Clotrimazole (BioDeep_00000002336)

 

Secondary id: BioDeep_00000229725, BioDeep_00000398929

human metabolite Chemicals and Drugs


代谢物信息卡片


1-(O-Chloro-alpha,alpha-diphenylbenzyl)imidazole

化学式: C22H17ClN2 (344.108)
中文名称: 克霉唑
谱图信息: 最多检出来源 Mentha canadensis(plant) 51.72%

分子结构信息

SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
InChI: InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H

描述信息

Clotrimazole is an imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. -- Pubchem; There is the potential for drug interactions with Clotrimazole if taken orally, as it is a potent, specific inhibitor of cytochrome P450 oxidase enzymes and so may alter the metabolism of other drugs.; Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. -- Wikipedia; An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.; Clotrimazole is a potent, specific inhibitor of cytochrome P450 oxidase enzymes. Hence, it may alter the metabolism of other drugs particularly if taken orally. -- Wikipedia; Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. It also used to treat athletes foot and jock itch. [HMDB]
Clotrimazole is an imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. -- Pubchem; There is the potential for drug interactions with Clotrimazole if taken orally, as it is a potent, specific inhibitor of cytochrome P450 oxidase enzymes and so may alter the metabolism of other drugs. Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. -- Wikipedia; An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Clotrimazole is a potent, specific inhibitor of cytochrome P450 oxidase enzymes. Hence, it may alter the metabolism of other drugs particularly if taken orally. -- Wikipedia; Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. It also used to treat athletes foot and jock itch.
G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AF - Imidazole derivatives
A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations > A01AB - Antiinfectives and antiseptics for local oral treatment
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use > D01AC - Imidazole and triazole derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D058888 - 14-alpha Demethylase Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent

同义名列表

89 个代谢物同义名

1-(O-Chloro-alpha,alpha-diphenylbenzyl)imidazole; 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole; 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole; 1-(a-(2-Chlorophenyl)benzhydryl)imidazole; 1-(Α-(2-chlorophenyl)benzhydryl)imidazole; 1-(O-Chloro-a,a-diphenylbenzyl)imidazole; 1-(O-Chloro-α,α-diphenylbenzyl)imidazole; Gyne-lotrimin 3 combination pack; Canesten combi-pak 3-day therapy; Canesten combi-pak 1-day therapy; Gyne-lotrimin3 combination pack; Gyne-lotrimin combination pack; Schering brand OF clotrimazole; Canesten 1-day cream combi-pak; Bayer brand 1 OF clotrimazole; Bayer brand 2 OF clotrimazole; Clotrimazole schering brand; 1-(O-Chlorotrityl)imidazole; Mycelex: mycosporinrimazole; Lotrimin af jock-itch cream; Mycelex-7 combination pack; (Chlorotrityl)imidazole; Canesten 1-day therapy; Canesten 6-day therapy; Canesten 3-day therapy; Myclo spray solution; Lotrimin af solution; Clotrimaderm cream; Lotrimin af lotion; Canesten solution; Mycelex twin pack; Lotrimin solution; Lotrimin af cream; Mycelex solution; Lotrimin lotion; Gyne-lotrimin 3; Mycelex troches; Lotrimin cream; Myclo solution; Canesten cream; Gyne-lotrimin3; mono-Baycuten; Trivagizole 3; Chlotrimazole; Gyne-lotrimin; Mycelex cream; Clotrimazolum; Neo-zol cream; Gyne lotrimin; Prestwick_120; Klotrimazole; clotrimazole; Lopac-C-6019; Clotrimaderm; Monobaycuten; Mycelex otc; Myclo cream; Lotrimin af; Clotrimazol; Mycosporin; Myclo-gyne; Mykosporin; Bay b 5097; Mycelex g; FB b 5097; Canestine; Mycelex-g; Mycelex 7; Mycelex-7; Trimysten; Desamix F; Lotrisone; Kanesten; Pedisafe; Lotrimax; Canesten; Fem care; Rimazole; Lotrimin; Empecid; Tibatin; FemCare; Mycelex; Veltrim; Mycelax; Otomax; Gynix; Clotrimazole



