Zidovudine (BioDeep_00000002509)
Secondary id: BioDeep_00000397845
human metabolite blood metabolite
代谢物信息卡片
1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
化学式: C10H13N5O4 (267.09674980000005)
中文名称: 3′-叠氮-3′-脱氧胸苷
谱图信息:
最多检出来源 Mus musculus(blood) 50%
分子结构信息
SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]
InChI: InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
描述信息
A dideoxynucleoside compound in which the 3-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. [PubChem]
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D009676 - Noxae > D000963 - Antimetabolites > D015224 - Dideoxynucleosides
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.
同义名列表
21 个代谢物同义名
1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione; 3-Azido-2,3-dideoxythymidine; 3 Azido 2,3 dideoxythymidine; 3 Azido 3 deoxythymidine; 3-Azido-3-deoxythymidine; AZT (antiviral); AZT, antiviral; Azidothymidine; Antiviral azt; AZT antiviral; Zidovudinum; Zidovudine; Zidovudin; NSC602670; BWA 509u; Retrovir; BW a509U; BWA-509u; BWA509u; AZT; ZDV
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:10110
- KEGG: C07210
- KEGGdrug: D00413
- KEGGdrug: D88500
- PubChem: 35370
- PubChem: 5726
- HMDB: HMDB0014638
- Metlin: METLIN3066
- DrugBank: DB00495
- ChEMBL: CHEMBL129
- Wikipedia: Zidovudine
- MeSH: Zidovudine
- MetaCyc: CPD-15110
- chemspider: 32555
- CAS: 30516-87-1
- PMhub: MS000002882
- PubChem: 9419
- PDB-CCD: AZZ
- NIKKAJI: J20.566D
- medchemexpress: HY-17413
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(1)
- Zidovudine Action Pathway:
Adenosine triphosphate ⟶ Adenosine monophosphate + Pyrophosphate
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dhananjay Singh, Nishu Mittal, Swati Verma, Anjali Singh, Mohammed Haris Siddiqui. Applications of some advanced sequencing, analytical, and computational approaches in medicinal plant research: a review.
Molecular biology reports.
2023 Dec; 51(1):23. doi:
10.1007/s11033-023-09057-1. [PMID: 38117315] - Jiří Sedlák, Jaroslava Přibylová, Igor Koloňuk, Josef Špak, Ondřej Lenz, Matěj Semerák. Elimination of Solanum nigrum ilarvirus 1 and Apple Hammerhead Viroid from Apple Cultivars Using Antivirals Ribavirin, Rimantadine, and Zidovudine.
Viruses.
2023 Aug; 15(8):. doi:
10.3390/v15081684. [PMID: 37632025] - Suwannee Saisin, Kanda Panthong, Sakchai Hongthong, Chutima Kuhakarn, Sariyarach Thanasansurapong, Arthit Chairoungdua, Kanoknetr Suksen, Radeekorn Akkarawongsapat, Chanita Napaswad, Samran Prabpai, Narong Nuntasaen, Vichai Reutrakul. Pyranonaphthoquinones and Naphthoquinones from the Stem Bark of Ventilago harmandiana and Their Anti-HIV-1 Activity.
Journal of natural products.
2023 03; 86(3):498-507. doi:
10.1021/acs.jnatprod.2c00980. [PMID: 36787536] - Naonobu Tanaka, Sakura Takahashi, Yuki Yoshino, Megumi Nakatani, Fakhruddin Ali Ahmed, Gazi Mosharof Hossain, Chin-Ho Chen, Kuo-Hsiung Lee, Yoshiki Kashiwada. Tigliane-Type Diterpene Esters from the Fruits of Shirakiopsis indica and Their Anti-HIV Activity.
Journal of natural products.
2022 11; 85(11):2687-2693. doi:
10.1021/acs.jnatprod.2c00752. [PMID: 36378070] - Lem Edith Abongwa, Anthony Kebira Nyamache, Fokunang Charles, Judith Torimiro, Nshom Emmanuel, Irénée Domkam, Mbu Eyongetah, Beriyuy Jude, Fung Holgar Mua, Sama Bella, Tankou Colman Tamboh, Erna Charlene Moungang, Victorine Ngum, Paul Okemo. Risk factors of severe hepatotoxicity among HIV-1 infected individuals initiated on highly active antiretroviral therapy in the Northwest Region of Cameroon.
BMC gastroenterology.
2022 Jun; 22(1):286. doi:
10.1186/s12876-022-02305-x. [PMID: 35658835] - Gentille Musengimana, Elysee Tuyishime, Athanase Kiromera, Samuel S Malamba, Augustin Mulindabigwi, Madjid R Habimana, Cyprien Baribwira, Muhayimpundu Ribakare, Savio D Habimana, Josh DeVos, Richard C N Mwesigwa, Eugenie Kayirangwa, Jules M Semuhore, Gallican N Rwibasira, Amitabh B Suthar, Eric Remera. Acquired HIV drug resistance among adults living with HIV receiving first-line antiretroviral therapy in Rwanda: A cross-sectional nationally representative survey.
Antiviral therapy.
2022 06; 27(3):13596535221102690. doi:
10.1177/13596535221102690. [PMID: 35593031] - Nicholas I Paton, Joseph Musaazi, Cissy Kityo, Stephen Walimbwa, Anne Hoppe, Apolo Balyegisawa, Jesca Asienzo, Arvind Kaimal, Grace Mirembe, Abbas Lugemwa, Gilbert Ategeka, Margaret Borok, Henry Mugerwa, Abraham Siika, Eva Laker A Odongpiny, Barbara Castelnuovo, Agnes Kiragga, Andrew Kambugu. Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial.
The lancet. HIV.
