Nitrendipine (BioDeep_00000002105)

 

Secondary id: BioDeep_00000399075

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester

化学式: C18H20N2O6 (360.13213)
中文名称: 尼群地平
谱图信息: 最多检出来源 Homo sapiens(blood) 1.81%

分子结构信息

SMILES: CCOC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OC)C
InChI: InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3

描述信息

Nitrendipine is only found in individuals that have used or taken this drug. It is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. [PubChem]By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nitrendipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
CONFIDENCE standard compound; INTERNAL_ID 8498
CONFIDENCE standard compound; INTERNAL_ID 2309
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

145 个代谢物同义名

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate ethyl methyl ester; 3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Prevision y salud brand OF nitrendipine; CT Arzneimittel brand OF nitrendipine; CT-Arzneimittel brand OF nitrendipine; Lichtenstein brand OF nitrendipine; Nitrendipine CT-arzneimittel brand; Lindopharm brand OF nitrendipine; Ratiopharm brand OF nitrendipine; KSK Pharma brand OF nitrendipine; Merck dura brand OF nitrendipine; Stadapharm brand OF nitrendipine; Betapharm brand OF nitrendipine; Jenapharm brand OF nitrendipine; Azupharma brand OF nitrendipine; Nitrendipine lichtenstein brand; Almirall brand OF nitrendipine; Apogepha brand OF nitrendipine; Alpharma brand OF nitrendipine; Docpharm brand OF nitrendipine; Nitrendipine ratiopharm brand; Nitrendipine lindopharm brand; Heumann brand OF nitrendipine; Q-Pharm brand OF nitrendipine; Nitrendipine stadapharm brand; Schwarz brand OF nitrendipine; Nitrendipine azupharma brand; Basics brand OF nitrendipine; Biomed brand OF nitrendipine; Wörwag brand OF nitrendipine; Dexcel brand OF nitrendipine; Nitrendipine jenapharm brand; Nitrendipine betapharm brand; Bayvit brand OF nitrendipine; Nitrendipine docpharm brand; Nitrendipine almirall brand; Bayer brand OF nitrendipine; Nitrendipine apogepha brand; Elfar brand OF nitrendipine; Hexal brand OF nitrendipine; Corax brand OF nitrendipine; Aliud brand OF nitrendipine; Nitrendipine alpharma brand; Juta brand OF nitrendipine; Nitrendipine Q-pharm brand; Acis brand OF nitrendipine; Seid brand OF nitrendipine; Nitrendipine heumann brand; Nitrendipine schwarz brand; Elan brand OF nitrendipine; TAD brand OF nitrendipine; Nitrendipine bayvit brand; Nitrendipine biomed brand; AbZ brand OF nitrendipine; Nitrendipine wörwag brand; Nitrendipine dexcel brand; Nitrendipine basics brand; Nitrendipine aliud brand; BC Brand OF nitrendipine; Nitrendipine corax brand; Ratiopharm, nitrendipino; 1a Brand OF nitrendipine; Nitrendipine elfar brand; Nitrendipine hexal brand; Nitrendipine bayer brand; Nitrendipino ratiopharm; Nitrendipine juta brand; Nitrendipine elan brand; Nitrendipine acis brand; Nitrendipine seid brand; Nitrendipin-ratiopharm; Jenapharm, nitrendipin; Nitrendipine tad brand; Nitrendipin ratiopharm; Nitrendipine abz brand; Nitrendipine BC brand; Nitrendipine 1a brand; Nitrendipin jenapharm; Apogepha, nitrendipin; Nitrendipinratiopharm; Bayvit, nitrendipino; Nitrendipin apogepha; Heumann, nitrendipin; Biochemie, nitrendi; Von CT, nitrendipin; Nitrendipin heumann; Basics, nitrendipin; Nitrendipino bayvit; CT, Nitrendipin von; Nitrendipin basics; Nitrendi biochemie; Lindo, nitrendipin; Nitrendipin von CT; Stada, nitrendipin; Nitrendipin corax; beta, Nitrendipin; Nitrendipin-corax; Nitrendipin lindo; Pharma, nitren 1a; 1a Pharma, nitren; Nitrendipin stada; Atid, nitrendipin; Nitrendipin atid; Nitren 1a pharma; Nitrendipincorax; Nitrendipin beta; AL, nitrendipin; Nitrendipin al; Nitrendimerck; Nitrendipinum; KSK, Nitrend; Nitrendipino; nitrendipine; Acis, nitren; Lich, nitren; Nitren lich; Nitrend KSK; Nitren acis; Tensogradal; Nitre puren; Nitrendidoc; Nitre-puren; Nitrendepat; Nitrendipin; Vastensium; Nitregamma; BAY e 5009; AbZ, nitre; Nitrepress; Bylotensin; NitrePuren; Bayotensin; Trendinol; Jutapress; Nitrensal; Baypresol; Nitre abz; Baypress; Balminil; Gericin; Niprina; Deiten; Nidrel; Nitrendipine



