Firocoxib (BioDeep_00000001973)
Secondary id: BioDeep_00001868533
human metabolite blood metabolite
代谢物信息卡片
3-(cyclopropylmethoxy)-4-(4-methanesulfonylphenyl)-5,5-dimethyl-2,5-dihydrofuran-2-one
化学式: C17H20O5S (336.10313900000006)
中文名称: 非罗考昔
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C(=C(C(=O)O1)OCC2CC2)C3=CC=C(C=C3)S(=O)(=O)C)C
InChI: InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3
描述信息
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:76136
- KEGG: C73637
- KEGG: C18363
- KEGGdrug: D03712
- PubChem: 208910
- HMDB: HMDB0252268
- Metlin: METLIN72180
- DrugBank: DB09217
- ChEMBL: CHEMBL69998
- Wikipedia: Firocoxib
- chemspider: 181008
- CAS: 189954-96-9
- PMhub: MS000001576
- PubChem: 124489037
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sarah A Wagner, Virginia R Fajt, Chih-Ping Lo, Christopher J Byrd. Pharmacokinetics of oral firocoxib in un-weaned calves.
Journal of veterinary pharmacology and therapeutics.
2021 Sep; 44(5):793-798. doi:
10.1111/jvp.12971. [PMID: 33817876] - T H Morris, S W Paine, P W Zahra, E C Li, S A Colgan, S L Karamatic. Pharmacokinetics of carprofen and firocoxib for medication control in racing greyhounds.
Australian veterinary journal.
2020 Dec; 98(12):578-585. doi:
10.1111/avj.13014. [PMID: 32875570] - Francielli Pereira Gobbi, Paula Alessandra Di Filippo, Luciana de Macêdo Mello, Gabriela Bravim Lemos, Carla Braga Martins, Antônio Peixoto Albernaz, Celia Raquel Quirino. Effects of Flunixin Meglumine, Firocoxib, and Meloxicam in Equines After Castration.
Journal of equine veterinary science.
2020 11; 94(?):103229. doi:
10.1016/j.jevs.2020.103229. [PMID: 33077071] - Michael D Kleinhenz, Carissa Odland, Todd E Williams, Yuntao Zhang, Alyson H Fitzgerald, Pritam K Sidhu, Larry W Wulf, Johann F Coetzee. Pharmacokinetics and tissue concentrations of firocoxib in sows following oral administration.
Journal of veterinary pharmacology and therapeutics.
2020 Sep; 43(5):491-498. doi:
10.1111/jvp.12864. [PMID: 32266983] - Amy K Stuart, Butch KuKanich, Luciano S Caixeta, Johann F Coetzee, Emily A Barrell. Pharmacokinetics and bioavailability of oral firocoxib in adult, mixed-breed goats.
Journal of veterinary pharmacology and therapeutics.
2019 Nov; 42(6):640-646. doi:
10.1111/jvp.12795. [PMID: 31435966] - Monchanok Vijarnsorn, Irin Kwananocha, Narudee Kashemsant, Thitichai Jarudecha, Chalermpol Lekcharoensuk, Brian Beale, Bruno Peirone, B Duncan X Lascelles. The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis.
BMC veterinary research.
2019 Oct; 15(1):349. doi:
10.1186/s12917-019-2110-7. [PMID: 31623621] - Johann F Coetzee, Pritam K Sidhu, Jon Seagen, Teresa Schieber, Katie Kleinhenz, Michael D Kleinhenz, Larry W Wulf, Vickie L Cooper, Reza Mazloom, Majid Jaberi-Douraki, Kelly Lechtenberg. Transmammary delivery of firocoxib to piglets reduces stress and improves average daily gain after castration, tail docking, and teeth clipping1.
Journal of animal science.
