Nevirapine (BioDeep_00000002098)

 

Secondary id: BioDeep_00000398961

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3,5,7,12,14-hexaen-10-one

化学式: C15H14N4O (266.1168)
中文名称: 奈韦拉平
谱图信息: 最多检出来源 Homo sapiens(blood) 20.1%

分子结构信息

SMILES: CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4
InChI: InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)

描述信息

Nevirapine is only found in individuals that have used or taken this drug. It is a potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV infection and AIDS. [PubChem]Nevirapine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzymes catalytic site. The activity of nevirapine does not compete with template or nucleoside triphosphates.
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AG - Non-nucleoside reverse transcriptase inhibitors
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97453 - Non-nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
D065693 - Cytochrome P-450 Enzyme Inducers > D065701 - Cytochrome P-450 CYP3A Inducers
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent

同义名列表

13 个代谢物同义名

2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3,5,7,12,14-hexaen-10-one; 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2,3-e)(1,4)diazepin-6-one; Hemihydrate, nevirapine; Nevirapine hemihydrate; ABBR NVP; nevirapine; BI-RG-587; BI RG 587; Viramune; BIRG587; NVP; NEV; Nevirapine



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, ALB, CYP2A6, CYP2B6, CYP2D6, CYP3A4, POLD3, SRY
Peripheral membrane protein 2 CYP1B1, CYP2B6
Endosome membrane 2 HLA-B, HLA-DRB1
Endoplasmic reticulum membrane 9 CD4, CYP1B1, CYP2A6, CYP2B6, CYP2D6, CYP3A4, HLA-B, HLA-C, HLA-DRB1
Nucleus 4 ALB, NR1I2, POLD3, SRY
cytosol 3 ALB, APOA1, GPT
nuclear body 1 NR1I2
centrosome 1 ALB
nucleoplasm 3 NR1I2, POLD3, SRY
Cell membrane 6 ABCB1, CD4, CD8A, HLA-B, HLA-C, HLA-DRB1
Early endosome membrane 3 HLA-B, HLA-C, HLA-DRB1
Multi-pass membrane protein 1 ABCB1
cell surface 4 ABCB1, HLA-B, HLA-C, HLA-DRB1
Golgi apparatus 3 ALB, HLA-B, HLA-C
Golgi membrane 4 HLA-B, HLA-C, HLA-DRB1, INS
lysosomal membrane 2 HLA-B, HLA-DRB1
plasma membrane 8 ABCB1, APOA1, CD4, CD8A, HLA-B, HLA-C, HLA-DRB1, IFNLR1
Membrane 9 ABCB1, CYP1B1, CYP2A6, CYP2D6, CYP3A4, HLA-B, HLA-C, HLA-DRB1, IFNLR1
apical plasma membrane 1 ABCB1
extracellular exosome 7 ABCB1, ALB, APOA1, GPT, HLA-B, HLA-C, HLA-DRB1
Lysosome membrane 2 HLA-B, HLA-DRB1
endoplasmic reticulum 4 ALB, CYP2D6, HLA-B, HLA-C
extracellular space 6 ALB, APOA1, HLA-B, HLA-C, HLA-DRB1, INS
mitochondrion 2 CYP1B1, CYP2D6
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 5 CYP1B1, CYP2A6, CYP2B6, CYP2D6, CYP3A4
Microsome membrane 4 CYP1B1, CYP2B6, CYP2D6, CYP3A4
Single-pass type I membrane protein 6 CD4, CD8A, HLA-B, HLA-C, HLA-DRB1, IFNLR1
Secreted 3 ALB, APOA1, INS
extracellular region 4 ALB, APOA1, CD8A, INS
Single-pass membrane protein 4 CYP2D6, HLA-B, HLA-C, HLA-DRB1
[Isoform 2]: Secreted 1 CD8A
anchoring junction 1 ALB
transcription regulator complex 1 NR1I2
external side of plasma membrane 5 CD4, CD8A, HLA-B, HLA-C, HLA-DRB1
Extracellular vesicle 1 APOA1
chylomicron 1 APOA1
high-density lipoprotein particle 1 APOA1
low-density lipoprotein particle 1 APOA1
very-low-density lipoprotein particle 1 APOA1
cytoplasmic vesicle 1 APOA1
Early endosome 2 APOA1, CD4
Apical cell membrane 1 ABCB1
Membrane raft 1 CD4
collagen-containing extracellular matrix 1 APOA1
intermediate filament 1 HLA-DRB1
nuclear speck 1 SRY
receptor complex 1 CD8A
ciliary basal body 1 ALB
chromatin 2 NR1I2, SRY
Late endosome membrane 1 HLA-DRB1
phagocytic vesicle membrane 3 HLA-B, HLA-C, HLA-DRB1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, APOA1
Recycling endosome membrane 3 HLA-B, HLA-C, HLA-DRB1
endosome lumen 1 INS
Nucleus speckle 1 SRY
intermediate filament cytoskeleton 1 NR1I2
trans-Golgi network membrane 1 HLA-DRB1
plasma membrane raft 1 CD8A
secretory granule lumen 2 APOA1, INS
secretory granule membrane 2 HLA-B, HLA-C
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, APOA1, CD4, INS
platelet alpha granule lumen 1 ALB
endocytic vesicle membrane 1 HLA-DRB1
endocytic vesicle 1 APOA1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 HLA-DRB1
ER to Golgi transport vesicle membrane 3 HLA-B, HLA-C, HLA-DRB1
clathrin-coated endocytic vesicle membrane 2 CD4, HLA-DRB1
cytoplasmic microtubule 1 CYP2A6
external side of apical plasma membrane 1 ABCB1
lumenal side of endoplasmic reticulum membrane 3 HLA-B, HLA-C, HLA-DRB1
[Isoform 1]: Cell membrane 1 CD8A
zeta DNA polymerase complex 1 POLD3
spherical high-density lipoprotein particle 1 APOA1
endocytic vesicle lumen 1 APOA1
T cell receptor complex 2 CD4, CD8A
MHC class I protein complex 2 HLA-B, HLA-C
Autolysosome membrane 1 HLA-DRB1
MHC class II protein complex 3 HLA-B, HLA-C, HLA-DRB1
transport vesicle membrane 1 HLA-DRB1
delta DNA polymerase complex 1 POLD3
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1


