Azidopine (BioDeep_00001876731)
Main id: BioDeep_00000008576
代谢物信息卡片
Azidopine
化学式: C27H26F3N5O5 (557.1885942)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)C1=C(C)NC(=C(C1c1ccccc1C(F)(F)F)C(=O)OCCNC(=O)c1ccc(cc1)N=[N+]=[N-])C
InChI: InChI=1S/C27H26F3N5O5/c1-4-39-25(37)21-15(2)33-16(3)22(23(21)19-7-5-6-8-20(19)27(28,29)30)26(38)40-14-13-32-24(36)17-9-11-18(12-10-17)34-35-31/h5-12,23,33H,4,13-14H2,1-3H3,(H,32,36)
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D000345 - Affinity Labels
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:2952
- KEGG: C11282
- PubChem: 656406
- ChEMBL: CHEMBL1993397
- CAS: 90523-31-2
- PubChem: 13459
- NIKKAJI: J393.489F
- RefMet: Azidopine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Francisco Muñoz-Martínez, Peihua Lu, Fernando Cortés-Selva, José María Pérez-Victoria, Ignacio A Jiménez, Angel G Ravelo, Frances J Sharom, Francisco Gamarro, Santiago Castanys. Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.
Cancer research.
2004 Oct; 64(19):7130-8. doi:
10.1158/0008-5472.can-04-1005. [PMID: 15466210] - Henrietta Venter, Richard A Shilling, Saroj Velamakanni, Lekshmy Balakrishnan, Hendrik W Van Veen. An ABC transporter with a secondary-active multidrug translocator domain.
Nature.
2003 Dec; 426(6968):866-70. doi:
10.1038/nature02173. [PMID: 14685244] - Cheppail Ramachandran, Thangaiyan Rabi, Hugo B Fonseca, Steven J Melnick, Enrique A Escalon. Novel plant triterpenoid drug amooranin overcomes multidrug resistance in human leukemia and colon carcinoma cell lines.
International journal of cancer.
2003 Jul; 105(6):784-9. doi:
10.1002/ijc.11180. [PMID: 12767063] - Shuzhong Zhang, Marilyn E Morris. Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport.
The Journal of pharmacology and experimental therapeutics.
2003 Mar; 304(3):1258-67. doi:
10.1124/jpet.102.044412. [PMID: 12604704] - Qin Qu, Joseph W K Chu, Frances J Sharom. Transition state P-glycoprotein binds drugs and modulators with unchanged affinity, suggesting a concerted transport mechanism.
Biochemistry.
2003 Feb; 42(5):1345-53. doi:
10.1021/bi0267745. [PMID: 12564938] - P Mistry, A J Stewart, W Dangerfield, S Okiji, C Liddle, D Bootle, J A Plumb, D Templeton, P Charlton. In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.
Cancer research.
2001 Jan; 61(2):749-58. doi:
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Japanese journal of cancer research : Gann.
2000 Feb; 91(2):248-54. doi:
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Biological & pharmaceutical bulletin.
1999 Dec; 22(12):1355-9. doi:
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Biochemical pharmacology.
1999 Aug; 58(4):571-86. doi:
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1999 Jun; 274(25):17649-54. doi:
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1998 Oct; 89(10):1047-54. doi:
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The American journal of physiology.
1998 06; 274(6):F1127-39. doi:
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1998 Apr; 26(4):360-6. doi:
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1997 Feb; 280(2):1043-50. doi:
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Biological & pharmaceutical bulletin.
1996 Jun; 19(6):886-9. doi:
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1996 Mar; 47(4):395-407. doi:
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The Journal of biological chemistry.
1995 Oct; 270(40):23461-7. doi:
10.1074/jbc.270.40.23461. [PMID: 7559508] - M Kawada, K Umezawa. Inostamycin, an inhibitor of P-glycoprotein function, interacts specifically with phosphatidylethanolamine.
Japanese journal of cancer research : Gann.
1995 Sep; 86(9):873-8. doi:
10.1111/j.1349-7006.1995.tb03099.x. [PMID: 7591966] - L Y Wei, M J Stutts, M M Hoffman, P D Roepe. Overexpression of the cystic fibrosis transmembrane conductance regulator in NIH 3T3 cells lowers membrane potential and intracellular pH and confers a multidrug resistance phenotype.
Biophysical journal.
1995 Sep; 69(3):883-95. doi:
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Biochemical pharmacology.
1995 Jul; 50(2):187-96. doi:
10.1016/0006-2952(95)00115-g. [PMID: 7632162] - J H Charuk, P Y Wong, R A Reithmeier. Differential interaction of human renal P-glycoprotein with various metabolites and analogues of cyclosporin A.
The American journal of physiology.
1995 Jul; 269(1 Pt 2):F31-9. doi:
10.1152/ajprenal.1995.269.1.f31. [PMID: 7631829] - F J Sharom, G DiDiodato, X Yu, K J Ashbourne. Interaction of the P-glycoprotein multidrug transporter with peptides and ionophores.
The Journal of biological chemistry.
