Nevirapine (BioDeep_00000002098)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3,5,7,12,14-hexaen-10-one

化学式: C15H14N4O (266.1167554)
中文名称: 奈韦拉平
谱图信息: 最多检出来源 Homo sapiens(blood) 2.24%

分子结构信息

SMILES: CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4
InChI: InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)

描述信息

Nevirapine is only found in individuals that have used or taken this drug. It is a potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV infection and AIDS. [PubChem]Nevirapine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzymes catalytic site. The activity of nevirapine does not compete with template or nucleoside triphosphates.
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AG - Non-nucleoside reverse transcriptase inhibitors
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97453 - Non-nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
D065693 - Cytochrome P-450 Enzyme Inducers > D065701 - Cytochrome P-450 CYP3A Inducers
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent

同义名列表

12 个代谢物同义名

2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3,5,7,12,14-hexaen-10-one; 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2,3-e)(1,4)diazepin-6-one; Hemihydrate, nevirapine; Nevirapine hemihydrate; ABBR NVP; nevirapine; BI-RG-587; BI RG 587; Viramune; BIRG587; NVP; NEV

数据库引用编号

17 个数据库交叉引用编号

ChEBI: CHEBI:63613
KEGG: C07263
KEGGdrug: D00435
PubChem: 4463
HMDB: HMDB0014383
Metlin: METLIN43275
DrugBank: DB00238
ChEMBL: CHEMBL57
Wikipedia: Nevirapine
MeSH: Nevirapine
chemspider: 4308
CAS: 129618-40-2
PMhub: MS000001832
PubChem: 9472
PDB-CCD: NVP
NIKKAJI: J420.601K
RefMet: Nevirapine

分类词条

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

Nevirapine Metabolism Pathway: 12-Hydroxynevirapine + Oxygen + Water ⟶ 4-Carboxynevirapine + Hydrogen peroxide

