Miglitol (BioDeep_00000002075)

 

Secondary id: BioDeep_00000405906

human metabolite blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


(2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

化学式: C8H17NO5 (207.1107)
中文名称: 米格列醇
谱图信息: 最多检出来源 Homo sapiens(blood) 5.22%

分子结构信息

SMILES: C(CO)N1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O
InChI: InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2

描述信息

Miglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body. Miglitol inhibits glycoside hydrolase enzymes called alpha-glucosidases. Since miglitol works by preventing digestion of carbohydrates, it lowers the degree of postprandial hyperglycemia. It must be taken at the start of main meals to have maximal effect. Its effect will depend on the amount of non-monosaccharide carbohydrates in a persons diet. In contrast to acarbose (another alpha-glucosidase inhibitor), miglitol is systemically absorbed; however, it is not metabolized and is excreted by the kidneys.
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BF - Alpha glucosidase inhibitors
D007004 - Hypoglycemic Agents > D065089 - Glycoside Hydrolase Inhibitors
C471 - Enzyme Inhibitor > C2846 - Glucosidase Inhibitor
D004791 - Enzyme Inhibitors

同义名列表

15 个代谢物同义名

(2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol; 1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol; Miglitol, 4-methylbenzenesulfonate salt, ((D)-isomer); Sanofi-synthelabo brand OF miglitol; N-Hydroxyethyl-1-desoxy-nojirimycin; N-Hydroxyethyl-1-desoxynojirimycin; Lacer brand OF miglitol; BAY-m 1099; BAY m 1099; BAY-m-1099; Diastabol; Plumarol; Miglitol; Glyset; Miglitol



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, S100A11, S100A6, S100A9, SLC2A2
Peripheral membrane protein 3 GBA1, S100A9, SORD
Mitochondrion membrane 1 SORD
Nucleus 4 ALB, S100A11, S100A6, S100A9
cytosol 4 ALB, S100A6, S100A9, SORD
mitochondrial membrane 1 SORD
trans-Golgi network 1 GBA1
centrosome 1 ALB
Cell membrane 6 DPP4, MGAM, S100A9, SELE, SLC2A2, SLC5A2
lamellipodium 1 DPP4
Multi-pass membrane protein 3 SLC2A2, SLC5A1, SLC5A2
cell junction 1 DPP4
cell surface 2 ADIPOQ, DPP4
glutamatergic synapse 1 GHRL
Golgi apparatus 2 ALB, GBA1
Golgi membrane 1 INS
lysosomal membrane 2 DPP4, GBA1
neuronal cell body 1 GIP
postsynapse 1 GHRL
Lysosome 1 GBA1
plasma membrane 9 DPP4, GCG, MGAM, S100A6, S100A9, SELE, SLC2A2, SLC5A1, SLC5A2
Membrane 5 DPP4, MGAM, SLC2A2, SLC5A2, SORD
apical plasma membrane 5 DPP4, MGAM, SLC2A2, SLC5A1, SLC5A2
axon 1 GHRL
brush border 1 SLC2A2
caveola 1 SELE
extracellular exosome 10 ALB, DPP4, GBA1, MGAM, S100A11, S100A6, S100A9, SLC5A1, SLC5A2, SORD
Lysosome membrane 1 GBA1
Lumenal side 1 GBA1
endoplasmic reticulum 3 ADIPOQ, ALB, GBA1
extracellular space 12 ADIPOQ, ALB, CRP, GCG, GHRL, GIP, INS, PYY, S100A11, S100A9, SELE, SORD
lysosomal lumen 1 GBA1
perinuclear region of cytoplasm 3 S100A6, SELE, SLC5A1
Schaffer collateral - CA1 synapse 1 GHRL
adherens junction 1 S100A11
intercellular canaliculus 1 DPP4
protein-containing complex 1 ALB
Single-pass type I membrane protein 1 SELE
Secreted 8 ADIPOQ, ALB, CRP, DPP4, GCG, GHRL, INS, MGAM
extracellular region 13 ADIPOQ, ALB, CRP, DPP4, GCG, GHRL, GIP, INS, MGAM, PYY, S100A11, S100A6, S100A9
cytoplasmic side of plasma membrane 1 S100A6
Single-pass membrane protein 2 DPP4, MGAM
anchoring junction 2 ALB, DPP4
motile cilium 1 SORD
external side of plasma membrane 1 SELE
neuronal dense core vesicle lumen 1 GHRL
Early endosome 1 SLC5A1
cell-cell junction 1 SLC2A2
clathrin-coated pit 1 SELE
Single-pass type II membrane protein 1 DPP4
Apical cell membrane 3 DPP4, SLC5A1, SLC5A2
Membrane raft 2 DPP4, SELE
Cytoplasm, cytoskeleton 1 S100A9
focal adhesion 1 DPP4
collagen trimer 1 ADIPOQ
intracellular vesicle 1 SLC5A1
collagen-containing extracellular matrix 3 ADIPOQ, S100A6, S100A9
ruffle 2 S100A11, S100A6
ciliary basal body 1 ALB
cytoskeleton 1 S100A9
centriole 1 ALB
brush border membrane 1 SLC5A1
spindle pole 1 ALB
blood microparticle 1 ALB
Cell projection, cilium, flagellum 1 SORD
nuclear envelope 1 S100A6
Endomembrane system 1 DPP4
endosome lumen 1 INS
tertiary granule membrane 1 MGAM
secretory granule lumen 6 GCG, GHRL, GIP, INS, S100A11, S100A9
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 ALB, GCG, GHRL, GIP, INS
platelet alpha granule lumen 1 ALB
endocytic vesicle 1 DPP4
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ficolin-1-rich granule membrane 1 MGAM
lamellipodium membrane 1 DPP4
hemoglobin complex 1 HBA1
[Glucagon-like peptide 1]: Secreted 1 GCG
cortical cytoskeleton 1 SELE
Cell projection, lamellipodium membrane 1 DPP4
calprotectin complex 1 S100A9
Cell projection, invadopodium membrane 1 DPP4
S100A9 complex 1 S100A9
intracellular organelle 1 SLC5A1
[Dipeptidyl peptidase 4 soluble form]: Secreted 1 DPP4
ciliary transition fiber 1 ALB


