Indinavir (BioDeep_00000002007)

 

Secondary id: BioDeep_00000405865

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


(1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamide

化学式: C36H47N5O4 (613.3627862)
中文名称: 茚地那韦
谱图信息: 最多检出来源 Homo sapiens(blood) 1.61%

分子结构信息

SMILES: CC(C)(C)NC(=O)C1CN(Cc2cccnc2)CCN1CC(O)CC(Cc1ccccc1)C(=O)NC1c2ccccc2CC1O
InChI: InChI=1S/C36H47N5O4/c1-36(2,3)39-35(45)31-24-40(22-26-12-9-15-37-21-26)16-17-41(31)23-29(42)19-28(18-25-10-5-4-6-11-25)34(44)38-33-30-14-8-7-13-27(30)20-32(33)43/h4-15,21,28-29,31-33,42-43H,16-20,22-24H2,1-3H3,(H,38,44)(H,39,45)/t28-,29+,31+,32-,33+/m1/s1

描述信息

Indinavir is only found in individuals that have used or taken this drug. It is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]Indinavir inhibits the HIV viral protease enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
CONFIDENCE standard compound; INTERNAL_ID 178; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3668; ORIGINAL_PRECURSOR_SCAN_NO 3666
CONFIDENCE standard compound; INTERNAL_ID 178; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7953; ORIGINAL_PRECURSOR_SCAN_NO 7951
CONFIDENCE standard compound; INTERNAL_ID 178; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7922; ORIGINAL_PRECURSOR_SCAN_NO 7919
CONFIDENCE standard compound; INTERNAL_ID 178; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3684; ORIGINAL_PRECURSOR_SCAN_NO 3682
CONFIDENCE standard compound; INTERNAL_ID 178; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7948; ORIGINAL_PRECURSOR_SCAN_NO 7944
INTERNAL_ID 178; CONFIDENCE standard compound; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3703; ORIGINAL_PRECURSOR_SCAN_NO 3700
CONFIDENCE standard compound; INTERNAL_ID 178; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7958; ORIGINAL_PRECURSOR_SCAN_NO 7956
CONFIDENCE standard compound; INTERNAL_ID 178; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7938; ORIGINAL_PRECURSOR_SCAN_NO 7936
CONFIDENCE standard compound; INTERNAL_ID 178; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3664; ORIGINAL_PRECURSOR_SCAN_NO 3662
CONFIDENCE standard compound; INTERNAL_ID 178; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7884; ORIGINAL_PRECURSOR_SCAN_NO 7882
CONFIDENCE standard compound; INTERNAL_ID 178; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3703; ORIGINAL_PRECURSOR_SCAN_NO 3700
CONFIDENCE standard compound; INTERNAL_ID 178; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3663; ORIGINAL_PRECURSOR_SCAN_NO 3661
CONFIDENCE standard compound; INTERNAL_ID 178; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3661; ORIGINAL_PRECURSOR_SCAN_NO 3659
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AE - Protease inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D000084762 - Viral Protease Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C97366 - HIV Protease Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent > C1660 - Anti-HIV Agent
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors

同义名列表

12 个代谢物同义名

(1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamide; (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}butyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide; Indinavir, sulfate (1:1); Indinavir sulphate; Sulfate, indinavir; Indinavir Sulfate; Indinavir-d6; Compound J; Indinavir; Crixivan; Indinavir sulfate; Indinavir



