6-Hydroxydaidzein (BioDeep_00000229861)
Secondary id: BioDeep_00000003623, BioDeep_00000270094, BioDeep_00000400509
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C15H10O5 (270.0528)
中文名称: 4,6,7-三羟基异黄酮, 4',6,7-三羟异黄酮
谱图信息:
最多检出来源 Homo sapiens(plant) 13.88%
Last reviewed on 2024-08-14.
Cite this Page
6-Hydroxydaidzein. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/6-hydroxydaidzein (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000229861). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: c1(c(cc2c(c1)occ(c2=O)c1ccc(cc1)O)O)O
InChI: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-14-6-13(18)12(17)5-10(14)15(11)19/h1-7,16-18H
描述信息
4,6,7-trihydroxyisoflavone is a hydroxyisoflavone that is daidzein bearing an additional hydroxy substituent at position 6. It has a role as a metabolite, a PPARalpha agonist, a PPARgamma agonist, an anti-inflammatory agent, an antimutagen and an EC 1.14.18.1 (tyrosinase) inhibitor. It is functionally related to a daidzein.
6,7,4-Trihydroxyisoflavone is a natural product found in Capsicum annuum with data available.
6-Hydroxydaidzein is found in pulses. 6-Hydroxydaidzein is isolated from fermented soybeans (Glycine max
Isolated from fermented soybeans (Glycine max). 6-Hydroxydaidzein is found in soy bean and pulses.
A hydroxyisoflavone that is daidzein bearing an additional hydroxy substituent at position 6.
同义名列表
23 个代谢物同义名
6,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, 9CI; 4H-1-Benzopyran-4-one, 6,7-dihydroxy-3-(4-hydroxyphenyl)-; 6,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 6,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-one; 6,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one; ISOFLAVONE, 4,6,7-TRIHYDROXY-; 4,6,7,-Trihydroxyisoflavone; 4,6,7,-trihydroxyisoflavone; 4,6,7-trihydroxy isoflavone; 6,7,4-Trihydroxyisoflavone; 4,6,7-trihydroxyisoflavone; 4,6,7-Trihydroxyisoflavone; 6,7,4-trihydroxyisoflavone; 6,7,3-trihydroxyisoflavone; Desmethylglycitein; 6-Hydroxydaidzein; Demethylglycitein; Soybean factor 2; UNII-PLM2K574GE; demethyltexasin; PLM2K574GE; A1-01444; 4',6,7-Trihydroxyisoflavone
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:74957
- KEGG: C14314
- PubChem: 5284649
- HMDB: HMDB0031715
- ChEMBL: CHEMBL239156
- LipidMAPS: LMPK12050102
- MeSH: 6,7,4-trihydroxyisoflavone
- ChemIDplus: 0017817311
- MetaCyc: CPD-6998
- KNApSAcK: C00009385
- foodb: FDB008378
- chemspider: 4447693
- CAS: 17817-31-1
- medchemexpress: HY-N5072
- MetaboLights: MTBLC74957
- PDB-CCD: 674
- NIKKAJI: J254.133E
- PubChem: 17395314
- KNApSAcK: 74957
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- J Hummelova, J Rondevaldova, A Balastikova, O Lapcik, L Kokoska. The relationship between structure and in vitro antibacterial activity of selected isoflavones and their metabolites with special focus on antistaphylococcal effect of demethyltexasin.
Letters in applied microbiology.
2015 Mar; 60(3):242-7. doi:
10.1111/lam.12361. [PMID: 25421722] - Sang Gwon Seo, Hee Yang, Seung Ho Shin, Soyun Min, Yeong A Kim, Jae Gak Yu, Dong Eun Lee, Min-Yu Chung, Yong-Seok Heo, Jung Yeon Kwon, Shuhua Yue, Kee Hong Kim, Ji-Xin Cheng, Ki Won Lee, Hyong Joo Lee. A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K.
Molecular nutrition & food research.
2013 Aug; 57(8):1446-55. doi:
10.1002/mnfr.201200593. [PMID: 23737351] - Qiang Luo, Quancheng Chen, Yao Wu, Miaomiao Jiang, Zhihong Chen, Xiaokun Zhang, Haifeng Chen. [Chemical constituents of bear bile].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2010 Sep; 35(18):2416-9. doi:
10.4268/cjcmm20101812. [PMID: 21141490] - Monika Mueller, Stefanie Hobiger, Alois Jungbauer. Red clover extract: a source for substances that activate peroxisome proliferator-activated receptor alpha and ameliorate the cytokine secretion profile of lipopolysaccharide-stimulated macrophages.
Menopause (New York, N.Y.).
2010 Mar; 17(2):379-87. doi:
10.1097/gme.0b013e3181c94617. [PMID: 20142789] - Jun-Seong Park, Dong Hyun Kim, Jae Kyoung Lee, Jin Young Lee, Duck Hee Kim, Han Kon Kim, Hak-Ju Lee, Ho Cheol Kim. Natural ortho-dihydroxyisoflavone derivatives from aged Korean fermented soybean paste as potent tyrosinase and melanin formation inhibitors.
Bioorganic & medicinal chemistry letters.
2010 Feb; 20(3):1162-4. doi:
10.1016/j.bmcl.2009.12.021. [PMID: 20022495] - Monika Mueller, Alois Jungbauer. Red clover extract: a putative source for simultaneous treatment of menopausal disorders and the metabolic syndrome.
Menopause (New York, N.Y.).
2008 Nov; 15(6):1120-31. doi:
10.1097/gme.0b013e31817062ce. [PMID: 18724264] - Angelika Pfitscher, Evelyne Reiter, Alois Jungbauer. Receptor binding and transactivation activities of red clover isoflavones and their metabolites.
The Journal of steroid biochemistry and molecular biology.
2008 Nov; 112(1-3):87-94. doi:
10.1016/j.jsbmb.2008.08.007. [PMID: 18809497] - Corinna E Rüfer, Ronald Maul, Eva Donauer, Eric J Fabian, Sabine E Kulling. In vitro and in vivo metabolism of the soy isoflavone glycitein.
Molecular nutrition & food research.
2007 Jul; 51(7):813-23. doi:
10.1002/mnfr.200700013. [PMID: 17579888] - Tammy E Hedlund, Adrie van Bokhoven, Widya U Johannes, Steven K Nordeen, Lorraine G Ogden. Prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro.
The Prostate.
2006 Apr; 66(5):557-66. doi:
10.1002/pros.20380. [PMID: 16372328] - Yu-Chi Chen, Yasumasa Sugiyama, Naoki Abe, Ryoko Kuruto-Niwa, Ryushi Nozawa, Akira Hirota. DPPH radical-scavenging compounds from dou-chi, a soybean fermented food.
Bioscience, biotechnology, and biochemistry.
2005 May; 69(5):999-1006. doi:
10.1271/bbb.69.999. [PMID: 15914921] - S E Kulling, D M Honig, M Metzler. Oxidative metabolism of the soy isoflavones daidzein and genistein in humans in vitro and in vivo.
Journal of agricultural and food chemistry.
2001 Jun; 49(6):3024-33. doi:
10.1021/jf0012695. [PMID: 11410004] - A O Latunde-Dada, F Cabello-Hurtado, N Czittrich, L Didierjean, C Schopfer, N Hertkorn, D Werck-Reichhart, J Ebel. Flavonoid 6-hydroxylase from soybean (Glycine max L.), a novel plant P-450 monooxygenase.
The Journal of biological chemistry.
2001 Jan; 276(3):1688-95. doi:
10.1074/jbc.m006277200. [PMID: 11027686]