文献列表

  • Parsa Bazdar, Ali R Jalalvand, Vali Akbari, Reza Khodarahmi, Hector C Goicoechea. Resolving interactions of miglitol with normal and glycated human serum albumin by multivariate methods. Analytical biochemistry. 2021 10; 630(?):114339. doi: 10.1016/j.ab.2021.114339. [PMID: 34411552]
  • Yasushi Honda, Anna Ozaki, Michihiro Iwaki, Takashi Kobayashi, Asako Nogami, Takaomi Kessoku, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Masato Yoneda, Satoru Saito, Yoji Nagashima, Atsushi Nakajima. Protective effect of SGL5213, a potent intestinal sodium-glucose cotransporter 1 inhibitor, in nonalcoholic fatty liver disease in mice. Journal of pharmacological sciences. 2021 Oct; 147(2):176-183. doi: 10.1016/j.jphs.2021.07.002. [PMID: 34384565]
  • Juan Yan, Xiao-Min Li, Yan-Xin Zhang, Su-Mei Xu, Wan-Li Liu, Jie Guo, Xiao-Lei Hu, Ting Zou, Yu-Ying Xu, Ping-Sheng Xu. Bioequivalence and Evaluation Parameters Based on the Pharmacodynamics of Miglitol in Healthy Volunteers. Clinical pharmacology in drug development. 2021 06; 10(6):582-587. doi: 10.1002/cpdd.873. [PMID: 33058553]
  • Fumitaka Okajima, Hitoshi Sugihara, Naoya Emoto. Efficacy and Safety of Miglitol- or Repaglinide-Based Combination Therapy with Alogliptin for Drug-Naïve Patients with Type 2 Diabetes: An Open-Label, Single-Center, Parallel, Randomized Controlled Pilot Study. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. 2021 Mar; 88(1):71-79. doi: 10.1272/jnms.jnms.2021_88-205. [PMID: 32475902]
  • Yu-Ying Xu, Su-Mei Xu, Xiao-Min Li, Dai Li, Juan Yan, Ping-Sheng Xu. Validation of the ADVIA Centaur® XP system for the determination of insulin and its application. Analytical biochemistry. 2020 02; 591(?):113567. doi: 10.1016/j.ab.2019.113567. [PMID: 31881181]
  • Genki Naruse, Hiromitsu Kanamori, Akihiro Yoshida, Shingo Minatoguchi, Tomonori Kawaguchi, Masamitsu Iwasa, Yoshihisa Yamada, Atsushi Mikami, Masanori Kawasaki, Kazuhiko Nishigaki, Shinya Minatoguchi. The intestine responds to heart failure by enhanced mitochondrial fusion through glucagon-like peptide-1 signalling. Cardiovascular research. 2019 Nov; 115(13):1873-1885. doi: 10.1093/cvr/cvz002. [PMID: 30629149]
  • Eun-Young Lee, Xilin Zhang, Junki Miyamoto, Ikuo Kimura, Tomoaki Taknaka, Kenichi Furusawa, Takahito Jomori, Kosuke Fujimoto, Satoshi Uematsu, Takashi Miki. Gut carbohydrate inhibits GIP secretion via a microbiota/SCFA/FFAR3 pathway. The Journal of endocrinology. 2018 12; 239(3):267-276. doi: 10.1530/joe-18-0241. [PMID: 30400014]
  • Xiaodan Liu, Jianan Feng, Yan Li. Preparation of carbon-functionalized magnetic graphene/mesoporous silica composites for selective extraction of miglitol and voglibose in rat plasma. Talanta. 2018 May; 182(?):405-413. doi: 10.1016/j.talanta.2018.01.079. [PMID: 29501171]
  • Yumi Kishida, Hirofumi Okubo, Haruya Ohno, Kenji Oki, Masayasu Yoneda. Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model. Journal of gastroenterology. 2017 Nov; 52(11):1180-1191. doi: 10.1007/s00535-017-1331-4. [PMID: 28349245]
