S-N-Methylcysteine (BioDeep_00000227119)
Main id: BioDeep_00000019380
human metabolite PANOMIX_OTCML-2023
代谢物信息卡片
S-methylcysteine, hydrochloride, (L-Cys)-isomer
化学式: C4H9NO2S (135.0354)
中文名称: S-甲基-L-半胱氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CSCC(C(=O)O)N
InChI: InChI=1S/C4H9NO2S/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1
描述信息
S-n-methylcysteine, also known as (2r)-2-amino-3-(methylsulfanyl)propanoic acid or 3-(methylthio)-L-alanine, is a member of the class of compounds known as L-cysteine-s-conjugates. L-cysteine-s-conjugates are compounds containing L-cysteine where the thio-group is conjugated. S-n-methylcysteine is soluble (in water) and a moderately acidic compound (based on its pKa). S-n-methylcysteine can be found in soft-necked garlic, which makes S-n-methylcysteine a potential biomarker for the consumption of this food product. S-n-methylcysteine can be found primarily in blood and urine.
S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.
同义名列表
25 个代谢物同义名
S-methylcysteine, hydrochloride, (L-Cys)-isomer; (2R)-2-Amino-3-(methylsulphanyl)propanoic acid; (2R)-2-amino-3-(methylsulfanyl)propanoic acid; (2R)-2-Amino-3-(methylsulphanyl)propanoate; (2R)-2-Amino-3-(methylsulfanyl)propanoate; (R)-2-amino-3-(methylthio)propanoic acid; (R)-2-Amino-3-(methylthio)propanoate; S-Acetamidomethyl-deamino-cysteine; S-methylcysteine, (DL-Cys)-isomer; S-methylcysteine, (L-Cys)-isomer; L-Aspartic acid dimethyl ester; 3-(Methylthio)-L-(8ci)alanine; S-Methyl-(9ci)-L-cysteine; 3-(methylthio)-L-alanine; S-11C-methyl-L-cysteine; Acm-thiopropionic acid; S-Methyl-DL-cysteine; S-Methyl-L-cysteine; S-N-Methylcysteine; Acm-thiopropionate; S-methyl-cysteine; S-methylcysteine; L-Methylcysteine; L-S-Methylcysteine; S-Methyl-L-cysteine
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:45658
- KEGG: C22040
- PubChem: 24417
- HMDB: HMDB0302211
- DrugBank: DB02216
- ChEMBL: CHEMBL394875
- MetaCyc: S-METHYL-L-CYSTEINE
- foodb: FDB003689
- chemspider: 22826
- CAS: 1187-84-4
- PubChem: 384585100
- PDB-CCD: SMC
- medchemexpress: HY-B2188
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fangxu Guan, Wenwen Du, Jiguo Zhang, Chang Su, Bing Zhang, Kui Deng, Shufa Du, Huijun Wang. Amino Acids and Lipids Associated with Long-Term and Short-Term Red Meat Consumption in the Chinese Population: An Untargeted Metabolomics Study.
Nutrients.
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Scientific reports.
2020 08; 10(1):13857. doi:
10.1038/s41598-020-70974-3. [PMID: 32807817] - Jaya Joshi, Justin B Renaud, Mark W Sumarah, Frédéric Marsolais. Deciphering S-methylcysteine biosynthesis in common bean by isotopic tracking with mass spectrometry.
The Plant journal : for cell and molecular biology.
2019 10; 100(1):176-186. doi:
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Food chemistry.
2016 Apr; 197(Pt A):692-8. doi:
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PLoS genetics.
2011 Dec; 7(12):e1002411. doi:
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BMC systems biology.
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2008 Sep; 5(3):281-7. doi:
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Journal of agricultural and food chemistry.
2008 Jul; 56(14):5647-54. doi:
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Journal of food science.
2007 Sep; 72(7):S511-5. doi:
10.1111/j.1750-3841.2007.00449.x. [PMID: 17995665] - Chiu-mei Chen, Mei-chin Yin, Cheng-chin Hsu, Ting-chun Liu. Antioxidative and anti-inflammatory effects of four cysteine-containing agents in striatum of MPTP-treated mice.
Nutrition (Burbank, Los Angeles County, Calif.).
2007 Jul; 23(7-8):589-97. doi:
10.1016/j.nut.2007.05.004. [PMID: 17574387] - Mei-chin Yin, Cheng-chin Hsu, Pei-fang Chiang, Wen-jean Wu. Antiinflammatory and antifibrogenic effects of s-ethyl cysteine and s-methyl cysteine in the kidney of diabetic mice.
Molecular nutrition & food research.
2007 May; 51(5):572-9. doi:
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Lipids.
2004 Sep; 39(9):843-8. doi:
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Nutrition journal.
2004 Sep; 3(?):10. doi:
10.1186/1475-2891-3-10. [PMID: 15341661] - Chien-Ning Huang, Joeu-Shyan Horng, Mei-Chin Yin. Antioxidative and antiglycative effects of six organosulfur compounds in low-density lipoprotein and plasma.
Journal of agricultural and food chemistry.
2004 Jun; 52(11):3674-8. doi:
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BMC plant biology.
2004 Jan; 4(?):1. doi:
10.1186/1471-2229-4-1. [PMID: 15005814] - Cheng-chin Hsu, Chien-ning Huang, Yu-chuan Hung, Mei-chin Yin. Five cysteine-containing compounds have antioxidative activity in Balb/cA mice.
The Journal of nutrition.
2004 Jan; 134(1):149-52. doi:
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2003 Nov; 51(24):7208-14. doi:
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