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Julien Allard, Simon Bucher, Julie Massart, Pierre-Jean Ferron, Dounia Le Guillou, Roxane Loyant, Yoann Daniel, Youenn Launay, Nelly Buron, Karima Begriche, Annie Borgne-Sanchez, Bernard Fromenty. Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell biology and toxicology. 2021 04; 37(2):151-175. doi: 10.1007/s10565-020-09537-1. [PMID: 32535746]
  • Wen-Shan Liu, Han-Gao Li, Chuan-Hua Ding, Hai-Xia Zhang, Rui-Rui Wang, Jia-Qiu Li. Screening potential FDA-approved inhibitors of the SARS-CoV-2 major protease 3CLpro through high-throughput virtual screening and molecular dynamics simulation. Aging. 2021 03; 13(5):6258-6272. doi: 10.18632/aging.202703. [PMID: 33678621]
  • Ana P Costa, Michael H Court, Nicolas F Villarino, Neal S Burke, Katrina L Mealey. Canine orosomucoid (alpha-1 acid glycoprotein) variants and their influence on drug plasma protein binding. Journal of veterinary pharmacology and therapeutics. 2021 Jan; 44(1):116-125. doi: 10.1111/jvp.12899. [PMID: 32744755]
  • Mohammad M Ghahremanpour, Julian Tirado-Rives, Maya Deshmukh, Joseph A Ippolito, Chun-Hui Zhang, Israel Cabeza de Vaca, Maria-Elena Liosi, Karen S Anderson, William L Jorgensen. Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2. ACS medicinal chemistry letters. 2020 Dec; 11(12):2526-2533. doi: 10.1021/acsmedchemlett.0c00521. [PMID: 33324471]
  • Purushothaman Indu, Marimuthu Ragavan Rameshkumar, Narasingam Arunagirinathan, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Savarimuthu Ignacimuthu. Raltegravir, Indinavir, Tipranavir, Dolutegravir, and Etravirine against main protease and RNA-dependent RNA polymerase of SARS-CoV-2: A molecular docking and drug repurposing approach. Journal of infection and public health. 2020 Dec; 13(12):1856-1861. doi: 10.1016/j.jiph.2020.10.015. [PMID: 33168456]
  • Teruhisa S Komatsu, Noriaki Okimoto, Yohei M Koyama, Yoshinori Hirano, Gentaro Morimoto, Yousuke Ohno, Makoto Taiji. Drug binding dynamics of the dimeric SARS-CoV-2 main protease, determined by molecular dynamics simulation. Scientific reports. 2020 10; 10(1):16986. doi: 10.1038/s41598-020-74099-5. [PMID: 33046764]
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  • Usisipho Feleni, Unathi Sidwaba, Hlamulo Makelane, Emmanuel Iwuoha. Core-Shell Palladium Telluride Quantum Dot-Hemethiolate Cytochrome Based Biosensor for Detecting Indinavir Drug. Journal of nanoscience and nanotechnology. 2019 12; 19(12):7974-7981. doi: 10.1166/jnn.2019.16866. [PMID: 31196318]
  • Masoumeh Kurd, Soroor Sadegh Malvajerd, Saeed Rezaee, Mehrdad Hamidi, Katayoun Derakhshandeh. Oral delivery of indinavir using mPEG-PCL nanoparticles: preparation, optimization, cellular uptake, transport and pharmacokinetic evaluation. Artificial cells, nanomedicine, and biotechnology. 2019 Dec; 47(1):2123-2133. doi: 10.1080/21691401.2019.1616553. [PMID: 31155961]
  • Fatma Kalleli, Iness Bettaieb Rebey, Wissem Aidi Wannes, Faycel Boughalleb, Majdi Hammami, Moufida Saidani Tounsi, Mahmoud M'hamdi. Chemical composition and antioxidant potential of essential oil and methanol extract from Tunisian and French fennel (Foeniculum vulgare Mill.) seeds. Journal of food biochemistry. 2019 08; 43(8):e12935. doi: 10.1111/jfbc.12935. [PMID: 31368565]
