Fenamiphos (BioDeep_00000002427)

 

Secondary id: BioDeep_00001867752

human metabolite Endogenous


代谢物信息卡片


Ethyl 3-methyl-4-(methylsulphanyl)phenyl (1-methylethyl)amidophosphoric acid

化学式: C13H22NO3PS (303.1058)
中文名称: 甲醇中苯线磷溶液
谱图信息: 最多检出来源 Mentha canadensis(plant) 19.69%

分子结构信息

SMILES: CCOP(=O)(NC(C)C)OC1=CC(=C(C=C1)SC)C
InChI: InChI=1S/C13H22NO3PS/c1-6-16-18(15,14-10(2)3)17-12-7-8-13(19-5)11(4)9-12/h7-10H,6H2,1-5H3,(H,14,15)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 1097; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9512; ORIGINAL_PRECURSOR_SCAN_NO 9511
CONFIDENCE standard compound; INTERNAL_ID 1097; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9468; ORIGINAL_PRECURSOR_SCAN_NO 9467
CONFIDENCE standard compound; INTERNAL_ID 1097; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9521; ORIGINAL_PRECURSOR_SCAN_NO 9519
CONFIDENCE standard compound; INTERNAL_ID 1097; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9503; ORIGINAL_PRECURSOR_SCAN_NO 9502
CONFIDENCE standard compound; INTERNAL_ID 1097; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9453; ORIGINAL_PRECURSOR_SCAN_NO 9452
CONFIDENCE standard compound; INTERNAL_ID 1097; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9474; ORIGINAL_PRECURSOR_SCAN_NO 9473
Systemic agricultural nematocide. Cholinesterase inhibitor Fenamiphos is an organophosphate acetylcholinesterase inhibitor used as an insecticide
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D016573 - Agrochemicals
D010575 - Pesticides

同义名列表

25 个代谢物同义名

Ethyl 3-methyl-4-(methylsulphanyl)phenyl (1-methylethyl)amidophosphoric acid; Ethyl 3-methyl-4-(methylsulfanyl)phenyl (1-methylethyl)amidophosphoric acid; {ethoxy[3-methyl-4-(methylsulfanyl)phenoxy]phosphoryl}(propan-2-yl)amine; Isopropylamino-O-ethyl-(4-methylmercapto-3-methylphenyl)phosphoric acid; Ethyl 3-methyl-4-(methylsulphanyl)phenyl (1-methylethyl)amidophosphate; Ethyl 3-methyl-4-(methylthio)phenyl 1-methylethylphosphoramidate, 9ci; Ethyl 3-methyl-4-(methylsulfanyl)phenyl (1-methylethyl)amidophosphate; Isopropylamino-O-ethyl-(4-methylmercapto-3-methylphenyl)phosphate; Ethyl 3-methyl-4-(methylthio)phenyl isopropylphosphoramidic acid; Ethyl 3-methyl-4-(methylthio)phenyl isopropylphosphoramidate; Ethyl 3-methyl-4-(methylthio)phenyl isopropylamidophosphate; Ethyl 4-(methylthio)-m-tolyl isopropylphosphoramidic acid; m-Cresol, 4-(methylthio)-, ethyl isopropylphosphoramidate; Ethyl 4-methylthio-m-tolyl isopropylphosphoramidate, 8ci; Ethyl 4-(methylthio)-m-tolyl isopropylphosphoramidate; Ethyl-4-(methylthio)-m-tolyl isopropylphosphoramidate; Ethyl 4-(methylthio)m-tolyl isopropylphosphoroamidate; Phenamifos sulfoxide; Methaphenamiphos; BAY sra 3886; Phenamiphos; FENAMIPHOS; Nemacur p; Nemacur; Fenamiphos



