Thromboxane B2 (BioDeep_00000002514)

 

Secondary id: BioDeep_00000629602, BioDeep_00001870902

human metabolite Endogenous blood metabolite Volatile Flavor Compounds natural product


代谢物信息卡片


(5Z)-7-[(2R,3S,4S)-4,6-dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]oxan-3-yl]hept-5-enoic acid

化学式: C20H34O6 (370.2355264)
中文名称: 凝血氧烷 B2
谱图信息: 最多检出来源 Homo sapiens(blood) 1.54%

分子结构信息

SMILES: CCCCCC(C=CC1C(C(CC(O1)O)O)CC=CCCCC(=O)O)O
InChI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20-/m0/s1

描述信息

Thromboxanes. A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin). -- Pubchem. Thromboxanes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways.
Thromboxanes

同义名列表

9 个代谢物同义名

(5Z)-7-[(2R,3S,4S)-4,6-dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]oxan-3-yl]hept-5-enoic acid; (Z)-7-[(2R,3S,4S,6S)-4,6-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]oxan-3-yl]hept-5-enoic acid; 9S,11,15S-trihydroxy-thromboxa-5Z,13E-dien-1-oic acid; TXB2 (Thromboxane B2); b2, Thromboxane; Thromboxane B2; TXB2; PhD; Thromboxane B2



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

59 个相关的代谢反应过程信息。

Reactome(5)

BioCyc(0)

