IDAZOXAN (BioDeep_00001871443)

Main id: BioDeep_00000008418

 


代谢物信息卡片


IDAZOXAN

化学式: C11H12N2O2 (204.0898732)
中文名称: 亚达唑散
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN=C(N1)C2COC3=CC=CC=C3O2
InChI: InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13)

描述信息

C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists

同义名列表

1 个代谢物同义名

IDAZOXAN



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Sònia Abás, Sergio Rodríguez-Arévalo, Andrea Bagán, Christian Griñán-Ferré, Foteini Vasilopoulou, Iria Brocos-Mosquera, Carolina Muguruza, Belén Pérez, Elies Molins, F Javier Luque, Pilar Pérez-Lozano, Steven de Jonghe, Dirk Daelemans, Lieve Naesens, José Brea, M Isabel Loza, Elena Hernández-Hernández, Jesús A García-Sevilla, M Julia García-Fuster, Milica Radan, Teodora Djikic, Katarina Nikolic, Mercè Pallàs, Luis F Callado, Carmen Escolano. Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer's Disease. Journal of medicinal chemistry. 2020 04; 63(7):3610-3633. doi: 10.1021/acs.jmedchem.9b02080. [PMID: 32150414]
  • M Julia García-Fuster, Jesús A García-Sevilla. Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration. Psychopharmacology. 2016 Aug; 233(15-16):2955-71. doi: 10.1007/s00213-016-4342-6. [PMID: 27259485]
  • Hilary R Smith, Thomas J R Beveridge, Michael A Nader, Linda J Porrino. Effects of abstinence from chronic cocaine self-administration on nonhuman primate dorsal and ventral noradrenergic bundle terminal field structures. Brain structure & function. 2016 06; 221(5):2703-15. doi: 10.1007/s00429-015-1066-z. [PMID: 26013302]
  • Xiangqin Li, Junyu Zhu, Wei Ma, Li Luo, Huaping Liang. [The anti-inflammatory effects of idazoxan on inflammatory mediator release in endotoxin-challenged mice in vivo and activated macrophages in vitro]. Zhonghua wei zhong bing ji jiu yi xue. 2016 May; 28(5):445-9. doi: . [PMID: 29920042]
  • Jibran Y Khokhar, David T Chau, Ree Dawson, Alan I Green. Clozapine reconstructed: Haloperidol's ability to reduce alcohol intake in the Syrian golden hamster can be enhanced through noradrenergic modulation by desipramine and idazoxan. Drug and alcohol dependence. 2015 Jul; 152(?):277-81. doi: 10.1016/j.drugalcdep.2015.04.003. [PMID: 25979645]
  • Nobuya Ogawa, Makoto Ito, Hideki Yamaguchi, Tetsuya Shiuchi, Shiki Okamoto, Korekiyo Wakitani, Yasuhiko Minokoshi, Masamitsu Nakazato. Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. Metabolism: clinical and experimental. 2012 Sep; 61(9):1312-20. doi: 10.1016/j.metabol.2012.02.011. [PMID: 22445513]
  • Jan Anker Jahnsen, Staffan Uhlén. The predicted N-terminal signal sequence of the human α₂C-adrenoceptor does not act as a functional cleavable signal peptide. European journal of pharmacology. 2012 Jun; 684(1-3):51-8. doi: 10.1016/j.ejphar.2012.03.044. [PMID: 22503931]
  • S R Gooneratne. Effects of clonidine and idazoxan on tetrathiomolybdate-induced copper and lysosomal enzyme excretion into sheep bile. Research in veterinary science. 2012 Jun; 92(3):456-61. doi: 10.1016/j.rvsc.2011.04.013. [PMID: 21570700]
  • Anders Borgkvist, Torun Malmlöf, Kristin Feltmann, Maria Lindskog, Björn Schilström. Dopamine in the hippocampus is cleared by the norepinephrine transporter. The international journal of neuropsychopharmacology. 2012 May; 15(4):531-40. doi: 10.1017/s1461145711000812. [PMID: 21669025]