文献列表

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  • Ceejay L Boyce, Tatiana Sils, Daisy Ko, Annie Wong-On-Wing, Ingrid A Beck, Sheila M Styrchak, Patricia DeMarrais, Camlin Tierney, Lynda Stranix-Chibanda, Patricia M Flynn, Taha E Taha, Maxensia Owor, Mary Glenn Fowler, Lisa M Frenkel. Maternal Human Immunodeficiency Virus (HIV) Drug Resistance Is Associated With Vertical Transmission and Is Prevalent in Infected Infants. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 06; 74(11):2001-2009. doi: 10.1093/cid/ciab744. [PMID: 34467974]
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  • Rosa Marlene Cuco, Osvaldo Loquiha, Adelino Juga, Aleny Couto, Bindiya Meggi, Adolfo Vubil, Esperança Sevene, Nafissa Osman, Marleen Temermam, Olivier Degomme, Mohsin Sidat, Nilesh Bhatt. Nevirapine hair and plasma concentrations and HIV-1 viral suppression among HIV infected ante-partum and post-partum women attended in a mother and child prevention program in Maputo city, Mozambique. PloS one. 2022; 17(2):e0261522. doi: 10.1371/journal.pone.0261522. [PMID: 35143515]
  • Musa Otieno Ngayo, Margaret Oluka, Wallace Dimbuson Bulimo, Faith Apolot Okalebo. Association between social psychological status and efavirenz and nevirapine plasma concentration among HIV patients in Kenya. Scientific reports. 2021 11; 11(1):22071. doi: 10.1038/s41598-021-01345-9. [PMID: 34764325]
  • Thaisa Cardoso de Oliveira, Antônia Carla de Jesus Oliveira, Yuri Basílio Gomes Patriota, Luise Lopes Chaves, Fabio de Oliveira Silva Ribeiro, Regina C M de Paula, Edson Cavalcanti Silva-Filho, Durcilene Alves da Silva, Mônica Felts de La Roca Soares, José Lamartine Soares-Sobrinho. Eco-friendly synthesis of phthalate angico gum towards nanoparticles engineering using Quality by Design (QbD) approach. International journal of biological macromolecules. 2021 Nov; 190(?):801-809. doi: 10.1016/j.ijbiomac.2021.09.012. [PMID: 34508723]
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  • Sipho Mdanda, Sphamandla Ntshangase, Sanil D Singh, Tricia Naicker, Hendrik G Kruger, Sooraj Baijnath, Thavendran Govender. Investigating time dependent brain distribution of nevirapine via mass spectrometric imaging. Journal of molecular histology. 2019 Dec; 50(6):593-599. doi: 10.1007/s10735-019-09852-w. [PMID: 31686324]
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