2022 06; 9(6):e381-e393. doi:
10.1016/s2352-3018(22)00092-3. [PMID: 35460601] - Rosa Marlene Cuco, Osvaldo Loquiha, Adelino Juga, Aleny Couto, Bindiya Meggi, Adolfo Vubil, Esperança Sevene, Nafissa Osman, Marleen Temermam, Olivier Degomme, Mohsin Sidat, Nilesh Bhatt. Nevirapine hair and plasma concentrations and HIV-1 viral suppression among HIV infected ante-partum and post-partum women attended in a mother and child prevention program in Maputo city, Mozambique.
PloS one.
2022; 17(2):e0261522. doi:
10.1371/journal.pone.0261522. [PMID: 35143515] - Yan-Ping Liu, Tong-Wei Wang, Zhen Xie, Yuan Bian, Yun-Yao Liu, Ruo-Qing Guan, Ze-Yu Liu, Lei Qiang, Guang-Ying Chen, Yan-Hui Fu. Artapilosines A and B, Unusual Phenanthrene Derivatives Related to Aporphine Alkaloids from Artabotrys pilosus.
Journal of natural products.
2021 12; 84(12):3117-3121. doi:
10.1021/acs.jnatprod.1c00896. [PMID: 34812640] - Jing Li, Lu Dou, Shuangfeng Chen, Honghao Zhou, Fangzheng Mou. Neochlorogenic acid: an anti-HIV active compound identified by screening of Cortex Mori [Morus Alba L. (Moraceae)].
Pharmaceutical biology.
2021 Dec; 59(1):1517-1527. doi:
10.1080/13880209.2021.1995005. [PMID: 34714196] - Lisa M Frenkel, R Leavitt Morrison, Trevon L Fuller, Maria Isabel Gouvêa, Maria de Lourdes Benamor Teixeira, Robert W Coombs, David E Shapiro, Mark Mirochnick, Roslyn Hennessey, Kyle Whitson, Nahida Chakhtoura, Esaú C João. Brief Report: Vaginal Viral Shedding With Undetectable Plasma HIV Viral Load in Pregnant Women Receiving 2 Different Antiretroviral Regimens: A Randomized Clinical Trial.
Journal of acquired immune deficiency syndromes (1999).
2021 12; 88(4):361-365. doi:
10.1097/qai.0000000000002771. [PMID: 34369908] - Maxensia Owor, Camlin Tierney, Lauren Ziemba, Renee Browning, John Moye, Bobbie Graham, Christina Reding, Diane Costello, Jennifer Norman, Lubbe Wiesner, Emma Hughes, Meghan E Whalen, Lynette Purdue, Blandina Theophil Mmbaga, Portia Kamthunzi, Rachel Kawalazira, Kusum Nathoo, Sarah Bradford, Anne Coletti, Francesca Aweeka, Philippa Musoke. Pharmacokinetics and Safety of Zidovudine, Lamivudine, and Lopinavir/Ritonavir in HIV-infected Children With Severe Acute Malnutrition in Sub-Saharan Africa: IMPAACT Protocol P1092.
The Pediatric infectious disease journal.
2021 05; 40(5):446-452. doi:
10.1097/inf.0000000000003055. [PMID: 33464021] - Ying Luo, Tianwei Jia, Jieqiong Fang, Dandan Liu, Varma Saikam, Xiaolin Sheng, Suri S Iyer. Rapid, user-friendly, and inexpensive detection of azidothymidine.
Analytical and bioanalytical chemistry.
2021 Mar; 413(7):1999-2006. doi:
10.1007/s00216-021-03168-z. [PMID: 33484329] - Taklo Simeneh Yazie. Derangement of Liver Enzymes, Hyperglycemia, Anemia, and Associated Factors among HIV-Infected Patients Treated with Tenofovir Disoproxil Fumarate-Based Regimen in Ethiopia: A Prospective Cohort Study.
BioMed research international.
2021; 2021(?):6613519. doi:
10.1155/2021/6613519. [PMID: 34222476] - Ei Kinai, Hoai Dung Thi Nguyen, Ha Quan Do, Shoko Matsumoto, Moeko Nagai, Junko Tanuma, Kinh Van Nguyen, Thach Ngoc Pham, Shinichi Oka. Influence of maternal use of tenofovir disoproxil fumarate or zidovudine in Vietnamese pregnant women with HIV on infant growth, renal function, and bone health.
PloS one.
2021; 16(4):e0250828. doi:
10.1371/journal.pone.0250828. [PMID: 33914827] - Alexander Kwarteng, Ebenezer Asiedu, Samuel Amoah Sakyi, Samuel Opoku Asiedu. Targeting the SARS-CoV2 nucleocapsid protein for potential therapeutics using immuno-informatics and structure-based drug discovery techniques.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Dec; 132(?):110914. doi:
10.1016/j.biopha.2020.110914. [PMID: 33254432] - Sanjeev Kumar, Himanshu Batra, Swarandeep Singh, Himanshi Chawla, Ravinder Singh, Sanket Katpara, Abdul Wahid Hussain, Bimal Kumar Das, Rakesh Lodha, Sushil Kumar Kabra, Kalpana Luthra. Effect of combination antiretroviral therapy on human immunodeficiency virus 1 specific antibody responses in subtype-C infected children.
The Journal of general virology.
2020 12; 101(12):1289-1299. doi:
10.1099/jgv.0.001480. [PMID: 32915123] - Jingyue Ju, Xiaoxu Li, Shiv Kumar, Steffen Jockusch, Minchen Chien, Chuanjuan Tao, Irina Morozova, Sergey Kalachikov, Robert N Kirchdoerfer, James J Russo. Nucleotide analogues as inhibitors of SARS-CoV Polymerase.
Pharmacology research & perspectives.
2020 12; 8(6):e00674. doi:
10.1002/prp2.674. [PMID: 33124786] - Pramod C Nair, Nuy Chau, Ross A McKinnon, John O Miners. Arginine-259 of UGT2B7 Confers UDP-Sugar Selectivity.
Molecular pharmacology.
