Deoxycorticosterone (BioDeep_00000002275)

 

Secondary id: BioDeep_00000405184, BioDeep_00000410538

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite natural product


代谢物信息卡片


(1S,2R,10S,11S,14S,15S)-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

化学式: C21H30O3 (330.2195)
中文名称: 11-脱氧皮质酮, 11-去氧皮质酮
谱图信息: 最多检出来源 Homo sapiens(blood) 23.84%

分子结构信息

SMILES: CC12CCC(=O)C=C1CCC1C2CCC2(C)C(C(=O)CO)CCC12
InChI: InChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3

描述信息

11-Deoxycorticosterone (also called desoxycortone, 21-hydroxyprogesterone, DOC, or simply deoxycorticosterone) is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. It is classified as a member of the 21-hydroxysteroids. 21-hydroxysteroids are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. Deoxycorticosterone is very hydrophobic, practically insoluble (in water), and relatively neutral. Deoxycorticosterone can be synthesized from progesterone by 21-beta-hydroxylase and is then converted to corticosterone by 11-beta-hydroxylase. Corticosterone is then converted to aldosterone by aldosterone synthase. Deoxycorticosterone stimulates the collecting tubules in the kidney to continue to excrete potassium in much the same way that aldosterone does. Deoxycorticosterone has about 1/20 of the sodium retaining power of aldosterone and about 1/5 the potassium excreting power of aldosterone (Wikipedia). Deoxycorticosterone can be found throughout all human tissues and has been detected in amniotic fluid and blood. When present in sufficiently high levels, deoxycorticosterone can act as a hypertensive agent and a metabotoxin. A hypertensive agent increases blood pressure and causes the production of more urine. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of deoxycorticosterone are associated with congenital adrenal hyperplasia (CAH) and with adrenal tumors producing deoxycorticosterone (PMID: 20671982). High levels of this mineralocorticoid are associated with resistant hypertension, which can result in polyuria, polydipsia, increased blood volume, edema, and cardiac enlargement. Deoxycorticosterone can be used to treat adrenal insufficiency. In particular, desoxycorticosterone acetate (DOCA) is used as replacement therapy in Addisons disease.
Desoxycorticosterol, also known as 21-hydroxy-4-pregnene-3,20-dione or 21-hydroxyprogesterone, is a member of the class of compounds known as 21-hydroxysteroids. 21-hydroxysteroids are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. Thus, desoxycorticosterol is considered to be a steroid lipid molecule. Desoxycorticosterol is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Desoxycorticosterol can be synthesized from progesterone. Desoxycorticosterol can also be synthesized into 11-deoxycorticosterone-21-hemisuccinate and 5beta-dihydrodeoxycorticosterone. Desoxycorticosterol can be found in rice, which makes desoxycorticosterol a potential biomarker for the consumption of this food product. Desoxycorticosterol can be found primarily in amniotic fluid and blood, as well as throughout all human tissues. In humans, desoxycorticosterol is involved in the steroidogenesis. Desoxycorticosterol is also involved in several metabolic disorders, some of which include corticosterone methyl oxidase I deficiency (CMO I), 21-hydroxylase deficiency (CYP21), corticosterone methyl oxidase II deficiency - CMO II, and 11-beta-hydroxylase deficiency (CYP11B1). Desoxycorticosterol is a non-carcinogenic (not listed by IARC) potentially toxic compound.
CONFIDENCE standard compound; INTERNAL_ID 793; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9334; ORIGINAL_PRECURSOR_SCAN_NO 9329
CONFIDENCE standard compound; INTERNAL_ID 793; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9427; ORIGINAL_PRECURSOR_SCAN_NO 9423
CONFIDENCE standard compound; INTERNAL_ID 793; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9386; ORIGINAL_PRECURSOR_SCAN_NO 9384
CONFIDENCE standard compound; INTERNAL_ID 793; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9356; ORIGINAL_PRECURSOR_SCAN_NO 9353
CONFIDENCE standard compound; INTERNAL_ID 793; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9399; ORIGINAL_PRECURSOR_SCAN_NO 9396
CONFIDENCE standard compound; INTERNAL_ID 793; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9378; ORIGINAL_PRECURSOR_SCAN_NO 9376
H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AA - Mineralocorticoids
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D008901 - Mineralocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
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Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor.
Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor.