  • C A F Andrade, L O Margatho, G M F Andrade-Franzé, L A De Luca, J Antunes-Rodrigues, J V Menani. Moxonidine into the lateral parabrachial nucleus reduces renal and hormonal responses to cell dehydration. Neuroscience. 2012 Apr; 208(?):69-78. doi: 10.1016/j.neuroscience.2012.02.013. [PMID: 22373877]
  • Natalie R Herr, Jinwoo Park, Zoé A McElligott, Anna M Belle, Regina M Carelli, R Mark Wightman. In vivo voltammetry monitoring of electrically evoked extracellular norepinephrine in subregions of the bed nucleus of the stria terminalis. Journal of neurophysiology. 2012 Mar; 107(6):1731-7. doi: 10.1152/jn.00620.2011. [PMID: 22190618]
  • Mercè Masana, Analía Bortolozzi, Francesc Artigas. Selective enhancement of mesocortical dopaminergic transmission by noradrenergic drugs: therapeutic opportunities in schizophrenia. The international journal of neuropsychopharmacology. 2011 Feb; 14(1):53-68. doi: 10.1017/s1461145710000908. [PMID: 20701825]
  • Kerstin Buck, Boris Ferger. The selective alpha1 adrenoceptor antagonist HEAT reduces L-DOPA-induced dyskinesia in a rat model of Parkinson's disease. Synapse (New York, N.Y.). 2010 Feb; 64(2):117-26. doi: 10.1002/syn.20709. [PMID: 19771592]
  • Kerstin Buck, Patrizia Voehringer, Boris Ferger. The alpha(2) adrenoceptor antagonist idazoxan alleviates L-DOPA-induced dyskinesia by reduction of striatal dopamine levels: an in vivo microdialysis study in 6-hydroxydopamine-lesioned rats. Journal of neurochemistry. 2010 Jan; 112(2):444-52. doi: 10.1111/j.1471-4159.2009.06482.x. [PMID: 19895663]
  • Liaoyuan A Hu, Tian Zhou, Jinwoo Ahn, Shuli Wang, Julia Zhou, Yi Hu, Qingyun Liu. Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands. The Biochemical journal. 2009 Oct; 424(1):39-45. doi: 10.1042/bj20090998. [PMID: 19725810]
  • Yia-Ping Liu, Yu-Lung Lin, Chia-Hsin Chuang, Yu-Cheng Kao, Shang-Tang Chang, Che-Se Tung. Alpha adrenergic modulation on effects of norepinephrine transporter inhibitor reboxetine in five-choice serial reaction time task. Journal of biomedical science. 2009 Aug; 16(?):72. doi: 10.1186/1423-0127-16-72. [PMID: 19678962]
  • Roshil Budhram, Cesar A Lau-Cam. Attenuating effect of melatonin on pyridoxal-stimulated release of adrenomedullary catecholamines in the rat. Life sciences. 2009 May; 84(19-20):696-704. doi: 10.1016/j.lfs.2009.02.017. [PMID: 19249317]
  • Gillian W Reierson, Claudio A Mastronardi, Julio Licinio, Ma-Li Wong. Chronic fluoxetine treatment increases daytime melatonin synthesis in the rodent. Clinical pharmacology : advances and applications. 2009; 1(?):1-6. doi: 10.2147/cpaa.s7157. [PMID: 22291481]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • P L Cedraz-Mercez, A S Mecawi, A Lepletier, I G Araújo, R H Costa-e-Sousa, F F Rocha, E L Olivares, M A Medeiros, L C Reis. Noradrenergic stimulation within midbrain raphe increases electrolyte excretion in rats. Experimental physiology. 2007 Sep; 92(5):923-31. doi: 10.1113/expphysiol.2007.037317. [PMID: 17591682]
