Enoxacin (BioDeep_00000002432)
Secondary id: BioDeep_00001868182
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
化学式: C15H17FN4O3 (320.1285)
中文名称: 依诺沙星
谱图信息:
最多检出来源 Homo sapiens(blood) 87.11%
分子结构信息
SMILES: CCN1C=C(C(=O)C2=CC(=C(N=C21)N3CCNCC3)F)C(=O)O
InChI: InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)
描述信息
Enoxacin is only found in individuals that have used or taken this drug. It is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. [PubChem]Enoxacin exerts its bactericidal action via the inhibition of the essential bacterial enzyme DNA gyrase (DNA Topoisomerase II).
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065609 - Cytochrome P-450 CYP1A2 Inhibitors
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3078
同义名列表
20 个代谢物同义名
1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid; 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylate; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylate; Rhône-poulenc rorer brand OF enoxacin sesquihydrate; Rhône poulenc rorer brand OF enoxacin sesquihydrate; Pierre fabre brand OF enoxacin sesquihydrate; Faulding brand OF enoxacin; Sesquihydrate, enoxacin; Enoxacin sesquihydrate; Enoxacinum; Enoxacine; Enoxacino; Penetrex; enoxacin; Enoxor; Enoxin; ENX; Enoxacin
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:157175
- KEGG: C06979
- KEGGdrug: D00310
- PubChem: 28230148
- PubChem: 3229
- HMDB: HMDB0014610
- Metlin: METLIN44460
- DrugBank: DB00467
- ChEMBL: CHEMBL826
- Wikipedia: Enoxacin
- MeSH: Enoxacin
- chemspider: 3116
- CAS: 74011-58-8
- MoNA: EQ307805
- MoNA: EQ307806
- MoNA: EQ307803
- MoNA: EQ307804
- MoNA: EQ307801
- MoNA: EQ307802
- PMhub: MS000002598
- PubChem: 9193
- NIKKAJI: J20.568K
- RefMet: Enoxacin
- KNApSAcK: 157175
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nezar Boreak, Ethar Awad Alrajab, Rayan Ali Nahari, Loay Ebrahim Najmi, Muhannad Ali Masmali, Atiah Abdulrahman Ghawi, Mohammed M Al Moaleem, Majed Yahya Alhazmi, Abdulrahman Abdullah Maqbul. Unveiling Therapeutic Potential: Targeting Fusobacterium nucleatum's Lipopolysaccharide Biosynthesis for Endodontic Infections-An In Silico Screening Study.
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2024 Apr; 25(8):. doi:
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2021 06; 64(11):7404-7421. doi:
10.1021/acs.jmedchem.1c00018. [PMID: 34038111] - Amirhossein Ahmadi, Sharif Moradi. In silico analysis suggests the RNAi-enhancing antibiotic enoxacin as a potential inhibitor of SARS-CoV-2 infection.
Scientific reports.
2021 05; 11(1):10271. doi:
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Talanta.
2006 Aug; 70(1):58-62. doi:
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Journal of fluorescence.
2006 Jul; 16(4):535-40. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2006 May; 64(1):130-5. doi:
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Journal of agricultural and food chemistry.
2006 Apr; 54(8):2822-7. doi:
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Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2006 Apr; 12(2):109-11. doi:
10.1007/s10156-006-0429-z. [PMID: 16648952] - Wei Bian, Yan-li Wei, Ya-ping Wang, Chuan Dong. [Study on interaction of caffeine and theophylline with bovine serum albumins].
Guang pu xue yu guang pu fen xi = Guang pu.
2006 Mar; 26(3):505-8. doi:
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Talanta.
2006 Feb; 68(4):1215-21. doi:
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Drug and chemical toxicology.
2006 Jan; 29(1):25-38. doi:
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Guang pu xue yu guang pu fen xi = Guang pu.
2005 Oct; 25(10):1634-6. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Aug; 822(1-2):185-93. doi:
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Therapeutic drug monitoring.
2005 Jun; 27(3):349-53. doi:
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Journal of separation science.
2005 Apr; 28(6):555-65. doi:
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The American journal of Chinese medicine.
2005; 33(4):671-82. doi:
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Asian Pacific journal of cancer prevention : APJCP.
2004 Apr; 5(2):196-204. doi:
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Talanta.
2004 Mar; 62(4):853-60. doi:
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The British journal of dermatology.
2003 Dec; 149(6):1232-41. doi:
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Talanta.
2003 Nov; 61(3):403-9. doi:
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Current drug metabolism.
2003 Oct; 4(5):371-80. doi:
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Analytical chemistry.
2003 Jun; 75(11):2640-6. doi:
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Analytical and bioanalytical chemistry.
2003 Mar; 375(5):623-9. doi:
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Toxicology mechanisms and methods.
2003; 13(3):221-6. doi:
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The Japanese journal of antibiotics.
2002 Jun; 55(3):259-69. doi:
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Journal of chromatography. A.
2002 Apr; 952(1-2):121-9. doi:
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JAMA.
2001 Dec; 286(24):3115-9. doi:
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The Journal of antimicrobial chemotherapy.
2001 Dec; 48(6):813-20. doi:
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Yao xue xue bao = Acta pharmaceutica Sinica.
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Journal of AOAC International.
2001 May; 84(3):684-8. doi:
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Masui. The Japanese journal of anesthesiology.
2001 Apr; 50(4):425-8. doi:
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
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Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao.
1999 Sep; 30(3):334-6. doi:
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Clinical pharmacology and therapeutics.
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