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Sharon Migeri, Muhammad A Lawal, Jeffrey Charles Hughes, Taruvinga Badza, Ovokeroye A Abafe, Bice S Martincigh, Alfred Oduor Odindo. Uptake of selected antiretrovirals by pepper (Capsicum annum), radish (Raphanus sativus), and ryegrass (Lolium perenne) grown on two contrasting soils and fertilized with human urine-derived fertilizers. The Science of the total environment. 2023 Jun; ?(?):164551. doi: 10.1016/j.scitotenv.2023.164551. [PMID: 37269997]
P N Kunene, P N Mahlambi. Case study on antiretroviral drugs uptake from soil irrigated with contaminated water: Bio-accumulation and bio-translocation to roots, stem, leaves, and fruits. Environmental pollution (Barking, Essex : 1987). 2023 Feb; 319(?):121004. doi: 10.1016/j.envpol.2023.121004. [PMID: 36608725]
Sa'ad T Abdullahi, Julius O Soyinka, Rahman A Bolarinwa, Olusola J Olarewaju, Alakija K Salami, Moji T Bakare-Odunola. Trough plasma nevirapine levels, immunologic and virologic responses in composite CYP2B6*6/*18 HIV-infected adult Nigerian patients. Basic & clinical pharmacology & toxicology. 2022 Jul; 131(1):45-52. doi: 10.1111/bcpt.13737. [PMID: 35484635]
Ceejay L Boyce, Tatiana Sils, Daisy Ko, Annie Wong-On-Wing, Ingrid A Beck, Sheila M Styrchak, Patricia DeMarrais, Camlin Tierney, Lynda Stranix-Chibanda, Patricia M Flynn, Taha E Taha, Maxensia Owor, Mary Glenn Fowler, Lisa M Frenkel. Maternal Human Immunodeficiency Virus (HIV) Drug Resistance Is Associated With Vertical Transmission and Is Prevalent in Infected Infants. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 06; 74(11):2001-2009. doi: 10.1093/cid/ciab744. [PMID: 34467974]
Gentille Musengimana, Elysee Tuyishime, Athanase Kiromera, Samuel S Malamba, Augustin Mulindabigwi, Madjid R Habimana, Cyprien Baribwira, Muhayimpundu Ribakare, Savio D Habimana, Josh DeVos, Richard C N Mwesigwa, Eugenie Kayirangwa, Jules M Semuhore, Gallican N Rwibasira, Amitabh B Suthar, Eric Remera. Acquired HIV drug resistance among adults living with HIV receiving first-line antiretroviral therapy in Rwanda: A cross-sectional nationally representative survey. Antiviral therapy. 2022 06; 27(3):13596535221102690. doi: 10.1177/13596535221102690. [PMID: 35593031]
Monkgomotsi J Maseng, Leabaneng Tawe, Prisca K Thami, Sikhulile Moyo, Ishmael Kasvosve, Vladimir Novitsky, Max Essex, Gianluca Russo, Simani Gaseitsiwe, Giacomo M Paganotti. The role of CYP2B6 516G>T polymorphism on efavirenz/nevirapine toxicity. Implications on treatment outcomes: Lessons from Botswana. Medicine. 2022 Apr; 101(17):e29066. doi: 10.1097/md.0000000000029066. [PMID: 35512066]
Rosa Marlene Cuco, Osvaldo Loquiha, Adelino Juga, Aleny Couto, Bindiya Meggi, Adolfo Vubil, Esperança Sevene, Nafissa Osman, Marleen Temermam, Olivier Degomme, Mohsin Sidat, Nilesh Bhatt. Nevirapine hair and plasma concentrations and HIV-1 viral suppression among HIV infected ante-partum and post-partum women attended in a mother and child prevention program in Maputo city, Mozambique. PloS one. 2022; 17(2):e0261522. doi: 10.1371/journal.pone.0261522. [PMID: 35143515]
Musa Otieno Ngayo, Margaret Oluka, Wallace Dimbuson Bulimo, Faith Apolot Okalebo. Association between social psychological status and efavirenz and nevirapine plasma concentration among HIV patients in Kenya. Scientific reports. 2021 11; 11(1):22071. doi: 10.1038/s41598-021-01345-9. [PMID: 34764325]
Thaisa Cardoso de Oliveira, Antônia Carla de Jesus Oliveira, Yuri Basílio Gomes Patriota, Luise Lopes Chaves, Fabio de Oliveira Silva Ribeiro, Regina C M de Paula, Edson Cavalcanti Silva-Filho, Durcilene Alves da Silva, Mônica Felts de La Roca Soares, José Lamartine Soares-Sobrinho. Eco-friendly synthesis of phthalate angico gum towards nanoparticles engineering using Quality by Design (QbD) approach. International journal of biological macromolecules. 2021 Nov; 190(?):801-809. doi: 10.1016/j.ijbiomac.2021.09.012. [PMID: 34508723]
Bayazid Hassan Pour, Nahid Haghnazari, Fatemeh Keshavarzi, Elahe Ahmadi, Bahareh Rahimian Zarif. A sensitive sensor based on molecularly imprinted polypyrrole on reduced graphene oxide modified glassy carbon electrode for nevirapine analysis. Analytical methods : advancing methods and applications. 2021 10; 13(40):4767-4777. doi: 10.1039/d1ay00500f. [PMID: 34569556]
Gavin Bart, Le Minh Giang, Hoang Yen, James S Hodges, Richard C Brundage. Effect of HIV, antiretrovirals, and genetics on methadone pharmacokinetics: Results from the methadone antiretroviral pharmacokinetics study. Drug and alcohol dependence. 2021 10; 227(?):109025. doi: 10.1016/j.drugalcdep.2021.109025. [PMID: 34482033]
U M C Nibamureke, G M Wagenaar. Histopathological changes in Oreochromis mossambicus (Peters, 1852) ovaries after a chronic exposure to a mixture of the HIV drug nevirapine and the antibiotics sulfamethoxazole and trimethoprim. Chemosphere. 2021 Jul; 274(?):129900. doi: 10.1016/j.chemosphere.2021.129900. [PMID: 33979944]