  • Bo-Wei Zhang, Yuan-Bin Sang, Wen-Long Sun, He-Shui Yu, Bai-Ping Ma, Zhi-Long Xiu, Yue-Sheng Dong. Combination of flavonoids from Oroxylum indicum seed extracts and acarbose improves the inhibition of postprandial blood glucose: In vivo and in vitro study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Jul; 91(?):890-898. doi: 10.1016/j.biopha.2017.04.080. [PMID: 28511342]
  • Marc Goetz, Anne Guivarćh, Jörg Hirsche, Martin Andreas Bauerfeind, María-Cruz González, Tae Kyung Hyun, Seung Hee Eom, Dominique Chriqui, Thomas Engelke, Dominik K Großkinsky, Thomas Roitsch. Metabolic Control of Tobacco Pollination by Sugars and Invertases. Plant physiology. 2017 02; 173(2):984-997. doi: 10.1104/pp.16.01601. [PMID: 27923989]
  • Takeshi Osonoi, Miyoko Saito, Natsuyo Hariya, Moritaka Goto, Kazuki Mochizuki. Add-on therapy with anagliptin in Japanese patients with type-2 diabetes mellitus treated with metformin and miglitol can maintain higher concentrations of biologically active GLP-1/total GIP and a lower concentration of leptin. Peptides. 2016 12; 86(?):118-125. doi: 10.1016/j.peptides.2016.10.011. [PMID: 27780736]
  • N Kasahara, H Fukase, Y Ohba, T Saito, K Miyata, S Iida, Y Takano, S Ikeda, M Harigai, K Terao. A Pharmacokinetic/Pharmacodynamic Drug-Drug Interaction Study of Tofogliflozin (a New SGLT2 Inhibitor) and Selected Anti-Type 2 Diabetes Mellitus Drugs. Drug research. 2016 Feb; 66(2):74-81. doi: 10.1055/s-0035-1549967. [PMID: 26158794]
  • Sachie Hirose, Yasuyuki Iwahashi, Akane Seo, Michitaka Sumiyoshi, Tetsuya Takahashi, Yoshikazu Tamori. Concurrent Therapy with a Low-carbohydrate Diet and Miglitol Remarkably Improved the Postprandial Blood Glucose and Insulin Levels in a Patient with Reactive Hypoglycemia due to Late Dumping Syndrome. Internal medicine (Tokyo, Japan). 2016; 55(9):1137-42. doi: 10.2169/internalmedicine.55.5655. [PMID: 27150868]
  • Eriko Shibata, Kazutaka Aoki, Kazuki Tajima, Masataka Taguri, Yasuo Terauchi. Comparison of efficacy and safety of taking miglitol dissolved in water during a meal and taking a miglitol tablet just before a meal in patients with type 2 diabetes. Expert opinion on pharmacotherapy. 2016; 17(7):889-94. doi: 10.1517/14656566.2016.1159297. [PMID: 26918556]
  • George Chinedu Ezeji, Taiga Inoue, Gul Bahtiyar, Alan Sacerdote. Hallucinations associated with miglitol use in a patient with chronic kidney disease and hypothyroidism. BMJ case reports. 2015 Feb; 2015(?):. doi: 10.1136/bcr-2014-207345. [PMID: 25666246]
  • Miyako Kishimoto, Mitsuhiko Noda. Additive effects of miglitol and anagliptin on insulin-treated type 2 diabetes mellitus: a case study. Clinical drug investigation. 2015 Feb; 35(2):141-7. doi: 10.1007/s40261-014-0260-8. [PMID: 25511640]
  • Hiromichi Asamoto, Yasuhito Nobushi, Takahiko Oi, Kazuo Uchikura. Determination of Miglitol by Column-Switching Ion-Pair HPLC with Tris(2,2'-bipyridine)ruthenium(II)-Electrogenerated Chemiluminescence Detection. Chemical & pharmaceutical bulletin. 2015; 63(6):476-80. doi: 10.1248/cpb.c14-00788. [PMID: 26027473]