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

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COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Mohammad Abdul-Azim Mohammad, Marianne Alphonse Mahrouse, Enas Abdel Hakeem Amer, Nouran Saleh Elharati. Validated LC-MS/MS method for the simultaneous determination of enalapril maleate, nitrendipine, hydrochlorothiazide, and their major metabolites in human plasma. Biomedical chromatography : BMC. 2020 Dec; 34(12):e4955. doi: 10.1002/bmc.4955. [PMID: 32706446]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Praveen Kumar Gaur, Shikha Mishra, Suresh Purohit. Nanovesicles of nitrendipine with lipid complex for transdermal delivery: pharmacokinetic and pharmacodynamic studies. Artificial cells, nanomedicine, and biotechnology. 2016 Nov; 44(7):1684-93. doi: 10.3109/21691401.2015.1080170. [PMID: 26375758]
  • Swathi Voruganti, Shravan Kumar Yamsani, Madhusudan Rao Yamsani. Effect of silibinin on the pharmacokinetics of nitrendipine in rabbits. European journal of drug metabolism and pharmacokinetics. 2014 Dec; 39(4):277-81. doi: 10.1007/s13318-013-0156-7. [PMID: 24092617]
  • Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Scientific reports. 2014 Sep; 4(?):6437. doi: 10.1038/srep06437. [PMID: 25257666]
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  • Swathi Voruganti, Shravan Kumar Yamsani, Shiva Kumar Ravula, Ramesh Gannu, Madhusudan Rao Yamsani. Effect of pomegranate juice on intestinal transport and pharmacokinetics of nitrendipine in rats. Phytotherapy research : PTR. 2012 Aug; 26(8):1240-5. doi: 10.1002/ptr.3704. [PMID: 22275232]
  • Swathi Voruganti, Kishore Rapolu, Santoshkumar Tota, Shravan Kumar Yamsani, Madhusudan Rao Yamsani. Effect of pomegranate juice on the pharmacokinetics of nitrendipine in rabbits. European journal of drug metabolism and pharmacokinetics. 2012 Jun; 37(2):77-81. doi: 10.1007/s13318-011-0075-4. [PMID: 22101410]
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  • K Manjunath, V Venkateswarlu, A Hussain. Preparation and characterization of nitrendipine solid lipid nanoparticles. Die Pharmazie. 2011 Mar; 66(3):178-86. doi: . [PMID: 21553647]
  • Yanhua Liu, Zhiyuan Wang, Jin Sun, Yongjun Wang, Zhonggui He. Ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of nitrendipine in dog plasma and its application to a pharmacokinetic study of a solid self-emulsifying pellet formulation. Arzneimittel-Forschung. 2011; 61(12):674-80. doi: 10.1055/s-0031-1300586. [PMID: 22282953]
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  • Jin Li, Qi-Xiong Li, Xian-Fei Xie, Ying Ao, Chao-Rong Tie, Ren-Jie Song. Differential roles of dihydropyridine calcium antagonist nifedipine, nitrendipine and amlodipine on gentamicin-induced renal tubular toxicity in rats. European journal of pharmacology. 2009 Oct; 620(1-3):97-104. doi: 10.1016/j.ejphar.2009.08.021. [PMID: 19698708]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
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  • Kesavan Bhaskar, Chinnala Krishna Mohan, Meka Lingam, Somagoni Jagan Mohan, Vobalaboina Venkateswarlu, Yamsani Madhusudan Rao, Kesavan Bhaskar, Jayaraman Anbu, Velayudam Ravichandran. Development of SLN and NLC enriched hydrogels for transdermal delivery of nitrendipine: in vitro and in vivo characteristics. Drug development and industrial pharmacy. 2009 Jan; 35(1):98-113. doi: 10.1080/03639040802192822. [PMID: 18665979]