C Zhou, S Liang, Y P Li, Y Yang, L J Liao, H Xing, Y H Ruan, D Yuan. [Influencing factors on the death of HIV/AIDS patients treated with antiviral treatment in Butuo county, Liangshan Yi Autonomous Prefecture, 2010-2019]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi. 2021 May; 42(5):886-890. doi: 10.3760/cma.j.cn112338-20200902-01115. [PMID: 34814483]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Theodore D Ruel, Edmund V Capparelli, Camlin Tierney, Bryan S Nelson, Anne Coletti, Yvonne Bryson, Mark F Cotton, Stephen A Spector, Mark Mirochnick, Rebecca LeBlanc, Christina Reding, Bonnie Zimmer, Deborah Persaud, Mutsa Bwakura-Dangarembizi, Kimesh L Naidoo, Rohan Hazra, Patrick Jean-Philippe, Ellen G Chadwick. Pharmacokinetics and safety of early nevirapine-based antiretroviral therapy for neonates at high risk for perinatal HIV infection: a phase 1/2 proof of concept study. The lancet. HIV. 2021 03; 8(3):e149-e157. doi: 10.1016/s2352-3018(20)30274-5. [PMID: 33242457]
David W Haas, Anthony T Podany, Yajing Bao, Susan Swindells, Richard E Chaisson, Noluthando Mwelase, Khuanchai Supparatpinyo, Lerato Mohapi, Amita Gupta, Constance A Benson, Paxton Baker, Courtney V Fletcher. Pharmacogenetic interactions of rifapentine plus isoniazid with efavirenz or nevirapine. Pharmacogenetics and genomics. 2021 01; 31(1):17-27. doi: 10.1097/fpc.0000000000000417. [PMID: 32815870]
Ha Young Yoon, Young Ah Cho, Jeong Yee, Hye Sun Gwak. Effects of CYP2B6 polymorphisms on plasma nevirapine concentrations: a systematic review and meta-analysis. Scientific reports. 2020 10; 10(1):17390. doi: 10.1038/s41598-020-74506-x. [PMID: 33060725]
S S Zulu, O Abboussi, N Simola, M V Mabandla, W M U Daniels. Anti-HIV drugs promote β-amyloid deposition and impair learning and memory in BALB/c mice. Acta neuropsychiatrica. 2020 Oct; 32(5):257-264. doi: 10.1017/neu.2020.19. [PMID: 32378496]
Lufuno Grace Mavhandu, Hua Cheng, Yeou-Cheng Bor, Denis Manga Tebit, Marie-Louise Hammarskjold, David Rekosh, Pascal Obong Bessong. Development of a pseudovirus assay and evaluation to screen natural products for inhibition of HIV-1 subtype C reverse transcriptase. Journal of ethnopharmacology. 2020 Aug; 258(?):112931. doi: 10.1016/j.jep.2020.112931. [PMID: 32360797]
HariOm Singh, Sonam Lata, Ranjana Choudhari, Tapan N Dhole. Prevalence of ABCC3-1767G/A polymorphism among patients with antiretroviral-associated hepatotoxicity. Molecular genetics & genomic medicine. 2020 06; 8(6):e1124. doi: 10.1002/mgg3.1124. [PMID: 32212330]
Chengbo Xu, Yijing Xin, Minghua Chen, Mingyu Ba, Qinglan Guo, Chenggen Zhu, Ying Guo, Jiangong Shi. Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root. European journal of medicinal chemistry. 2020 Mar; 189(?):112071. doi: 10.1016/j.ejmech.2020.112071. [PMID: 32004936]
Sa'ad T Abdullahi, Julius O Soyinka, Adeniyi Olagunju, Rahman A Bolarinwa, Olusola J Olarewaju, Moji T Bakare-Odunola, Markus Winterberg, Joel Tarning, Andrew Owen, Saye Khoo. Differential Impact of Nevirapine on Artemether-Lumefantrine Pharmacokinetics in Individuals Stratified by CYP2B6 c.516G>T Genotypes. Antimicrobial agents and chemotherapy. 2020 02; 64(3):. doi: 10.1128/aac.00947-19. [PMID: 31871092]
C R Kahlert, M Cipriani, P Vernazza. Novel dual HIV maintenance therapy with nevirapine plus lamivudine retain viral suppression through 144 weeks-A proof-of-concept study. PloS one. 2020; 15(9):e0237770. doi: 10.1371/journal.pone.0237770. [PMID: 32966293]
Juan Tiraboschi, Natalia Lattour, Hernando Knobel, Pere Domingo, Esteve Ribera, Daniel Podzamczer. Long-term efficacy and safety of nevirapine-containing regimens in virologically suppressed patients: a 17-year follow up. HIV research & clinical practice. 2019 12; 20(6):151-155. doi: 10.1080/25787489.2020.1724760. [PMID: 32065079]
Sipho Mdanda, Sphamandla Ntshangase, Sanil D Singh, Tricia Naicker, Hendrik G Kruger, Sooraj Baijnath, Thavendran Govender. Investigating time dependent brain distribution of nevirapine via mass spectrometric imaging. Journal of molecular histology. 2019 Dec; 50(6):593-599. doi: 10.1007/s10735-019-09852-w. [PMID: 31686324]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Rena C Patel, Randy M Stalter, Katherine K Thomas, Bani Tamraz, Steven W Blue, David W Erikson, Christina J Kim, Edward J Kelly, Kavita Nanda, Athena P Kourtis, Jairam R Lingappa, Nelly Mugo, Jared M Baeten, Kimberly K Scarsi. A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda. AIDS (London, England). 2019 11; 33(13):1995-2004. doi: 10.1097/qad.0000000000002308. [PMID: 31306173]
Eliza D Hompe, Denise L Jacobson, Joshua A Eudailey, Kevin Butler, Whitney Edwards, Justin Pollara, Sean S Brummel, Genevieve G Fouda, Lameck Chinula, Melvin Kamanga, Aarti Kinikar, Dhayendre Moodley, Maxensia Owor, Mary Glenn Fowler, Sallie R Permar. Maternal Humoral Immune Responses Do Not Predict Postnatal HIV-1 Transmission Risk in Antiretroviral-Treated Mothers from the IMPAACT PROMISE Study. mSphere. 2019 10; 4(5):. doi: 10.1128/msphere.00716-19. [PMID: 31645430]
Valerie F Boltz, Wei Shao, Michael J Bale, Elias K Halvas, Brian Luke, James A McIntyre, Robert T Schooley, Shahin Lockman, Judith S Currier, Fred Sawe, Evelyn Hogg, Michael D Hughes, Mary F Kearney, John M Coffin, John W Mellors. Linked dual-class HIV resistance mutations are associated with treatment failure. JCI insight. 2019 10; 4(19):. doi: 10.1172/jci.insight.130118. [PMID: 31487271]