  • Dan-Dan Tian, Cathrine Leonowens, Emily J Cox, Vanessa González-Pérez, Kosea S Frederick, Yolanda V Scarlett, Michael B Fisher, Mary F Paine. Indinavir Increases Midazolam N-Glucuronidation in Humans: Identification of an Alternate CYP3A Inhibitor Using an In Vitro to In Vivo Approach. Drug metabolism and disposition: the biological fate of chemicals. 2019 07; 47(7):724-731. doi: 10.1124/dmd.119.087007. [PMID: 31028057]
  • Bartłomiej Matłosz, Ewa Pietraszkiewicz, Ewa Firląg-Burkacka, Ewa Grycner, Andrzej Horban, Justyna D Kowalska. Risk factors for kidney disease among HIV-1 positive persons in the methadone program. Clinical and experimental nephrology. 2019 Mar; 23(3):342-348. doi: 10.1007/s10157-018-1644-5. [PMID: 30218298]
  • Mohammad Nasiri, Amir Azadi, Mohammad Reza Saghatchi Zanjani, Mehrdad Hamidi. Indinavir-Loaded Nanostructured Lipid Carriers to Brain Drug Delivery: Optimization, Characterization and Neuropharmacokinetic Evaluation. Current drug delivery. 2019; 16(4):341-354. doi: 10.2174/1567201816666190123124429. [PMID: 30674257]
  • Mohd Sayeed, Sudeep Gautam, Devesh Pratap Verma, Tayyaba Afshan, Tripti Kumari, Arvind Kumar Srivastava, Jimut Kanti Ghosh. A collagen domain-derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms. The Journal of biological chemistry. 2018 08; 293(35):13509-13523. doi: 10.1074/jbc.ra118.001801. [PMID: 29991592]
  • Kaylee Havenga, Efrem Abay, Lubbe Wiesner, Alvaro Viljoen, Dewald Steyn, Josias Hamman. The In Vitro and In Vivo Effects of Hypoxis hemerocallidea on Indinavir Pharmacokinetics: Modulation of Efflux. Planta medica. 2018 Aug; 84(12-13):895-901. doi: 10.1055/a-0607-2743. [PMID: 29672818]
  • Qing Li, Zhi Ye, Peng Zhu, Dong Guo, Hong Yang, Jin Huang, Wei Zhang, James E Polli, Yan Shu. Indinavir Alters the Pharmacokinetics of Lamivudine Partially via Inhibition of Multidrug and Toxin Extrusion Protein 1 (MATE1). Pharmaceutical research. 2018 01; 35(1):14. doi: 10.1007/s11095-017-2290-4. [PMID: 29302757]
  • K Yang, C Battista, J L Woodhead, S H Stahl, J T Mettetal, P B Watkins, S Q Siler, B A Howell. Systems pharmacology modeling of drug-induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters. Clinical pharmacology and therapeutics. 2017 04; 101(4):501-509. doi: 10.1002/cpt.619. [PMID: 28074467]
  • Candace M Reno, Erwin C Puente, Zhenyu Sheng, Dorit Daphna-Iken, Adam J Bree, Vanessa H Routh, Barbara B Kahn, Simon J Fisher. Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation. Diabetes. 2017 03; 66(3):587-597. doi: 10.2337/db16-0917. [PMID: 27797912]
  • Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers. AJKD Atlas of Renal Pathology: Indinavir Nephrotoxicity. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2017 01; 69(1):e3. doi: 10.1053/j.ajkd.2016.11.004. [PMID: 28007196]
  • Sandra Medina-Moreno, Thomas C Dowling, Juan C Zapata, Nhut M Le, Edward Sausville, Joseph Bryant, Robert R Redfield, Alonso Heredia. Targeting of CDK9 with indirubin 3'-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice. PloS one. 2017; 12(8):e0183425. doi: 10.1371/journal.pone.0183425. [PMID: 28817720]