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, ANXA5, CAT, CYP1A1, CYP3A4, HPGDS, PIK3CA, SLC9A1, VEGFA
Peripheral membrane protein 3 ANXA5, CYP1A1, CYP1B1
Endoplasmic reticulum membrane 7 CYP19A1, CYP1A1, CYP1B1, CYP3A4, CYP3A5, CYP51A1, SLN
Nucleus 2 NR1I2, VEGFA
cytosol 5 ANXA5, CAT, HPGDS, KCNN4, PIK3CA
nuclear body 1 NR1I2
nucleoplasm 3 HPGDS, NR1I2, SLC9A1
Cell membrane 5 ABCB1, KCNN4, SLC9A1, TNF, TRPM2
lamellipodium 2 PIK3CA, SLC9A1
ruffle membrane 1 KCNN4
Multi-pass membrane protein 7 ABCB1, CATSPER3, CYP19A1, KCNA3, KCNN4, SLC9A1, TRPM2
cell surface 4 ABCB1, SLC9A1, TNF, VEGFA
glutamatergic synapse 1 KCNA3
Golgi apparatus 1 VEGFA
lysosomal membrane 1 TRPM2
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 2 KCNN4, TNF
presynaptic membrane 1 KCNA3
sarcolemma 1 ANXA5
Lysosome 1 TRPM2
acrosomal vesicle 1 CATSPER3
plasma membrane 8 ABCB1, CATSPER3, KCNA3, KCNN4, PIK3CA, SLC9A1, TNF, TRPM2
Membrane 14 ABCB1, ANXA5, CAT, CYP19A1, CYP1B1, CYP3A4, CYP3A5, CYP51A1, KCNA3, KCNN4, SLC9A1, SLN, TRPM2, VEGFA
apical plasma membrane 2 ABCB1, SLC9A1
axon 1 KCNA3
basolateral plasma membrane 1 SLC9A1
extracellular exosome 4 ABCB1, ANXA5, CAT, SLC9A1
endoplasmic reticulum 3 CATSPER3, CYP19A1, VEGFA
extracellular space 2 TNF, VEGFA
perinuclear region of cytoplasm 3 KCNA3, PIK3CA, SLC9A1
adherens junction 1 VEGFA
intercalated disc 2 PIK3CA, SLC9A1
mitochondrion 4 CAT, CYP1A1, CYP1B1, SLC9A1
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 7 CAT, CYP1A1, CYP1B1, CYP3A4, CYP3A5, CYP51A1, HPGDS
Microsome membrane 6 CYP19A1, CYP1A1, CYP1B1, CYP3A4, CYP3A5, CYP51A1
Secreted 1 VEGFA
extracellular region 4 ANXA5, CAT, TNF, VEGFA
Single-pass membrane protein 2 CYP51A1, SLN
mitochondrial matrix 1 CAT
transcription regulator complex 1 NR1I2
motile cilium 1 CATSPER3
external side of plasma membrane 2 ANXA5, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
T-tubule 1 SLC9A1
perikaryon 1 TRPM2
cytoplasmic vesicle 1 TRPM2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 KCNN4
postsynaptic membrane 1 KCNA3
Apical cell membrane 1 ABCB1
Cell projection, ruffle membrane 1 KCNN4
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 3 KCNA3, SLC9A1, TNF
focal adhesion 3 ANXA5, CAT, SLC9A1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
sarcoplasmic reticulum 1 SLN
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
Zymogen granule membrane 1 ANXA5
neuron projection 1 KCNN4
chromatin 1 NR1I2
cell projection 1 TRPM2
phagocytic cup 1 TNF
Basolateral cell membrane 1 SLC9A1
[Isoform 2]: Cell membrane 2 KCNA3, TRPM2
Cell projection, cilium, flagellum membrane 1 CATSPER3
Cytoplasmic vesicle membrane 1 TRPM2
specific granule membrane 1 TRPM2
tertiary granule membrane 1 TRPM2
intermediate filament cytoskeleton 1 NR1I2
voltage-gated potassium channel complex 2 KCNA3, KCNN4
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
Sarcoplasmic reticulum membrane 1 SLN
calyx of Held 1 KCNA3
vesicle membrane 1 ANXA5
ficolin-1-rich granule membrane 1 TRPM2
external side of apical plasma membrane 1 ABCB1
[Isoform 1]: Cell membrane 2 KCNA3, TRPM2
[Isoform 3]: Cell membrane 1 TRPM2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
endothelial microparticle 1 ANXA5
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cation-transporting ATPase complex 1 SLC9A1
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
CatSper complex 1 CATSPER3
