Cefaclor (BioDeep_00000002405)

 

Secondary id: BioDeep_00000398908

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


(6R,7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

化学式: C15H14ClN3O4S (367.03935140000004)
中文名称: 头孢克洛杂质C, 头孢克洛
谱图信息: 最多检出来源 Escherichia coli(natural_products) 25%

分子结构信息

SMILES: C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)Cl
InChI: InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1

描述信息

Cefaclor is only found in individuals that have used or taken this drug. It is a semisynthetic, broad-spectrum antibiotic derivative of cephalexin. [PubChem]Cefaclor, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is possible that cefaclor interferes with an autolysin inhibitor.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DC - Second-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3069
Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections[1][2][3][4].

同义名列表

17 个代谢物同义名

(6R,7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid; 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylate; Monohydrate, cefaclor; Cefaclor Monohydrate; Anhydrous, cefaclor; Cefaclor Impurity C; Cefaclor anhydrous; Lilly 99638; Cefaclorum; Cephaclor; Alenfral; cefaclor; Ceclor; Keclor; CCL; Cefaclor



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • A Alper Öztürk, İrem Namlı, Abdurrahman Aygül. Cefaclor Monohydrate-Loaded Colon-Targeted Nanoparticles for Use in COVID-19 Dependent Coinfections and Intestinal Symptoms: Formulation, Characterization, Release Kinetics, and Antimicrobial Activity. Assay and drug development technologies. 2021 04; 19(3):156-175. doi: 10.1089/adt.2020.1014. [PMID: 33728979]
  • Young Hee Nam, So Hee Lee, Hyo In Rhyou, Young Soo Lee, Seung Hee Park, Young Hee Lee, Yoo Seob Shin, Hae Sim Park, Young Min Ye. Proper Cut-off Levels of Serum Specific IgE to Cefaclor for Patients with Cefaclor Allergy. Yonsei medical journal. 2018 Oct; 59(8):968-974. doi: 10.3349/ymj.2018.59.8.968. [PMID: 30187704]
  • M Ali Fadel, Reem H El-Gebaly, Shaimaa A Mohamed, Ashraf M M Abdelbacki. Biophysical control of the growth of Agrobacterium tumefaciens using extremely low frequency electromagnetic waves at resonance frequency. Biochemical and biophysical research communications. 2017 12; 494(1-2):365-371. doi: 10.1016/j.bbrc.2017.10.008. [PMID: 28988110]
  • Shazia Naz, Muhammad Harris Shoaib, Lubna Bashir, Rabia Ismail Yousuf, Fakhsheena Anjum, Fahad Siddiqui, Saima Yaseen. HPLC method development and validation for the determination of Cefaclor in human plasma. Pakistan journal of pharmaceutical sciences. 2017 Sep; 30(5):1645-1649. doi: NULL. [PMID: 29084685]
  • Adel Alagl, Sumit Bedi, Khalid Hassan, Jehan AlHumaid. Use of platelet-rich plasma for regeneration in non-vital immature permanent teeth: Clinical and cone-beam computed tomography evaluation. The Journal of international medical research. 2017 Apr; 45(2):583-593. doi: 10.1177/0300060517692935. [PMID: 28415948]
  • Zdenko Tomić, Ana Tomas, Saša Vukmirović, Momir Mikov, Olga Horvat, Nataša Tomić, Ana Sabo. Do We Bury Antibacterials When Launching? Cefaclor Example. Journal of pharmaceutical sciences. 2016 Mar; 105(3):1295-300. doi: 10.1016/j.xphs.2015.12.003. [PMID: 26886327]
  • Giorgio Piccinelli, Valeria Biscaro, Franco Gargiulo, Arnaldo Caruso, Maria Antonia De Francesco. Characterization and antibiotic susceptibility of Streptococcus agalactiae isolates causing urinary tract infections. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2015 Aug; 34(?):1-6. doi: 10.1016/j.meegid.2015.07.001. [PMID: 26144658]
  • Hye-Soo Yoo, Seung-Hyun Kim, Hyouk-Soo Kwon, Tae-Bum Kim, Young-Hee Nam, Young-Min Ye, Hae-Sim Park. Immunologic evaluation of immediate hypersensitivity to cefaclor. Yonsei medical journal. 2014 Nov; 55(6):1473-83. doi: 10.3349/ymj.2014.55.6.1473. [PMID: 25323882]
  • Chenrong Huang, Wei Wang, Liyan Miao. Determination of cefaclor by UPLC-MS-MS for a Chinese pharmacokinetic study. Journal of chromatographic science. 2014 Aug; 52(7):636-40. doi: 10.1093/chromsci/bmt092. [PMID: 23839802]
