cefaclor (BioDeep_00000398908)

Main id: BioDeep_00000002405

 

natural product


代谢物信息卡片


Cefaclor Impurity C

化学式: C15H14ClN3O4S (367.03935140000004)
中文名称: 头孢克洛杂质C, 头孢克洛
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)Cl
InChI: InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DC - Second-generation cephalosporins
A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections[1][2][3][4].

同义名列表

3 个代谢物同义名

Cefaclor Impurity C; cefaclor; Cefaclor (Ceclor)



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • A Alper Öztürk, İrem Namlı, Abdurrahman Aygül. Cefaclor Monohydrate-Loaded Colon-Targeted Nanoparticles for Use in COVID-19 Dependent Coinfections and Intestinal Symptoms: Formulation, Characterization, Release Kinetics, and Antimicrobial Activity. Assay and drug development technologies. 2021 04; 19(3):156-175. doi: 10.1089/adt.2020.1014. [PMID: 33728979]
  • Young Hee Nam, So Hee Lee, Hyo In Rhyou, Young Soo Lee, Seung Hee Park, Young Hee Lee, Yoo Seob Shin, Hae Sim Park, Young Min Ye. Proper Cut-off Levels of Serum Specific IgE to Cefaclor for Patients with Cefaclor Allergy. Yonsei medical journal. 2018 Oct; 59(8):968-974. doi: 10.3349/ymj.2018.59.8.968. [PMID: 30187704]
  • M Ali Fadel, Reem H El-Gebaly, Shaimaa A Mohamed, Ashraf M M Abdelbacki. Biophysical control of the growth of Agrobacterium tumefaciens using extremely low frequency electromagnetic waves at resonance frequency. Biochemical and biophysical research communications. 2017 12; 494(1-2):365-371. doi: 10.1016/j.bbrc.2017.10.008. [PMID: 28988110]
  • Shazia Naz, Muhammad Harris Shoaib, Lubna Bashir, Rabia Ismail Yousuf, Fakhsheena Anjum, Fahad Siddiqui, Saima Yaseen. HPLC method development and validation for the determination of Cefaclor in human plasma. Pakistan journal of pharmaceutical sciences. 2017 Sep; 30(5):1645-1649. doi: NULL. [PMID: 29084685]
  • Adel Alagl, Sumit Bedi, Khalid Hassan, Jehan AlHumaid. Use of platelet-rich plasma for regeneration in non-vital immature permanent teeth: Clinical and cone-beam computed tomography evaluation. The Journal of international medical research. 2017 Apr; 45(2):583-593. doi: 10.1177/0300060517692935. [PMID: 28415948]
  • Zdenko Tomić, Ana Tomas, Saša Vukmirović, Momir Mikov, Olga Horvat, Nataša Tomić, Ana Sabo. Do We Bury Antibacterials When Launching? Cefaclor Example. Journal of pharmaceutical sciences. 2016 Mar; 105(3):1295-300. doi: 10.1016/j.xphs.2015.12.003. [PMID: 26886327]
  • Giorgio Piccinelli, Valeria Biscaro, Franco Gargiulo, Arnaldo Caruso, Maria Antonia De Francesco. Characterization and antibiotic susceptibility of Streptococcus agalactiae isolates causing urinary tract infections. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2015 Aug; 34(?):1-6. doi: 10.1016/j.meegid.2015.07.001. [PMID: 26144658]
  • Hye-Soo Yoo, Seung-Hyun Kim, Hyouk-Soo Kwon, Tae-Bum Kim, Young-Hee Nam, Young-Min Ye, Hae-Sim Park. Immunologic evaluation of immediate hypersensitivity to cefaclor. Yonsei medical journal. 2014 Nov; 55(6):1473-83. doi: 10.3349/ymj.2014.55.6.1473. [PMID: 25323882]
  • Chenrong Huang, Wei Wang, Liyan Miao. Determination of cefaclor by UPLC-MS-MS for a Chinese pharmacokinetic study. Journal of chromatographic science. 2014 Aug; 52(7):636-40. doi: 10.1093/chromsci/bmt092. [PMID: 23839802]
  • T Bezgin, A D Yilmaz, B N Celik, H Sönmez. Concentrated platelet-rich plasma used in root canal revascularization: 2 case reports. International endodontic journal. 2014 Jan; 47(1):41-9. doi: 10.1111/iej.12144. [PMID: 23772873]
