Thiophanate-methyl (BioDeep_00000002378)
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
化学式: C12H14N4O4S2 (342.0456444)
中文名称: 甲基托布津
谱图信息:
最多检出来源 Homo sapiens(blood) 25%
分子结构信息
SMILES: COC(=O)NC(=S)NC1=C(NC(=S)NC(=O)OC)C=CC=C1
InChI: InChI=1S/C12H14N4O4S2/c1-19-11(17)15-9(21)13-7-5-3-4-6-8(7)14-10(22)16-12(18)20-2/h3-6H,1-2H3,(H2,13,15,17,21)(H2,14,16,18,22)
描述信息
CONFIDENCE standard compound; INTERNAL_ID 805; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7987; ORIGINAL_PRECURSOR_SCAN_NO 7982
CONFIDENCE standard compound; INTERNAL_ID 805; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7998; ORIGINAL_PRECURSOR_SCAN_NO 7997
CONFIDENCE standard compound; INTERNAL_ID 805; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3833; ORIGINAL_PRECURSOR_SCAN_NO 3831
CONFIDENCE standard compound; INTERNAL_ID 805; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3865; ORIGINAL_PRECURSOR_SCAN_NO 3862
CONFIDENCE standard compound; INTERNAL_ID 805; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3858; ORIGINAL_PRECURSOR_SCAN_NO 3857
CONFIDENCE standard compound; INTERNAL_ID 805; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7945; ORIGINAL_PRECURSOR_SCAN_NO 7943
CONFIDENCE standard compound; INTERNAL_ID 805; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3838; ORIGINAL_PRECURSOR_SCAN_NO 3835
CONFIDENCE standard compound; INTERNAL_ID 805; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3837; ORIGINAL_PRECURSOR_SCAN_NO 3832
CONFIDENCE standard compound; INTERNAL_ID 805; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3853; ORIGINAL_PRECURSOR_SCAN_NO 3849
CONFIDENCE standard compound; INTERNAL_ID 805; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8013; ORIGINAL_PRECURSOR_SCAN_NO 8011
CONFIDENCE standard compound; INTERNAL_ID 805; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7980; ORIGINAL_PRECURSOR_SCAN_NO 7977
CONFIDENCE standard compound; INTERNAL_ID 805; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7934; ORIGINAL_PRECURSOR_SCAN_NO 7932
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
CONFIDENCE standard compound; INTERNAL_ID 2620
D016573 - Agrochemicals
D010575 - Pesticides
同义名列表
31 个代谢物同义名
methyl N-{[2-({[(methoxycarbonyl)amino]methanethioyl}amino)phenyl]carbamothioyl}carbamate; Dimethyl N,n-[1,2-phenylenebis(azanediylcarbonothioyl)]dicarbamic acid; Dimethyl N,n-[1,2-phenylenebis(iminocarbonothioyl)]bis[carbamic acid]; Dimethyl N,n-[1,2-phenylenebis(azanediylcarbonothioyl)]dicarbamate; Dimethyl N,n-[1,2-phenylenebis(iminocarbonothioyl)]bis[carbamate]; Dimethyl 4,4-(O-phenylene)bis(3-thioallophanic acid); Dimethyl 4,4-(O-phenylene)bis(3-thioallophanate); 1,2-Bis(3-(methoxycarbonyl)-2-thioureido)benzene; 1,2-Di-(3-methoxycarbonyl-2-thioureido)benzene; DIMETHYL 4,4-o-PHENYLENE-BIS (3-THIOPHANATE); O-Bis(3-methoxycarbonyl-2-thioureido)benzene; 1,2-Bis(methoxycarbonylthioureido)benzene; Bis-thioallophanate, dimethylphenylene; Dimethylphenylene bis thioallophanate; Dimethylphenylene bis-thioallophanate; Thiophanic acid-methyl; Methyl thiophanic acid; Methylthiophanic acid; Methylthiofanic acid; Thiophanate methyl; Thiophanate-methyl; Methyl thiophanate; Methylthiophanate; Methylthiofanate; Cercobin m-70; Cercobin m 70; Cercobin m70; Thiophanate; Mildothane; Zyban; Thiophanate-methyl
数据库引用编号
32 个数据库交叉引用编号
- ChEBI: CHEBI:35014
- KEGG: C14432
- PubChem: 3032791
- PubChem: 3085
- HMDB: HMDB0259025
- Metlin: METLIN43980
- ChEMBL: CHEMBL487187
- Wikipedia: Thiophanate-methyl
- MeSH: Thiophanate
- chemspider: 2297683
- CAS: 23564-05-8
- MoNA: LU080556
- MoNA: AU262006
- MoNA: LU080553
- MoNA: LU080506
- MoNA: LU080504
- MoNA: LU080552
- MoNA: LU080501
- MoNA: LU080554
- MoNA: AU262002
- MoNA: LU080502
- MoNA: AU262001
- MoNA: LU080555
- MoNA: LU080505
- MoNA: AU262005
- MoNA: LU080551
- MoNA: LU080503
- MoNA: AU262003
- PMhub: MS000002467
- PubChem: 17395432
- NIKKAJI: J3.471A
- KNApSAcK: 35014
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Song Bai, Miaohe Zhang, Shouying Tang, Miao Li, Rong Wu, Suran Wan, Lijun Chen, Xian Wei, Feifei Li. Research Progress on Benzimidazole Fungicides: A Review.