  • Sonya VanPatten, Shan Sun, Mingzhu He, Kai Fan Cheng, Ahmad Altiti, Angelos Papatheodorou, Czeslawa Kowal, Venkatesh Jeganathan, James M Crawford, Ona Bloom, Bruce T Volpe, Christian Grant, Nathalie Meurice, Thomas R Coleman, Betty Diamond, Yousef Al-Abed. Amending HIV Drugs: A Novel Small-Molecule Approach To Target Lupus Anti-DNA Antibodies. Journal of medicinal chemistry. 2016 10; 59(19):8859-8867. doi: 10.1021/acs.jmedchem.6b00694. [PMID: 27603688]
  • Lonette Wallis, Maides Malan, Chrisna Gouws, Dewald Steyn, Suria Ellis, Efrem Abay, Lubbe Wiesner, Daniel P Otto, Josias Hamman. Evaluation of Isolated Fractions of Aloe vera Gel Materials on Indinavir Pharmacokinetics: In vitro and in vivo Studies. Current drug delivery. 2016; 13(3):471-80. doi: 10.2174/1567201813888160302163208. [PMID: 26568138]
  • Carlemi Calitz, Chrisna Gouws, Joe Viljoen, Jan Steenekamp, Lubbe Wiesner, Efrem Abay, Josias Hamman. Herb-Drug Pharmacokinetic Interactions: Transport and Metabolism of Indinavir in the Presence of Selected Herbal Products. Molecules (Basel, Switzerland). 2015 Dec; 20(12):22113-27. doi: 10.3390/molecules201219838. [PMID: 26690396]
  • Z X Lin, C T Che, S S Lee, R C Y Chan, P S P Ip, J M Yang. Sophora flavescens (Ku-Shen) as a booster for antiretroviral therapy through cytochrome P450 3A4 inhibition. Hong Kong medical journal = Xianggang yi xue za zhi. 2015 Dec; 21 Suppl 7(?):S18-21. doi: ". [PMID: 26908268]
  • Yijin Liu, Michael Jann, Chad Vandenberg, Chin B Eap, Shahab A Shamsi. Development of an enantioselective assay for simultaneous separation of venlafaxine and O-desmethylvenlafaxine by micellar electrokinetic chromatography-tandem mass spectrometry: Application to the analysis of drug-drug interaction. Journal of chromatography. A. 2015 Nov; 1420(?):119-28. doi: 10.1016/j.chroma.2015.09.088. [PMID: 26460073]
  • Jennifer P Freeling, Josefin Koehn, Cuiling Shu, Jianguo Sun, Rodney J Y Ho. Anti-HIV drug-combination nanoparticles enhance plasma drug exposure duration as well as triple-drug combination levels in cells within lymph nodes and blood in primates. AIDS research and human retroviruses. 2015 Jan; 31(1):107-14. doi: 10.1089/aid.2014.0210. [PMID: 25402233]
  • Eduardo Milton Ramos-Sanchez, Hiro Goto, Dolores Helena Rodriguez Ferreira Rivero, Thais Mauad, Fernando Nogueira de Souza, Andrea Moreira Monteiro, Magnus Gidlund. In vivo assessment of antiretroviral therapy-associated side effects. Memorias do Instituto Oswaldo Cruz. 2014 Jul; 109(4):484-7. doi: 10.1590/0074-0276130559. [PMID: 25075786]
  • André Mateus, Pär Matsson, Per Artursson. A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry. 2014 Apr; 57(7):3005-10. doi: 10.1021/jm401963n. [PMID: 24601604]
  • Leslie O Ofori, Thomas A Hilimire, Ryan P Bennett, Nathaniel W Brown, Harold C Smith, Benjamin L Miller. High-affinity recognition of HIV-1 frameshift-stimulating RNA alters frameshifting in vitro and interferes with HIV-1 infectivity. Journal of medicinal chemistry. 2014 Feb; 57(3):723-32. doi: 10.1021/jm401438g. [PMID: 24387306]
  • Igbe Ighodaro, Omogbai Kelly Eric, Oyekan Adebayo. Interactions of PPAR α and GLUT4 in DOCA/salt-induced renal injury in mice. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. 2013 Dec; 28(2):127-33. doi: . [PMID: 24937386]
