Zidovudine (BioDeep_00000397845)

Main id: BioDeep_00000002509

 


代谢物信息卡片


Zidovudine

化学式: C10H13N5O4 (267.0967)
中文名称: 3′-叠氮-3′-脱氧胸苷
谱图信息: 最多检出来源 Homo sapiens(urine) 6.09%

分子结构信息

SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]
InChI: InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

描述信息

J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D009676 - Noxae > D000963 - Antimetabolites > D015224 - Dideoxynucleosides
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3287
Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.

同义名列表

6 个代谢物同义名

Zidovudine; Azidothymidine; AZT; ZDV; Zidovudine; Zidovudine



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ABCB1, ALB, DTYMK, MT4, SRY, TK2
Peripheral membrane protein 1 CYP1B1
Endoplasmic reticulum membrane 3 CD4, CYP1B1, UGT2B7
Mitochondrion membrane 1 ABCG2
Nucleus 4 ALB, DTYMK, MT4, SRY
cytosol 3 ALB, DTYMK, GPT
mitochondrial membrane 1 ABCG2
centrosome 1 ALB
nucleoplasm 2 ABCG2, SRY
Cell membrane 5 ABCB1, ABCG2, CD4, CD8A, TNF
Multi-pass membrane protein 2 ABCB1, ABCG2
cell surface 3 ABCB1, EPO, TNF
Golgi apparatus 1 ALB
Golgi membrane 1 INS
neuronal cell body 1 TNF
plasma membrane 6 ABCB1, ABCG2, CD4, CD8A, IFNLR1, TNF
Membrane 5 ABCB1, ABCG2, CYP1B1, IFNLR1, UGT2B7
apical plasma membrane 2 ABCB1, ABCG2
extracellular exosome 4 ABCB1, ALB, EPO, GPT
endoplasmic reticulum 1 ALB
extracellular space 7 ALB, EPO, IFNA1, IL2, IL6, INS, TNF
mitochondrion 3 CYP1B1, DTYMK, TK2
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 1 CYP1B1
Single-pass type I membrane protein 3 CD4, CD8A, IFNLR1
Secreted 6 ALB, EPO, IFNA1, IL2, IL6, INS
extracellular region 7 ALB, CD8A, EPO, IL2, IL6, INS, TNF
Single-pass membrane protein 1 UGT2B7
[Isoform 2]: Secreted 1 CD8A
mitochondrial matrix 2 DTYMK, TK2
anchoring junction 1 ALB
external side of plasma membrane 3 CD4, CD8A, TNF
Early endosome 1 CD4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 2 ABCB1, ABCG2
Membrane raft 3 ABCG2, CD4, TNF
nuclear speck 1 SRY
receptor complex 1 CD8A
ciliary basal body 1 ALB
chromatin 1 SRY
phagocytic cup 1 TNF
centriole 1 ALB
brush border membrane 1 ABCG2
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 1 INS
Nucleus speckle 1 SRY
cell body 1 EPO
plasma membrane raft 1 CD8A
secretory granule lumen 2 EPO, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, CD4, IL6, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 CD4
external side of apical plasma membrane 2 ABCB1, ABCG2
[Isoform 1]: Cell membrane 1 CD8A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 2 CD4, CD8A
interleukin-6 receptor complex 1 IL6
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Dhananjay Singh, Nishu Mittal, Swati Verma, Anjali Singh, Mohammed Haris Siddiqui. Applications of some advanced sequencing, analytical, and computational approaches in medicinal plant research: a review. Molecular biology reports. 2023 Dec; 51(1):23. doi: 10.1007/s11033-023-09057-1. [PMID: 38117315]
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