  • Zhen Zhang, Yun Xiang, Baoxiang Wang, Hongbo Chen, Xiaofang Cai, Xiaomei Wang, Lin Mei, Yi Zheng. Intestinal mucosal permeability of children with cefaclor-associated serum sickness-like reactions. European journal of pediatrics. 2013 Apr; 172(4):537-43. doi: 10.1007/s00431-012-1926-y. [PMID: 23296953]
  • Aaron T Wolman, Michael R Gionfriddo, Gregory A Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy, Adam L Vanwert. Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. Drug metabolism and disposition: the biological fate of chemicals. 2013 Apr; 41(4):791-800. doi: 10.1124/dmd.112.049569. [PMID: 23344796]
  • Bazigha K Abdul Rasool, Sahar A Fahmy. Development of coated beads for oral controlled delivery of cefaclor: In vitro evaluation. Acta pharmaceutica (Zagreb, Croatia). 2013 Mar; 63(1):31-44. doi: 10.2478/acph-2013-0003. [PMID: 23482311]
  • S M Abdel Azeem, H M Kuss, M F El-Shahat. Cationic polyelectrolyte copolymer modified polyurethane foam for flow injection preconcentration and separation of trace amounts of β-lactam antibiotics. Talanta. 2012 Aug; 97(?):513-20. doi: 10.1016/j.talanta.2012.05.007. [PMID: 22841116]
  • Iram Shaifali, Uma Gupta, Syed Esam Mahmood, Jawed Ahmed. Antibiotic susceptibility patterns of urinary pathogens in female outpatients. North American journal of medical sciences. 2012 Apr; 4(4):163-9. doi: 10.4103/1947-2714.94940. [PMID: 22536558]
  • Janak Kishore. Isolation, identification & characterization of Proteus penneri--a missed rare pathogen. The Indian journal of medical research. 2012 Mar; 135(?):341-5. doi: . [PMID: 22561620]
  • Dirk R de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C Paulusma, Ronald P J Oude Elferink. Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug metabolism and disposition: the biological fate of chemicals. 2012 Mar; 40(3):515-21. doi: 10.1124/dmd.111.041731. [PMID: 22166395]
  • J Chen, B Jiang, H Lou, L Yu, Z Ruan. Bioequivalence studies of 2 oral cefaclor capsule formulations in chinese healthy subjects. Arzneimittel-Forschung. 2012 Mar; 62(3):134-7. doi: 10.1055/s-0031-1298012. [PMID: 22286978]
  • Richard Colgan, Mozella Williams. Diagnosis and treatment of acute uncomplicated cystitis. American family physician. 2011 Oct; 84(7):771-6. doi: . [PMID: 22010614]
  • Manisone Khennavong, Viengmon Davone, Manivanh Vongsouvath, Rattanaphone Phetsouvanh, Joy Silisouk, Olay Rattana, Mayfong Mayxay, Josée Castonguay-Vanier, Catrin E Moore, Michel Strobel, Paul N Newton. Urine antibiotic activity in patients presenting to hospitals in Laos: implications for worsening antibiotic resistance. The American journal of tropical medicine and hygiene. 2011 Aug; 85(2):295-302. doi: 10.4269/ajtmh.2011.11-0076. [PMID: 21813851]
  • Daniele Minardi, Gianluca d'Anzeo, Daniele Cantoro, Alessandro Conti, Giovanni Muzzonigro. Urinary tract infections in women: etiology and treatment options. International journal of general medicine. 2011; 4(?):333-43. doi: 10.2147/ijgm.s11767. [PMID: 21674026]
  • Zhuming Wang, Zhenghua Song, Donghua Chen. Study on the binding behavior of bovine serum albumin with cephalosporin analogues by chemiluminescence method. Talanta. 2010 Dec; 83(2):312-9. doi: 10.1016/j.talanta.2010.09.029. [PMID: 21111139]
  • Jun-Mei Li, Cen Li, Ye Jiang, Shu-Meng Ren. Pretreatment of plasma samples by a novel hollow fiber centrifugal ultrafiltrate device for the determination of cefaclor concentrations in human plasma. Journal of chromatography. A. 2010 Oct; 1217(44):6824-8. doi: 10.1016/j.chroma.2010.08.059. [PMID: 20863507]
