Angiotensin III (BioDeep_00001874465)
BioNovoGene_Lab2019
代谢物信息卡片
Angiotensin III, human, mouse(Acetate)
化学式: C46H66N12O9 (930.5075)
中文名称: 人血管紧缩素II醋酸盐水合物, 血管紧张素III, 血管紧张素 III
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)N
InChI: InChI=1S/C46H66N12O9/c1-5-27(4)38(57-40(61)33(21-29-15-17-31(59)18-16-29)53-42(63)37(26(2)3)56-39(60)32(47)13-9-19-51-46(48)49)43(64)54-34(23-30-24-50-25-52-30)44(65)58-20-10-14-36(58)41(62)55-35(45(66)67)22-28-11-7-6-8-12-28/h6-8,11-12,15-18,24-27,32-38,59H,5,9-10,13-14,19-23,47H2,1-4H3,(H,50,52)(H,53,63)(H,54,64)(H,55,62)(H,56,60)(H,57,61)(H,66,67)(H4,48,49,51)/t27-,32-,33-,34-,35-,36-,37-,38-/m0/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.
Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:89666
- PubChem: 3082042
- ChEMBL: CHEMBL1702539
- MeSH: Angiotensin III
- CAS: 12687-51-3
- CAS: 13602-53-4
- RefMet: Angiotensin III
- medchemexpress: HY-P1540
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-940
- KEGG: C15848
- PubChem: 47205168
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ann Tenneil O'Connor, Dhanush Haspula, Ahmed Z Alanazi, Michelle A Clark. Roles of Angiotensin III in the brain and periphery.
Peptides.
2022 07; 153(?):170802. doi:
10.1016/j.peptides.2022.170802. [PMID: 35489649] - Ana Belén Segarra, Germán Domínguez-Vías, José Redondo, Magdalena Martínez-Cañamero, Manuel Ramírez-Sánchez, Isabel Prieto. Hypothalamic Renin-Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet.
Nutrients.
2021 Jan; 13(2):. doi:
10.3390/nu13020480. [PMID: 33572630] - Guoqing Yao, Wenjing Li, Wenzhao Liu, Jingbo Xing, Cheng Zhang. The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2021; 2021(?):1704762. doi:
10.1155/2021/1704762. [PMID: 34603502] - Erkan Cure, Tevfik Bulent Ilcol, Medine Cumhur Cure. Angiotensin II, III, and IV may be important in the progression of COVID-19.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2020 Oct; 21(4):1470320320972019. doi:
10.1177/1470320320972019. [PMID: 33169633] - Lucinda M Hilliard Krause, Brandon A Kemp, Amanda Suan Jui Tan, Emma S Jones, Mark P Del Borgo, Marie-Isabel Aguilar, Kate M Denton, Robert M Carey, Robert E Widdop. Renal functional effects of the highly selective AT2R agonist, β-Pro7 Ang III, in normotensive rats.
Clinical science (London, England : 1979).
2020 04; 134(7):871-884. doi:
10.1042/cs20200153. [PMID: 32202299] - F K Suessenbach, B B Burckhardt. Levels of angiotensin peptides in healthy and cardiovascular/renal-diseased paediatric population-an investigative review.
Heart failure reviews.
2019 09; 24(5):709-723. doi:
10.1007/s10741-019-09797-y. [PMID: 31104255] - Jia L Zhuo, Xiao C Li. Angiotensin III/AT2 Receptor/NHE3 Signaling Pathway in the Proximal Tubules of the Kidney: A Novel Natriuretic and Antihypertensive Mechanism in Hypertension.
Journal of the American Heart Association.
2019 05; 8(9):e012644. doi:
10.1161/jaha.119.012644. [PMID: 31039655] - Brandon A Kemp, Nancy L Howell, Susanna R Keller, John J Gildea, Weijian Shao, Luis Gabriel Navar, Robert M Carey. Defective Renal Angiotensin III and AT2 Receptor Signaling in Prehypertensive Spontaneously Hypertensive Rats.
Journal of the American Heart Association.
2019 05; 8(9):e012016. doi:
10.1161/jaha.119.012016. [PMID: 31039659] - Frans H H Leenen, Monir Ahmad, Yannick Marc, Catherine Llorens-Cortes. Specific Inhibition of Brain Angiotensin III Formation as a New Strategy for Prevention of Heart Failure After Myocardial Infarction.
Journal of cardiovascular pharmacology.
2019 02; 73(2):82-91. doi:
10.1097/fjc.0000000000000638. [PMID: 30531435] - Jürgen M Bohlender, Jürg Nussberger, Hendrik Tevaearai, Hans Imboden. Angiotensinergic Innervation of the Human Right Atrium: Implications for Cardiac Reflexes.
American journal of hypertension.
2018 01; 31(2):188-196. doi:
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Current opinion in nephrology and hypertension.
2017 03; 26(2):91-96. doi:
10.1097/mnh.0000000000000304. [PMID: 27906747] - Hyung Wook Kim, Young Ok Kim, Sun Ae Yoon, Jeong-Sun Han, Hyun-Bae Chun, Young Soo Kim. Angiotensin III increases monocyte chemoattractant protein-1 expression in cultured human proximal tubular epithelial cells.