  • Atsushi Mikada, Takuma Narita, Hiroki Yokoyama, Risa Yamashita, Yohei Horikawa, Katsushi Tsukiyama, Yuichiro Yamada. Effects of miglitol, sitagliptin, and initial combination therapy with both on plasma incretin responses to a mixed meal and visceral fat in over-weight Japanese patients with type 2 diabetes. "the MASTER randomized, controlled trial". Diabetes research and clinical practice. 2014 Dec; 106(3):538-47. doi: 10.1016/j.diabres.2014.09.040. [PMID: 25451890]
  • Akiko Mizuno-Yasuhira, Kohnosuke Kinoshita, Shigeji Jingu, Jun-ichi Yamaguchi. A sensitive and selective method for the quantitative analysis of miglitol in rat plasma using unique solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC. 2014 Oct; 28(10):1423-9. doi: 10.1002/bmc.3185. [PMID: 24706526]
  • Natsuyo Hariya, Kazuki Mochizuki, Seiya Inoue, Miyoko Saito, Masahiro Fuchigami, Toshinao Goda, Takeshi Osonoi. Switching α-glucosidase inhibitors to miglitol reduced glucose fluctuations and circulating cardiovascular disease risk factors in type 2 diabetic Japanese patients. Drugs in R&D. 2014 Sep; 14(3):177-84. doi: 10.1007/s40268-014-0055-7. [PMID: 25079671]
  • Akiko Mizuno-Yasuhira, Yasuhiro Nakai, Emi Gunji, Saeko Uchida, Teisuke Takahashi, Kohnosuke Kinoshita, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa, Jun-Ichi Yamaguchi. A Strategy for assessing potential drug-drug interactions of a concomitant agent against a drug absorbed via an intestinal transporter in humans. Drug metabolism and disposition: the biological fate of chemicals. 2014 Sep; 42(9):1456-65. doi: 10.1124/dmd.114.058305. [PMID: 25005603]
  • Chihiro Imai, Miyoko Saito, Kazuki Mochizuki, Masahiro Fuchigami, Toshinao Goda, Takeshi Osonoi. Cotreatment with the α-glucosidase inhibitor miglitol and DPP-4 inhibitor sitagliptin improves glycemic control and reduces the expressions of CVD risk factors in type 2 diabetic Japanese patients. Metabolism: clinical and experimental. 2014 Jun; 63(6):746-53. doi: 10.1016/j.metabol.2013.12.014. [PMID: 24559582]
  • Jun Shirakawa, Yuko Murohashi, Noriko Okazaki, Shunsuke Yamazaki, Tetsuya Tamura, Tomoko Okuyama, Yu Togashi, Yasuo Terauchi. Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy. Endocrine journal. 2014; 61(11):1115-23. doi: 10.1507/endocrj.ej14-0290. [PMID: 25142087]
  • Hyun-Gyu Choi, Ji-Young Jeon, Yong-Jin Im, Yunjeong Kim, Haejong Jang, Seungwoo Kang, Kyeong Ho Kim, Soo-Wan Chae, Sun Young Lee, Min-Gul Kim. Pharmacokinetic comparisons between two formulations containing 100 mg of miglitol in healthy male Korean volunteers: a randomized, open-label, single-dose, two-period, two-sequence crossover bioequivalence study. International journal of clinical pharmacology and therapeutics. 2014 Jan; 52(1):55-63. doi: 10.5414/cp201994. [PMID: 24290415]