2020 12; 98(6):710-718. doi:
10.1124/molpharm.120.000104. [PMID: 33008919] - Christian Eggers, Richard Hoetelmans, Stephanie Läer. Zidovudine and lamivudine reach higher concentrations in ventricular than in lumbar human cerebrospinal fluid.
AIDS (London, England).
2020 11; 34(13):1883-1889. doi:
10.1097/qad.0000000000002626. [PMID: 32694416] - Luca Docci, Kenichi Umehara, Stephan Krähenbühl, Stephen Fowler, Neil Parrott. Construction and Verification of Physiologically Based Pharmacokinetic Models for Four Drugs Majorly Cleared by Glucuronidation: Lorazepam, Oxazepam, Naloxone, and Zidovudine.
The AAPS journal.
2020 10; 22(6):128. doi:
10.1208/s12248-020-00513-5. [PMID: 33033903] - Tung-Che Hung, Li-Cheng Lu, Mei-Hui Lin, Yu-Chia Hu, Chien-Yu Cheng, Shu-Hsing Cheng, Chien-Yu Lee. Characteristics of HIV-positive pregnant women and HIV- and antiretroviral therapy-exposed fetuses: A case-control study.
Journal of infection in developing countries.
2020 08; 14(8):901-907. doi:
10.3855/jidc.11745. [PMID: 32903235] - Songkai Sun, Boshi Huang, Zhuo Li, Zhao Wang, Lin Sun, Ping Gao, Dongwei Kang, Chin-Ho Chen, Kuo-Hsiung Lee, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu. Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7.
Bioorganic & medicinal chemistry letters.
2020 08; 30(16):127287. doi:
10.1016/j.bmcl.2020.127287. [PMID: 32631509] - Lufuno Grace Mavhandu, Hua Cheng, Yeou-Cheng Bor, Denis Manga Tebit, Marie-Louise Hammarskjold, David Rekosh, Pascal Obong Bessong. Development of a pseudovirus assay and evaluation to screen natural products for inhibition of HIV-1 subtype C reverse transcriptase.
Journal of ethnopharmacology.
2020 Aug; 258(?):112931. doi:
10.1016/j.jep.2020.112931. [PMID: 32360797] - Wu Menghua, Zheng Xin, Liu Jianwei, Zhang Yu, Yao Qinwei. Case report: one case of coronavirus disease 2019 (COVID-19) in a patient co-infected by HIV with a normal CD4+ T cell count.
AIDS research and therapy.
2020 07; 17(1):46. doi:
10.1186/s12981-020-00301-3. [PMID: 32703286] - Ameet N Dravid, Raviraj Gawali, Tarun P Betha, Avadesh K Sharma, Mahenderkumar Medisetty, Kartik Natrajan, Milind M Kulkarni, Chinmay K Saraf, Uma S Mahajan, Sachin D Kore, Niranjan M Rathod, Umakant S Mahajan, Scott L Letendre, Rustom S Wadia, Andrea Calcagno. Two treatment strategies for management of Neurosymptomatic cerebrospinal fluid HIV escape in Pune, India.
Medicine.
2020 Jun; 99(24):e20516. doi:
10.1097/md.0000000000020516. [PMID: 32541474] - Jessica Hernández-Pineda, Helgi Helene Jung-Cook, Norah Lucky Katende-Kyenda, Norma Galindo-Sevilla, Mauricio Domínguez-Castro, José Romo-Yañéz, Alicia Ramírez-Ramírez, Claudine Irles, Ricardo Figueroa-Damián. Assessment of lamivudine, zidovudine, lopinavir, and ritonavir plasma levels in HIV-positive pregnant women: Drug monitoring application to improve patient safety.
Medicine.
2020 May; 99(22):e20487. doi:
10.1097/md.0000000000020487. [PMID: 32481459] - Esaú C João, R Leavitt Morrison, David E Shapiro, Nahida Chakhtoura, Maria Isabel S Gouvèa, Maria de Lourdes B Teixeira, Trevon L Fuller, Blandina T Mmbaga, James S Ngocho, Boniface N Njau, Avy Violari, Ruth Mathiba, Zaakirah Essack, Jose Henrique S Pilotto, Luis Felipe Moreira, Maria Jose Rolon, Pedro Cahn, Sinart Prommas, Timothy R Cressey, Kulkanya Chokephaibulkit, Peerawong Werarak, Lauren Laimon, Roslyn Hennessy, Lisa M Frenkel, Patricia Anthony, Brookie M Best, George K Siberry, Mark Mirochnick. Raltegravir versus efavirenz in antiretroviral-naive pregnant women living with HIV (NICHD P1081): an open-label, randomised, controlled, phase 4 trial.
The lancet. HIV.
2020 05; 7(5):e322-e331. doi:
10.1016/s2352-3018(20)30038-2. [PMID: 32386720] - Thanyalak Saetang, Chutintorn Sriphrapradang, Angsana Phuphuakrat, Somnuek Sungkanuparph. Correlation between plasma glucose and hemoglobin A1c in HIV-infected individuals receiving zidovudine and non-zidovudine containing antiretroviral therapy regimens.
HIV research & clinical practice.
2020 Apr; 21(2-3):56-62. doi:
10.1080/25787489.2020.1766864. [PMID: 32431248] - Andrew W McCrary, Winstone M Nyandiko, Alicia M Ellis, Hrishikesh Chakraborty, Michael J Muehlbauer, Myra M Koech, Ibrahim Daud, Elcy Birgen, Nathan M Thielman, Joseph A Kisslo, Piers C A Barker, Gerald S Bloomfield. Early cardiac dysfunction in children and young adults with perinatally acquired HIV.
AIDS (London, England).
2020 03; 34(4):539-548. doi:
10.1097/qad.0000000000002445. [PMID: 31794518] - Chengbo Xu, Yijing Xin, Minghua Chen, Mingyu Ba, Qinglan Guo, Chenggen Zhu, Ying Guo, Jiangong Shi. Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root.
European journal of medicinal chemistry.
