Ticarcillin (BioDeep_00000001974)
Secondary id: BioDeep_00001868066
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(2S,5R,6R)-6-{[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
化学式: C15H16N2O6S2 (384.045)
中文名称: 替卡西林
谱图信息:
最多检出来源 Homo sapiens(blood) 67.86%
分子结构信息
SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CSC=C3)C(=O)O)C(=O)O)C
InChI: InChI=1S/C15H16N2O6S2/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23)/t7-,8-,9+,12-/m1/s1
描述信息
Ticarcillin is only found in individuals that have used or taken this drug. It is an antibiotic derived from penicillin similar to carbenicillin in action.Ticarcillins antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis when the bacteria tries to divide, causing death.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CA - Penicillins with extended spectrum
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
25 个代谢物同义名
(2S,5R,6R)-6-{[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-[(2R)-2-carboxy-2-(thiophen-3-yl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-{[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; SmithKline beecham brand OF ticarcillin disodium salt; GlaxoSmithKline brand OF ticarcillin disodium salt; SmithKline beecham brand OF ticarcillin disodium; GlaxoSmithKline brand OF ticarcillin disodium; alpha-Carboxy-3-thienylmethylpenicillin; Α-carboxy-3-thienylmethylpenicillin; a-Carboxy-3-thienylmethylpenicillin; CSL Brand OF ticarcillin disodium; Ticarcillin supplement; Disodium, ticarcillin; Ticarcillin disodium; SCHEMBL5047437; Ticarcillinum; Ticarcilline; Ticarcillin; Ticarcilina; Ticillin; Ticarpen; Tarcil; Ticar; TIPC; Ticarcillin
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:9587
- KEGG: C07139
- KEGGdrug: D08593
- PubChem: 36921
- PubChem: 5471
- HMDB: HMDB0015545
- Metlin: METLIN2851
- DrugBank: DB01607
- ChEMBL: CHEMBL1449
- Wikipedia: Ticarcillin
- MeSH: Ticarcillin
- chemspider: 33876
- CAS: 34787-01-4
- PMhub: MS000001577
- PubChem: 9348
- NIKKAJI: J17.850K
- KNApSAcK: 9587
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 3708 - Brassica napus: 10.3389/FNUT.2022.822033
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Moli Wang, Yanxia Gao, Xueli Liu, Jing Zhang, Qiang Wang, Junshan Chang, Lantong Zhang. Determination and pharmacokinetic analysis of ticarcillin disodium-clavulanate potassium for injection in rat plasma by UPLC-ESI-MS/MS.
The Journal of international medical research.
2020 Dec; 48(12):300060520967822. doi:
10.1177/0300060520967822. [PMID: 33356736] - Caleb J P Economou, Jennifer Ordoñez, Steven C Wallis, Brent Richards, Brett McWhinney, Jeffrey Lipman, Jason A Roberts. Ticarcillin and piperacillin adsorption on to polyethersulfone haemodiafilter membranes in an ex-vivo circuit.
International journal of antimicrobial agents.
2020 Sep; 56(3):106058. doi:
10.1016/j.ijantimicag.2020.106058. [PMID: 32590056] - Caleb J P Economou, Jiao Xie, Gregory Comadira, Brent Richards, Mandy Tallott, Steven C Wallis, Jenny Ordoñez, Jeffrey Lipman, Jason A Roberts. Population pharmacokinetics of ticarcillin in critically ill patients receiving extended daily diafiltration.
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2019 Sep; 54(3):351-355. doi:
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