2019 Jul; 97(7):2750-2768. doi:
10.1093/jas/skz143. [PMID: 31100113] - A L Ziegler, C K Freeman, C A Fogle, M J Burke, J L Davis, V L Cook, L L Southwood, A T Blikslager. Multicentre, blinded, randomised clinical trial comparing the use of flunixin meglumine with firocoxib in horses with small intestinal strangulating obstruction.
Equine veterinary journal.
2019 May; 51(3):329-335. doi:
10.1111/evj.13013. [PMID: 30156312] - Lauren M Richardson, Canaan M Whitfield-Cargile, Noah D Cohen, Ana M Chamoun-Emanuelli, Hannah J Dockery. Effect of selective versus nonselective cyclooxygenase inhibitors on gastric ulceration scores and intestinal inflammation in horses.
Veterinary surgery : VS.
2018 Aug; 47(6):784-791. doi:
10.1111/vsu.12941. [PMID: 30094858] - Canaan M Whitfield-Cargile, Ana M Chamoun-Emanuelli, Noah D Cohen, Lauren M Richardson, Nadim J Ajami, Hannah J Dockery. Differential effects of selective and non-selective cyclooxygenase inhibitors on fecal microbiota in adult horses.
PloS one.
2018; 13(8):e0202527. doi:
10.1371/journal.pone.0202527. [PMID: 30138339] - K F Ortved, M B Goodale, C Ober, G A Maylin, L A Fortier. Plasma firocoxib concentrations after intra-articular injection of autologous conditioned serum prepared from firocoxib positive horses.
Veterinary journal (London, England : 1997).
2017 Dec; 230(?):20-23. doi:
10.1016/j.tvjl.2017.11.005. [PMID: 29208211] - K E Wilson, J L Davis, M V Crisman, V Kvaternick, C Zarabadipour, H Cheramie, D R Hodgson. Pharmacokinetics of firocoxib after intravenous administration of multiple consecutive doses in neonatal foals.
Journal of veterinary pharmacology and therapeutics.
2017 Dec; 40(6):e23-e29. doi:
10.1111/jvp.12410. [PMID: 28456000] - S Giguère, M L Macpherson, S M Benson, S Cox, J W McNaughten, M A Pozor. Disposition of firocoxib in late pregnant and early postpartum mares.
Journal of veterinary pharmacology and therapeutics.
2016 Apr; 39(2):196-8. doi:
10.1111/jvp.12253. [PMID: 26202842] - M L Stock, S T Millman, L A Barth, N K Van Engen, W H Hsu, C Wang, R Gehring, R L Parsons, J F Coetzee. The effects of firocoxib on cautery disbudding pain and stress responses in preweaned dairy calves.
Journal of dairy science.
2015 Sep; 98(9):6058-69. doi:
10.3168/jds.2014-8877. [PMID: 26142860] - B Holland, C Fogle, A T Blikslager, A Curling, B M Barlow, J Schirmer, J L Davis. Pharmacokinetics and pharmacodynamics of three formulations of firocoxib in healthy horses.
Journal of veterinary pharmacology and therapeutics.
2015 Jun; 38(3):249-56. doi:
10.1111/jvp.12177. [PMID: 25378135] - Marco Duz, Tim D Parkin, Rose M Cullander, John F Marshall. Effect of flunixin meglumine and firocoxib on ex vivo cyclooxygenase activity in horses undergoing elective surgery.
American journal of veterinary research.
2015 Mar; 76(3):208-15. doi:
10.2460/ajvr.76.3.208. [PMID: 25710756] - Ibrahim A Wasfi, Hanan M Saeed, B A Agha, Asmaa M Kamel, Nasreen A Al Biriki, Khaled M Al Neaimi, Waleed A Al Ali, Saeed Mahmoud Sultan. Pharmacokinetics and metabolism study of firocoxib in camels after intravenous administration by using high-resolution bench-top orbitrap mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Jan; 974(?):17-23. doi:
10.1016/j.jchromb.2014.10.021. [PMID: 25463193] - H K Knych, S D Stanley, R M Arthur, M M Mitchell. Detection and pharmacokinetics of three formulations of firocoxib following multiple administrations to horses.
