Levomepromazine (BioDeep_00000408935)

Main id: BioDeep_00000002015

 


代谢物信息卡片


Levomepromazine

化学式: C19H24N2OS (328.1609254)
中文名称: 左美吗嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C
InChI: InChI=1S/C19H24N2OS/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21/h5-11,14H,12-13H2,1-4H3/t14-/m1/s1

描述信息

N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AA - Phenothiazines with aliphatic side-chain
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent > C740 - Phenothiazine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
Levomepromazine (Methotrimeprazine) is an orally available neuroleptic agent, which is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter receptor sites, including dopaminergic, cholinergic, serotonin and histamine receptors[1].

同义名列表

2 个代谢物同义名

Levomepromazine; Methotrimeprazine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Bárbara Antunes, Ben Bowers, Isaac Winterburn, Michael P Kelly, Robert Brodrick, Kristian Pollock, Megha Majumder, Anna Spathis, Iain Lawrie, Rob George, Richella Ryan, Stephen Barclay. Anticipatory prescribing in community end-of-life care in the UK and Ireland during the COVID-19 pandemic: online survey. BMJ supportive & palliative care. 2020 Sep; 10(3):343-349. doi: 10.1136/bmjspcare-2020-002394. [PMID: 32546559]
  • Virginie Bulot, Cédric Lemogne, Nicaise Nebot, Hugues Blondon, Paul Roux. Systematic prevention of severe constipation induced by antipsychotic agents: A quasi-experimental study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2016 10; 26(10):1690-1. doi: 10.1016/j.euroneuro.2016.08.004. [PMID: 27546374]
  • Kyoko Uekusa, Makiko Hayashida, Youkichi Ohno. Forensic toxicological analyses of drugs in tissues in formalin solutions and in fixatives. Forensic science international. 2015 Apr; 249(?):165-72. doi: 10.1016/j.forsciint.2015.01.028. [PMID: 25700112]
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  • Britta Haenisch, Eva Drescher, Lidia Thiemer, Hu Xin, Bruno Giros, Sophie Gautron, Heinz Bönisch. Interaction of antidepressant and antipsychotic drugs with the human organic cation transporters hOCT1, hOCT2 and hOCT3. Naunyn-Schmiedeberg's archives of pharmacology. 2012 Oct; 385(10):1017-23. doi: 10.1007/s00210-012-0781-8. [PMID: 22806583]
  • Takeshi Kumazawa, Chika Hasegawa, Seisaku Uchigasaki, Xiao-Pen Lee, Osamu Suzuki, Keizo Sato. Quantitative determination of phenothiazine derivatives in human plasma using monolithic silica solid-phase extraction tips and gas chromatography-mass spectrometry. Journal of chromatography. A. 2011 May; 1218(18):2521-7. doi: 10.1016/j.chroma.2011.02.070. [PMID: 21429493]
  • Y Otheman, H Khalloufi, I Benhima, A Ouanass. [Neuropsychiatric symptoms revealing pseudohypoparathyroidism with Fahr's syndrome]. L'Encephale. 2011 Feb; 37(1):54-8. doi: 10.1016/j.encep.2010.03.001. [PMID: 21349375]
  • Iida Peltonen, Pekka T Männistö. Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase. Basic & clinical pharmacology & toxicology. 2011 Jan; 108(1):46-54. doi: 10.1111/j.1742-7843.2010.00626.x. [PMID: 20825390]
  • S J C Davies, A A Westin, I Castberg, G Lewis, M S Lennard, S Taylor, O Spigset. Characterisation of zuclopenthixol metabolism by in vitro and therapeutic drug monitoring studies. Acta psychiatrica Scandinavica. 2010 Dec; 122(6):444-53. doi: 10.1111/j.1600-0447.2010.01619.x. [PMID: 20946203]