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Vasile-Ion Iancu, Laura-Florentina Chiriac, Iuliana Paun, Florinela Pirvu, Cristina Dinu, Lidia Kim, Luoana Florentina Pascu, Marcela Niculescu. Occurrence and distribution of azole antifungal agents in eight urban Romanian waste water treatment plants. The Science of the total environment. 2024 Apr; 920(?):170898. doi: 10.1016/j.scitotenv.2024.170898. [PMID: 38369155]
  • Daniel Escorsim Machado, Enrico Mendes Saggioro, Sidney Fernandes Sales Junior, Jéssica Alessandra-Perini, Luciana de Campos Gomes Diniz, Wagner Santos Coelho, Patrícia Zancan, Jamila Alessandra Perini. Clotrimazole is effective, safe and tolerable for the treatment of endometriosis and functions by downregulating inducible nitric oxide synthase and modulating oxidative stress biomarkers. Molecular and cellular endocrinology. 2023 Mar; 564(?):111883. doi: 10.1016/j.mce.2023.111883. [PMID: 36736881]
  • Serhat S Çiçek, Mayra Galarza Pérez, Arlette Wenzel-Storjohann, Roberto M Bezerra, Jorge F O Segovia, Ulrich Girreser, Isamu Kanzaki, Deniz Tasdemir. Antimicrobial Prenylated Isoflavones from the Leaves of the Amazonian Medicinal Plant Vatairea guianensis Aubl. Journal of natural products. 2022 04; 85(4):927-935. doi: 10.1021/acs.jnatprod.1c01035. [PMID: 35271771]
  • Temitope Dadewura Melefa, Christopher Didigwu Nwani. Imidazole antifungal drug clotrimazole alters the behavior, brain acetylcholinesterase and oxidative stress biomarkers in African catfish Clarias gariepinus (Burchell 1822). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2021 Oct; 248(?):109108. doi: 10.1016/j.cbpc.2021.109108. [PMID: 34126252]
  • Alessio Ausili, Illya Yakymenko, José A Teruel, Juan C Gómez-Fernández. Clotrimazole Fluidizes Phospholipid Membranes and Localizes at the Hydrophobic Part near the Polar Part of the Membrane. Biomolecules. 2021 09; 11(9):. doi: 10.3390/biom11091304. [PMID: 34572517]
  • Monica Kam Draskau, Anna Kjerstine Rosenmai, Martin Scholze, Mikael Pedersen, Julie Boberg, Sofie Christiansen, Terje Svingen. Human-relevant concentrations of the antifungal drug clotrimazole disrupt maternal and fetal steroid hormone profiles in rats. Toxicology and applied pharmacology. 2021 07; 422(?):115554. doi: 10.1016/j.taap.2021.115554. [PMID: 33910022]
  • Anas El-Sayed, Jennifer Vidal, Kamran Khanmoradi, John P Knorr. Impact of Clotrimazole Fungal Prophylaxis on Tacrolimus Exposure in Kidney Transplant Recipients: A Retrospective Study. Transplantation proceedings. 2021 Jun; 53(5):1583-1588. doi: 10.1016/j.transproceed.2021.03.032. [PMID: 33962777]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ryan C Love, Heather L Osachoff, Christopher J Kennedy. Short communication: Tissue-specific transcript expression of P-glycoprotein isoforms abcb1a and abcb1b in rainbow trout (Oncorhynchus mykiss) following induction with clotrimazole. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2021 Feb; 252(?):110538. doi: 10.1016/j.cbpb.2020.110538. [PMID: 33227421]
  • Shirin Jaldani, Mahnaz Fatahinia, Elham Maraghi, Eskandar Moghimipour, Mojgan Javadnoori. Comparison of the effectiveness of Satureja khuzestanica and clotrimazole vaginal creams for the treatment of vulvovaginal candidiasis. Journal of medicine and life. 2021 Jan; 14(1):111-117. doi: 10.25122/jml-2020-0014. [PMID: 33767795]
  • Tingting Zhao, Dalong Wang, Shan Zhao, Jing Chen, Tongyi Dou, Guangbo Ge, Changyuan Wang, Qiang Meng, Huijun Sun, Kexin Liu, Jingjing Wu. Comparison of the Inhibitory Effects of Clotrimazole and Ketoconazole against Human Carboxylesterase 2. Current drug metabolism. 2021; 22(5):391-398. doi: 10.2174/1389200222666210210115509. [PMID: 33568030]