  • Candy K S Chan, Sandra L Burke, Geoffrey A Head. Contribution of imidazoline receptors and alpha2-adrenoceptors in the rostral ventrolateral medulla to sympathetic baroreflex inhibition by systemic rilmenidine. Journal of hypertension. 2007 Jan; 25(1):147-55. doi: 10.1097/hjh.0b013e3280105ef0. [PMID: 17143186]
  • C A F Andrade, L A De Luca, D S A Colombari, J V Menani. Alpha2-adrenergic activation in the lateral parabrachial nucleus induces NaCl intake under conditions of systemic hyperosmolarity. Neuroscience. 2006 Sep; 142(1):21-8. doi: 10.1016/j.neuroscience.2006.04.015. [PMID: 16890365]
  • Neil J Anderson, Isabelle Seif, David J Nutt, Alan L Hudson, Emma S J Robinson. Autoradiographical distribution of imidazoline binding sites in monoamine oxidase A deficient mice. Journal of neurochemistry. 2006 Mar; 96(6):1551-9. doi: 10.1111/j.1471-4159.2006.03662.x. [PMID: 16476082]
  • R Gilsbach, A Faron-Górecka, Z Rogóz, M Brüss, M G Caron, M Dziedzicka-Wasylewska, H Bönisch. Norepinephrine transporter knockout-induced up-regulation of brain alpha2A/C-adrenergic receptors. Journal of neurochemistry. 2006 Feb; 96(4):1111-20. doi: 10.1111/j.1471-4159.2005.03598.x. [PMID: 16417582]
  • Patricia Szot, Sylvia S White, J Lynne Greenup, James B Leverenz, Elaine R Peskind, Murray A Raskind. Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Jan; 26(2):467-78. doi: 10.1523/jneurosci.4265-05.2006. [PMID: 16407544]
  • Valentina Jovanovska, Eveline Eitle, Peter J Harris. Effects of rilmenidine on proximal tubular fluid absorption in rats. Clinical and experimental pharmacology & physiology. 2004 May; 31(5-6):348-53. doi: 10.1111/j.1440-1681.2004.04008.x. [PMID: 15191410]
  • Ayşegül Ozerdem, Mark E Schmidt, Husseini K Manji, Robert C Risinger, William Z Potter. Chronic lithium administration enhances noradrenergic responses to intravenous administration of the alpha2 antagonist idazoxan in healthy volunteers. Journal of clinical psychopharmacology. 2004 Apr; 24(2):150-4. doi: 10.1097/01.jcp.0000115667.45074.9f. [PMID: 15206661]
  • David P Finn, Alan L Hudson, Hiroshi Kinoshita, Toni L Coventry, David S Jessop, David J Nutt, Michael S Harbuz. Imidazoline2 (I2) receptor- and alpha2-adrenoceptor-mediated modulation of hypothalamic-pituitary-adrenal axis activity in control and acute restraint stressed rats. Journal of psychopharmacology (Oxford, England). 2004 Mar; 18(1):47-53. doi: 10.1177/0269881104040231. [PMID: 15107184]
  • Gerhard J Molderings, Michael Bruss, Heinz Bonisch, Manfred Gothert. Identification and pharmacological characterization of a specific agmatine transport system in human tumor cell lines. Annals of the New York Academy of Sciences. 2003 Dec; 1009(?):75-81. doi: 10.1196/annals.1304.008. [PMID: 15028572]
  • Georgianna G Gould, Marie-Christine Pardon, David A Morilak, Alan Frazer. Regulatory effects of reboxetine treatment alone, or following paroxetine treatment, on brain noradrenergic and serotonergic systems. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2003 Sep; 28(9):1633-41. doi: 10.1038/sj.npp.1300236. [PMID: 12825093]
  • Staffan Uhlén, Jonas Lindblom, Anna Kindlundh, Paul Mugisha, Fred Nyberg. Nandrolone treatment decreases the level of rat kidney alpha(1B)-adrenoceptors. Naunyn-Schmiedeberg's archives of pharmacology. 2003 Aug; 368(2):91-8. doi: 10.1007/s00210-003-0763-y. [PMID: 12861436]