1995 Apr; 270(17):10334-41. doi:
10.1074/jbc.270.17.10334. [PMID: 7730340] - I L Urbatsch, A E Senior. Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein.
Archives of biochemistry and biophysics.
1995 Jan; 316(1):135-40. doi:
10.1006/abbi.1995.1020. [PMID: 7840607] - J Drímal, L Bohácik. The effect of photogenerated site-directed free radicals on surface dihydropyridine binding sites identified with photoaffinity probe (-)-[3H]-azidopine on cultured monkey renal cells.
Methods and findings in experimental and clinical pharmacology.
1994 Jul; 16(6):397-404. doi:
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Biochemistry.
1994 Apr; 33(14):4163-74. doi:
10.1021/bi00180a009. [PMID: 7908829] - J Drímal. Identification of dihydropyridine (DHP) binding sites on cultured monkey renal cells (GMRC) with a photoaffinity probe (-)-[3H]-azidopine.
General physiology and biophysics.
1994 Apr; 13(2):137-48. doi:
. [PMID: 7528701] - T W Loo, D M Clarke. Functional consequences of glycine mutations in the predicted cytoplasmic loops of P-glycoprotein.
The Journal of biological chemistry.
1994 Mar; 269(10):7243-8. doi:
10.1016/s0021-9258(17)37274-5. [PMID: 7907326] - J H Charuk, T W Loo, D M Clarke, R A Reithmeier. Interaction of rat kidney P-glycoprotein with a urinary component and various drugs including cyclosporin A.
The American journal of physiology.
1994 Jan; 266(1 Pt 2):F66-75. doi:
10.1152/ajprenal.1994.266.1.f66. [PMID: 7905714] - T Zordan-Nudo, V Ling, Z Liu, E Georges. Effects of nonionic detergents on P-glycoprotein drug binding and reversal of multidrug resistance.
Cancer research.
1993 Dec; 53(24):5994-6000. doi:
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Cancer.
1993 Jun; 71(11):3611-9. doi:
10.1002/1097-0142(19930601)71:11<3611::aid-cncr2820711124>3.0.co;2-t. [PMID: 8098269] - G Chen, C Ramachandran, A Krishan. Thaliblastine, a plant alkaloid, circumvents multidrug resistance by direct binding to P-glycoprotein.
Cancer research.
1993 Jun; 53(11):2544-7. doi:
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Cancer research.
1993 Apr; 53(7):1555-9. doi:
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The Journal of biological chemistry.
1993 Feb; 268(5):3143-9. doi:
NULL. [PMID: 8094081] - E Friche, E J Demant, M Sehested, N I Nissen. Effect of anthracycline analogs on photolabelling of p-glycoprotein by [125I]iodomycin and [3H]azidopine: relation to lipophilicity and inhibition of daunorubicin transport in multidrug resistant cells.
British journal of cancer.
1993 Feb; 67(2):226-31. doi:
10.1038/bjc.1993.44. [PMID: 8094288] - S Léonce, A Pierré, M Anstett, V Pérez, A Genton, J P Bizzari, G Atassi. Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance.
Biochemical pharmacology.
1992 Nov; 44(9):1707-15. doi:
10.1016/0006-2952(92)90063-o. [PMID: 1360210] - S Wakusawa, K Takeda, K Miyamoto, H Hidaka. Increase of vinblastine accumulation by inhibitors of calmodulin-dependent cell functions in rat ascites hepatoma AH66 cells.
Anticancer research.
1992 Nov; 12(6B):2021-4. doi:
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Cancer research.
1992 Oct; 52(20):5701-6. doi:
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Biochemical and biophysical research communications.
1992 Jul; 186(2):796-802. doi:
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1992 Jul; 267(19):13513-9. doi:
10.1016/s0021-9258(18)42241-7. [PMID: 1352295] - K Miyamoto, S Wakusawa, K Inoko, K Takagi, M Koyama. Reversal of vinblastine resistance by a new staurosporine derivative, NA-382, in P388/ADR cells.
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1992 Jun; 64(2):177-83. doi:
10.1016/0304-3835(92)90079-b. [PMID: 1351792] - T Saeki, A M Shimabuku, K Ueda, T Komano. Specific drug binding by purified lipid-reconstituted P-glycoprotein: dependence on the lipid composition.
Biochimica et biophysica acta.
1992 Jun; 1107(1):105-10. doi:
10.1016/0005-2736(92)90334-i. [PMID: 1352129] - I Tamai, A R Safa. Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells.
The Journal of biological chemistry.
1991 Sep; 266(25):16796-800. doi:
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Agricultural and biological chemistry.
1991 Jul; 55(7):1859-65. doi:
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The Journal of clinical endocrinology and metabolism.
1991 Jul; 73(1):18-29. doi:
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1991 May; 51(9):2420-4. doi:
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Biochimica et biophysica acta.
1991 Mar; 1073(2):309-15. doi:
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The Journal of biological chemistry.
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Biochemical and biophysical research communications.
1990 Jan; 166(1):74-80. doi:
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