2020 Mar; 189(?):112071. doi:
10.1016/j.ejmech.2020.112071. [PMID: 32004936] - Yuan-Yuan Qin, Ping Xu, Tong Wu, Chao-Qun Qian, Yi-Lin Fan, Dong-Hao Gen, Liang Zhu, Wei-Min Kong, Han-Yu Yang, Feng Xu, Yi-Ting Yang, Li Liu, Xiao-Dong Liu. Bile duct ligation enhances AZT CNS toxicity partly by impairing the expression and function of BCRP in rat brain.
Acta pharmacologica Sinica.
2020 Feb; 41(2):181-191. doi:
10.1038/s41401-019-0242-8. [PMID: 31142800] - Alisen Ayitewala, Fred Kyeyune, Pamela Ainembabazi, Eva Nabulime, Charles Drago Kato, Immaculate Nankya. Comparison of HIV drug resistance profiles across HIV-1 subtypes A and D for patients receiving a tenofovir-based and zidovudine-based first line regimens in Uganda.
AIDS research and therapy.
2020 01; 17(1):2. doi:
10.1186/s12981-020-0258-7. [PMID: 32005262] - Hua-Ding Zhao, Yan Lu, Min Yan, Chin-Ho Chen, Susan L Morris-Natschke, Kuo-Hsiung Lee, Dao-Feng Chen. Rapid Recognition and Targeted Isolation of Anti-HIV Daphnane Diterpenes from Daphne genkwa Guided by UPLC-MSn.
Journal of natural products.
2020 01; 83(1):134-141. doi:
10.1021/acs.jnatprod.9b00993. [PMID: 31860304] - Qijian Su, Zhenzhen Lu, Yunxia Tang, Suosu Wei, Zhipin Zhou, Feng Jiang. Influence of a herbal preparation on the pharmacokinetics of highly active antiretroviral therapy drugs in rats.
Pakistan journal of pharmaceutical sciences.
2020 Jan; 33(1):49-52. doi:
NULL. [PMID: 32122830] - Wenjuan Ma, Fang Liu, Lingyan Yuan, Chuan Zhao, Che Chen. Emodin and AZT synergistically inhibit the proliferation and induce the apoptosis of leukemia K562 cells through the EGR1 and the Wnt/β‑catenin pathway.
Oncology reports.
2020 01; 43(1):260-269. doi:
10.3892/or.2019.7408. [PMID: 31746437] - Zhi Xu, Shi-Jia Zhao, Yi Liu. 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.
European journal of medicinal chemistry.
2019 Dec; 183(?):111700. doi:
10.1016/j.ejmech.2019.111700. [PMID: 31546197] - Alison C Roxby, Krista Yuhas, Carey Farquhar, Rose Bosire, Dorothy Mbori-Ngacha, Barbra A Richardson, Patricia A Totten, Grace John-Stewart. Mycoplasma genitalium infection among HIV-infected pregnant African women and implications for mother-to-child transmission of HIV.
AIDS (London, England).
2019 11; 33(14):2211-2217. doi:
10.1097/qad.0000000000002335. [PMID: 31385863] - Xiaobo Gao, Alan Rosales, Heidi Karttunen, Geetha M Bommana, Buadi Tandoh, Zhengzi Yi, Zainab Habib, Vivette D'Agati, Weijia Zhang, Michael J Ross. The HIV protease inhibitor darunavir prevents kidney injury via HIV-independent mechanisms.
Scientific reports.
2019 11; 9(1):15857. doi:
10.1038/s41598-019-52278-3. [PMID: 31676833] - Geoffroy Liegeon, Linda Harrison, Anouar Nechba, Guttiga Halue, Sukit Banchongkit, Ampaipith Nilmanat, Naruepon Yutthakasemsunt, Panita Pathipvanich, Suchart Thongpaen, Rittha Lertkoonalak, Thomas Althaus, Marc Lallemant, Jean-Yves Mary, Gonzague Jourdain. Long term renal function in Asian HIV-1 infected adults receiving tenofovir disoproxil fumarate without protease inhibitors.
The Journal of infection.
2019 11; 79(5):454-461. doi:
10.1016/j.jinf.2019.08.006. [PMID: 31401085] - Liuya Wei, Najia Mansoor, Rafeeq Alam Khan, Martin Czejka, Tasneem Ahmad, Mansoor Ahmed, Mohsin Ali, Dong-Hua Yang. WB-PBPK approach in predicting zidovudine pharmacokinetics in preterm neonates.
Biopharmaceutics & drug disposition.
2019 Nov; 40(9):341-349. doi:
10.1002/bdd.2208. [PMID: 31693190] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Alessandro Dalpiaz, Marco Fogagnolo, Luca Ferraro, Sarah Beggiato, Miriam Hanuskova, Eleonora Maretti, Francesca Sacchetti, Eliana Leo, Barbara Pavan. Bile salt-coating modulates the macrophage uptake of nanocores constituted by a zidovudine prodrug and enhances its nose-to-brain delivery.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2019 Nov; 144(?):91-100. doi:
10.1016/j.ejpb.2019.09.008. [PMID: 31521715] - Lisa J Frigati, Karryn Brown, Sana Mahtab, Leah Githinji, Diane Gray, Liesl Zühlke, Peter Nourse, Dan J Stein, Jaqueline Hoare, Mark F Cotton, Landon Myer, Heather J Zar. Multisystem impairment in South African adolescents with Perinatally acquired HIV on antiretroviral therapy (ART).
Journal of the International AIDS Society.
2019 08; 22(8):e25386. doi:
10.1002/jia2.25386. [PMID: 31441211] - Hadi Savaloni, Shokoofe Goli-Haghighi, Reza Babaei. Application of Mn-Cu Helical Star-Shaped (Pine-Tree-Like) Sculpted Thin Films with Different Symmetries Using Surface-Enhanced Raman Spectroscopy (SERS).
Applied spectroscopy.