同义名列表

33 个代谢物同义名

(1S,2R,10S,11S,14S,15S)-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one; 17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one; 21-Hydroxy-pregn-4-ene-3,20-dione; 21-Hydroxy-D4-pregnene-3,20-dione; 21-Hydroxy-D4-pregnane-3,20-dione; 21 Hydroxy 4 pregnene 3,20 dione; 21-Hydroxy-3,20-dioxopregn-4-ene; 21-Hydroxy-4-pregnene-3,20-dione; 21-hydroxypregn-4-ene-3,20-dione; D4-Pregnene-21-ol-3,20-dione; Kendalls desoxy compound b; 4-Pregnen-21-ol-3,20-dione; 11-Dehydroxycorticosterone; Reichsteins substance Q; 11-Deoxy-corticosterone; 21-Hydroxy-progesterone; 11-Desoxycorticosterone; 21-hydroxyProgesterone; 11-deoxycorticosterone; 21 Hydroxyprogesterone; Desoxycorticosterone; 11-Decorticosterone; 11 Decorticosterone; Desoxycorticosterol; Deoxycorticosterone; Desoxycortone; Deoxycortone; Reichstein Q; ST 21:3;O3; Cortexone; Doca; DOC; 11-Deoxycorticosterone



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(13)

BioCyc(0)

PlantCyc(0)

代谢反应

122 个相关的代谢反应过程信息。

Reactome(81)

BioCyc(0)

WikiPathways(6)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(35)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ACE, NR3C1, NR3C2, POMC
Peripheral membrane protein 4 CYP11A1, CYP11B1, CYP21A2, FDXR
Endoplasmic reticulum membrane 5 CYP11B1, CYP17A1, CYP19A1, CYP21A2, NR3C2
Mitochondrion membrane 1 CYP11A1
Nucleus 2 NR3C1, NR3C2
cytosol 4 AVP, COMT, NR3C1, NR3C2
dendrite 2 AVP, COMT
centrosome 1 NR3C1
nucleoplasm 3 ATP2B1, NR3C1, NR3C2
Cell membrane 3 ACE, ATP2B1, COMT
Multi-pass membrane protein 2 ATP2B1, CYP19A1
Synapse 4 ATP2B1, COMT, CRH, NR3C1
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 CCN2
Golgi membrane 1 INS
mitochondrial inner membrane 3 CYP11A1, CYP11B1, FDXR
neuronal cell body 1 CYP17A1
presynaptic membrane 1 ATP2B1
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 6 ACE, ATP2B1, CCN2, COMT, KNG1, REN
synaptic vesicle membrane 1 ATP2B1
Membrane 8 ACE, ATP2B1, COMT, CYP11A1, CYP19A1, CYP21A2, NR3C1, REN
axon 2 COMT, CYP17A1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 5 ACE, ATP2B1, COMT, KNG1, SERPINA6
endoplasmic reticulum 2 CYP17A1, CYP19A1
extracellular space 9 ACE, AVP, CCN2, CRH, INS, KNG1, POMC, REN, SERPINA6
mitochondrion 5 CYP11A1, CYP11B1, FDX1, FDXR, NR3C1
protein-containing complex 1 NR3C1
intracellular membrane-bounded organelle 3 ATP2B1, CCN2, COMT
Microsome membrane 3 CYP17A1, CYP19A1, CYP21A2
Single-pass type I membrane protein 1 ACE
Secreted 7 ACE, AVP, CCN2, CRH, INS, POMC, REN
extracellular region 9 ACE, AVP, CCN2, CRH, INS, KNG1, POMC, REN, SERPINA6
Single-pass membrane protein 1 CYP21A2
Mitochondrion matrix 1 FDX1
mitochondrial matrix 4 CYP11A1, FDX1, FDXR, NR3C1
Extracellular side 1 COMT
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 ACE
varicosity 1 CRH
Secreted, extracellular space, extracellular matrix 1 CCN2
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
apical part of cell 1 REN
Single-pass type II membrane protein 1 COMT
Mitochondrion inner membrane 3 CYP11A1, CYP11B1, FDXR
Cytoplasm, cytoskeleton, spindle 1 NR3C1
spindle 1 NR3C1
extracellular matrix 1 CCN2
collagen-containing extracellular matrix 1 KNG1
secretory granule 2 AVP, POMC
lateral plasma membrane 1 ATP2B1
nuclear speck 1 NR3C1
receptor complex 1 NR3C2
chromatin 2 NR3C1, NR3C2
cell projection 1 ATP2B1
Chromosome 1 NR3C1
Secreted, extracellular space 1 KNG1
brush border membrane 1 ACE
blood microparticle 1 KNG1
sperm midpiece 1 ACE
Basolateral cell membrane 1 ATP2B1
endosome lumen 1 INS
Nucleus, nucleoplasm 1 NR3C1
Presynaptic cell membrane 1 ATP2B1
basal plasma membrane 1 ACE
secretory granule lumen 2 INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, KNG1
platelet alpha granule lumen 1 KNG1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
neuronal dense core vesicle 1 AVP
clathrin-coated endocytic vesicle membrane 1 AVP
[Isoform Alpha]: Cytoplasm 1 NR3C1
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
photoreceptor ribbon synapse 1 ATP2B1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT


文献列表

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