  • Ashu Mittal, Udai Vir Singh Sara, Asgar Ali, Mohammed Aqil. The effect of penetration enhancers on permeation kinetics of nitrendipine in two different skin models. Biological & pharmaceutical bulletin. 2008 Sep; 31(9):1766-72. doi: 10.1248/bpb.31.1766. [PMID: 18758074]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Kesavan Bhaskar, Chinnala Krishna Mohan, Meka Lingam, Veerareddy Prabhakar Reddy, Vobalaboina Venkateswarlu, Yamsani Madhusudan Rao. Development of nitrendipine controlled release formulations based on SLN and NLC for topical delivery: in vitro and ex vivo characterization. Drug development and industrial pharmacy. 2008 Jul; 34(7):719-25. doi: 10.1080/03639040701842485. [PMID: 18612912]
  • A Armenia, Munavvar Abdul Sattar, Nor Azizan Abdullah, Md Abdul Hye Khan, Edward James Johns. Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension. Acta pharmacologica Sinica. 2008 May; 29(5):564-72. doi: 10.1111/j.1745-7254.2008.00788.x. [PMID: 18430364]
  • Pedro J Gomez-Pinilla, Pedro J Camello, María J Pozo. Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. Journal of pineal research. 2008 Apr; 44(3):250-60. doi: 10.1111/j.1600-079x.2007.00520.x. [PMID: 18339120]
  • M A Sattar, N A Abdullah, Md A H Khan, E J Johns. Alpha1A- and alpha1D-adrenoceptors are the major functional subtypes of renal alpha1-adrenoceptors in streptozotocin-induced diabetic and normal Sprague-Dawley rats. Autonomic & autacoid pharmacology. 2008 Jan; 28(1):1-10. doi: 10.1111/j.1474-8673.2007.00412.x. [PMID: 18257746]
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  • Ying Liu, Feng-Guo Xul, Zun-Jian Zhang, Rui Song, Yuan Tian, Yun Chen. Quantitative determination of nitrendipine in human plasma using high-performance liquid chromatography-mass spectrometry. Arzneimittel-Forschung. 2008; 58(3):111-6. doi: 10.1055/s-0031-1296478. [PMID: 18488806]
  • Zheng-hai Long, Zai-chang Yang, Xiong-zhi Yang. [Study on skin toxicology and penetration enhancement of skin absorption of volatile oil extracted from tender branchers of Camellia oleifera]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Sep; 32(17):1780-3. doi: ". [PMID: 17993001]
  • Kavi J Littlewood, Wolfgang Greiner, Dominique Baum, York Zoellner. Adjunctive treatment with moxonidine versus nitrendipine for hypertensive patients with advanced renal failure: a cost-effectiveness analysis. BMC nephrology. 2007 Jul; 8(?):9. doi: 10.1186/1471-2369-8-9. [PMID: 17645811]
  • Venishetty Vinay Kumar, Durairaj Chandrasekar, Sistla Ramakrishna, Veerabrahma Kishan, Yamsani Madhusudan Rao, Prakash Vamanrao Diwan. Development and evaluation of nitrendipine loaded solid lipid nanoparticles: influence of wax and glyceride lipids on plasma pharmacokinetics. International journal of pharmaceutics. 2007 Apr; 335(1-2):167-175. doi: 10.1016/j.ijpharm.2006.11.004. [PMID: 17161566]
  • Vinay Kumar Venishetty, Chandrasekar Durairaj, Ramakrishna Sistla, Madhusudhan Rao Yamsani, Prakash V Diwan. Development and validation of a reversed-phase HPLC method for determination of nitrendipine in rat plasma: application to pharmacokinetic studies. Biomedical chromatography : BMC. 2007 Apr; 21(4):363-8. doi: 10.1002/bmc.761. [PMID: 17236247]
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