WikiPathways(8)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Neven Žarković, Wojciech Łuczaj, Iwona Jarocka-Karpowicz, Biserka Orehovec, Bruno Baršić, Marko Tarle, Marta Kmet, Ivica Lukšić, Michał Biernacki, Elżbieta Skrzydlewska. Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital. International journal of molecular sciences. 2022 Oct; 23(19):. doi: 10.3390/ijms231911810. [PMID: 36233111]
  • Jeffrey J Rade, Bruce A Barton, Ramachandran S Vasan, Shari S Kronsberg, Vanessa Xanthakis, John F Keaney, Naomi M Hamburg, Nikolaos Kakouros, Thomas A Kickler. Association of Thromboxane Generation With Survival in Aspirin Users and Nonusers. Journal of the American College of Cardiology. 2022 07; 80(3):233-250. doi: 10.1016/j.jacc.2022.04.034. [PMID: 35660296]
  • Essa Hariri, Nikolaos Kakouros, David A Bunsick, Stuart D Russell, James O Mudd, Katherine Laws, Mikhailia W Lake, Jeffrey J Rade. Nonplatelet thromboxane generation is associated with impaired cardiovascular performance and mortality in heart failure. American journal of physiology. Heart and circulatory physiology. 2022 07; 323(1):H248-H255. doi: 10.1152/ajpheart.00212.2022. [PMID: 35714178]
  • Alexander A Boucher, Brenton J Francisco, Amanda Pfeiffer, Matthew Martin, Janine Martin, Amy Shova, Jaimie D Nathan, Gregory M Tiao, Lori Luchtman-Jones. Urinary 11-dehydrothromboxane B2 aspirin efficacy testing is sensitive to perioperative inflammation in pediatric solid-organ transplant patients. Pediatric blood & cancer. 2022 02; 69(2):e29413. doi: 10.1002/pbc.29413. [PMID: 34676969]
  • Maeve Kiely, Ginger L Milne, Tsion Z Minas, Tiffany H Dorsey, Wei Tang, Cheryl J Smith, Francine Baker, Christopher A Loffredo, Clayton Yates, Michael B Cook, Stefan Ambs. Urinary Thromboxane B2 and Lethal Prostate Cancer in African American Men. Journal of the National Cancer Institute. 2022 01; 114(1):123-129. doi: 10.1093/jnci/djab129. [PMID: 34264335]
  • Mingwen Yang, Zekang Ye, Lianlian Mei, Inam Ullah, Chuchu Tan, Guoyu Wang, Qian Gu, Yi Lu, Samee Abdus, Lu Shi, Xiaoxuan Gong, Jianling Bai, John W Eikelboom, Chunjian Li. Pharmacodynamic effects of indobufen compared with aspirin in patients with coronary atherosclerosis. European journal of clinical pharmacology. 2021 Dec; 77(12):1815-1823. doi: 10.1007/s00228-021-03177-y. [PMID: 34331551]
  • Pandarisamy Sundaravadivel, Rita Christopher, Nitin Ramanujam, Sadanandavalli Retnaswami Chandra. Serum thromboxane B2 but not soluble P-selectin levels identify ischemic stroke patients with persistent platelet reactivity while on aspirin therapy. Thrombosis research. 2021 Dec; 208(?):92-98. doi: 10.1016/j.thromres.2021.10.021. [PMID: 34742142]
  • Theresa Wolfram, Leonie M Weidenbach, Johanna Adolf, Maria Schwarz, Patrick Schädel, André Gollowitzer, Oliver Werz, Andreas Koeberle, Anna P Kipp, Solveigh C Koeberle. The Trace Element Selenium Is Important for Redox Signaling in Phorbol Ester-Differentiated THP-1 Macrophages. International journal of molecular sciences. 2021 Oct; 22(20):. doi: 10.3390/ijms222011060. [PMID: 34681720]
  • Silvia Lee, Beate Eichelberger, Christoph W Kopp, Simon Panzer, Thomas Gremmel. Residual platelet reactivity in low-dose aspirin-treated patients with class 1 obesity. Vascular pharmacology. 2021 02; 136(?):106819. doi: 10.1016/j.vph.2020.106819. [PMID: 33207279]
  • Anindita A Nandi, Nisha S Wadhwani, Karuna N Randhir, Shweta D Madiwale, Juilee S Deshpande, Girija N Wagh, Sadhana R Joshi. Maternal vitamin D deficiency influences long-chain polyunsaturated fatty acids and pregnancy outcome in association with alterations in one-carbon metabolism. Nutrition research (New York, N.Y.). 2021 02; 86(?):37-49. doi: 10.1016/j.nutres.2020.11.009. [PMID: 33482597]
  • Paul A Gurbel, Kevin P Bliden, Udaya S Tantry. Defining platelet response to acetylsalicylic acid: the relation between inhibition of serum thromboxane B2 and agonist-induced platelet aggregation. Journal of thrombosis and thrombolysis. 2021 Feb; 51(2):260-264. doi: 10.1007/s11239-020-02334-x. [PMID: 33170486]
  • Miltan Chandra Roy, Kiwoong Nam, Jaesu Kim, David Stanley, Yonggyun Kim. Thromboxane Mobilizes Insect Blood Cells to Infection Foci. Frontiers in immunology. 2021; 12(?):791319. doi: 10.3389/fimmu.2021.791319. [PMID: 34987515]
  • Beatrice Mainoli, Gonçalo S Duarte, João Costa, Joaquim Ferreira, Daniel Caldeira. Once- versus Twice-Daily Aspirin in Patients at High Risk of Thrombotic Events: Systematic Review and Meta-Analysis. American journal of cardiovascular drugs : drugs, devices, and other interventions. 2021 Jan; 21(1):63-71. doi: 10.1007/s40256-020-00409-x. [PMID: 32394295]