J Rueff, A S Rodrigues, M Kranendonk. A personally guided tour on some of our data with the Ames assay-A tribute to Professor Bruce Ames. Mutation research. Genetic toxicology and environmental mutagenesis. 2019 Oct; 846(?):503094. doi: 10.1016/j.mrgentox.2019.503094. [PMID: 31585631]
C Allavena, C Volteau, E André-Garnier, T Guimard, N Hall, L Khatchatourian, M Morrier, E Billaud, A Rodallec, V Reliquet, T Jovelin, L Le Guen, P Perré, M Grégoire, F Raffi. Switching from abacavir/lamivudine plus nevirapine to abacavir/lamivudine/dolutegravir in virologically controlled HIV-infected adults (SWAD study). Medecine et maladies infectieuses. 2019 Oct; 49(7):505-510. doi: 10.1016/j.medmal.2018.11.012. [PMID: 30583867]
Ahmad Haeri Mazanderani, Tanya Y Murray, Gayle G Sherman, Tracy Snyman, Jaya George, Theunis Avenant, Ameena E Goga, Michael S Pepper, Nicolette du Plessis. Non-nucleoside reverse transcriptase inhibitor levels among HIV-exposed uninfected infants at the time of HIV PCR testing - findings from a tertiary healthcare facility in Pretoria, South Africa. Journal of the International AIDS Society. 2019 06; 22(6):e25284. doi: 10.1002/jia2.25284. [PMID: 31215757]
Tavitiya Sudjaritruk, David C Boettiger, Lam Van Nguyen, Thahira J Mohamed, Dewi K Wati, Torsak Bunupuradah, Rawiwan Hansudewechakul, Penh S Ly, Pagakrong Lumbiganon, Revathy A Nallusamy, Moy S Fong, Kulkanya Chokephaibulkit, Nik K Nik Yusoff, Khanh H Truong, Viet C Do, Annette H Sohn, Virat Sirisanthana. Impact of the frequency of plasma viral load monitoring on treatment outcomes among children with perinatally acquired HIV. Journal of the International AIDS Society. 2019 06; 22(6):e25312. doi: 10.1002/jia2.25312. [PMID: 31179641]
Xiao-Lu Luo, Li-da Mo, Guo-Sheng Su, Jin-Ping Huang, Jing-Yu Wu, Han-Zhen Su, Wan-Hong Huang, Shun-da Luo, Zu-Yan Ni. Incidence and types of HIV-1 drug resistance mutation among patients failing first-line antiretroviral therapy. Journal of pharmacological sciences. 2019 Apr; 139(4):275-279. doi: 10.1016/j.jphs.2018.11.016. [PMID: 30928089]
Mehregan Safari, Mojtaba Shamsipur, Parvin Zohrabi, Homeira Ebrahimzadeh. Solid-phase extraction combined with dispersive liquid-liquid microextraction/HPLC-UV as a sensitive and efficient method for extraction, pre-concentration and simultaneous determination of antiretroviral drugs nevirapine, efavirenz and nelfinavir in pharmaceutical formulations and biological samples. Journal of pharmaceutical and biomedical analysis. 2019 Mar; 166(?):95-104. doi: 10.1016/j.jpba.2019.01.003. [PMID: 30639934]
Neda Hosseinpour Moghadam, Sadegh Salehzadeh, Jamshid Rakhtshah, Ashkan Hosseinpour Moghadam, Hamid Tanzadehpanah, Massoud Saidijam. Preparation of a highly stable drug carrier by efficient immobilization of human serum albumin (HSA) on drug-loaded magnetic iron oxide nanoparticles. International journal of biological macromolecules. 2019 Mar; 125(?):931-940. doi: 10.1016/j.ijbiomac.2018.12.143. [PMID: 30572041]
Sa'ad T Abdullahi, Adeniyi Olagunju, Julius O Soyinka, Rahman A Bolarinwa, Olusola J Olarewaju, Moji T Bakare-Odunola, Andrew Owen, Saye Khoo. Pharmacogenetics of artemether-lumefantrine influence on nevirapine disposition: Clinically significant drug-drug interaction?. British journal of clinical pharmacology. 2019 03; 85(3):540-550. doi: 10.1111/bcp.13821. [PMID: 30471138]
Suvaporn Anugulruengkitt, Tim R Cressey, Piyarat Suntarattiwong, Pradthana Ounchanum, Ussanee Srirompotong, Watsamon Jantarabenjakul, Jiratchaya Sophonphan, Yardpiroon Tawon, Sunti Punnahitanon, Chitsanu Pancharoen, Kulkanya Chokephaibulkit, Thanyawee Puthanakit. Nevirapine Concentrations During the First Month of Life and Maternal Efavirenz Washout in High-Risk HIV-Exposed Infants Receiving Triple Antiretroviral Prophylaxis. The Pediatric infectious disease journal. 2019 02; 38(2):152-156. doi: 10.1097/inf.0000000000002195. [PMID: 30204660]
Shujing Ji, Yufan Xu, Dating Han, Xiuming Peng, Xiangyun Lu, Norbert H Brockmeyer, Nanping Wu. Changes in Lipid Indices in HIV+ Cases on HAART. BioMed research international. 2019; 2019(?):2870647. doi: 10.1155/2019/2870647. [PMID: 30868068]
Seiji Kageyama, Alfredo Amolong Hinay, Elizabeth Freda Omengan Telan, Genesis May Jopson Samonte, Prisca Susan Agustin Leano, Akeno Tsuneki-Tokunaga, Kyosuke Kanai. Intrinsic Replication Competences of HIV Strains After Zidovudine/Lamivudine/Nevirapine Treatment in the Philippines. Journal of the International Association of Providers of AIDS Care. 2019 Jan; 18(?):2325958219856579. doi: 10.1177/2325958219856579. [PMID: 31216920]
Sunita Lahkar, Malay Kumar Das. Surface modified kokum butter lipid nanoparticles for the brain targeted delivery of nevirapine. Journal of microencapsulation. 2018 Nov; 35(7-8):680-694. doi: 10.1080/02652048.2019.1573857. [PMID: 30702369]
Richard E Haaland, Kephas Otieno, Amy Martin, Abraham Katana, Chuong Dinh, Laurence Slutsker, Clara Menendez, Raquel Gonzalez, John Williamson, Walid Heneine, Meghna Desai. Short Communication: Reduced Nevirapine Concentrations Among HIV-Positive Women Receiving Mefloquine for Intermittent Preventive Treatment for Malaria Control During Pregnancy. AIDS research and human retroviruses. 2018 11; 34(11):912-915. doi: 10.1089/aid.2018.0042. [PMID: 30173559]