  • Seong Taeck Kim, Jae Woong Koh, Joon Mo Kim, Won Young Kim, Gwang Ju Choi. Methotrimeprazine-induced corneal deposits and cataract revealed by urine drug profiling test. Journal of Korean medical science. 2010 Nov; 25(11):1688-91. doi: 10.3346/jkms.2010.25.11.1688. [PMID: 21060765]
  • Britta Haenisch, Heinz Bönisch. Interaction of the human plasma membrane monoamine transporter (hPMAT) with antidepressants and antipsychotics. Naunyn-Schmiedeberg's archives of pharmacology. 2010 Jan; 381(1):33-9. doi: 10.1007/s00210-009-0479-8. [PMID: 20012264]
  • Naoki Hiroi, Aya Yoshihara, Mariko Sue, Gen Yoshino, Mariko Higa. Central adrenal insufficiency and diabetes insipidus misdiagnosed as severe depression. Clinical medicine insights. Case reports. 2010; 3(?):55-8. doi: 10.4137/ccrep.s5812. [PMID: 21769255]
  • W Manati, F Vaillant, M Bost, V Maffre, D Belhani, J Descotes, A Tabib, B Bui-Xuan, L Hamdan, Q Timour. Protective role of selenium supplementation against cardiac lesions induced by the combination of levomepromazine and risperidone in the rabbit. Human & experimental toxicology. 2009 Aug; 28(8):461-7. doi: 10.1177/0960327109106968. [PMID: 19736279]
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  • Johannes Kornhuber, Lothar Terfloth, Stefan Bleich, Jens Wiltfang, Rainer Rupprecht. Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors. European journal of medicinal chemistry. 2009 Jun; 44(6):2667-72. doi: 10.1016/j.ejmech.2008.12.003. [PMID: 19144451]
  • Marcin Kolaczkowski, Anna Kolaczkowska, Noboru Motohashi, Krystyna Michalak. New high-throughput screening assay to reveal similarities and differences in inhibitory sensitivities of multidrug ATP-binding cassette transporters. Antimicrobial agents and chemotherapy. 2009 Apr; 53(4):1516-27. doi: 10.1128/aac.00956-08. [PMID: 19188399]
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  • Linda Hanssens, Gilbert L'Italien, Jean-Yves Loze, Ronald N Marcus, Miranda Pans, Wendy Kerselaers. The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913). BMC psychiatry. 2008 Dec; 8(?):95. doi: 10.1186/1471-244x-8-95. [PMID: 19102734]
  • Natsuko Shinmen, Xiao-Pen Lee, Takeshi Kumazawa, Chika Hasegawa, Yasuhiro Ishiwata, Keizo Sato, Hiroshi Seno, Osamu Suzuki. Simultaneous determination of some phenothiazine derivatives in human blood by headspace solid-phase microextraction and gas chromatography with nitrogen-phosphorus detection. Journal of AOAC International. 2008 Nov; 91(6):1354-62. doi: . [PMID: 19202796]
  • Buster Mannheimer, Christer von Bahr, Hans Pettersson, Erik Eliasson. Impact of multiple inhibitors or substrates of cytochrome P450 2D6 on plasma risperidone levels in patients on polypharmacy. Therapeutic drug monitoring. 2008 Oct; 30(5):565-9. doi: 10.1097/ftd.0b013e31818679c9. [PMID: 18728628]
  • Vera Maresova, Jiri Chadt, Eva Novakova. Screening and semiquantitative analysis of drugs and drugs of abuse in human serum samples using gas chromatography-mass spectrometry. Neuro endocrinology letters. 2008 Oct; 29(5):749-54. doi: NULL. [PMID: 18987582]
  • Maria Addolorata Saracino, Mario Amore, Elena Baioni, Carmine Petio, Maria Augusta Raggi. Determination of selected phenothiazines in human plasma by solid-phase extraction and liquid chromatography with coulometric detection. Analytica chimica acta. 2008 Aug; 624(2):308-16. doi: 10.1016/j.aca.2008.06.040. [PMID: 18706338]
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  • Ingrid Castberg, Eirik Skogvoll, Olav Spigset. Quetiapine and drug interactions: evidence from a routine therapeutic drug monitoring service. The Journal of clinical psychiatry. 2007 Oct; 68(10):1540-5. doi: 10.4088/jcp.v68n1011. [PMID: 17960969]