  • Frédérique Touzeau, Axelle Arrault, Gérald Guillaumet, Elizabeth Scalbert, Bruno Pfeiffer, Marie-Claire Rettori, Pierre Renard, Jean-Yves Mérour. Synthesis and biological evaluation of new 2-(4,5-dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine derivatives. Journal of medicinal chemistry. 2003 May; 46(10):1962-79. doi: 10.1021/jm021050c. [PMID: 12723959]
  • Alexander J Rouch, Lúcia H Kudo. Agmatine inhibits arginine vasopressin-stimulated urea transport in the rat inner medullary collecting duct. Kidney international. 2002 Dec; 62(6):2101-8. doi: 10.1046/j.1523-1755.2002.00655.x. [PMID: 12427134]
  • Christine Vayssettes-Courchay, Françoise Bouysset, Alex Cordi, Michel Laubie, Tony J Verbeuren. Effects of medullary alpha2-adrenoceptor blockade in the rat. European journal of pharmacology. 2002 Oct; 453(2-3):287-97. doi: 10.1016/s0014-2999(02)02456-1. [PMID: 12398917]
  • Linda F Hayward, Alecia P Riley, Robert B Felder. alpha(2)-Adrenergic receptors in NTS facilitate baroreflex function in adult spontaneously hypertensive rats. American journal of physiology. Heart and circulatory physiology. 2002 Jun; 282(6):H2336-45. doi: 10.1152/ajpheart.00167.2001. [PMID: 12003844]
  • D P Finn, M D Lalies, M S Harbuz, D S Jessop, A L Hudson, D J Nutt. Imidazoline(2) (I(2)) binding site- and alpha(2)-adrenoceptor-mediated modulation of central noradrenergic and HPA axis function in control rats and chronically stressed rats with adjuvant-induced arthritis. Neuropharmacology. 2002 Jun; 42(7):958-65. doi: 10.1016/s0028-3908(02)00046-1. [PMID: 12069906]
  • Daniel Cussac, Stéphane Schaak, Céline Gales, Christodoulos Flordellis, Colette Denis, Hervé Paris. alpha(2B)-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells. American journal of physiology. Renal physiology. 2002 May; 282(5):F943-52. doi: 10.1152/ajprenal.0108.2001. [PMID: 11934705]
  • Xinhui Li, Dawn Conklin, Weiya Ma, Xiaoying Zhu, James C Eisenach. Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain. Pain. 2002 May; 97(1-2):117-25. doi: 10.1016/s0304-3959(02)00011-8. [PMID: 12031785]
  • Xavier Ferry, Yves Landry. Agmatine: a mastoparan-like activity related to direct activation of heterotrimeric G proteins. European journal of pharmacology. 2002 Jan; 435(1):19-26. doi: 10.1016/s0014-2999(01)01561-8. [PMID: 11790374]
  • Francesco Gentili, Pascal Bousquet, Livio Brasili, Mariangela Caretto, Antonio Carrieri, Monique Dontenwill, Mario Giannella, Gabriella Marucci, Marina Perfumi, Alessandro Piergentili, Wilma Quaglia, Carla Rascente, Maria Pigini. Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole. Journal of medicinal chemistry. 2002 Jan; 45(1):32-40. doi: 10.1021/jm0110082. [PMID: 11754577]
  • Mostafa Khalid, Norelyaquine Ilhami, Yves Giudicelli, Jean-Pierre Dausse. Testosterone dependence of salt-induced hypertension in Sabra rats and role of renal alpha(2)-adrenoceptor subtypes. The Journal of pharmacology and experimental therapeutics. 2002 Jan; 300(1):43-9. doi: 10.1124/jpet.300.1.43. [PMID: 11752095]