Equine veterinary journal.
2014 Nov; 46(6):734-8. doi:
10.1111/evj.12211. [PMID: 24393414] - M L Stock, R Gehring, L A Barth, L W Wulf, J F Coetzee. Pharmacokinetics of firocoxib in preweaned calves after oral and intravenous administration.
Journal of veterinary pharmacology and therapeutics.
2014 Oct; 37(5):457-63. doi:
10.1111/jvp.12124. [PMID: 24708198] - L Kivett, J Taintor, J Wright. Evaluation of the safety of a combination of oral administration of phenylbutazone and firocoxib in horses.
Journal of veterinary pharmacology and therapeutics.
2014 Aug; 37(4):413-6. doi:
10.1111/jvp.12097. [PMID: 24354928] - N Hovanessian, J L Davis, H C McKenzie, J L Hodgson, D R Hodgson, M V Crisman. Pharmacokinetics and safety of firocoxib after oral administration of repeated consecutive doses to neonatal foals.
Journal of veterinary pharmacology and therapeutics.
2014 Jun; 37(3):243-51. doi:
10.1111/jvp.12082. [PMID: 24749691] - M H Barton, E Paske, N Norton, D King, S Giguère, S Budsberg. Efficacy of cyclo-oxygenase inhibition by two commercially available firocoxib products in horses.
Equine veterinary journal.
2014 Jan; 46(1):72-5. doi:
10.1111/evj.12095. [PMID: 23662599] - S Cox, N Villarino, C Sommardahl, V Kvaternick, C Zarabadipour, L Siger, J Yarbrough, A Amicucci, K Reed, D Breeding, T Doherty. Disposition of firocoxib in equine plasma after an oral loading dose and a multiple dose regimen.
Veterinary journal (London, England : 1997).
2013 Nov; 198(2):382-5. doi:
10.1016/j.tvjl.2013.07.035. [PMID: 24076125] - Diana Davila, Thomas P Keeshen, Richard B Evans, Mike G Conzemius. Comparison of the analgesic efficacy of perioperative firocoxib and tramadol administration in dogs undergoing tibial plateau leveling osteotomy.
Journal of the American Veterinary Medical Association.
2013 Jul; 243(2):225-31. doi:
10.2460/javma.243.2.225. [PMID: 23822079] - D W Knapp, C J Henry, W R Widmer, K M Tan, G E Moore, J A Ramos-Vara, M D Lucroy, C B Greenberg, S N Greene, A H Abbo, P D Hanson, R Alva, P L Bonney. Randomized trial of cisplatin versus firocoxib versus cisplatin/firocoxib in dogs with transitional cell carcinoma of the urinary bladder.
Journal of veterinary internal medicine.
2013 Jan; 27(1):126-33. doi:
10.1111/jvim.12013. [PMID: 23205923] - Geraldine Dowling, Edward Malone. Analytical strategy for the confirmatory analysis of the non-steroidal anti-inflammatory drugs firocoxib, propyphenazone, ramifenazone and piroxicam in bovine plasma by liquid chromatography tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2011 Sep; 56(2):359-65. doi:
10.1016/j.jpba.2011.05.029. [PMID: 21684706] - H G Hilton, K G Magdesian, A D Groth, H Knych, S D Stanley, S R Hollingsworth. Distribution of flunixin meglumine and firocoxib into aqueous humor of horses.
Journal of veterinary internal medicine.
2011 Sep; 25(5):1127-33. doi:
10.1111/j.1939-1676.2011.0763.x. [PMID: 21781166] - O Lecoindre, C Pepin-Richard. Tolerance of firocoxib in dogs with osteoarthritis during 90 days.
Journal of veterinary pharmacology and therapeutics.