  • T Bezgin, A D Yilmaz, B N Celik, H Sönmez. Concentrated platelet-rich plasma used in root canal revascularization: 2 case reports. International endodontic journal. 2014 Jan; 47(1):41-9. doi: 10.1111/iej.12144. [PMID: 23772873]
  • Zhen Zhang, Yun Xiang, Baoxiang Wang, Hongbo Chen, Xiaofang Cai, Xiaomei Wang, Lin Mei, Yi Zheng. Intestinal mucosal permeability of children with cefaclor-associated serum sickness-like reactions. European journal of pediatrics. 2013 Apr; 172(4):537-43. doi: 10.1007/s00431-012-1926-y. [PMID: 23296953]
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  • Jun-Mei Li, Cen Li, Ye Jiang, Shu-Meng Ren. Pretreatment of plasma samples by a novel hollow fiber centrifugal ultrafiltrate device for the determination of cefaclor concentrations in human plasma. Journal of chromatography. A. 2010 Oct; 1217(44):6824-8. doi: 10.1016/j.chroma.2010.08.059. [PMID: 20863507]
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  • Jing Ma, Max Bellon, Judith M Wishart, Richard L Young, Karen L Jones, Michael Horowitz, Christopher K Rayner. Effects of cefaclor on gastric emptying and cholecystokinin release in healthy humans. Regulatory peptides. 2010 Jan; 159(1-3):156-9. doi: 10.1016/j.regpep.2009.11.009. [PMID: 19914303]
  • Sang-Jun Choi, Ju-Hee Ryu, Heon-Woo Lee, Myung-Jae Lee, Ji-Hyung Seo, Seong-Kun Tak, Kyung-Tae Lee. Rapid and simple method for determination of cephradine in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS): application to the bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Dec; 877(31):4059-64. doi: 10.1016/j.jchromb.2009.10.011. [PMID: 19854118]
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  • Lichuan Niu, Zhenghua Song, Xili He. A study of the chemiluminescence behavior of cephalosporins with luminol and its analytical application. Drug metabolism letters. 2009 Aug; 3(3):144-51. doi: 10.2174/187231209789352157. [PMID: 19702549]
  • April Barbour, Stephan Schmidt, Sreedharan Nair Sabarinath, Maria Grant, Christoph Seubert, Donna Skee, Bindu Murthy, Hartmut Derendorf. Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis. Antimicrobial agents and chemotherapy. 2009 Jul; 53(7):2773-6. doi: 10.1128/aac.01409-08. [PMID: 19364847]
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  • Ayan Sen. Recurrent cystitis in non-pregnant women. BMJ clinical evidence. 2008 Jul; 2008(?):. doi: NULL. [PMID: 19445741]
  • Sadhana Ravishankar, Libin Zhu, Bibiana Law, Lynn Joens, Mendel Friedman. Plant-derived compounds inactivate antibiotic-resistant Campylobacter jejuni strains. Journal of food protection. 2008 Jun; 71(6):1145-9. doi: 10.4315/0362-028x-71.6.1145. [PMID: 18592739]
  • Matthew E Falagas, Michael Polemis, Vangelis G Alexiou, Alexandra Marini-Mastrogiannaki, Jeni Kremastinou, Alkiviadis C Vatopoulos. Antimicrobial resistance of Esherichia coli urinary isolates from primary care patients in Greece. Medical science monitor : international medical journal of experimental and clinical research. 2008 Feb; 14(2):CR75-79. doi: . [PMID: 18227764]
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  • Qian Gong, Zhe-yi Hu, Zhi-zhuang Huang, Li-qing Wang, Wen-fang Liu, Xin Guo, Wei Cao, Ting Wang, Ze-neng Cheng. Pharmacokinetic interaction between cefaclor and bromhexine in healthy Chinese volunteers. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2007 Oct; 32(5):855-61. doi: NULL. [PMID: 18007084]
  • Rajani Katta, Vijayalaxmi Anusuri. Serum sickness-like reaction to cefuroxime: a case report and review of the literature. Journal of drugs in dermatology : JDD. 2007 Jul; 6(7):747-8. doi: . [PMID: 17763603]
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  • Meng Li, Gail D Anderson, Brian R Phillips, Wei Kong, Danny D Shen, Joanne Wang. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug metabolism and disposition: the biological fate of chemicals. 2006 Apr; 34(4):547-55. doi: 10.1124/dmd.105.006791. [PMID: 16434549]
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