Urs Duthaler, Benjamin Berger, Stefan Erb, Manuel Battegay, Emili Letang, Stefan Gaugler, Alex Natamatungiro, Dorcas Mnzava, Massimiliano Donzelli, Stephan Krähenbühl, Manuel Haschke. Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions. The Journal of antimicrobial chemotherapy. 2018 10; 73(10):2729-2737. doi: 10.1093/jac/dky254. [PMID: 30052975]
Iris Usach, José-Maria Ferrer, José-Esteban Peris. In vitro assessment of competitive and time-dependent inhibition of the nevirapine metabolism by nortriptyline in rats. Biochemical pharmacology. 2018 08; 154(?):1-9. doi: 10.1016/j.bcp.2018.04.016. [PMID: 29674001]
Iris Usach, Pablo Compañ, José-Esteban Peris. Sex-dependent metabolism of nevirapine in rats: impact on plasma levels, pharmacokinetics and interaction with nortriptyline. International journal of antimicrobial agents. 2018 May; 51(5):707-713. doi: 10.1016/j.ijantimicag.2017.12.026. [PMID: 29309900]
Boshi Huang, Xinhao Liu, Ye Tian, Dongwei Kang, Zhongxia Zhou, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu. First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain. Bioorganic & medicinal chemistry letters. 2018 05; 28(8):1348-1351. doi: 10.1016/j.bmcl.2018.03.012. [PMID: 29534929]
Jayram Sastry, Heba Mohammed, Maria Mercedes Campos, Jack Uetrecht, Mones Abu-Asab. Nevirapine-induced liver lipid-SER inclusions and other ultrastructural aberrations. Ultrastructural pathology. 2018 Mar; 42(2):108-115. doi: 10.1080/01913123.2017.1422831. [PMID: 29424579]
Barbara Castelnuovo, Frank Mubiru, Agnes N Kiragga, Rachel Musomba, Olive Mbabazi, Paul Gonza, Andrew Kambugu, Rosalind Parks Ratanshi. Antiretroviral treatment Long-Term (ALT) cohort: a prospective cohort of 10 years of ART-experienced patients in Uganda. BMJ open. 2018 02; 8(2):e015490. doi: 10.1136/bmjopen-2016-015490. [PMID: 29467129]
D Mukeba-Tshialala, J B Nachega, M Mutombo-Tshingwali, V Arendt, G Gilson, M Moutschen. [Obesity, high blood pressure, hypercholesterolaemia, and untreated diabetes in HIV-infected and HIV-uninfected Adults in Mbuji-Mayi (Democratic republic of congo)]. Bulletin de la Societe de pathologie exotique (1990). 2017 Dec; 110(5):301-309. doi: 10.1007/s13149-017-0561-2. [PMID: 28623554]
Chan-Loi Yong, Joseph C Gathe, Gabriele Knecht, Catherine Orrell, Josep Mallolas, Daniel Podzamczer, Benoit Trottier, Wei Zhang, John P Sabo, Richard Vinisko, Murray Drulak, Anne-Marie Quinson. Pharmacokinetic analysis of nevirapine extended release 400 mg once daily vs nevirapine immediate release 200 mg twice daily formulation in treatment-naïve patients with HIV-1 infection. HIV clinical trials. 2017 Nov; 18(5-6):189-195. doi: 10.1080/15284336.2017.1386811. [PMID: 29210627]
Helen McIlleron, Paolo Denti, Silvia Cohn, Fildah Mashabela, Jennifer D Hoffmann, Saba Shembe, Regina Msandiwa, Lubbe Wiesner, Sithembiso Velaphi, Sanjay G Lala, Richard E Chaisson, Neil Martinson, Kelly E Dooley. Prevention of TB using rifampicin plus isoniazid reduces nevirapine concentrations in HIV-exposed infants. The Journal of antimicrobial chemotherapy. 2017 07; 72(7):2028-2034. doi: 10.1093/jac/dkx112. [PMID: 28419277]
Xiaoli Du, Huijuan Kou, Qiang Fu, Yanling Li, Zhu Zhu, Taisheng Li. Steady-state pharmacokinetics of tenofovir disoproxil fumarate in human immunodeficiency virus-infected Chinese patients. Expert review of clinical pharmacology. 2017 Jul; 10(7):783-788. doi: 10.1080/17512433.2017.1321480. [PMID: 28480762]
Alex J Ntamatungiro, Lukas Muri, Tracy R Glass, Stefan Erb, Manuel Battegay, Hansjakob Furrer, Christoph Hatz, Marcel Tanner, Ingrid Felger, Thomas Klimkait, Emilio Letang. Strengthening HIV therapy and care in rural Tanzania affects rates of viral suppression. The Journal of antimicrobial chemotherapy. 2017 07; 72(7):2069-2074. doi: 10.1093/jac/dkx095. [PMID: 28387865]
Hong-Jie Zhang, Emily Rumschlag-Booms, Yi-Fu Guan, Dong-Ying Wang, Kang-Lun Liu, Wan-Fei Li, Van H Nguyen, Nguyen M Cuong, Djaja D Soejarto, Harry H S Fong, Lijun Rong. Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa. Journal of natural products. 2017 06; 80(6):1798-1807. doi: 10.1021/acs.jnatprod.7b00004. [PMID: 28613071]
Wanzhu Tu, Winstone M Nyandiko, Hai Liu, James E Slaven, Michael L Scanlon, Samuel O Ayaya, Rachel C Vreeman. Pharmacokinetics-based adherence measures for antiretroviral therapy in HIV-infected Kenyan children. Journal of the International AIDS Society. 2017 Jun; 20(1):21157. doi: 10.7448/ias.20.1.21157. [PMID: 28605170]
Rena C Patel, Chelsea Morroni, Kimberly K Scarsi, Tabitha Sripipatana, James Kiarie, Craig R Cohen. Concomitant contraceptive implant and efavirenz use in women living with HIV: perspectives on current evidence and policy implications for family planning and HIV treatment guidelines. Journal of the International AIDS Society. 2017 05; 20(1):21396. doi: 10.7448/ias.20.1.21396. [PMID: 28530033]
C Padmapriyadarsini, K Ramesh, L Sekar, Geetha Ramachandran, Devaraj Reddy, G Narendran, S Sekar, C Chandrasekar, D Anbarasu, Christine Wanke, Soumya Swaminathan. Factors affecting high-density lipoprotein cholesterol in HIV-infected patients on nevirapine-based antiretroviral therapy. The Indian journal of medical research. 2017 May; 145(5):641-650. doi: 10.4103/ijmr.ijmr_1611_15. [PMID: 28948955]