  • Yohannes Hagos, Natascha A Wolff. Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity. Toxins. 2010 08; 2(8):2055-82. doi: 10.3390/toxins2082055. [PMID: 22069672]
  • Adenike Adedayo O Ogunshe, Abosede Oyeyemi Fawole, Victoria Abosede Ajayi. Microbial evaluation and public health implications of urine as alternative therapy in clinical pediatric cases: health implication of urine therapy. The Pan African medical journal. 2010 May; 5(?):12. doi: 10.4314/pamj.v5i1.56188. [PMID: 21293739]
  • Sreyashi Sarkar, Arnab Pramanik, Anindita Mitra, Joydeep Mukherjee. Bioprocessing data for the production of marine enzymes. Marine drugs. 2010 Apr; 8(4):1323-72. doi: 10.3390/md8041323. [PMID: 20479981]
  • . Cefaclor: serum sickness. Prescrire international. 2010 Apr; 19(106):75. doi: . [PMID: 20568494]
  • Jing Ma, Max Bellon, Judith M Wishart, Richard L Young, Karen L Jones, Michael Horowitz, Christopher K Rayner. Effects of cefaclor on gastric emptying and cholecystokinin release in healthy humans. Regulatory peptides. 2010 Jan; 159(1-3):156-9. doi: 10.1016/j.regpep.2009.11.009. [PMID: 19914303]
  • Sang-Jun Choi, Ju-Hee Ryu, Heon-Woo Lee, Myung-Jae Lee, Ji-Hyung Seo, Seong-Kun Tak, Kyung-Tae Lee. Rapid and simple method for determination of cephradine in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS): application to the bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Dec; 877(31):4059-64. doi: 10.1016/j.jchromb.2009.10.011. [PMID: 19854118]
  • Kenneth Chibuzor Ofokansi, Ogbonna Okorie, Michael Umale Adikwu. Biodegradable microspheres based on gelatin-porcine mucin admixtures: in vitro and in vivo delivery studies. Biological & pharmaceutical bulletin. 2009 Oct; 32(10):1754-9. doi: 10.1248/bpb.32.1754. [PMID: 19801839]
  • Lichuan Niu, Zhenghua Song, Xili He. A study of the chemiluminescence behavior of cephalosporins with luminol and its analytical application. Drug metabolism letters. 2009 Aug; 3(3):144-51. doi: 10.2174/187231209789352157. [PMID: 19702549]
  • April Barbour, Stephan Schmidt, Sreedharan Nair Sabarinath, Maria Grant, Christoph Seubert, Donna Skee, Bindu Murthy, Hartmut Derendorf. Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis. Antimicrobial agents and chemotherapy. 2009 Jul; 53(7):2773-6. doi: 10.1128/aac.01409-08. [PMID: 19364847]
  • Antonino Romano, Francesco Gaeta, Rocco Luigi Valluzzi, Cristiana Alonzi, Marinella Viola, Philippe Jean Bousquet. Diagnosing hypersensitivity reactions to cephalosporins in children. Pediatrics. 2008 Sep; 122(3):521-7. doi: 10.1542/peds.2007-3178. [PMID: 18762521]
  • Ayan Sen. Recurrent cystitis in non-pregnant women. BMJ clinical evidence. 2008 Jul; 2008(?):. doi: NULL. [PMID: 19445741]
  • Sadhana Ravishankar, Libin Zhu, Bibiana Law, Lynn Joens, Mendel Friedman. Plant-derived compounds inactivate antibiotic-resistant Campylobacter jejuni strains. Journal of food protection. 2008 Jun; 71(6):1145-9. doi: 10.4315/0362-028x-71.6.1145. [PMID: 18592739]
  • Matthew E Falagas, Michael Polemis, Vangelis G Alexiou, Alexandra Marini-Mastrogiannaki, Jeni Kremastinou, Alkiviadis C Vatopoulos. Antimicrobial resistance of Esherichia coli urinary isolates from primary care patients in Greece. Medical science monitor : international medical journal of experimental and clinical research. 2008 Feb; 14(2):CR75-79. doi: . [PMID: 18227764]
  • A J Watkinson, E J Murby, S D Costanzo. Removal of antibiotics in conventional and advanced wastewater treatment: implications for environmental discharge and wastewater recycling. Water research. 2007 Oct; 41(18):4164-76. doi: 10.1016/j.watres.2007.04.005. [PMID: 17524445]