  • Einosuke Tanaka, Takako Nakamura, Masaru Terada, Tatsuo Shinozuka, Chikako Hashimoto, Katsuyoshi Kurihara, Katsuya Honda. Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jul; 854(1-2):116-20. doi: 10.1016/j.jchromb.2007.04.004. [PMID: 17459789]
  • Francesca Bugamelli, Roberto Mandrioli, Ernst Kenndler, Claudio Bartoletti, Giancarlo Boncompagni, Maria Augusta Raggi. Possible levomepromazine-clozapine interaction: two case reports. Progress in neuro-psychopharmacology & biological psychiatry. 2007 Mar; 31(2):567-70. doi: 10.1016/j.pnpbp.2006.11.003. [PMID: 17174461]
  • Laura Mercolini, Francesca Bugamelli, Ernst Kenndler, Giancarlo Boncompagni, Livia Franchini, Maria Augusta Raggi. Simultaneous determination of the antipsychotic drugs levomepromazine and clozapine and their main metabolites in human plasma by a HPLC-UV method with solid-phase extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Feb; 846(1-2):273-80. doi: 10.1016/j.jchromb.2006.09.019. [PMID: 17045854]
  • H Kirchherr, W N Kühn-Velten. Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Oct; 843(1):100-13. doi: 10.1016/j.jchromb.2006.05.031. [PMID: 16798119]
  • Frédérique Lancelin, Linda Kraoul, Nadia Flatischler, Sophie Brovedani-Rousset, Marie-Liesse Piketty. False-positive results in the detection of methadone in urines of patients treated with psychotropic substances. Clinical chemistry. 2005 Nov; 51(11):2176-7. doi: 10.1373/clinchem.2005.055350. [PMID: 16244295]
  • Guido Mannaioni, Roberto Baronti, Flavio Moroni. Gastrointestinal bleeding and massive liver damage in neuroleptic malignant syndrome. Therapeutics and clinical risk management. 2005 Sep; 1(3):225-30. doi: NULL. [PMID: 18360563]
  • R Yoshimura, K Shinkai, S Kakihara, M Goto, Y Yamada, K Kaji, N Ueda, J Nakamura. Little effects of low dosage of levomepromazine on plasma risperidone levels. Pharmacopsychiatry. 2005 Mar; 38(2):98-100. doi: 10.1055/s-2005-837811. [PMID: 15744635]
  • Joeri Sterken, Joris Troubleyn, Frank Gasthuys, Viviane Maes, Mark Diltoer, Christian Verborgh. Intentional overdose of Large Animal Immobilon. European journal of emergency medicine : official journal of the European Society for Emergency Medicine. 2004 Oct; 11(5):298-301. doi: 10.1097/00063110-200410000-00013. [PMID: 15359207]
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  • I A Platonov, V G Vonogel', T A Andreeva. [Effect of a levopromazine-thymalin combination on the development of toxic edema and swelling in the brain]. Eksperimental'naia i klinicheskaia farmakologiia. 2004 Jan; 67(1):48-50. doi: . [PMID: 15079910]
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  • P G J ter Horst, N A Foudraine, G Cuypers, E A van Dijk, N J J Oldenhof. Simultaneous determination of levomepromazine, midazolam and their major metabolites in human plasma by reversed-phase liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jul; 791(1-2):389-98. doi: 10.1016/s1570-0232(03)00253-8. [PMID: 12798199]
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  • Adrián LLerena, Roland Berecz, Pedro Dorado, César Sanz de la Garza, Maria Jesús Norberto, Macarena Cáceres, José Ramón Gutiérrez. Determination of risperidone and 9-hydroxyrisperidone in human plasma by liquid chromatography: application to the evaluation of CYP2D6 drug interactions. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jan; 783(1):213-9. doi: 10.1016/s1570-0232(02)00661-x. [PMID: 12450541]
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