2019 Aug; 73(8):879-892. doi:
10.1177/0003702819841913. [PMID: 30990064] - Michael J Boivin, Limbika Maliwichi-Senganimalunje, Lillian W Ogwang, Rachel Kawalazira, Alla Sikorskii, Itziar Familiar-Lopez, Agatha Kuteesa, Mary Nyakato, Alex Mutebe, Jackie L Namukooli, MacPherson Mallewa, Horacio Ruiseñor-Escudero, Jim Aizire, Taha E Taha, Mary G Fowler. Neurodevelopmental effects of ante-partum and post-partum antiretroviral exposure in HIV-exposed and uninfected children versus HIV-unexposed and uninfected children in Uganda and Malawi: a prospective cohort study.
The lancet. HIV.
2019 08; 6(8):e518-e530. doi:
10.1016/s2352-3018(19)30083-9. [PMID: 31122797] - Ardiana Kusumaningrum, Fera Ibrahim, Evy Yunihastuti, Budiman Bela. HIV Drug Resistance after Failure of 6 Month First-line Therapy in a Hospital: A Case Series.
Acta medica Indonesiana.
2019 Jul; 51(3):253-257. doi:
NULL. [PMID: 31699949] - Maria Loose, Kurt G Naber, Yanmin Hu, Anthony Coates, Florian M E Wagenlehner. Urinary bactericidal activity of colistin and azidothymidine combinations against mcr-1-positive colistin-resistant Escherichia coli.
International journal of antimicrobial agents.
2019 Jul; 54(1):55-61. doi:
10.1016/j.ijantimicag.2019.04.011. [PMID: 31034939] - Ya-Si Huang, Yan Lu, Chin-Ho Chen, Kuo-Hsiung Lee, Dao-Feng Chen. Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata.
Journal of natural products.
2019 06; 82(6):1587-1592. doi:
10.1021/acs.jnatprod.9b00088. [PMID: 31184480] - Nongodo Firmin Kaboré, Armel Poda, Jacques Zoungrana, Ollo Da, Laura Ciaffi, Aoua Semdé, Issouf Yaméogo, Adrien B Sawadogo, Eric Delaporte, Nicolas Meda, Sophie Limou, Amandine Cournil. Chronic kidney disease and HIV in the era of antiretroviral treatment: findings from a 10-year cohort study in a west African setting.
BMC nephrology.
2019 05; 20(1):155. doi:
10.1186/s12882-019-1335-9. [PMID: 31064340] - Kentaro Konishi, Tsuyoshi Minematsu, Yasuhisa Nagasaka, Kenji Tabata. Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment.
Biopharmaceutics & drug disposition.
2019 May; 40(5-6):176-187. doi:
10.1002/bdd.2181. [PMID: 30985942] - Nicole L Davis, Amanda Corbett, Josh Kaullen, Julie A E Nelson, Charles S Chasela, Dorothy Sichali, Michael G Hudgens, William C Miller, Denise J Jamieson, Athena P Kourtis. Antiretroviral Drug Concentrations in Breastmilk, Maternal HIV Viral Load, and HIV Transmission to the Infant: Results From the BAN Study.
Journal of acquired immune deficiency syndromes (1999).
2019 04; 80(4):467-473. doi:
10.1097/qai.0000000000001941. [PMID: 30570527] - Xiao-Lu Luo, Li-da Mo, Guo-Sheng Su, Jin-Ping Huang, Jing-Yu Wu, Han-Zhen Su, Wan-Hong Huang, Shun-da Luo, Zu-Yan Ni. Incidence and types of HIV-1 drug resistance mutation among patients failing first-line antiretroviral therapy.
Journal of pharmacological sciences.
2019 Apr; 139(4):275-279. doi:
10.1016/j.jphs.2018.11.016. [PMID: 30928089] - Haifeng Wu, Guoxu Ma, Qinwen Yang, Yindi Zhu, Li Huang, Yu Tian, Xiaoming Yang, Menghan Zhang, Chin-Ho Chen, Susan L Morris-Natschke, Meihua Yang, Xudong Xu, Kuo-Hsiung Lee. Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity.
European journal of medicinal chemistry.
2019 Mar; 166(?):159-166. doi:
10.1016/j.ejmech.2019.01.020. [PMID: 30703659] - Raghu Ramanathan, Karthikeyan Sivanesan. Investigations on the Influence of Zidovudine in the Pharmacokinetics of Isoniazid and Its Hepatotoxic Metabolites in Rats.
Journal of pharmacy practice.
2019 Feb; 32(1):9-18. doi:
10.1177/0897190017735424. [PMID: 29017426] - Zhang-Xin Yu, Cai-Juan Zheng, Guang-Ying Chen, Rong-Li Huang, Xue-Ming Zhou, Zhi-Gang Niu, Xiao-Bao Li, Chang-Ri Han, Xiao-Ping Song. 3,4- seco-Norclerodane Diterpenoids from the Roots of Polyalthia laui.
Journal of natural products.
2019 01; 82(1):27-34. doi:
10.1021/acs.jnatprod.8b00243. [PMID: 30596489] - Seiji Kageyama, Alfredo Amolong Hinay, Elizabeth Freda Omengan Telan, Genesis May Jopson Samonte, Prisca Susan Agustin Leano, Akeno Tsuneki-Tokunaga, Kyosuke Kanai. Intrinsic Replication Competences of HIV Strains After Zidovudine/Lamivudine/Nevirapine Treatment in the Philippines.
Journal of the International Association of Providers of AIDS Care.
2019 Jan; 18(?):2325958219856579. doi:
10.1177/2325958219856579. [PMID: 31216920] - Piotr Mucha, Jaroslaw Ruczynski, Michal Dobkowski, Ewelina Backtrog, Piotr Rekowski. Capillary electrophoresis study of systemin peptides spreading in tomato plant.
Electrophoresis.