  • Qian Gong, Zhe-yi Hu, Zhi-zhuang Huang, Li-qing Wang, Wen-fang Liu, Xin Guo, Wei Cao, Ting Wang, Ze-neng Cheng. Pharmacokinetic interaction between cefaclor and bromhexine in healthy Chinese volunteers. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2007 Oct; 32(5):855-61. doi: NULL. [PMID: 18007084]
  • Rajani Katta, Vijayalaxmi Anusuri. Serum sickness-like reaction to cefuroxime: a case report and review of the literature. Journal of drugs in dermatology : JDD. 2007 Jul; 6(7):747-8. doi: . [PMID: 17763603]
  • Velusamy Srinivasan, Lien T Nguyen, Susan I Headrick, Shelton E Murinda, Stephen P Oliver. Antimicrobial resistance patterns of Shiga toxin-producing Escherichia coli O157:H7 and O157:H7- from different origins. Microbial drug resistance (Larchmont, N.Y.). 2007; 13(1):44-51. doi: 10.1089/mdr.2006.9996. [PMID: 17536933]
  • K Stamatiou, A Alevizos, G Petrakos, I Lentzas, M Papathanasiou, A Mariolis, P Panagopoulos, F Sofras. Study on the efficacy of cefaclor for the treatment of asymptomatic bacteriuria and lower urinary tract infections in pregnant women with a history of hypersensitivity to penicillin. Clinical and experimental obstetrics & gynecology. 2007; 34(2):85-7. doi: . [PMID: 17629158]
  • C Ponvert, C Weilenmann, J Wassenberg, P Walecki, M L Bourgeois, J de Blic, P Scheinmann. Allergy to betalactam antibiotics in children: a prospective follow-up study in retreated children after negative responses in skin and challenge tests. Allergy. 2007 Jan; 62(1):42-6. doi: 10.1111/j.1398-9995.2006.01246.x. [PMID: 17156340]
  • Kenta Adachi, Hitoshi Watarai. Binding behavior of subphthalocyanine-tagged testosterone with human serum albumin at the n-hexane/water interface. Analytical chemistry. 2006 Oct; 78(19):6840-6. doi: 10.1021/ac060720+. [PMID: 17007504]
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  • Zhang-jing Chen, Jing Zhang, Ji-cheng Yu, Guo-ying Cao, Xiao-jie Wu, Yao-guo Shi. Selective method for the determination of cefdinir in human plasma using liquid chromatography electrospray ionization tandam mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Apr; 834(1-2):163-9. doi: 10.1016/j.jchromb.2006.02.047. [PMID: 16531128]
  • Meng Li, Gail D Anderson, Brian R Phillips, Wei Kong, Danny D Shen, Joanne Wang. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug metabolism and disposition: the biological fate of chemicals. 2006 Apr; 34(4):547-55. doi: 10.1124/dmd.105.006791. [PMID: 16434549]
  • Michael Brucculeri, Marian Charlton, David Serur. Serum sickness-like reaction associated with cefazolin. BMC clinical pharmacology. 2006 Feb; 6(?):3. doi: 10.1186/1472-6904-6-3. [PMID: 16504095]
  • Yukoh Aihara, Shuichi Ito, Michiko Aihara, Yoshinori Kobayashi, Shumpei Yokota. Different patterns of cytokines, ECP and immunoglobulin profiles at two adverse drug reactions in a patient. Pediatrics international : official journal of the Japan Pediatric Society. 2005 Dec; 47(6):616-21. doi: 10.1111/j.1442-200x.2005.02143.x. [PMID: 16354212]
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  • Sang-Hoon Kim, Jeong-Hee Choi, Hae-Sim Park. Heterogeneity of the IgE response to allergenic determinants of cefaclor in serum samples from patients with cefaclor-induced anaphylaxis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2005 Jun; 94(6):700-4. doi: 10.1016/s1081-1206(10)61331-2. [PMID: 15984605]
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