  • I Rustenbeck, C Dickel, T Grimmsmanns. Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. II. Electrophysiological and fluorimetric studies. Biochemical pharmacology. 2001 Dec; 62(12):1695-703. doi: 10.1016/s0006-2952(01)00793-6. [PMID: 11755123]
  • I Rustenbeck, M Winkler, A Jörns. Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. I. Secretory and morphological studies. Biochemical pharmacology. 2001 Dec; 62(12):1685-94. doi: 10.1016/s0006-2952(01)00792-4. [PMID: 11755122]
  • S Gesta, J Hejnova, M Berlan, D Daviaud, F Crampes, V Stich, P Valet, J S Saulnier-Blache. In vitro and in vivo impairment of alpha2-adrenergic receptor-dependent antilipolysis by fatty acids in human adipose tissue. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2001 Dec; 33(12):701-7. doi: 10.1055/s-2001-19140. [PMID: 11753754]
  • Q Li, Z Z Fan, Y H Wang, R R He. Differential responses of regional vascular beds to local injection of agmatine in rats. Sheng li xue bao : [Acta physiologica Sinica]. 2001 Dec; 53(6):451-5. doi: NULL. [PMID: 11930224]
  • R M Edwards, D P Brooks. Dopamine inhibits vasopressin action in the rat inner medullary collecting duct via alpha(2)-adrenoceptors. The Journal of pharmacology and experimental therapeutics. 2001 Sep; 298(3):1001-6. doi: NULL. [PMID: 11504796]
  • M J Millan, A Gobert, F Lejeune, A Newman-Tancredi, J M Rivet, A Auclair, J L Peglion. S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. The Journal of pharmacology and experimental therapeutics. 2001 Aug; 298(2):565-80. doi: . [PMID: 11454918]
  • U Wethmar, W Raasch, A Dendorfer, P Dominiak. Interactions of ligands at angiotensin II-receptors and imidazoline receptors. Japanese journal of pharmacology. 2001 Feb; 85(2):167-74. doi: 10.1254/jjp.85.167. [PMID: 11286399]
  • B T Jackson, G J Piasecki, H E Cohn, W R Cohen. Control of fetal insulin secretion. American journal of physiology. Regulatory, integrative and comparative physiology. 2000 Dec; 279(6):R2179-88. doi: 10.1152/ajpregu.2000.279.6.r2179. [PMID: 11080084]
  • G A Head, S L Burke. Comparison of renal sympathetic baroreflex effects of rilmenidine and alpha-methylnoradrenaline in the ventrolateral medulla of the rabbit. Journal of hypertension. 2000 Sep; 18(9):1263-76. doi: 10.1097/00004872-200018090-00013. [PMID: 10994758]
  • C Thalamas, J Galitzky, J M Sénard, M Lafontan, J L Montastruc, M Berlan, P Barbe. Glucose-induced sympathetic activity and energy expenditure during acute alpha2-adrenergic antagonism in obese subjects. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 2000 Jun; 24(6):695-700. doi: 10.1038/sj.ijo.0801221. [PMID: 10878675]
  • J Yamada, Y Sugimoto, T Noma. Involvement of adrenaline in diazepam-induced hyperglycemia in mice. Life sciences. 2000 Feb; 66(13):1213-21. doi: 10.1016/s0024-3205(00)00426-4. [PMID: 10737416]
  • Y Cheng, F Planta, P Ladure, C Julien, C Barrès. Acute cardiovascular effects of the alpha2-adrenoceptor antagonist, idazoxan, in rats: influence of the basal sympathetic tone. Journal of cardiovascular pharmacology. 2000 Jan; 35(1):156-63. doi: 10.1097/00005344-200001000-00021. [PMID: 10630747]
  • J Chariot, A Tsocas, A Souli, O Presset, C Rozé. Neural mechanism of the antisecretory effect of peptide YY in the rat colon in vivo. Peptides. 2000 Jan; 21(1):59-63. doi: 10.1016/s0196-9781(99)00174-6. [PMID: 10704720]
