Methotrimeprazine (BioDeep_00000002015)

 

Secondary id: BioDeep_00000408935

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(-)-(2R)-3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine

化学式: C19H24N2OS (328.1609)
中文名称: 左美吗嗪
谱图信息: 最多检出来源 Homo sapiens(blood) 52.09%

分子结构信息

SMILES: CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C
InChI: InChI=1S/C19H24N2OS/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21/h5-11,14H,12-13H2,1-4H3

描述信息

Methotrimeprazine is only found in individuals that have used or taken this drug. It is a phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)Methotrimeprazines antipsychotic effect is largely due to its antagonism of dopamine receptors in the brain. In addition, its binding to 5HT2 receptors may also play a role.
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AA - Phenothiazines with aliphatic side-chain
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent > C740 - Phenothiazine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
KEIO_ID M099; [MS2] KO009123
KEIO_ID M099
Levomepromazine (Methotrimeprazine) is an orally available neuroleptic agent, which is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter receptor sites, including dopaminergic, cholinergic, serotonin and histamine receptors[1].

同义名列表

16 个代谢物同义名

(-)-(2R)-3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine; (-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine; 2-Methoxy-N,N,beta-trimethyl-10H-phenothiazine-10-propylamine; 2-Methoxytrimeprazine; Methotrimeprazine; Levomepromazinum; Levomepromazina; Levomepromazine; Levopromazine; Levomeprazin; Tizercine; Tizertsin; Levoprome; Neurocil; Tisercin; Methotrimeprazine



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ANXA5, AXIN2, CYP1A1, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4, MTOR, NLRP3, NR3C1
Peripheral membrane protein 6 ANXA5, CYP1A1, CYP1B1, CYP2B6, CYP2E1, MTOR
Endoplasmic reticulum membrane 12 CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4, MTOR
Nucleus 4 AXIN2, MTOR, NLRP3, NR3C1
cytosol 5 ANXA5, AXIN2, MTOR, NLRP3, NR3C1
dendrite 2 DRD2, MTOR
phagocytic vesicle 1 MTOR
centrosome 2 AXIN2, NR3C1
nucleoplasm 2 MTOR, NR3C1
Cell membrane 2 ADRB3, DRD2
Cytoplasmic side 1 MTOR
Multi-pass membrane protein 3 ADRB3, CACNA1I, DRD2
Golgi apparatus membrane 3 DRD2, MTOR, NLRP3
Synapse 2 DRD2, NR3C1
glutamatergic synapse 1 DRD2
Golgi membrane 3 DRD2, MTOR, NLRP3
lysosomal membrane 1 MTOR
mitochondrial inner membrane 2 CYP1A1, CYP2E1
presynaptic membrane 1 DRD2
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 NLRP3
Lysosome 1 MTOR
acrosomal vesicle 1 DRD2
plasma membrane 8 ADRB3, AXIN2, BCHE, CACNA1I, CYP2C19, CYP2C8, CYP2C9, DRD2
synaptic vesicle membrane 1 DRD2
Membrane 9 ANXA5, CACNA1I, CYP1B1, CYP2A6, CYP2D6, CYP3A4, MTOR, NLRP3, NR3C1
axon 1 DRD2
extracellular exosome 1 ANXA5
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 CYP2D6, NLRP3
extracellular space 1 BCHE
mitochondrion 5 CYP1A1, CYP1B1, CYP2D6, NLRP3, NR3C1
protein-containing complex 1 NR3C1
intracellular membrane-bounded organelle 11 CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Microsome membrane 9 CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C9, CYP2D6, CYP2E1, CYP3A4, MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 2 BCHE, NLRP3
extracellular region 3 ANXA5, BCHE, NLRP3
Mitochondrion outer membrane 1 MTOR
Single-pass membrane protein 1 CYP2D6
mitochondrial outer membrane 1 MTOR
mitochondrial matrix 1 NR3C1
ciliary membrane 1 DRD2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
external side of plasma membrane 1 ANXA5
dendritic spine 1 DRD2
perikaryon 1 DRD2
beta-catenin destruction complex 1 AXIN2
postsynaptic membrane 1 DRD2
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
Cytoplasm, cytoskeleton, spindle 1 NR3C1
focal adhesion 1 ANXA5
spindle 1 NR3C1
GABA-ergic synapse 1 DRD2
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 ANXA5
lateral plasma membrane 1 DRD2
nuclear speck 1 NR3C1
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
receptor complex 1 ADRB3
Zymogen granule membrane 1 ANXA5
cilium 1 DRD2
chromatin 1 NR3C1
Chromosome 1 NR3C1
blood microparticle 1 BCHE
non-motile cilium 1 DRD2
sperm flagellum 1 DRD2
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, NLRP3
microtubule organizing center 1 NLRP3
Nucleus, nucleoplasm 1 NR3C1
endoplasmic reticulum lumen 1 BCHE
axon terminus 1 DRD2
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle 1 DRD2
nuclear envelope lumen 1 BCHE
vesicle membrane 1 ANXA5
cytoplasmic microtubule 1 CYP2A6
dopaminergic synapse 1 DRD2
Cytoplasmic vesicle, phagosome 1 MTOR
[Isoform Alpha]: Cytoplasm 1 NR3C1
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
endothelial microparticle 1 ANXA5
G protein-coupled receptor complex 1 DRD2


文献列表

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