  • Jae H Chang, Emile Plise, Jonathan Cheong, Quynh Ho, Molly Lin. Evaluating the in vitro inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in predicting drug-induced hyperbilirubinemia. Molecular pharmaceutics. 2013 Aug; 10(8):3067-75. doi: 10.1021/mp4001348. [PMID: 23750830]
  • Aaron N Endsley, Rodney J Y Ho. Enhanced anti-HIV efficacy of indinavir after inclusion in CD4-targeted lipid nanoparticles. Journal of acquired immune deficiency syndromes (1999). 2012 Dec; 61(4):417-24. doi: 10.1097/qai.0b013e3182653c1f. [PMID: 22743598]
  • Haitao Liu, Shuchun Liu, Liangdong Guo, Yonggang Zhang, Langjun Cui, Gang Ding. New furanones from the plant endophytic fungus Pestalotiopsis besseyi. Molecules (Basel, Switzerland). 2012 Nov; 17(12):14015-21. doi: 10.3390/molecules171214015. [PMID: 23187285]
  • Edward P Acosta, Kay L Limoli, Lan Trinh, Neil T Parkin, Jennifer R King, Jodi M Weidler, Ighovwerha Ofotokun, Christos J Petropoulos. Novel method to assess antiretroviral target trough concentrations using in vitro susceptibility data. Antimicrobial agents and chemotherapy. 2012 Nov; 56(11):5938-45. doi: 10.1128/aac.00691-12. [PMID: 22964257]
  • Lisiane Turatti, Eduardo Sprinz, Rosmeri K Lazzaretti, Regina Kuhmmer, Grasiela Agnes, Jussara M Silveira, Rossana P Basso, Cezar A T Pinheiro, Mariângela F Silveira, Silvana de Almeida, Jorge P Ribeiro, Vanessa S Mattevi. Short communication: UGT1A1*28 variant allele is a predictor of severe hyperbilirubinemia in HIV-infected patients on HAART in southern Brazil. AIDS research and human retroviruses. 2012 Sep; 28(9):1015-8. doi: 10.1089/aid.2011.0261. [PMID: 22050734]
  • Magnus G Rasch, Frederik N Engsig, Bo Feldt-Rasmussen, Ole Kirk, Gitte Kronborg, Court Pedersen, Jan Gerstoft, Niels Obel. Renal function and incidence of chronic kidney disease in HIV patients: a Danish cohort study. Scandinavian journal of infectious diseases. 2012 Sep; 44(9):689-96. doi: 10.3109/00365548.2012.673730. [PMID: 22680981]
  • Tulsi Das Mishra, Hemal Kurani, Puran Singhal, Pranav S Shrivastav. Simultaneous quantitation of HIV-protease inhibitors ritonavir, lopinavir and indinavir in human plasma by UPLC-ESI-MS-MS. Journal of chromatographic science. 2012 Aug; 50(7):625-35. doi: 10.1093/chromsci/bms048. [PMID: 22562821]
  • Fawzia H Toulah, Amal A El-Shafei, Hyat S Al-Rashidi. Evaluation of garlic plant and indinavir drug efficacy in the treatment of cryptosporidiosis in experimentally immumosuppressed rats. Journal of the Egyptian Society of Parasitology. 2012 Aug; 42(2):321-8. doi: 10.12816/0006320. [PMID: 23214211]
  • Omer A Raheem, Hossein S Mirheydar, Kerrin Palazzi, Marianne Chenoweth, Charles Lakin, Roger L Sur. Prevalence of nephrolithiasis in human immunodeficiency virus infected patients on the highly active antiretroviral therapy. Journal of endourology. 2012 Aug; 26(8):1095-8. doi: 10.1089/end.2011.0639. [PMID: 22429050]
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  • Michael W Jann, Vicky Spratlin, Kathryn Momary, Hailing Zhang, David Turner, Scott R Penzak, Alan Wright, Chad VanDenBerg. Lack of a pharmacokinetic drug-drug interaction with venlafaxine extended-release/indinavir and desvenlafaxine extended-release/indinavir. European journal of clinical pharmacology. 2012 May; 68(5):715-21. doi: 10.1007/s00228-011-1180-7. [PMID: 22173281]
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