2019 01; 40(2):336-342. doi:
10.1002/elps.201800206. [PMID: 30259532] - Assis Ecker, Rafael S da Silva, Matheus Mulling Dos Santos, Daniel Ardisson-Araújo, Oscar E D Rodrigues, João Batista Teixeira da Rocha, Nilda Vargas Barbosa. Safety profile of AZT derivatives: Organoselenium moieties confer different cytotoxic responses in fresh human erythrocytes during in vitro exposures.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2018 Dec; 50(?):240-248. doi:
10.1016/j.jtemb.2018.07.002. [PMID: 30262286] - Maria Loose, Kurt G Naber, Yanmin Hu, Anthony Coates, Florian M E Wagenlehner. Serum bactericidal activity of colistin and azidothymidine combinations against mcr-1-positive colistin-resistant Escherichia coli.
International journal of antimicrobial agents.
2018 Dec; 52(6):783-789. doi:
10.1016/j.ijantimicag.2018.08.010. [PMID: 30138665] - Richard E Haaland, Kephas Otieno, Amy Martin, Abraham Katana, Chuong Dinh, Laurence Slutsker, Clara Menendez, Raquel Gonzalez, John Williamson, Walid Heneine, Meghna Desai. Short Communication: Reduced Nevirapine Concentrations Among HIV-Positive Women Receiving Mefloquine for Intermittent Preventive Treatment for Malaria Control During Pregnancy.
AIDS research and human retroviruses.
2018 11; 34(11):912-915. doi:
10.1089/aid.2018.0042. [PMID: 30173559] - Selemani Saidi Sungi, Eliford Ngaimisi, Nzovu Ulenga, Philip Sasi, Sabina Mugusi. Variability of efavirenz plasma concentrations among pediatric HIV patients treated with efavirenz based combination antiretroviral therapy in Dar es Salaam, Tanzania.
BMC pharmacology & toxicology.
2018 Oct; 19(1):66. doi:
10.1186/s40360-018-0258-6. [PMID: 30352627] - S M T Cavalcanti, C Nunes, S A Costa Lima, J L Soares-Sobrinho, S Reis. Optimization of nanostructured lipid carriers for Zidovudine delivery using a microwave-assisted production method.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Sep; 122(?):22-30. doi:
10.1016/j.ejps.2018.06.017. [PMID: 29933076] - Marieke Emonts, Hylke Waalewijn, Angela Colbers, Ailsa Pickering, David Burger. First reported use of zidovudine for prevention of perinatal HIV transmission in a premature neonate on extra corporal membrane oxygenation.
AIDS (London, England).
2018 09; 32(14):2084-2085. doi:
10.1097/qad.0000000000001940. [PMID: 30157085] - Song Chen, Xiaoyu Wang, Haipeng Zhu, Qin Tang, Wei Du, Huanhuan Cao, Chunhui Lai, Weizhong Guo, Linchun Fu, Wei Lu. Zidovudine-Based Treatments Inhibit the Glycosylation of ADAM17 and Reduce CD163 Shedding From Monocytes.
Journal of acquired immune deficiency syndromes (1999).
2018 09; 79(1):126-134. doi:
10.1097/qai.0000000000001769. [PMID: 29794822] - Qingbo Liu, Wei Li, Li Huang, Yoshihisa Asada, Susan L Morris-Natschke, Chin-Ho Chen, Kuo-Hsiung Lee, Kazuo Koike. Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui.
European journal of medicinal chemistry.
2018 Aug; 156(?):618-627. doi:
10.1016/j.ejmech.2018.07.020. [PMID: 30031972] - David Moreno-Ajona, José Ramón Yuste, Paloma Martín, Jaime Gállego Pérez-Larraya. HTLV-1 myelopathy after renal transplant and antiviral prophylaxis: the need for screening.
Journal of neurovirology.
2018 08; 24(4):523-525. doi:
10.1007/s13365-018-0627-3. [PMID: 29532443] - Abdul Rahim, Yohei Saito, Katsunori Miyake, Masuo Goto, Chin-Ho Chen, Gemini Alam, Susan Morris-Natschke, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto. Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita.
Journal of natural products.
2018 07; 81(7):1619-1627. doi:
10.1021/acs.jnatprod.8b00211. [PMID: 30010341] - Kislay Singh, Swadha Jaiswal, Richa Singh, Sana Fatma, Bhim Bali Prasad. One-by-one imprinting in two eccentric layers of hollow core-shells: Sequential electroanalysis of anti-HIV drugs.
Biosensors & bioelectronics.
2018 Jul; 111(?):82-89. doi:
10.1016/j.bios.2018.03.068. [PMID: 29653420] - Yao Hu, Kai-Heng Fang, Lu-Ping Shen, Shi-Ying Cao, Fang Yuan, Yuwen Su, Min Xu, Yufeng Pan, Yaoyu Chen, Yan Liu. The telomerase inhibitor AZT enhances differentiation and prevents overgrowth of human pluripotent stem cell-derived neural progenitors.
The Journal of biological chemistry.
2018 06; 293(23):8722-8733. doi:
10.1074/jbc.m117.809889. [PMID: 29628445] - Ana Santos-Llamas, Maria J Monte, Jose J G Marin, Maria J Perez. Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine.
Archives of toxicology.
2018 06; 92(6):2109-2118. doi:
10.1007/s00204-018-2200-5. [PMID: 29594326] - Esteban M Schenfeld, Sergio R Ribone, Mario A Quevedo. Stability and plasmatic protein binding of novel zidovudine prodrugs: Targeting site ii of human serum albumin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Mar; 115(?):109-118. doi:
10.1016/j.ejps.2018.01.024. [PMID: 29339228] - Barbara Castelnuovo, Frank Mubiru, Agnes N Kiragga, Rachel Musomba, Olive Mbabazi, Paul Gonza, Andrew Kambugu, Rosalind Parks Ratanshi. Antiretroviral treatment Long-Term (ALT) cohort: a prospective cohort of 10 years of ART-experienced patients in Uganda.
BMJ open.