Andrzej Bienczak, Paolo Denti, Adrian Cook, Lubbe Wiesner, Veronica Mulenga, Cissy Kityo, Addy Kekitiinwa, Diana M Gibb, David Burger, Ann S Walker, Helen McIlleron. Determinants of virological outcome and adverse events in African children treated with paediatric nevirapine fixed-dose-combination tablets. AIDS (London, England). 2017 04; 31(7):905-915. doi: 10.1097/qad.0000000000001376. [PMID: 28060017]
Anil B Jindal, Sagar S Bachhav, Padma V Devarajan. In situ hybrid nano drug delivery system (IHN-DDS) of antiretroviral drug for simultaneous targeting to multiple viral reservoirs: An in vivo proof of concept. International journal of pharmaceutics. 2017 Apr; 521(1-2):196-203. doi: 10.1016/j.ijpharm.2017.02.024. [PMID: 28229943]
Chun-Yuan Lee, Hui-Min Chang, Calvin M Kunin, Susan Shin-Jung Lee, Yao-Shen Chen, Hung-Chin Tsai. Efficacy and safety of switching from nevirapine immediate-release twice daily to nevirapine extended-release once daily in virologically suppressed HIV-infected patients: a retrospective cohort study in Taiwan. BMC infectious diseases. 2017 04; 17(1):261. doi: 10.1186/s12879-017-2371-3. [PMID: 28399808]
Bingyu Liang, Junjun Jiang, Peijiang Pan, Rongfeng Chen, Daomin Zhuang, Fangning Zhao, Hui Chen, Jiegang Huang, Qijian Su, Cunwei Cao, Jingyun Li, Hao Liang, Li Ye. Morphine Increases Lamivudine- and Nevirapine-Induced Human Immunodeficiency Virus-1 Drug-Resistant Mutations In Vitro. Microbial drug resistance (Larchmont, N.Y.). 2017 Apr; 23(3):285-293. doi: 10.1089/mdr.2015.0347. [PMID: 27420739]
Ugochukwu Offor, Sunday Adelaja Ajayi, Isaac Ayoola Jegede, Salem Kharwa, Edwin Coleridge Naidu, Onyemaechi Okpara Azu. Renal histoarchitectural changes in nevirapine therapy: possible role of kolaviron and vitamin C in an experimental animal model. African health sciences. 2017 Mar; 17(1):164-174. doi: 10.4314/ahs.v17i1.21. [PMID: 29026390]
Michael A Bolaris, Margaret A Keller, Brian L Robbins, Anthony T Podany, Courtney V Fletcher. Nevirapine Plasma Concentrations in Human Immunodeficiency Virus-Exposed Neonates Receiving High-Dose Nevirapine Prophylaxis as Part of 3-Drug Regimen. Journal of the Pediatric Infectious Diseases Society. 2017 Mar; 6(1):102-104. doi: 10.1093/jpids/piv084. [PMID: 26803329]
A I Jegede, U Offor, I O Onanuga, E C S Naidu, O O Azu. Effect of co-administration of Hypoxis hemerocallidea extract and antiretroviral therapy (HAART) on the histomorphology and seminal parameters in Sprague Dawley rats. Andrologia. 2017 Mar; 49(2):. doi: 10.1111/and.12640. [PMID: 27401301]
Ravi Kanth Bhamidipati, Ramesh Mullangi, Nuggehally R Srinivas. Interspecies scaling of urinary excretory amounts of nine drugs belonging to different therapeutic areas with diverse chemical structures - accurate prediction of the human urinary excretory amounts. Xenobiotica; the fate of foreign compounds in biological systems. 2017 Feb; 47(2):112-118. doi: 10.3109/00498254.2016.1166290. [PMID: 27093131]
Jenny Svärd, Sabina Mugusi, Doreen Mloka, Ujjwal Neogi, Genny Meini, Ferdinand Mugusi, Francesca Incardona, Maurizio Zazzi, Anders Sönnerborg. Drug resistance testing through remote genotyping and predicted treatment options in human immunodeficiency virus type 1 infected Tanzanian subjects failing first or second line antiretroviral therapy. PloS one. 2017; 12(6):e0178942. doi: 10.1371/journal.pone.0178942. [PMID: 28582463]
Maureen J Kimulwo, Javan Okendo, Rashid A Aman, Bernhards R Ogutu, Gilbert O Kokwaro, Dorothy J Ochieng, Anne W T Muigai, Florence A Oloo, Washingtone Ochieng. Plasma nevirapine concentrations predict virological and adherence failure in Kenyan HIV-1 infected patients with extensive antiretroviral treatment exposure. PloS one. 2017; 12(2):e0172960. doi: 10.1371/journal.pone.0172960. [PMID: 28235021]
Bindu Parachalil Gopalan, Kayur Mehta, Reena R D'souza, Niharika Rajnala, Hemanth Kumar A K, Geetha Ramachandran, Anita Shet. Sub-therapeutic nevirapine concentration during antiretroviral treatment initiation among children living with HIV: Implications for therapeutic drug monitoring. PloS one. 2017; 12(8):e0183080. doi: 10.1371/journal.pone.0183080. [PMID: 28827836]
Tsitsi G Monera-Penduka, Charles C Maponga, Alan R Wolfe, Lubbe Wiesner, Gene D Morse, Charles F B Nhachi. Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study. AIDS research and therapy. 2017; 14(?):12. doi: 10.1186/s12981-017-0140-4. [PMID: 28293270]
Andrzej Bienczak, Adrian Cook, Lubbe Wiesner, Veronica Mulenga, Cissy Kityo, Addy Kekitiinwa, A Sarah Walker, Andrew Owen, Diana M Gibb, David Burger, Helen McIlleron, Paolo Denti. Effect of diurnal variation, CYP2B6 genotype and age on the pharmacokinetics of nevirapine in African children. The Journal of antimicrobial chemotherapy. 2017 01; 72(1):190-199. doi: 10.1093/jac/dkw388. [PMID: 27707991]
Liusheng Huang, Vincent Carey, Jane C Lindsey, Florence Marzan, David Gingrich, Bobbie Graham, Linda Barlow-Mosha, Phionah K Ssemambo, Portia Kamthunzi, Sharon Nachman, Sunil Parikh, Francesca T Aweeka. Concomitant nevirapine impacts pharmacokinetic exposure to the antimalarial artemether-lumefantrine in African children. PloS one. 2017; 12(10):e0186589. doi: 10.1371/journal.pone.0186589. [PMID: 29065172]