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CYP2B6, CYP2C19, CYP2E1, CYP3A4
Peripheral membrane protein 5 ACHE, CYP1B1, CYP2B6, CYP2E1, TMT1B
Endoplasmic reticulum membrane 10 CYP1A2, CYP1B1, CYP2B6, CYP2C19, CYP2E1, CYP3A4, CYP3A5, PNPLA6, PON1, TMT1B
Nucleus 1 ACHE
cytosol 2 PNPLA6, TMT1B
nucleoplasm 1 ATP2B1
Cell membrane 3 ACHE, ATP2B1, PLXNB2
Multi-pass membrane protein 3 ATP2B1, SLC22A6, SLC22A8
Synapse 3 ACHE, ATP2B1, TAC1
cell surface 3 ACHE, PLXNB2, TNR
glutamatergic synapse 2 ATP2B1, TNR
Golgi apparatus 2 ACHE, ATRN
mitochondrial inner membrane 1 CYP2E1
neuromuscular junction 1 ACHE
neuronal cell body 1 TAC1
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 TMT1B
plasma membrane 8 ACHE, ATP2B1, ATRN, BCHE, CYP2C19, PLXNB2, SLC22A6, SLC22A8
synaptic vesicle membrane 1 ATP2B1
Membrane 7 ACHE, ATP2B1, CYP1B1, CYP3A4, CYP3A5, PNPLA6, SLC22A6
apical plasma membrane 1 SLC22A8
axon 1 TAC1
basolateral plasma membrane 3 ATP2B1, SLC22A6, SLC22A8
caveola 1 SLC22A6
extracellular exosome 7 ATP2B1, ATRN, PLXNB2, PON1, SLC22A6, SLC22A8, TTR
endoplasmic reticulum 1 PNPLA6
extracellular space 7 ACHE, ATRN, BCHE, PON1, TAC1, TNR, TTR
perinuclear region of cytoplasm 1 ACHE
Schaffer collateral - CA1 synapse 1 TNR
mitochondrion 1 CYP1B1
protein-containing complex 1 SLC22A6
intracellular membrane-bounded organelle 8 ATP2B1, CYP1A2, CYP1B1, CYP2B6, CYP2C19, CYP2E1, CYP3A4, CYP3A5
Microsome membrane 6 CYP1A2, CYP1B1, CYP2B6, CYP2E1, CYP3A4, CYP3A5
Single-pass type I membrane protein 2 ATRN, PLXNB2
Secreted 3 ACHE, BCHE, TTR
extracellular region 6 ACHE, BCHE, PON1, TAC1, TNR, TTR
[Isoform 2]: Secreted 1 ATRN
Extracellular side 1 ACHE
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Secreted, extracellular space, extracellular matrix 1 TNR
high-density lipoprotein particle 1 PON1
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 1 TNR
basement membrane 1 ACHE
collagen-containing extracellular matrix 1 TNR
lateral plasma membrane 2 ATP2B1, SLC22A8
cell projection 1 ATP2B1
blood microparticle 2 BCHE, PON1
Basolateral cell membrane 3 ATP2B1, SLC22A6, SLC22A8
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 3]: Secreted 1 ATRN
Lipid droplet 1 TMT1B
Presynaptic cell membrane 1 ATP2B1
side of membrane 1 ACHE
basal plasma membrane 1 SLC22A6
Microsome 1 TMT1B
endoplasmic reticulum lumen 1 BCHE
Single-pass type III membrane protein 1 PNPLA6
azurophil granule lumen 1 TTR
immunological synapse 1 ATP2B1
perineuronal net 1 TNR
nuclear envelope lumen 1 BCHE
semaphorin receptor complex 1 PLXNB2
synaptic cleft 1 ACHE
Basal cell membrane 1 SLC22A6
[Isoform 1]: Cell membrane 1 ATRN
spherical high-density lipoprotein particle 1 PON1
photoreceptor ribbon synapse 1 ATP2B1
tenascin complex 1 TNR
[Isoform H]: Cell membrane 1 ACHE