  • B Sjöholm, J Lähdesmäki, K Pyykkö, M Hillilä, M Scheinin. Non-adrenergic binding of [3H]atipamezole in rat kidney--regional distribution and comparison to alpha2-adrenoceptors. British journal of pharmacology. 1999 Nov; 128(6):1215-22. doi: 10.1038/sj.bjp.0702917. [PMID: 10578134]
  • T Olli-Lähdesmäki, J Kallio, M Scheinin. Receptor subtype-induced targeting and subtype-specific internalization of human alpha(2)-adrenoceptors in PC12 cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Nov; 19(21):9281-8. doi: 10.1523/jneurosci.19-21-09281.1999. [PMID: 10531432]
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  • M E Schmidt, R J Oshinsky, H G Kim, J L Schouten, B S Folley, W Z Potter. Cerebral glucose metabolic and plasma catecholamine responses to the alpha(2) adrenoceptor antagonist ethoxyidazoxan given to healthy volunteers. Psychopharmacology. 1999 Sep; 146(2):119-27. doi: 10.1007/s002130051097. [PMID: 10525746]
  • I Rustenbeck, M Köpp, P Ratzka, L Leupolt, A Hasselblatt. Imidazolines and the pancreatic B-cell. Actions and binding sites. Annals of the New York Academy of Sciences. 1999 Jun; 881(?):229-40. doi: 10.1111/j.1749-6632.1999.tb09365.x. [PMID: 10415921]
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  • W Zhang, V Klimek, J T Farley, M Y Zhu, G A Ordway. alpha2C adrenoceptors inhibit adenylyl cyclase in mouse striatum: potential activation by dopamine. The Journal of pharmacology and experimental therapeutics. 1999 Jun; 289(3):1286-92. doi: NULL. [PMID: 10336518]
  • G Le Bihan, F Rondu, A Pelé-Tounian, X Wang, S Lidy, E Touboul, A Lamouri, G Dive, J Huet, B Pfeiffer, P Renard, B Guardiola-Lemaître, D Manéchez, L Pénicaud, A Ktorza, J J Godfroid. Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 2. Syntheses and biological activities of 1,4-dialkyl-, 1,4-dibenzyl, and 1-benzyl-4-alkyl-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines and isosteric analogues of imidazoline. Journal of medicinal chemistry. 1999 May; 42(9):1587-603. doi: 10.1021/jm981099b. [PMID: 10229628]
  • I Rustenbeck, L Leupolt, R Kowalewski, A Hasselblatt. Heterogeneous characteristics of imidazoline-induced insulin secretion. Naunyn-Schmiedeberg's archives of pharmacology. 1999 Mar; 359(3):235-42. doi: 10.1007/pl00005347. [PMID: 10208311]
  • L F Callado, A M Gabilondo, J J Meana. Differential modulation of alpha2-adrenoceptor subtypes in rat kidney by chronic desipramine treatment. Life sciences. 1999; 64(25):2327-39. doi: 10.1016/s0024-3205(99)00186-1. [PMID: 10374896]
  • M Pigini, P Bousquet, L Brasili, A Carrieri, R Cavagna, M Dontenwill, F Gentili, M Giannella, F Leonetti, A Piergentili, W Quaglia, A Carotti. Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models. Bioorganic & medicinal chemistry. 1998 Dec; 6(12):2245-60. doi: 10.1016/s0968-0896(98)80005-9. [PMID: 9925287]
  • D D Smyth, S B Penner. Imidazoline receptor mediated natriuresis: central and/or peripheral effect?. Journal of the autonomic nervous system. 1998 Oct; 72(2-3):155-62. doi: 10.1016/s0165-1838(98)00100-3. [PMID: 9851564]
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