Molecules (Basel, Switzerland).
2024 Mar; 29(6):. doi:
10.3390/molecules29061218
. [PMID: 38542855] - William P Gura, Jhulia Gelain, Edward J Sikora, Edgar L Vinson, Phillip M Brannen, Guido Schnabel. Low frequency of resistance to thiophanate-methyl in Monilinia fructicola populations from southeastern United States peach orchards.
Pesticide biochemistry and physiology.
2023 Dec; 197(?):105642. doi:
10.1016/j.pestbp.2023.105642
. [PMID: 38072561] - Nabil Touzout, Mahfoud Ainas, Rabia Alloti, Chahinez Boussahoua, Aicha Douma, Amel Hind Hassein-Bey, Zahia Brara, Hichem Tahraoui, Jie Zhang, Abdeltif Amrane. Unveiling the Impact of Thiophanate-Methyl on Arthrospira platensis: Growth, Photosynthetic Pigments, Biomolecules, and Detoxification Enzyme Activities.
Frontiers in bioscience (Landmark edition).
2023 10; 28(10):264. doi:
10.31083/j.fbl2810264
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Plant disease.
2023 Aug; ?(?):. doi:
10.1094/pdis-07-23-1440-sc
. [PMID: 37606958] - Jhonatan Barro, Emerson Medeiros Del Ponte, Tom Allen, Jason P Bond, Travis R Faske, Clayton Hollier, Yuba Raj Kandel, Daren S Mueller, Heather M Kelly, Nathan Michael Kleczewski, Keith A Ames, Paul Price, Edward Sikora, Carl Bradley. Efficacy and profitability of fungicides for managing frogeye leaf spot on soybean in the United States: A 10-year quantitative summary.
Plant disease.
2023 May; ?(?):. doi:
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. [PMID: 37157104] - Xiaofeng Su, Shuo Yan, Weisong Zhao, Haiyang Liu, Qinhong Jiang, Ying Wei, Huiming Guo, Meizhen Yin, Jie Shen, Hongmei Cheng. Self-assembled thiophanate-methyl/star polycation complex prevents plant cell-wall penetration and fungal carbon utilization during cotton infection by Verticillium dahliae.
International journal of biological macromolecules.
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. [PMID: 37028625] - Dufang Ke, Han Meng, Wenting Lei, Yulong Zheng, Linhan Li, Mingyi Wang, Rui Zhong, Mo Wang, Fengping Chen. Prevalence of H6Y mutation in β-tubulin causing thiophanate-methyl resistant in Monilinia fructicola from Fujian, China.
Pesticide biochemistry and physiology.
2022 Nov; 188(?):105262. doi:
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. [PMID: 36464367] - Georgios Makris, Nikolaos Nikoloudakis, Anastasios Samaras, Georgios S Karaoglanidis, Loukas I Kanetis. Under Pressure: A Comparative Study of Botrytis cinerea Populations from Conventional and Organic Farms in Cyprus and Greece.
Phytopathology.
2022 Oct; 112(10):2236-2247. doi:
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Plant disease.
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Pest management science.
2022 Jul; 78(7):2985-2994. doi:
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Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
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Plant disease.
2022 Feb; 106(2):634-640. doi:
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. [PMID: 34494869] - Qiuchen Luo, Anita Schoeneberg, Mengjun Hu. Resistance to Azoxystrobin and Thiophanate-Methyl Is Widespread in Colletotrichum spp. Isolates From the Mid-Atlantic Strawberry Fields.
Plant disease.
2021 Aug; 105(8):2202-2208. doi:
10.1094/pdis-09-20-2048-re
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Plant disease.
2021 Feb; 105(2):377-383. doi:
10.1094/pdis-04-20-0889-re
. [PMID: 32729799] - Farag Malhat, Osama Abdallah, Fayza Ahmed, Shokr Abdel Salam, Chris Anagnostopoulos, Mohamed Tawfic Ahmed. Dissipation behavior of thiophanate-methyl in strawberry under open field condition in Egypt and consumer risk assessment.
Environmental science and pollution research international.