  • Kazutaka Aoki, Hiroshi Kamiyama, Kiyomi Masuda, Kazunari Kamiko, Yoshihiko Noguchi, Kazuki Tajima, Yasuo Terauchi. Effects of miglitol, vildagliptin, or their combination on serum insulin and peptide YY levels and plasma glucose, cholecystokinin, ghrelin, and obestatin levels. Endocrine journal. 2014; 61(3):249-56. doi: 10.1507/endocrj.ej13-0399. [PMID: 24389993]
  • Keita Ishibashi, Akemi Hara, Yoshio Fujitani, Toyoyoshi Uchida, Koji Komiya, Motoyuki Tamaki, Hiroko Abe, Takeshi Ogihara, Akio Kanazawa, Ryuzo Kawamori, Hirotaka Watada. Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlled db/db mice. Biochemical and biophysical research communications. 2013 Nov; 440(4):570-5. doi: 10.1016/j.bbrc.2013.09.110. [PMID: 24103756]
  • Michio Shimabukuro, Moritake Higa, Ken Yamakawa, Hiroaki Masuzaki, Masataka Sata. Miglitol, α-glycosidase inhibitor, reduces visceral fat accumulation and cardiovascular risk factors in subjects with the metabolic syndrome: a randomized comparable study. International journal of cardiology. 2013 Sep; 167(5):2108-13. doi: 10.1016/j.ijcard.2012.05.109. [PMID: 22721642]
  • Fuminori Tatsumi, Mitsuru Hashiramoto, Hidenori Hirukawa, Tomohiko Kimura, Masashi Shimoda, Kazuhito Tawaramoto, Yukiko Kanda-Kimura, Takatoshi Anno, Fumiko Kawasaki, Tomoatsu Mune, Michihiro Matsuki, Kohei Kaku. Concomitant use of miglitol and mitiglinide as initial combination therapy in type 2 diabetes mellitus. Diabetes research and clinical practice. 2013 Jul; 101(1):35-44. doi: 10.1016/j.diabres.2013.04.007. [PMID: 23711593]
  • Atul Shrivastava, Upma Chaturvedi, Shiv Vardan Singh, Jitendra Kumar Saxena, Gitika Bhatia. Lipid lowering and antioxidant effect of miglitol in triton treated hyperlipidemic and high fat diet induced obese rats. Lipids. 2013 Jun; 48(6):597-607. doi: 10.1007/s11745-012-3753-3. [PMID: 23334955]
  • Yoji Hamada, Hiroshi Nagasaki, Masahiro Fuchigami, Shinji Furuta, Yusuke Seino, Jiro Nakamura, Yutaka Oiso. The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice. Metabolism: clinical and experimental. 2013 May; 62(5):734-42. doi: 10.1016/j.metabol.2012.10.015. [PMID: 23194643]
  • Kenta Okada, Hiroaki Yagyu, Kazuhiko Kotani, Hisataka Yamazaki, Kazufumi Ozaki, Manabu Takahashi, Shuichi Nagashima, Jun-Ichi Osuga, Shun Ishibashi. Effects of miglitol versus sitagliptin on postprandial glucose and lipoprotein metabolism in patients with type 2 diabetes mellitus. Endocrine journal. 2013; 60(7):913-22. doi: 10.1507/endocrj.ej13-0019. [PMID: 23574730]
  • Miyako Kishimoto, Mitsuhiko Noda. Effect of the addition of sitagliptin and miglitol on insulin-treated type 2 diabetes. Diabetes therapy : research, treatment and education of diabetes and related disorders. 2012 Nov; 3(1):11. doi: 10.1007/s13300-012-0011-x. [PMID: 23055336]
  • K S Kesavanarayanan, S Sathiya, V Ranju, A G Sunil, R Ilavarasan, C Saravana Babu, S Kavimani, D Prathiba. In vitro cytotoxic, antioxidative and alpha-glucosidase inhibitory potential of a herbal mixture comprised of Allium sativum and Lagerstroemia speciosa. European review for medical and pharmacological sciences. 2012 Jul; 16 Suppl 3(?):58-68. doi: . [PMID: 22957419]