2011 Apr; 34(2):190-2. doi:
10.1111/j.1365-2885.2010.01227.x. [PMID: 21395612] - S Cox, J Yarbrough. Determination of firocoxib in equine plasma using high performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Jan; 879(2):205-8. doi:
10.1016/j.jchromb.2010.11.026. [PMID: 21185237] - Włodzimierz Matysiak, Barbara Jodłowska-Jedrych. Does administration of non-steroidal anti-inflammatory drug determine morphological changes in adrenal cortex: ultrastructural studies.
Protoplasma.
2010 Oct; 246(1-4):109-18. doi:
10.1007/s00709-010-0194-9. [PMID: 20721677] - Laura A Goodman, Bryan T Torres, Lisa R Reynolds, Steven C Budsberg. Effects of firocoxib, meloxicam, and tepoxalin administration on eicosanoid production in target tissues of healthy cats.
American journal of veterinary research.
2010 Sep; 71(9):1067-73. doi:
10.2460/ajvr.71.9.1067. [PMID: 20807147] - K E Joubert. The effects of firocoxib (Previcox) in geriatric dogs over a period of 90 days.
Journal of the South African Veterinary Association.
2009 Sep; 80(3):179-84. doi:
10.4102/jsava.v80i3.198. [PMID: 20169752] - Vanessa L Cook, Colleen T Meyer, Nigel B Campbell, Anthony T Blikslager. Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum.
American journal of veterinary research.
2009 Aug; 70(8):992-1000. doi:
10.2460/ajvr.70.8.992. [PMID: 19645580] - L Goodman, B Torres, J Punke, L Reynolds, A Speas, A Ellis, S Budsberg. Effects of firocoxib and tepoxalin on healing in a canine gastric mucosal injury model.
Journal of veterinary internal medicine.
2009 Jan; 23(1):56-62. doi:
10.1111/j.1939-1676.2008.0226.x. [PMID: 19175721] - Laura T Letendre, Ronald K Tessman, Scott R McClure, Valerie J Kvaternick, James B Fischer, Peter D Hanson. Pharmacokinetics of firocoxib after administration of multiple consecutive daily doses to horses.
American journal of veterinary research.
2008 Nov; 69(11):1399-405. doi:
10.2460/ajvr.69.11.1399. [PMID: 18980421] - John P Punke, Abbie L Speas, Lisa R Reynolds, Steven C Budsberg. Effects of firocoxib, meloxicam, and tepoxalin on prostanoid and leukotriene production by duodenal mucosa and other tissues of osteoarthritic dogs.
American journal of veterinary research.
2008 Sep; 69(9):1203-9. doi:
10.2460/ajvr.69.9.1203. [PMID: 18764695] - Valerie Kvaternick, Thomas Malinski, Jill Wortmann, James Fischer. Quantitative HPLC-UV method for the determination of firocoxib from horse and dog plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jul; 854(1-2):313-9. doi:
10.1016/j.jchromb.2007.04.037. [PMID: 17537684] - Laura Letendre, Valerie Kvaternick, Berhane Tecle, James Fischer. Automated liquid chromatography-tandem mass spectrometry method for the analysis of firocoxib in urine and plasma from horse and dog.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 853(1-2):333-45. doi:
10.1016/j.jchromb.2007.03.049. [PMID: 17459786] - P V M Steagall, F B Mantovani, T H Ferreira, E S Salcedo, F Q Moutinho, S P L Luna. Evaluation of the adverse effects of oral firocoxib in healthy dogs.
Journal of veterinary pharmacology and therapeutics.
2007 Jun; 30(3):218-23. doi:
10.1111/j.1365-2885.2007.00842.x. [PMID: 17472653] - Margaret E McCann, Eric L Rickes, Donald F Hora, Paul K Cunningham, Donghui Zhang, Christine Brideau, W Cameron Black, Gerard J Hickey. In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in cats with lipopolysaccharide-induced pyrexia.
American journal of veterinary research.
2005 Jul; 66(7):1278-84. doi:
10.2460/ajvr.2005.66.1278. [PMID: 16111170]