2018 02; 8(2):e015490. doi:
10.1136/bmjopen-2016-015490. [PMID: 29467129] - Adrian Pîrnău, Mihaela Mic, Silvia Neamţu, Călin G Floare, Mircea Bogdan. Calorimetric and spectroscopic studies of the interaction between zidovudine and human serum albumin.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Feb; 191(?):226-232. doi:
10.1016/j.saa.2017.10.032. [PMID: 29040928] - Byoung Hoon You, Eun Chae Gong, Young Hee Choi. Inhibitory Effect of Sauchinone on UDP-Glucuronosyltransferase (UGT) 2B7 Activity.
Molecules (Basel, Switzerland).
2018 Feb; 23(2):. doi:
10.3390/molecules23020366. [PMID: 29425147] - Raquel M Alves-Paiva, Sachiko Kajigaya, Xingmin Feng, Jichun Chen, Marie Desierto, Susan Wong, Danielle M Townsley, Flávia S Donaires, Adeline Bertola, Bin Gao, Neal S Young, Rodrigo T Calado. Telomerase enzyme deficiency promotes metabolic dysfunction in murine hepatocytes upon dietary stress.
Liver international : official journal of the International Association for the Study of the Liver.
2018 01; 38(1):144-154. doi:
10.1111/liv.13529. [PMID: 28741793] - K S Joshy, S Snigdha, George Anne, Kalarikkal Nandakumar, Pothen Laly A, Thomas Sabu. Poly (vinyl pyrrolidone)-lipid based hybrid nanoparticles for anti viral drug delivery.
Chemistry and physics of lipids.
2018 01; 210(?):82-89. doi:
10.1016/j.chemphyslip.2017.11.003. [PMID: 29129570] - Chuan Zhao, Mei Wang, Yu Liu, Yongjuan Liang, Li Han, Che Chen. Effects of the combination of As2O3 and AZT on proliferation inhibition and apoptosis induction of hepatoma HepG2 cells following silencing of Egr-1.
OncoTargets and therapy.
2018; 11(?):3293-3301. doi:
10.2147/ott.s155169. [PMID: 29910624] - Assis Ecker, Pauline Christ Ledur, Rafael S da Silva, Daniela Bitencourt Rosa Leal, Oscar E D Rodrigues, Daniel Ardisson-Araújo, Emily Pansera Waczuk, João Batista Teixeira da Rocha, Nilda Vargas Barbosa. Chalcogenozidovudine Derivatives With Antitumor Activity: Comparative Toxicities in Cultured Human Mononuclear Cells.
Toxicological sciences : an official journal of the Society of Toxicology.
2017 Nov; 160(1):30-46. doi:
10.1093/toxsci/kfx152. [PMID: 29036705] - Felix Mashingaidze, Yahya E Choonara, Pradeep Kumar, Lisa C du Toit, Vinesh Maharaj, Eckhart Buchmann, Viness Pillay. Submicron Matrices Embedded in a Polymeric Caplet for Extended Intravaginal Delivery of Zidovudine.
The AAPS journal.
2017 11; 19(6):1745-1759. doi:
10.1208/s12248-017-0130-4. [PMID: 28779379] - Fan Wang, Ming-Xing Miao, Bin-Bin Sun, Zhong-Jian Wang, Xian-Ge Tang, Yang Chen, Kai-Jing Zhao, Xiao-Dong Liu, Li Liu. Acute liver failure enhances oral plasma exposure of zidovudine in rats by downregulation of hepatic UGT2B7 and intestinal P-gp.
Acta pharmacologica Sinica.
2017 Nov; 38(11):1554-1565. doi:
10.1038/aps.2017.54. [PMID: 28770824] - K S Joshy, Anne George, Jiya Jose, Nandakumar Kalarikkal, Laly A Pothen, Sabu Thomas. Novel dendritic structure of alginate hybrid nanoparticles for effective anti-viral drug delivery.
International journal of biological macromolecules.
2017 Oct; 103(?):1265-1275. doi:
10.1016/j.ijbiomac.2017.05.094. [PMID: 28559185] - Joshy K S, Snigdha S, Nandakumar Kalarikkal, Laly A Pothen, Sabu Thomas. Gelatin modified lipid nanoparticles for anti- viral drug delivery.
Chemistry and physics of lipids.
2017 10; 207(Pt A):24-37. doi:
10.1016/j.chemphyslip.2017.07.002. [PMID: 28698149] - Kristine M Erlandson, Suzanne P Fiorillo, Sandra Wagner Cardoso, Cynthia Riviere, Jorge Sanchez, James Hakim, Nagalingeswaran Kumarasamy, Sharlaa Badal-Faesen, Umesh Lalloo, Johnstone Kumwenda, Thomas B Campbell, Todd T Brown. Insulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiation.
AIDS research and human retroviruses.
2017 Sep; 33(9):929-934. doi:
10.1089/aid.2016.0327. [PMID: 28403619] - María Fernanda Filia, Timoteo Marchini, Juan Mauricio Minoia, Martín Ignacio Roma, Fernanda Teresa De Fino, Modesto Carlos Rubio, Guillermo J Copello, Pablo A Evelson, Roxana Noemí Peroni. Induction of ABCG2/BCRP restricts the distribution of zidovudine to the fetal brain in rats.
Toxicology and applied pharmacology.
2017 09; 330(?):74-83. doi:
10.1016/j.taap.2017.07.005. [PMID: 28705594] - Zufei Zhang, Jashvant D Unadkat. Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model II: Verification of the model for passive placental permeability drugs.
Drug metabolism and disposition: the biological fate of chemicals.
2017 08; 45(8):939-946. doi:
10.1124/dmd.116.073957. [PMID: 28049636] - Raghu Ramanathan, Karthikeyan Sivanesan. Evaluation of ameliorative ability of Silibinin against zidovudine and isoniazid-induced hepatotoxicity and hyperlipidaemia in rats: Role of Silibinin in Phase I and II drug metabolism.