  • Yao Tang, Sunhua Huang, Wenhao Lin, Ke Wen, Zhexuan Lin, Ming Han. Arachidonic Acid-Dependent Pathway Inhibition in Platelets: its Role in Multiple Injury-Induced Coagulopathy and the Potential Mechanisms. Shock (Augusta, Ga.). 2021 01; 55(1):121-127. doi: 10.1097/shk.0000000000001563. [PMID: 32433211]
  • Jia Ke, Meng-Ting Li, Ya-Jing Huo, Yan-Qiong Cheng, Shu-Fen Guo, Yang Wu, Lei Zhang, Jianpeng Ma, Ai-Jun Liu, Yan Han. The Synergistic Effect of Ginkgo biloba Extract 50 and Aspirin Against Platelet Aggregation. Drug design, development and therapy. 2021; 15(?):3543-3560. doi: 10.2147/dddt.s318515. [PMID: 34429584]
  • Mariangela Scavone, Jessica Rizzo, Eti A Femia, Gian Marco Podda, Elena Bossi, Sabrina Caberlon, Rita Paroni, Marco Cattaneo. Patients with Essential Thrombocythemia may be Poor Responders to Enteric-Coated Aspirin, but not to Plain Aspirin. Thrombosis and haemostasis. 2020 Oct; 120(10):1442-1453. doi: 10.1055/s-0040-1714351. [PMID: 32717754]
  • Marie Michèle Boulet, David Cheillan, Mathilde Di Filippo, Taïssia Lelekov-Boissard, Charline Buisson, Stéphanie Lambert-Porcheron, Julie-Anne Nazare, Jessica Tressou, Marie-Caroline Michalski, Catherine Calzada, Philippe Moulin. Postprandial Triglyceride-Rich Lipoproteins from Type 2 Diabetic Women Stimulate Platelet Activation Regardless of the Fat Source in the Meal. Molecular nutrition & food research. 2020 10; 64(19):e2000694. doi: 10.1002/mnfr.202000694. [PMID: 32844550]
  • Tessa J Barrett, Angela H Lee, Yuhe Xia, Lawrence H Lin, Margaret Black, Paolo Cotzia, Judith Hochman, Jeffrey S Berger. Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease. Circulation research. 2020 09; 127(7):945-947. doi: 10.1161/circresaha.120.317803. [PMID: 32757722]
  • Elżbieta Cecerska-Heryć, Rafał Heryć, Magda Wiśniewska, Natalia Serwin, Bartłomiej Grygorcewicz, Barbara Dołęgowska. Effect of renal replacement therapy on selected arachidonic acid derivatives concentration. BMC nephrology. 2020 09; 21(1):394. doi: 10.1186/s12882-020-02053-8. [PMID: 32917166]
  • Laura Lucarini, Mariaconcetta Durante, Silvia Sgambellone, Cecilia Lanzi, Elisabetta Bigagli, Ozlem Akgul, Emanuela Masini, Claudiu T Supuran, Fabrizio Carta. Effects of New NSAID-CAI Hybrid Compounds in Inflammation and Lung Fibrosis. Biomolecules. 2020 09; 10(9):. doi: 10.3390/biom10091307. [PMID: 32927723]
  • Pavel Chrbolka, Stefan Alusik, Dagmar Kalatova, Zoltan Paluch. Increased platelet activity in tinnitus patients. Neuro endocrinology letters. 2020 Sep; 41(2):102-106. doi: . [PMID: 33185996]
  • Tomokazu Tokoro, Isamu Makino, Shinichi Harada, Koichi Okamoto, Shinichi Nakanuma, Seisho Sakai, Jun Kinoshita, Keishi Nakamura, Tomoharu Miyashita, Hidehiro Tajima, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta. Interactions Between Neutrophils and Platelets in the Progression of Acute Pancreatitis. Pancreas. 2020 07; 49(6):830-836. doi: 10.1097/mpa.0000000000001585. [PMID: 32541639]
  • Yeek Tat Ng, Sonia Chew Wen Phang, Gerald Chen Jie Tan, En Yng Ng, Nevein Philip Botross Henien, Uma Devi M Palanisamy, Badariah Ahmad, Khalid Abdul Kadir. The Effects of Tocotrienol-Rich Vitamin E (Tocovid) on Diabetic Neuropathy: A Phase II Randomized Controlled Trial. Nutrients. 2020 May; 12(5):. doi: 10.3390/nu12051522. [PMID: 32456230]
  • Jiawen Huang, Xiangyu Wang, Liyuan Xie, Mingan Wu, Wei Zhao, Yongbin Zhang, Qi Wang, Limei Yao, Weirong Li. Extract of Danggui-Shaoyao-San ameliorates cognition deficits by regulating DHA metabolism in APP/PS1 mice. Journal of ethnopharmacology. 2020 May; 253(?):112673. doi: 10.1016/j.jep.2020.112673. [PMID: 32084555]
  • Michael S Garshick, Michael Tawil, Tessa J Barrett, Charissa M Salud-Gnilo, Michael Eppler, Angela Lee, Jose U Scher, Andrea L Neimann, Sanja Jelic, Nehal N Mehta, Edward A Fisher, James G Krueger, Jeffrey S Berger. Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis via COX-1. Arteriosclerosis, thrombosis, and vascular biology. 2020 05; 40(5):1340-1351. doi: 10.1161/atvbaha.119.314008. [PMID: 32131611]
  • Mohamed Nabil Elshafei, Yahia Imam, Mouhand F H Mohamed, Arwa Ebrahim AlSaud, Mohamed Sayed Ahmed, Khaldun Obeidat, Razan Saeid, Mohamed Ali, Ibtihal M Abdallah, Aeijaz Sultan Parray, Mohammed Ibn-Masoud Danjuma. An investigation into the impact of enteric coated of aspirin in patients with newly diagnosed ischemic stroke (ECASIS). Medicine. 2020 May; 99(20):e20307. doi: 10.1097/md.0000000000020307. [PMID: 32443379]