  • Kilian Patrick Dunphy. Euphorbia urethritis: The minor scourge of the Garden Spurge. International journal of STD & AIDS. 2020 12; 31(14):1423-1425. doi: 10.1177/0956462419894447. [PMID: 32469623]
  • Somayeh Zakeri, Seddigheh Esmaeilzadeh, Narjes Gorji, Zahra Memariani, Reihaneh Moeini, Ali Bijani. The effect of Achillea Millefolium L. on vulvovaginal candidiasis compared with clotrimazole: A randomized controlled trial. Complementary therapies in medicine. 2020 Aug; 52(?):102483. doi: 10.1016/j.ctim.2020.102483. [PMID: 32951733]
  • Daniel Escorsim Machado, Jéssica Alessandra-Perini, Erika Menezes de Mendonça, Marllow Caetano Claudino, Luiz Eurico Nasciutti, Mauro Sola-Penna, Patrícia Zancan, Jamila Alessandra Perini. Clotrimazole reduces endometriosis and the estrogen concentration by downregulating aromatase. Reproduction (Cambridge, England). 2020 06; 159(6):779-786. doi: 10.1530/rep-19-0502. [PMID: 32240980]
  • Trudi Denoon, Siddharth Sunilkumar, Sue M Ford. Acetoacetate enhances oxidative metabolism and response to toxicants of cultured kidney cells. Toxicology letters. 2020 May; 323(?):19-24. doi: 10.1016/j.toxlet.2020.01.015. [PMID: 31962156]
  • C Carbone, V Fuochi, A Zielińska, T Musumeci, E B Souto, A Bonaccorso, C Puglia, G Petronio Petronio, P M Furneri. Dual-drugs delivery in solid lipid nanoparticles for the treatment of Candida albicans mycosis. Colloids and surfaces. B, Biointerfaces. 2020 Feb; 186(?):110705. doi: 10.1016/j.colsurfb.2019.110705. [PMID: 31830707]
  • Maha M Abou El-Alamin, Maha A Sultan, Mostafa A Atia, Hassan Y Aboul-Enein. Novel Application of Pentabromobenzyl Column for Simultaneous Determination of Eight Antifungal Drugs Using High-performance Liquid Chromatography. Combinatorial chemistry & high throughput screening. 2020; 23(10):991-1001. doi: 10.2174/1386207323666200220114818. [PMID: 32077818]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Cecilie Hurup Munkboel, Tobias Bangsgaard Rasmussen, Camilla Elgaard, Maja-Luna Kingo Olesen, Andreas Christopher Kretschmann, Bjarne Styrishave. The classic azole antifungal drugs are highly potent endocrine disruptors in vitro inhibiting steroidogenic CYP enzymes at concentrations lower than therapeutic Cmax. Toxicology. 2019 09; 425(?):152247. doi: 10.1016/j.tox.2019.152247. [PMID: 31330226]
  • Stephen Boulton, Rajeevan Selvaratnam, Rashik Ahmed, Katherine Van, Xiaodong Cheng, Giuseppe Melacini. Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators. Journal of medicinal chemistry. 2019 05; 62(10):5063-5079. doi: 10.1021/acs.jmedchem.9b00258. [PMID: 31074269]
  • Weicang Wang, Jun Yang, Matthew L Edin, Yuxin Wang, Ying Luo, Debin Wan, Haixia Yang, Chun-Qing Song, Wen Xue, Katherine Z Sanidad, Mingyue Song, Heather A Bisbee, Jennifer A Bradbury, Guanjun Nan, Jianan Zhang, Pei-An Betty Shih, Kin Sing Stephen Lee, Lisa M Minter, Daeyoung Kim, Hang Xiao, Jun-Yan Liu, Bruce D Hammock, Darryl C Zeldin, Guodong Zhang. Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis. Cancer research. 2019 04; 79(8):1822-1830. doi: 10.1158/0008-5472.can-18-3221. [PMID: 30803995]
  • James Simpson, Adrienn Pálvölgyi, Ferenc A Antoni. Direct stimulation of adenylyl cyclase 9 by the fungicide imidazole miconazole. Naunyn-Schmiedeberg's archives of pharmacology. 2019 04; 392(4):497-504. doi: 10.1007/s00210-018-01610-1. [PMID: 30607468]