Chemico-biological interactions.
2017 Aug; 273(?):142-153. doi:
10.1016/j.cbi.2017.06.008. [PMID: 28619387] - Sandra Hernández, Marc Catalán-García, Constanza Morén, Laura García-Otero, Marta López, Mariona Guitart-Mampel, José Milisenda, Oriol Coll, Francesc Cardellach, Eduard Gratacós, Òscar Miró, Glòria Garrabou. Placental Mitochondrial Toxicity, Oxidative Stress, Apoptosis, and Adverse Perinatal Outcomes in HIV Pregnancies Under Antiretroviral Treatment Containing Zidovudine.
Journal of acquired immune deficiency syndromes (1999).
2017 08; 75(4):e113-e119. doi:
10.1097/qai.0000000000001334. [PMID: 28234688] - Min Luo, Elisabetta Groaz, Graciela Andrei, Robert Snoeck, Raj Kalkeri, Roger G Ptak, Tracy Hartman, Robert W Buckheit, Dominique Schols, Steven De Jonghe, Piet Herdewijn. Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
Journal of medicinal chemistry.
2017 07; 60(14):6220-6238. doi:
10.1021/acs.jmedchem.7b00416. [PMID: 28682067] - Navriti Chadha, Om Silakari. Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.
European journal of medicinal chemistry.
2017 Jul; 134(?):159-184. doi:
10.1016/j.ejmech.2017.04.003. [PMID: 28412530] - Hong-Jie Zhang, Emily Rumschlag-Booms, Yi-Fu Guan, Dong-Ying Wang, Kang-Lun Liu, Wan-Fei Li, Van H Nguyen, Nguyen M Cuong, Djaja D Soejarto, Harry H S Fong, Lijun Rong. Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa.
Journal of natural products.
2017 06; 80(6):1798-1807. doi:
10.1021/acs.jnatprod.7b00004. [PMID: 28613071] - Raquel Mello da Rosa, Bruna Candia Piccoli, Fernanda D'Avila da Silva, Luciano Dornelles, João B T Rocha, Mariana Souza Sonego, Karine Rech Begnini, Tiago Collares, Fabiana K Seixas, Oscar E D Rodrigues. Synthesis, antioxidant and antitumoral activities of 5'-arylchalcogeno-3-aminothymidine (ACAT) derivatives.
MedChemComm.
2017 Feb; 8(2):408-414. doi:
10.1039/c6md00640j. [PMID: 30108758] - Armando Butanda-Ochoa, Diego Rolando Hernández-Espinosa, Marisela Olguín-Martínez, Lourdes Sánchez-Sevilla, Mario R Rodríguez, Benito Chávez-Rentería, Alberto Aranda-Fraustro, Rolando Hernández-Muñoz. A Single Zidovudine (AZT) Administration Delays Hepatic Cell Proliferation by Altering Oxidative State in the Regenerating Rat Liver.
Oxidative medicine and cellular longevity.
2017; 2017(?):8356175. doi:
10.1155/2017/8356175. [PMID: 28479956] - Michal Antoszczak, Ewa Maj, Natalia Kleczewska, Joanna Wietrzyk, Lech Celewicz, Adam Huczynski. Differences in Antiproliferative Activity Between Salinomycin-AZT Conjugates Obtained via 'Click' and Esterification Reactions.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2017; 13(2):127-136. doi:
10.2174/1573406412666160823165522. [PMID: 27557629] - Paolo Palma, Paola Zangari, Claudia Alteri, Hyppolite K Tchidjou, Emma Concetta Manno, Giuseppina Liuzzi, Carlo Federico Perno, Paolo Rossi, Ada Bertoli, Stefania Bernardi. Early antiretroviral treatment (eART) limits viral diversity over time in a long-term HIV viral suppressed perinatally infected child.
BMC infectious diseases.
2016 Dec; 16(1):742. doi:
10.1186/s12879-016-2092-z. [PMID: 27938348] - Ramanathan Raghu, Sivanesan Karthikeyan. Zidovudine and isoniazid induced liver toxicity and oxidative stress: Evaluation of mitigating properties of silibinin.
Environmental toxicology and pharmacology.
2016 Sep; 46(?):217-226. doi:
10.1016/j.etap.2016.07.014. [PMID: 27497728] - Joshy K S, Chandra P Sharma, Nandakumar Kalarikkal, K Sandeep, Sabu Thomas, Laly A Pothen. Evaluation of in-vitro cytotoxicity and cellular uptake efficiency of zidovudine-loaded solid lipid nanoparticles modified with Aloe Vera in glioma cells.
Materials science & engineering. C, Materials for biological applications.
2016 Sep; 66(?):40-50. doi:
10.1016/j.msec.2016.03.031. [PMID: 27207037] - Rebecca M Zash, Roger L Shapiro, Jean Leidner, Carolyn Wester, Alexander J McAdam, Richard L Hodinka, Ibou Thior, Claire Moffat, Joseph Makhema, Kenneth McIntosh, Max Essex, Shahin Lockman. The aetiology of diarrhoea, pneumonia and respiratory colonization of HIV-exposed infants randomized to breast- or formula-feeding.
Paediatrics and international child health.
2016 Aug; 36(3):189-97. doi:
10.1179/2046905515y.0000000038. [PMID: 27595698] - Ei Kinai, Shingo Kato, Shinichi Hosokawa, Miyuki Sadatsuki, Hiroyuki Gatanaga, Yoshimi Kikuchi, Nguyen Van Lam, Do Quan Ha, Nguyen Van Kinh, Nguyen Thanh Liem, Shinichi Oka. High Plasma Concentrations of Zidovudine (AZT) Do Not Parallel Intracellular Concentrations of AZT-Triphosphates in Infants During Prevention of Mother-to-Child HIV-1 Transmission.
Journal of acquired immune deficiency syndromes (1999).
2016 07; 72(3):246-53. doi:
10.1097/qai.0000000000000950. [PMID: 26859826]