTGS1
Microsome membrane 2 PTGS1, PTGS2
Secreted 10 ALB, C3, CCL2, EDN1, F2, IL10, IL6, INS, PF4, PLA2G12A
extracellular region 14 ALB, ALOX5, C3, CCL2, EDN1, F2, IL10, IL6, INS, PF4, PLA2G12A, PPBP, SERPINC1, TNF
basal part of cell 1 EDN1
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
photoreceptor outer segment 1 PTGS1
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
external side of plasma membrane 1 TNF
Early endosome 1 AP1S2
Membrane, clathrin-coated pit 1 AP1S2
clathrin-coated pit 1 AP1S2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 ALOX5
Membrane raft 1 TNF
collagen-containing extracellular matrix 3 F2, PF4, SERPINC1
nuclear speck 1 TBXA2R
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 PTGS1, PTGS2
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
Secreted, extracellular space 1 SERPINC1
spindle pole 1 ALB
blood microparticle 4 ALB, C3, F2, SERPINC1
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
Endomembrane system 2 AP1S2, PTGS1
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 AP1S2
trans-Golgi network membrane 1 AP1S2
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 3 ALOX5, C3, INS
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 7 ALB, C3, F2, IL6, INS, PTGS2, SERPINC1
nuclear matrix 1 ALOX5
platelet alpha granule lumen 3 ALB, PF4, PPBP
tertiary granule lumen 1 PPBP
transport vesicle 2 EDN1, INS
azurophil granule lumen 1 C3
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
AP-type membrane coat adaptor complex 1 AP1S2
membrane coat 1 AP1S2
AP-1 adaptor complex 1 AP1S2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
interleukin-6 receptor complex 1 IL6
Nucleus intermembrane space 1 ALOX5
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Neven Žarković, Wojciech Łuczaj, Iwona Jarocka-Karpowicz, Biserka Orehovec, Bruno Baršić, Marko Tarle, Marta Kmet, Ivica Lukšić, Michał Biernacki, Elżbieta Skrzydlewska. Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital. International journal of molecular sciences. 2022 Oct; 23(19):. doi: 10.3390/ijms231911810. [PMID: 36233111]
  • Jeffrey J Rade, Bruce A Barton, Ramachandran S Vasan, Shari S Kronsberg, Vanessa Xanthakis, John F Keaney, Naomi M Hamburg, Nikolaos Kakouros, Thomas A Kickler. Association of Thromboxane Generation With Survival in Aspirin Users and Nonusers. Journal of the American College of Cardiology. 2022 07; 80(3):233-250. doi: 10.1016/j.jacc.2022.04.034. [PMID: 35660296]
  • Essa Hariri, Nikolaos Kakouros, David A Bunsick, Stuart D Russell, James O Mudd, Katherine Laws, Mikhailia W Lake, Jeffrey J Rade. Nonplatelet thromboxane generation is associated with impaired cardiovascular performance and mortality in heart failure. American journal of physiology. Heart and circulatory physiology. 2022 07; 323(1):H248-H255. doi: 10.1152/ajpheart.00212.2022. [PMID: 35714178]
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