文献列表

  • Azza G A Reyad, Moustafa A Abbassy, Gehan I Kh Marei, Entsar I Rabea, Mohamed E I Badawy. Removal of fenamiphos, imidacloprid, and oxamyl pesticides from water by microalgal Nannochloropsis oculata biomass and their determination by validated HPLC method. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2023 Apr; ?(?):1-12. doi: 10.1080/03601234.2023.2195530. [PMID: 37006160]
  • Jung-Kai Hsu, Chia-Wei Weng, Jeremy J W Chen, Peichen Janet Chen. The ACE genes in Aphelenchoides besseyi isolates and their expression correlation to the fenamiphos treatment. Scientific reports. 2022 02; 12(1):1975. doi: 10.1038/s41598-022-05998-y. [PMID: 35132122]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Sherif B Abdel Ghani, Suloiman Al-Rehiayani, Moustafa El Agamy, Luigi Lucini. Effects of biochar amendment on sorption, dissipation, and uptake of fenamiphos and cadusafos nematicides in sandy soil. Pest management science. 2018 Nov; 74(11):2652-2659. doi: 10.1002/ps.5075. [PMID: 29761623]
  • Ahmed Ali Romeh, Mohamed Yousef Hendawi. Biochemical interactions between Glycine max L. silicon dioxide (SiO2) and plant growth-promoting bacteria (PGPR) for improving phytoremediation of soil contaminated with fenamiphos and its degradation products. Pesticide biochemistry and physiology. 2017 Oct; 142(?):32-43. doi: 10.1016/j.pestbp.2017.01.001. [PMID: 29107245]
  • Almenares-López Damianys, Martínez-Salazar María Fernanda, Ortiz-Hernández María Laura, Vazquez-Duhalt Rafael, Monroy-Noyola Antonio. Fenamiphos is recalcitrant to the hydrolysis by alloforms PON1 Q192R of human serum. Toxicology in vitro : an international journal published in association with BIBRA. 2013 Mar; 27(2):681-5. doi: 10.1016/j.tiv.2012.11.014. [PMID: 23201180]
  • Marcos Paradelo, Paula Pérez-Rodríguez, Manuel Arias-Estévez, J Eugenio López-Periago. Influence of pore water velocity on the release of carbofuran and fenamiphos from commercial granulates embedded in a porous matrix. Journal of contaminant hydrology. 2012 Nov; 142-143(?):75-81. doi: 10.1016/j.jconhyd.2012.10.004. [PMID: 23143183]
  • Rui Su, Xu Xu, Xinghua Wang, Dan Li, Xueyuan Li, Hanqi Zhang, Aimin Yu. Determination of organophosphorus pesticides in peanut oil by dispersive solid phase extraction gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Nov; 879(30):3423-8. doi: 10.1016/j.jchromb.2011.09.016. [PMID: 21963478]
  • Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb; 280(3):77-87. doi: 10.1016/j.tox.2010.11.008. [PMID: 21115097]
  • Fa Yuan Wang, Rui Jian Tong, Zhao Yong Shi, Xiao Feng Xu, Xin Hua He. Inoculations with arbuscular mycorrhizal fungi increase vegetable yields and decrease phoxim concentrations in carrot and green onion and their soils. PloS one. 2011 Feb; 6(2):e16949. doi: 10.1371/journal.pone.0016949. [PMID: 21347374]
  • Hari C Meher, Vijay T Gajbhiye, Ghanendra Singh, Anju Kamra, Gautam Chawla. Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions. Journal of agricultural and food chemistry. 2010 Feb; 58(3):1815-22. doi: 10.1021/jf903609d. [PMID: 20085277]
  • Yuji Oka, Shimshon Shuker, Nadia Tkachi. Nematicidal efficacy of MCW-2, a new nematicide of the fluoroalkenyl group, against the root-knot nematode Meloidogyne javanica. Pest management science. 2009 Oct; 65(10):1082-9. doi: 10.1002/ps.1796. [PMID: 19488996]
  • William T Crow, James P Cuda, Bruce R Stevens. Efficacy of methionine against ectoparasitic nematodes on golf course turf. Journal of nematology. 2009 Sep; 41(3):217-20. doi: . [PMID: 22736817]
  • John A Lewis, Maria Szilagyi, Elizabeth Gehman, William E Dennis, David A Jackson. Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans. BMC genomics. 2009 Apr; 10(?):202. doi: 10.1186/1471-2164-10-202. [PMID: 19402892]
  • Sara Sánchez-Moreno, Elena Alonso-Prados, J Luis Alonso-Prados, José M García-Baudín. Multivariate analysis of toxicological and environmental properties of soil nematicides. Pest management science. 2009 Jan; 65(1):82-92. doi: 10.1002/ps.1650. [PMID: 18823060]
  • J Alfonso Cabrera, Richard A Sikora, Alexander Schouten. Involvement of microorganisms other than pseudomonad's on the degradation of the non-fumigant organophosphate nematicide fenamiphos. Communications in agricultural and applied biological sciences. 2009; 74(1):91-105. doi: ". [PMID: 20218515]