  • Tomoko Kimura, Jinya Suzuki, Mai Ichikawa, Michiko Imagawa, Satsuki Sato, Miki Fujii, Yasuo Zenimaru, Satoru Inaba, Sadao Takahashi, Tadashi Konoshita, Isamu Miyamori. Differential effects of α-glucosidase inhibitors on postprandial plasma glucose and lipid profile in patients with type 2 diabetes under control with insulin lispro mix 50/50. Diabetes technology & therapeutics. 2012 Jul; 14(7):545-51. doi: 10.1089/dia.2012.0015. [PMID: 22519736]
  • Kazutaka Aoki, Hiroshi Kamiyama, Kouichiro Yoshimura, Makoto Shibuya, Kiyomi Masuda, Yasuo Terauchi. Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin. Acta diabetologica. 2012 Jun; 49(3):225-30. doi: 10.1007/s00592-011-0322-9. [PMID: 21898126]
  • Ruchita V Kumar, Vivek Ranjan Sinha. Newer insights into the drug delivery approaches of α-glucosidase inhibitors. Expert opinion on drug delivery. 2012 Apr; 9(4):403-16. doi: 10.1517/17425247.2012.663080. [PMID: 22364261]
  • T Narita, H Yokoyama, R Yamashita, T Sato, M Hosoba, T Morii, H Fujita, K Tsukiyama, Y Yamada. Comparisons of the effects of 12-week administration of miglitol and voglibose on the responses of plasma incretins after a mixed meal in Japanese type 2 diabetic patients. Diabetes, obesity & metabolism. 2012 Mar; 14(3):283-7. doi: 10.1111/j.1463-1326.2011.01526.x. [PMID: 22051162]
  • Takuo Emoto, Takahiro Sawada, Megumi Hashimoto, Hiroko Kageyama, Daisuke Terashita, Taiji Mizoguchi, Takao Mizuguchi, Yoshiki Motodi, Masamichi Iwasaki, Kazuki Taira, Hiroshi Okamoto, Yosuke Matsuo, Sushi-ku Kim, Akira Takarada, Mitsuhiro Yokoyama. Effect of 3-month repeated administration of miglitol on vascular endothelial function in patients with diabetes mellitus and coronary artery disease. The American journal of cardiology. 2012 Jan; 109(1):42-6. doi: 10.1016/j.amjcard.2011.08.005. [PMID: 21944671]
  • Nalinee Poolsup, Naeti Suksomboon, Wanwaree Setwiwattanakul. Efficacy of various antidiabetic agents as add-on treatments to metformin in type 2 diabetes mellitus: systematic review and meta-analysis. ISRN endocrinology. 2012; 2012(?):798146. doi: 10.5402/2012/798146. [PMID: 22619731]
  • Man-Wo Tsang. The management of type 2 diabetic patients with hypoglycaemic agents. ISRN endocrinology. 2012; 2012(?):478120. doi: 10.5402/2012/478120. [PMID: 22645689]
  • Miyako Kishimoto, Mitsuhiko Noda. A pilot study of the efficacy of miglitol and sitagliptin for type 2 diabetes with a continuous glucose monitoring system and incretin-related markers. Cardiovascular diabetology. 2011 Dec; 10(?):115. doi: 10.1186/1475-2840-10-115. [PMID: 22189184]
  • Kosuke Fukao, Kazunori Shimada, Makoto Hiki, Takashi Kiyanagi, Kuniaki Hirose, Atsumi Kume, Hiromichi Ohsaka, Rie Matsumori, Takeshi Kurata, Tetsuro Miyazaki, Hiroyuki Daida. Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function--a crossover trial (AGENT). Cardiovascular diabetology. 2011 Sep; 10(?):79. doi: 10.1186/1475-2840-10-79. [PMID: 21906391]
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