The Korean journal of internal medicine.
2016 Jan; 31(1):116-24. doi:
10.3904/kjim.2016.31.1.116. [PMID: 26767865] - Mark Del Borgo, Yan Wang, Sanja Bosnyak, Morimer Khan, Pia Walters, Iresha Spizzo, Patrick Perlmutter, Lucinda Hilliard, Kate Denton, Marie-Isabel Aguilar, Robert E Widdop, Emma S Jones. β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats.
Clinical science (London, England : 1979).
2015 Sep; 129(6):505-13. doi:
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Journal of chromatography. A.
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Journal of the American Society for Mass Spectrometry.
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Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2013 Aug; 17(4):425-30. doi:
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Peptides.
2013 Apr; 42(?):131-7. doi:
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Current hypertension reports.
2013 Feb; 15(1):25-30. doi:
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Pflugers Archiv : European journal of physiology.
2013 Jan; 465(1):79-85. doi:
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Hypertension (Dallas, Tex. : 1979).
2012 Aug; 60(2):387-95. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
2012 Aug; 303(3):R311-20. doi:
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American journal of physiology. Endocrinology and metabolism.
2012 Apr; 302(8):E1016-24. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2011 Jun; 34(6):674-83. doi:
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Endocrinology.
2011 Apr; 152(4):1582-8. doi:
10.1210/en.2010-1070. [PMID: 21303953] - Felicia M Rabey, Vardan T Karamyan, Robert C Speth. Distribution of a novel binding site for angiotensins II and III in mouse tissues.
Regulatory peptides.
2010 Jun; 162(1-3):5-11. doi:
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Experimental physiology.
2010 Feb; 95(2):282-95. doi:
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Kidney international.
2009 Sep; 76(5):521-7. doi:
10.1038/ki.2009.234. [PMID: 19553911] - Shetal H Padia, Brandon A Kemp, Nancy L Howell, John J Gildea, Susanna R Keller, Robert M Carey. Intrarenal angiotensin III infusion induces natriuresis and angiotensin type 2 receptor translocation in Wistar-Kyoto but not in spontaneously hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
2009 Feb; 53(2):338-43. doi:
10.1161/hypertensionaha.108.124198. [PMID: 19075092] - Manuel A Méndez, Michel Prudent, Bin Su, Hubert H Girault. Peptide-phospholipid complex formation at liquid-liquid interfaces.
Analytical chemistry.
2008 Dec; 80(24):9499-507. doi:
10.1021/ac801651f. [PMID: 19072264] - Peter Rossing. Is renal Na+,K+-ATPase a new target for renin-angiotensin blocking agents in diabetic nephropathy?.
The Journal of physiology.
2008 Nov; 586(22):5283. doi:
10.1113/jphysiol.2008.164723. [PMID: 19011129] - Shetal H Padia, Brandon A Kemp, Nancy L Howell, Marie-Claude Fournie-Zaluski, Bernard P Roques, Robert M Carey. Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats.
Hypertension (Dallas, Tex. : 1979).
2008 Feb; 51(2):460-5. doi:
10.1161/hypertensionaha.107.103242. [PMID: 18158338] - Susana de la Chica-Rodríguez, Pedro Cortés-Denia, María Jesús Ramírez-Expósito, José Manuel Arias de Saavedra, Rafael Sánchez-Agesta, María del Cármen Pérez, José Manuel Martínez-Martos. Doxazosin blockade of alpha 1-adrenergic receptors increases rat serum progesterone levels: a putative role of ovarian angiotensin III in steroidogenesis.
Fertility and sterility.
2007 Oct; 88(4 Suppl):1071-5. doi:
10.1016/j.fertnstert.2006.12.021. [PMID: 17445810] - Shetal H Padia, Brandon A Kemp, Nancy L Howell, Helmy M Siragy, Marie-Claude Fournie-Zaluski, Bernard P Roques, Robert M Carey. Intrarenal aminopeptidase N inhibition augments natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked rats.
Hypertension (Dallas, Tex. : 1979).
2007 Mar; 49(3):625-30. doi:
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Acta physiologica (Oxford, England).
2006 Oct; 188(2):129-38. doi:
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Regulatory peptides.
2006 Sep; 136(1-3):130-7. doi:
10.1016/j.regpep.2006.06.001. [PMID: 16889841] - Shetal H Padia, Nancy L Howell, Helmy M Siragy, Robert M Carey. Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat.
Hypertension (Dallas, Tex. : 1979).
2006 Mar; 47(3):537-44. doi:
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2006 Jan; 38(1):48-52. doi:
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Thrombosis and haemostasis.
2005 Jun; 93(6):1069-76. doi:
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The American journal of cardiology.
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Rapid communications in mass spectrometry : RCM.
2005; 19(18):2689-98. doi:
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Circulation.
2004 Dec; 110(25):3849-57. doi:
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Journal of the renin-angiotensin-aldosterone system : JRAAS.
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Regulatory peptides.
2004 Aug; 120(1-3):15-22. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
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American journal of physiology. Regulatory, integrative and comparative physiology.
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