  • Rosa Ma González-Rodríguez, Raquel Rial-Otero, Beatriz Cancho-Grande, Jesús Simal-Gándara. Determination of 23 pesticide residues in leafy vegetables using gas chromatography-ion trap mass spectrometry and analyte protectants. Journal of chromatography. A. 2008 Jul; 1196-1197(?):100-9. doi: 10.1016/j.chroma.2008.02.087. [PMID: 18343389]
  • Wt Crow, Dl Porazinska, Rm Giblin-Davis, Ps Grewal. Entomopathogenic nematodes are not an alternative to fenamiphos for management of plant-parasitic nematodes on golf courses in Florida. Journal of nematology. 2006 Mar; 38(1):52-8. doi: ". [PMID: 19259430]
  • C C Fleming, S J Turner, M Hunt. Management of root knot nematodes in turfgrass using mustard formulations and biostimulants. Communications in agricultural and applied biological sciences. 2006; 71(3 Pt A):653-8. doi: ". [PMID: 17390806]
  • W T Crow. Alternatives to fenamiphos for management of plant-parasitic nematodes on bermudagrass. Journal of nematology. 2005 Dec; 37(4):477-82. doi: ". [PMID: 19262894]
  • Dimitrios Georgios Karpouzas, Polydoros Hatziapostolou, Euphemia Papadopoulou-Mourkidou, Ioannis O Giannakou, Athena Georgiadou. The enhanced biodegradation of fenamiphos in soils from previously treated sites and the effect of soil fumigants. Environmental toxicology and chemistry. 2004 Sep; 23(9):2099-107. doi: 10.1897/03-531. [PMID: 15378984]
  • Qingli Ma, R Don Wauchope, Liwang Ma, Kenneth W Rojas, Robert W Malone, Lajpat R Ahuja. Test of the Root Zone Water Quality Model (RZWQM) for predicting runoff of atrazine, alachlor and fenamiphos species from conventional-tillage corn mesoplots. Pest management science. 2004 Mar; 60(3):267-76. doi: 10.1002/ps.846. [PMID: 15025238]
  • Emmanuel A Tzortzakakis, Serafim E Petsas. Investigation of alternatives to methyl bromide for management of Meloidogyne javanica on greenhouse grown tomato. Pest management science. 2003 Dec; 59(12):1311-20. doi: 10.1002/ps.764. [PMID: 14667053]
  • Brajesh K Singh, Allan Walker, J Alun W Morgan, Denis J Wright. Role of soil pH in the development of enhanced biodegradation of fenamiphos. Applied and environmental microbiology. 2003 Dec; 69(12):7035-43. doi: 10.1128/aem.69.12.7035-7043.2003. [PMID: 14660347]
  • Ioannis O Giannakou, Dimitrios G Karpouzas. Evaluation of chemical and integrated strategies as alternatives to methyl bromide for the control of root-knot nematodes in Greece. Pest management science. 2003 Aug; 59(8):883-92. doi: 10.1002/ps.692. [PMID: 12916769]
  • N Sasanelli, P Greco, T D'addabbo, M I Coiro, F Lamberti. The use of olive mill wastes for the control of root-knot nematodes. Communications in agricultural and applied biological sciences. 2003; 68(4 Pt A):135-8. doi: ". [PMID: 15149102]
  • F Lamberti, T D'Addabbo, P Greco, A Carella. Efficacy of the liquid formulation of some nematicides. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen). 2002; 67(3):699-702. doi: ". [PMID: 12696439]
  • A Ramesh, M Balasubramanian. Kinetics and hydrolysis of fenamiphos, fipronil, and trifluralin in aqueous buffer solutions. Journal of agricultural and food chemistry. 1999 Aug; 47(8):3367-71. doi: 10.1021/jf980885m. [PMID: 10552659]
  • M M el-Morshedy, N H Aziz. Effects of fenamiphos, carbofuran, and aldicarb on zearalenone production by toxigenic Fusarium spp. contaminating roots and fruits of tomato. Bulletin of environmental contamination and toxicology. 1995 Apr; 54(4):514-8. doi: 10.1007/bf00192593. [PMID: 7767028]
  • J B Kotcon, M Wimmer. Monitoring movement of fenamiphos through soil water in peach orchards using quantitation by gas chromatography/mass spectrometry. Bulletin of environmental contamination and toxicology. 1993 Jan; 50(1):35-42. doi: 10.1007/bf00196538. [PMID: 8418936]
  • A K Salama, M A Radwan, F I el-Shahawi. Pharmacokinetic profile and anticholinesterase properties of phenamiphos in male rats. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1992 Jun; 27(3):307-23. doi: 10.1080/03601239209372782. [PMID: 1619216]
  • J Pauluhn, L Machemer, G Kimmerle. Effects of inhaled cholinesterase inhibitors on bronchial tonus and on plasma and erythrocyte acetylcholine esterase activity in rats. Toxicology. 1987 Oct; 46(2):177-90. doi: 10.1016/0300-483x(87)90126-0. [PMID: 3672530]
  • J S Thornton. Determination of residues of nemacur and its metabolites in plant and animal tissues. Journal of agricultural and food chemistry. 1971 Sep; 19(5):890-3. doi: 10.1021/jf60177a007. [PMID: 5134651]