  • Fatemeh Ahangari, Azizeh Farshbaf-Khalili, Yousef Javadzadeh, Mohammad Adibpour, Behnaz Sadeghzadeh Oskouei. Comparing the effectiveness of Salvia officinalis, clotrimazole and their combination on vulvovaginal candidiasis: A randomized, controlled clinical trial. The journal of obstetrics and gynaecology research. 2019 Apr; 45(4):897-907. doi: 10.1111/jog.13918. [PMID: 30663184]
  • E Bohmova, E Conkova, M Harcarova, Z Sihelska. Interactions between Clotrimazole and selected essential oils against Malassezia pachydermatis clinical isolates. Polish journal of veterinary sciences. 2019 Mar; 22(1):173-175. doi: 10.24425/pjvs.2019.127082. [PMID: 30997781]
  • Andrew J McDonald, Katherine M Curt, Ruchi P Patel, Hanna Kozlowski, Dan L Sackett, Robert W Robey, Michael M Gottesman, Susan E Bates. Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models. Experimental cell research. 2019 02; 375(2):106-112. doi: 10.1016/j.yexcr.2018.12.012. [PMID: 30579954]
  • Nafiseh Saghafi, Maryam Karjalian, Masumeh Ghazanfarpour, Imaneh Khorsand, Hassan Rakhshandeh, Masumeh Mirteimouri, Masoudeh Babakhanian, Talat Khadivzadeh, Mohammad Javad Najafzadeh, Ahmad Ghorbani, Leila Pourali, Sara Bahman. The effect of a vaginal suppository formulation of dill (Anethum graveolens) in comparison to clotrimazole vaginal tablet on the treatment of vulvovaginal candidiasis. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2018 Oct; 38(7):985-988. doi: 10.1080/01443615.2018.1432578. [PMID: 29553834]
  • A Pacholak, J Simlat, A Zgoła-Grześkowiak, E Kaczorek. Biodegradation of clotrimazole and modification of cell properties after metabolic stress and upon addition of saponins. Ecotoxicology and environmental safety. 2018 10; 161(?):676-682. doi: 10.1016/j.ecoenv.2018.06.050. [PMID: 29935432]
  • M Yaralizadeh, P Abedi, F Namjoyan, M Fatahinia, S Nezamivand Chegini. A comparison of the effects of Lawsonia inermis (Iranian henna) and clotrimazole on Candida albicans in rats. Journal de mycologie medicale. 2018 Sep; 28(3):419-423. doi: 10.1016/j.mycmed.2018.05.012. [PMID: 29891221]
  • Suwasin Udomkarnjananun, Natavudh Townamchai, Mathurot Virojanawat, Yingyos Avihingsanon, Kearkiat Praditpornsilpa. An Unusual Manifestation of Calcineurin Inhibitor-Induced Pain Syndrome in Kidney Transplantation: A Case Report and Literature Review. The American journal of case reports. 2018 Apr; 19(?):442-446. doi: 10.12659/ajcr.908886. [PMID: 29654227]
  • Sabrin R M Ibrahim, Gamal A Mohamed, Rwaida A Al Haidari, Mohamed F Zayed, Amal A El-Kholy, Ehab S Elkhayat, Samir A Ross. Fusarithioamide B, a new benzamide derivative from the endophytic fungus Fusarium chlamydosporium with potent cytotoxic and antimicrobial activities. Bioorganic & medicinal chemistry. 2018 02; 26(3):786-790. doi: 10.1016/j.bmc.2017.12.049. [PMID: 29317147]
  • Elnaz Saffari, Sakineh Mohammad-Alizadeh-Charandabi, Mohammad Adibpour, Mojgan Mirghafourvand, Yousef Javadzadeh. Comparing the effects of Calendula officinalis and clotrimazole on vaginal Candidiasis: A randomized controlled trial. Women & health. 2017 Nov; 57(10):1145-1160. doi: 10.1080/03630242.2016.1263272. [PMID: 27880086]
  • Thalita Gagini, Luana Pereira Borba-Santos, Anderson Messias Rodrigues, Zoilo Pires de Camargo, Sonia Rozental. Clotrimazole is highly effective in vitro against feline Sporothrix brasiliensis isolates. Journal of medical microbiology. 2017 Nov; 66(11):1573-1580. doi: 10.1099/jmm.0.000608. [PMID: 28984226]
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