Suzana Mustafa, Norul Badriah Hassan, Soo Choon Tan, Ahmad Kashfi Ab Rahman, Lee Lee Low, Wan Nazirah Wan Yusuf. Exploring CYP2B6 activity by measuring the presence ofnevirapine hydroxy metabolites in plasma. Turkish journal of medical sciences. 2016 Dec; 46(6):1875-1881. doi: 10.3906/sag-1503-116. [PMID: 28081342]
Lawrence Mbuagbaw, Sara Mursleen, James H Irlam, Alicen B Spaulding, George W Rutherford, Nandi Siegfried. Efavirenz or nevirapine in three-drug combination therapy with two nucleoside or nucleotide-reverse transcriptase inhibitors for initial treatment of HIV infection in antiretroviral-naïve individuals. The Cochrane database of systematic reviews. 2016 12; 12(?):CD004246. doi: 10.1002/14651858.cd004246.pub4. [PMID: 27943261]
Paolo Palma, Paola Zangari, Claudia Alteri, Hyppolite K Tchidjou, Emma Concetta Manno, Giuseppina Liuzzi, Carlo Federico Perno, Paolo Rossi, Ada Bertoli, Stefania Bernardi. Early antiretroviral treatment (eART) limits viral diversity over time in a long-term HIV viral suppressed perinatally infected child. BMC infectious diseases. 2016 Dec; 16(1):742. doi: 10.1186/s12879-016-2092-z. [PMID: 27938348]
Retsilisitsoe R Moholisa, Michael Schomaker, Louise Kuhn, Sandra Castel, Lubbe Wiesner, Ashraf Coovadia, Renate Strehlau, Faeezah Patel, Francoise Pinillos, Elaine J Abrams, Gary Maartens, Helen McIlleron. Effect of Lopinavir and Nevirapine Concentrations on Viral Outcomes in Protease Inhibitor-experienced HIV-infected Children. The Pediatric infectious disease journal. 2016 12; 35(12):e378-e383. doi: 10.1097/inf.0000000000001319. [PMID: 27583591]
Maria Grazia Capretti, Concetta Marsico, Matteo Conti, Luigi Tommaso Corvaglia, Santo Arcuri, Giacomo Faldella, Maria Carla Re. Nevirapine prophylaxis to prevent HIV-1 mother-to-child transmission: pharmacokinetic considerations in preterm infants. The new microbiologica. 2016 Oct; 39(4):314-316. doi: . [PMID: 27284987]
Ylva Terelius, Robert A Figler, Svetlana Marukian, Maria S Collado, Mark J Lawson, Aaron J Mackey, David Manka, Charles W Qualls, Brett R Blackman, Brian R Wamhoff, Ajit Dash. Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. Chemico-biological interactions. 2016 Aug; 255(?):31-44. doi: 10.1016/j.cbi.2015.11.023. [PMID: 26626330]
Adeniyi Olagunju, Oluseye Bolaji, Megan Neary, David Back, Saye Khoo, Andrew Owen. Pregnancy affects nevirapine pharmacokinetics: evidence from a CYP2B6 genotype-guided observational study. Pharmacogenetics and genomics. 2016 08; 26(8):381-9. doi: 10.1097/fpc.0000000000000227. [PMID: 27195527]
Suzana Mustafa, Wan Nazirah Wan Yusuf, Jean Baptiste Woillard, Tan Soo Choon, Norul Badriah Hassan. Population pharmacokinetics of nevirapine in Malaysian HIV patients: a non-parametric approach. European journal of clinical pharmacology. 2016 Jul; 72(7):831-8. doi: 10.1007/s00228-016-2049-6. [PMID: 27025609]
Adeniyi Olagunju, Saye Khoo, Andrew Owen. Pharmacogenetics of nevirapine excretion into breast milk and infants' exposure through breast milk versus postexposure prophylaxis. Pharmacogenomics. 2016 06; 17(8):891-906. doi: 10.2217/pgs-2015-0016. [PMID: 27268507]
Alexander N Geisman, Vladimir T Valuev-Elliston, Alexander A Ozerov, Anastasia L Khandazhinskaya, Alexander O Chizhov, Sergey N Kochetkov, Christophe Pannecouque, Lieve Naesens, Katherine L Seley-Radtke, Mikhail S Novikov. 1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus. Bioorganic & medicinal chemistry. 2016 06; 24(11):2476-85. doi: 10.1016/j.bmc.2016.04.010. [PMID: 27112451]
Sarwar Beg, Vandna Chaudhary, Gajanand Sharma, Babita Garg, Sagar Suman Panda, Bhupinder Singh. QbD-oriented development and validation of a bioanalytical method for nevirapine with enhanced liquid-liquid extraction and chromatographic separation. Biomedical chromatography : BMC. 2016 Jun; 30(6):818-28. doi: 10.1002/bmc.3613. [PMID: 26352459]
Silvia Baroncelli, Clementina Maria Galluzzo, Sandro Mancinelli, Mauro Andreotti, Haswell Jere, Roberta Amici, Maria Cristina Marazzi, Stefano Vella, Leonardo Palombi, Marina Giuliano. Antibodies against pneumococcal capsular polysaccharide in Malawian HIV-positive mothers and their HIV-exposed uninfected children. Infectious diseases (London, England). 2016 Apr; 48(4):317-321. doi: 10.3109/23744235.2015.1115895. [PMID: 26609569]
M Rougemont, P Nchotu Ngang, B Stoll, C Delhumeau, A Hill, L Ciaffi, F Bonnet, G Menga, J-C Fampou, A Calmy. Safety of zidovudine dose reduction in treatment-naïve HIV infected patients. A randomized controlled study (MiniZID). HIV medicine. 2016 Mar; 17(3):206-15. doi: 10.1111/hiv.12303. [PMID: 26354678]
Nicholas E Thomford, Charles Awortwe, Kevin Dzobo, Faustina Adu, Denis Chopera, Ambroise Wonkam, Michelle Skelton, Dee Blackhurst, Collet Dandara. Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings. Molecules (Basel, Switzerland). 2016 Feb; 21(2):. doi: 10.3390/molecules21020211. [PMID: 26891286]
B A Maganda, O M S Minzi, E Ngaimisi, A A R Kamuhabwa, E Aklillu. CYP2B6*6 genotype and high efavirenz plasma concentration but not nevirapine are associated with low lumefantrine plasma exposure and poor treatment response in HIV-malaria-coinfected patients. The pharmacogenomics journal. 2016 Feb; 16(1):88-95. doi: 10.1038/tpj.2015.37. [PMID: 25963334]