  • Kijeong Lee, Sang Hag Lee, Tae Hoon Kim. The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy. International journal of molecular sciences. 2020 Mar; 21(5):. doi: 10.3390/ijms21051851. [PMID: 32182661]
  • Malgorzata Cebo, Jörg Schlotterbeck, Meinrad Gawaz, Madhumita Chatterjee, Michael Lämmerhofer. Simultaneous targeted and untargeted UHPLC-ESI-MS/MS method with data-independent acquisition for quantification and profiling of (oxidized) fatty acids released upon platelet activation by thrombin. Analytica chimica acta. 2020 Jan; 1094(?):57-69. doi: 10.1016/j.aca.2019.10.005. [PMID: 31761048]
  • Vikas Kumar, A Aneesh Kumar, Vinod Joseph, Vipin Mohan Dan, Abdul Jaleel, T R Santhosh Kumar, Chandrasekharan C Kartha. Untargeted metabolomics reveals alterations in metabolites of lipid metabolism and immune pathways in the serum of rats after long-term oral administration of Amalaki rasayana. Molecular and cellular biochemistry. 2020 Jan; 463(1-2):147-160. doi: 10.1007/s11010-019-03637-1. [PMID: 31595424]
  • Giusy Tiseo, Elena Cavarretta, Arianna Forniti, Cristina Nocella, Sebastiano Sciarretta, Ornella Spagnolello, Enrico Baldini, Mariangela Peruzzi, Giuliano Bertazzoni, Francesco Menichetti, Antonino G M Marullo, Fabio Miraldi, Andrea Morelli, Giacomo Frati, Roberto Carnevale, Falcone Marco. Interplay between Nox2 Activity and Platelet Activation in Patients with Sepsis and Septic Shock: A Prospective Study. Oxidative medicine and cellular longevity. 2020; 2020(?):4165358. doi: 10.1155/2020/4165358. [PMID: 33194001]
  • Changqin Li, Miyun Hu, Shengjun Jiang, Zhenhua Liang, Jinmei Wang, Zhenhua Liu, Hui-Min David Wang, Wenyi Kang. Evaluation Procoagulant Activity and Mechanism of Astragalin. Molecules (Basel, Switzerland). 2020 Jan; 25(1):. doi: 10.3390/molecules25010177. [PMID: 31906332]
  • Ramona C Dolscheid-Pommerich, Juliane Weikert, Madlen Reinicke, Rolf Fimmers, Birgit Stoffel-Wagner, Felix Erdfelder, Uta Ceglarek, Lars Eichhorn. Changes in PUFA and eicosanoid metabolism during/after apnea diving: a prospective single-center study. Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc. 2020 Fou; 47(4):539-549. doi: . [PMID: 33227829]
  • Xuqiang Liu, Jing Dong, Qiongxin Liang, Hui-Min David Wang, Zhenhua Liu, Ruian Xu, Wenyi Kang. Coagulant Effects and Mechanism of Schefflera heptaphylla (L.) Frodin. Molecules (Basel, Switzerland). 2019 Dec; 24(24):. doi: 10.3390/molecules24244547. [PMID: 31842361]
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  • Minghui Ou, Yunfeng Zhang, Shichao Cui, Shibo Zhao, Jie Tu. Upregulated MiR-9-5p Protects Against Inflammatory Response in Rats with Deep Vein Thrombosis via Inhibition of NF-κB p50. Inflammation. 2019 Dec; 42(6):1925-1938. doi: 10.1007/s10753-019-01031-z. [PMID: 31463646]
  • Patrudu Makena, Gang Liu, Peter Chen, Charles R Yates, G L Prasad. Urinary Leukotriene E4 and 2,3-Dinor Thromboxane B2 Are Biomarkers of Potential Harm in Short-Term Tobacco Switching Studies. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2019 Dec; 28(12):2095-2105. doi: 10.1158/1055-9965.epi-19-0342. [PMID: 31558507]
  • Dominick J Angiolillo, Deepak L Bhatt, Frank Lanza, Byron Cryer, Jin-Fei Dong, Walter Jeske, Ronald R Zimmerman, Estela von Chong, Jayne Prats, Efthymios N Deliargyris, Upendra Marathi. Pharmacokinetic/pharmacodynamic assessment of a novel, pharmaceutical lipid-aspirin complex: results of a randomized, crossover, bioequivalence study. Journal of thrombosis and thrombolysis. 2019 Nov; 48(4):554-562. doi: 10.1007/s11239-019-01933-7. [PMID: 31420787]
  • Chunpeng Lu, Yanping Yin, Yongliang Cui, Lili Wang, Yan Bai, Jian Li, Tingting Huang, Maimaiti Reziwanguli, Lifu Miao. 1,25(OH)2D3 improves blood lipid metabolism, liver function, and atherosclerosis by constraining the TGF-β/Smad signaling pathway in rats with hyperlipidemia. Cell cycle (Georgetown, Tex.). 2019 Nov; 18(22):3111-3124. doi: 10.1080/15384101.2019.1669389. [PMID: 31544583]
  • Remo H M Furtado, Robert P Giugliano, Talia F Dalcoquio, Flavia B B Arantes, Carlos J D G Barbosa, Paulo R R Genestreti, André Franci, Fernando R Menezes, Carlos A K Nakashima, Marco A Scanavini Filho, Aline G Ferrari, Rocio Salsoso, Luciano M Baracioli, Jose C Nicolau. Increased bodyweight and inadequate response to aspirin in individuals with coronary artery disease. Journal of thrombosis and thrombolysis. 2019 Aug; 48(2):217-224. doi: 10.1007/s11239-019-01830-z. [PMID: 30879169]
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