2021 Jan; 28(1):1029-1039. doi:
10.1007/s11356-020-10186-4
. [PMID: 32827299] - Lorraine Smith, Wendy Klément, Léonie Dopavogui, Frédéric de Bock, Frédéric Lasserre, Sharon Barretto, Céline Lukowicz, Anne Fougerat, Arnaud Polizzi, Benoist Schaal, Bruno Patris, Colette Denis, Guylène Feuillet, Cécile Canlet, Emilien L Jamin, Laurent Debrauwer, Laila Mselli-Lakhal, Nicolas Loiseau, Hervé Guillou, Nicola Marchi, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre. Perinatal exposure to a dietary pesticide cocktail does not increase susceptibility to high-fat diet-induced metabolic perturbations at adulthood but modifies urinary and fecal metabolic fingerprints in C57Bl6/J mice.
Environment international.
2020 11; 144(?):106010. doi:
10.1016/j.envint.2020.106010
. [PMID: 32745781] - Pingliang Li, Pingyang Sun, Xiangli Dong, Baohua Li. Residue analysis and kinetics modeling of thiophanate-methyl, carbendazim, tebuconazole and pyraclostrobin in apple tree bark using QuEChERS/HPLC-VWD.
Biomedical chromatography : BMC.
2020 Sep; 34(9):e4851. doi:
10.1002/bmc.4851
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Plant disease.
2020 Apr; 104(4):1069-1075. doi:
10.1094/pdis-02-19-0353-re
. [PMID: 32027568] - Jaqueline N DA Silva, Nayara R Monteiro, Patricia A Antunes, Ana Paula A Favareto. Maternal and developmental toxicity after exposure to formulation of chlorothalonil and thiophanate-methyl during organogenesis in rats.
Anais da Academia Brasileira de Ciencias.
2020; 92(4):e20191026. doi:
10.1590/0001-3765202020191026
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Pesticide biochemistry and physiology.
2020 Jan; 162(?):60-68. doi:
10.1016/j.pestbp.2019.08.008
. [PMID: 31836056] - A Chechi, J Stahlecker, M E Dowling, G Schnabel. Diversity in species composition and fungicide resistance profiles in Colletotrichum isolates from apples.
Pesticide biochemistry and physiology.
2019 Jul; 158(?):18-24. doi:
10.1016/j.pestbp.2019.04.002
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Pesticide biochemistry and physiology.
2019 May; 156(?):123-128. doi:
10.1016/j.pestbp.2019.02.011
. [PMID: 31027571] - Di Wu, Liuwei Meng, Liang Yang, Jingyu Wang, Xiaping Fu, Xiaoqiang Du, Shaojia Li, Yong He, Lingxia Huang. Feasibility of Laser-Induced Breakdown Spectroscopy and Hyperspectral Imaging for Rapid Detection of Thiophanate-Methyl Residue on Mulberry Fruit.
International journal of molecular sciences.
2019 Apr; 20(8):. doi:
10.3390/ijms20082017
. [PMID: 31022906] - Yuran Wang, Sen Lian, Xiangli Dong, Caixia Wang, Baohua Li, Pingliang Li. Analysis of the dissipation kinetics of thiophanate-methyl and its metabolite carbendazim in apple leaves using a modified QuEChERS-UPLC-MS/MS method.
Biomedical chromatography : BMC.
2019 Feb; 33(2):e4394. doi:
10.1002/bmc.4394
. [PMID: 30248717] - Haruhisa Suga, Mitsuhiro Arai, Emi Fukasawa, Keiichi Motohashi, Hiroyuki Nakagawa, Hideaki Tateishi, Shin-Ichi Fuji, Masafumi Shimizu, Koji Kageyama, Mitsuro Hyakumachi. Genetic Differentiation Associated with Fumonisin and Gibberellin Production in Japanese Fusarium fujikuroi.
Applied and environmental microbiology.
2019 01; 85(1):. doi:
10.1128/aem.02414-18
. [PMID: 30341078] - Sumit Pradhan, Lee Miller, Vanessa Marcillo, Alma R Koch, Nathalia Graf Grachet, Julio E Molineros, Nathan R Walker, Hassan Melouk, Carla D Garzon. Hormetic Effects of Thiophanate-Methyl in Multiple Isolates of Sclerotinia homoeocarpa.
Plant disease.
2019 Jan; 103(1):89-94. doi:
10.1094/pdis-05-18-0872-re
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Plant disease.
2018 11; 102(11):2142-2148. doi:
10.1094/pdis-11-17-1810-re
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Pesticide biochemistry and physiology.
2018 Nov; 152(?):84-89. doi:
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. [PMID: 30497716] - Juliana S Baggio, Natalia A Peres, Lilian Amorim. Sensitivity of Botrytis cinerea Isolates from Conventional and Organic Strawberry Fields in Brazil to Azoxystrobin, Iprodione, Pyrimethanil, and Thiophanate-Methyl.
Plant disease.
2018 Sep; 102(9):1803-1810. doi:
10.1094/pdis-08-17-1221-re
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International journal of biological macromolecules.
2018 Jul; 114(?):295-305. doi:
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Plant disease.
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Cellular and molecular biology (Noisy-le-Grand, France).
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Pest management science.
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