Sirirat Likanonsakul, Bussakorn Suntisuklappon, Ravee Nitiyanontakij, Wisit Prasithsirikul, Emi E Nakayama, Tatsuo Shioda, Chariya Sangsajja. A Single-Nucleotide Polymorphism in ABCC4 Is Associated with Tenofovir-Related Beta2-Microglobulinuria in Thai Patients with HIV-1 Infection. PloS one. 2016; 11(1):e0147724. doi: 10.1371/journal.pone.0147724. [PMID: 26807589]
Leonardo Calza, Eleonora Magistrelli, Vincenzo Colangeli, Marco Borderi, Matteo Conti, Rita Mancini, Pierluigi Viale. Improvement in renal function and bone mineral density after a switch from tenofovir/emtricitabine plus ritonavir-boosted protease inhibitor to raltegravir plus nevirapine: a pilot study. Antiviral therapy. 2016; 21(3):217-24. doi: 10.3851/imp2995. [PMID: 26405177]
Andrea Calcagno, Chiara Montrucchio, Amedeo Capetti, G Guaraldi, G Cenderello, Leonardo Calza, M Lanzafame, Letizia Marinaro, M C Tettoni, Laura Trentini, Aantonio D'Avolio, Giovanni Di Perri, Stefano Bonora. Raltegravir Plus Nevirapine as Maintenance Antiretroviral Therapy in HIV-Positive Patients: Safety, Efficacy and Pharmacokinetics. Current HIV research. 2016; 14(1):54-60. doi: 10.2174/1570162x13666150929112135. [PMID: 26415700]
Maja Kiselinova, Anna Maria Geretti, Eva Malatinkova, Karen Vervisch, Apostolos Beloukas, Peter Messiaen, Pawel Bonczkowski, Wim Trypsteen, Steven Callens, Chris Verhofstede, Ward De Spiegelaere, Linos Vandekerckhove. HIV-1 RNA and HIV-1 DNA persistence during suppressive ART with PI-based or nevirapine-based regimens. The Journal of antimicrobial chemotherapy. 2015 Dec; 70(12):3311-6. doi: 10.1093/jac/dkv250. [PMID: 26324076]
Eric Dailly, Clotilde Allavena, Matthieu Grégoire, Véronique Reliquet, Régis Bouquié, Eric Billaud, Hélène Hernando, Sabelline Bouchez, Guillaume Deslandes, Nolwenn Hall, Pascale Jolliet, François Raffi. Influence of nevirapine administration on the pharmacokinetics of dolutegravir in patients infected with HIV-1. The Journal of antimicrobial chemotherapy. 2015 Dec; 70(12):3307-10. doi: 10.1093/jac/dkv245. [PMID: 26271944]
Athena P Kourtis, Jeffrey Wiener, Tiffany S Chang, Sheila C Dollard, Minal M Amin, Sascha Ellington, Dumbani Kayira, Charles van der Horst, Denise J Jamieson. Cytomegalovirus IgG Level and Avidity in Breastfeeding Infants of HIV-Infected Mothers in Malawi. Clinical and vaccine immunology : CVI. 2015 Dec; 22(12):1222-6. doi: 10.1128/cvi.00460-15. [PMID: 26424831]
Ashraf Coovadia, Elaine J Abrams, Renate Strehlau, Stephanie Shiau, Francoise Pinillos, Leigh Martens, Faeezah Patel, Gillian Hunt, Wei-Yann Tsai, Louise Kuhn. Efavirenz-Based Antiretroviral Therapy Among Nevirapine-Exposed HIV-Infected Children in South Africa: A Randomized Clinical Trial. JAMA. 2015 Nov; 314(17):1808-17. doi: 10.1001/jama.2015.13631. [PMID: 26529159]
E Pedrol, J M Llibre, M Tasias, A Currán, J M Guardiola, E Deig, A Guelar, O Martínez-Madrid, L Tikhomirova, R Ramírez. Outcome of neuropsychiatric symptoms related to an antiretroviral drug following its substitution by nevirapine: the RELAX study. HIV medicine. 2015 Nov; 16(10):628-34. doi: 10.1111/hiv.12298. [PMID: 26238151]
Julie A E Nelson, Ali Fokar, Michael G Hudgens, Kara J Compliment, Justin Tyler Hawkins, Gerald Tegha, Deborah D Kamwendo, Dumbani Kayira, Innocent A Mofolo, Athena P Kourtis, Denise J Jamieson, Charles M Van Der Horst, Susan A Fiscus. Frequent nevirapine resistance in infants infected by HIV-1 via breastfeeding while on nevirapine prophylaxis. AIDS (London, England). 2015 Oct; 29(16):2131-8. doi: 10.1097/qad.0000000000000814. [PMID: 26186128]
Dickson Shey Nsagha, Benjamin Thumamo Pokam, Jules Clement Nguedia Assob, Anna Longdoh Njunda, Odette Dzemo Kibu, Elvis Asangbeng Tanue, Charlotte Wenze Ayima, Patrick Elroy Weledji. HAART, DOTS and renal disease of patients co-infected with HIV/AIDS and TB in the South West Region of Cameroon. BMC public health. 2015 Oct; 15(?):1040. doi: 10.1186/s12889-015-2331-z. [PMID: 26452646]
Adeniyi Olagunju, Alieu Amara, Catriona Waitt, Laura Else, Sujan D Penchala, Oluseye Bolaji, Julius Soyinka, Marco Siccardi, David Back, Andrew Owen, Saye Khoo. Validation and clinical application of a method to quantify nevirapine in dried blood spots and dried breast-milk spots. The Journal of antimicrobial chemotherapy. 2015 Oct; 70(10):2816-22. doi: 10.1093/jac/dkv174. [PMID: 26108608]
Leonardo Palombi, Clementina Maria Galluzzo, Mauro Andreotti, Giuseppe Liotta, Haswel Jere, Jean-Baptiste Sagno, Richard Luhanga, Sandro Mancinelli, Roberta Amici, Maria Cristina Marazzi, Stefano Vella, Marina Giuliano. Drug resistance mutations 18 months after discontinuation of nevirapine-based ART for prevention of mother-to-child transmission of HIV in Malawi. The Journal of antimicrobial chemotherapy. 2015 Oct; 70(10):2881-4. doi: 10.1093/jac/dkv171. [PMID: 26111981]
Jennifer Jao, Brian Kirmse, Chunli Yu, Yunping Qiu, Kathleen Powis, Emmanuel Nshom, Fanny Epie, Pius Muffih Tih, Rhoda S Sperling, Elaine J Abrams, Mitchell E Geffner, Derek LeRoith, Irwin J Kurland. Lower Preprandial Insulin and Altered Fuel Use in HIV/Antiretroviral-Exposed Infants in Cameroon. The Journal of clinical endocrinology and metabolism. 2015 Sep; 100(9):3260-9. doi: 10.1210/jc.2015-2198. [PMID: 26133363]