(4beta,12R)-12,13-epoxytrichothec-9-en-4-yl acetate (BioDeep_00001870061)

Main id: BioDeep_00000007583

 


代谢物信息卡片


(4beta,12R)-12,13-epoxytrichothec-9-en-4-yl acetate

化学式: C17H24O4 (292.1675)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC2C(CC1)(C3(C(CC(C34CO4)O2)OC(=O)C)C)C
InChI: InChI=1S/C17H24O4/c1-10-5-6-15(3)12(7-10)21-14-8-13(20-11(2)18)16(15,4)17(14)9-19-17/h7,12-14H,5-6,8-9H2,1-4H3/t12-,13-,14-,15+,16-,17-/m1/s1

描述信息

D009676 - Noxae > D011042 - Poisons > D014255 - Trichothecenes
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins

同义名列表

2 个代谢物同义名

(4beta,12R)-12,13-epoxytrichothec-9-en-4-yl acetate; Trichodermin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 ATF4, BCL2, CCNB1, CCND1, CDC25A, CDK2, CDK4, CDKN1B, CDKN2A, HDAC2, HDAC9, MYC, RPL3, STAT3, XBP1, XIAP
Peripheral membrane protein 1 XBP1
Endoplasmic reticulum membrane 2 BCL2, XBP1
Nucleus 17 ATF4, BCL2, CCNB1, CCND1, CDC25A, CDK2, CDK4, CDKN1B, CDKN2A, HDAC2, HDAC9, MYC, PARP1, RPL3, STAT3, XBP1, XIAP
cytosol 14 ATF4, BCL2, CCNB1, CCND1, CDC25A, CDK2, CDK4, CDKN1B, CDKN2A, PARP1, RPL3, STAT3, XBP1, XIAP
nuclear body 1 PARP1
centrosome 4 ATF4, CCNB1, CCND1, CDK2
nucleoplasm 15 ATF4, CCNB1, CCND1, CDC25A, CDK2, CDK4, CDKN1B, CDKN2A, HDAC2, HDAC9, MYC, PARP1, STAT3, XBP1, XIAP
RNA polymerase II transcription regulator complex 3 ATF4, STAT3, XBP1
Cell membrane 1 ATF4
Cytoplasm, cytosol 1 PARP1
endosome 2 CDK2, CDKN1B
plasma membrane 1 STAT3
Membrane 6 BCL2, CCNB1, HDAC2, MYC, PARP1, XBP1
extracellular exosome 1 RPL3
endoplasmic reticulum 2 BCL2, XBP1
extracellular space 1 IL6
bicellular tight junction 2 CCND1, CDK4
mitochondrion 3 BCL2, CDKN2A, PARP1
protein-containing complex 8 ATF4, BCL2, CDKN1B, CDKN2A, HDAC2, MYC, PARP1, RPL3
intracellular membrane-bounded organelle 1 CDKN1B
ESC/E(Z) complex 1 HDAC2
Secreted 1 IL6
extracellular region 1 IL6
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 2 CCNB1, CDKN2A
transcription regulator complex 5 CDK2, CDK4, HDAC9, PARP1, STAT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 ATF4, CDK2
Nucleus membrane 3 BCL2, CCND1, CDK4
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, CCND1, CDK4
nucleolus 5 CDK4, CDKN2A, MYC, PARP1, RPL3
Single-pass type II membrane protein 1 XBP1
pore complex 1 BCL2
focal adhesion 1 RPL3
nuclear speck 1 ATF4
neuron projection 1 ATF4
chromatin 6 ATF4, CDK4, HDAC2, MYC, PARP1, STAT3
Chromosome 1 PARP1
Nucleus, nucleolus 4 CDKN2A, MYC, PARP1, RPL3
spindle pole 1 CCNB1
nuclear replication fork 1 PARP1
chromosome, telomeric region 3 CDK2, HDAC2, PARP1
site of double-strand break 1 PARP1
nuclear envelope 3 CDK2, MYC, PARP1
Nucleus, nucleoplasm 2 CDKN2A, MYC
Nucleus speckle 1 ATF4
myelin sheath 1 BCL2
endoplasmic reticulum lumen 1 IL6
histone methyltransferase complex 1 HDAC9
transcription repressor complex 1 CCND1
male germ cell nucleus 1 CDK2
histone deacetylase complex 2 HDAC2, HDAC9
RNA polymerase II transcription repressor complex 1 MYC
NuRD complex 1 HDAC2
outer kinetochore 1 CCNB1
Cajal body 1 CDK2
ribonucleoprotein complex 1 RPL3
[Isoform 2]: Nucleus 1 XBP1
[Isoform 1]: Nucleus 1 XBP1
Sin3-type complex 1 HDAC2
protein-DNA complex 1 PARP1
dendrite membrane 1 ATF4
Rough endoplasmic reticulum 1 MYC
condensed chromosome 1 CDK2
cytosolic ribosome 1 RPL3
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
site of DNA damage 1 PARP1
nuclear periphery 1 ATF4
cyclin-dependent protein kinase holoenzyme complex 3 CCND1, CDK2, CDK4
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
ribosome 1 RPL3
Myc-Max complex 1 MYC
interleukin-6 receptor complex 1 IL6
cytosolic large ribosomal subunit 1 RPL3
cyclin B1-CDK1 complex 1 CCNB1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 2 CCND1, CDK4
cyclin D2-CDK4 complex 1 CDK4
cyclin D3-CDK4 complex 1 CDK4
ATF4-CREB1 transcription factor complex 1 ATF4
senescence-associated heterochromatin focus 1 CDKN2A
[X-box-binding protein 1, cytoplasmic form]: Cytoplasm 1 XBP1
ATF1-ATF4 transcription factor complex 1 ATF4
CHOP-ATF4 complex 1 ATF4
Lewy body core 1 ATF4
cyclin A2-CDK2 complex 1 CDK2
cyclin D1-CDK6 complex 1 CCND1
cyclin A1-CDK2 complex 1 CDK2
Cul4A-RING E3 ubiquitin ligase complex 1 CDKN1B
[Isoform smARF]: Mitochondrion 1 CDKN2A
nucleoplasmic reticulum 1 MYC


文献列表

  • Xiajun Yao, Jin Xie, Yanhua Qi, Bin Wang, Wenxia Fang, Gang Tao, Xiliang Jiang. [Screening and evaluation of the biocontrol efficacy of a Trichoderma brevicompactum strain and its metabolite trichodermin against banana Fusarium wilt]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2024 Jan; 40(1):211-225. doi: 10.13345/j.cjb.230170. [PMID: 38258642]
  • Yunfan Bai, Yuran Gao, Xin Lu, Huiyu Wang. Lipidomics characterization of the alterations of Trichoderma brevicompactum membrane glycerophospholipids during the fermentation phase. Journal of industrial microbiology & biotechnology. 2019 Jun; 46(6):809-818. doi: 10.1007/s10295-019-02152-y. [PMID: 30847610]
  • R E Cardoza, S P McCormick, M G Malmierca, E R Olivera, N J Alexander, E Monte, S Gutiérrez. Effects of Trichothecene Production on the Plant Defense Response and Fungal Physiology: Overexpression of the Trichoderma arundinaceum tri4 Gene in T. harzianum. Applied and environmental microbiology. 2015 Sep; 81(18):6355-66. doi: 10.1128/aem.01626-15. [PMID: 26150463]
  • Xiaojun Xu, Jingli Cheng, Yong Zhou, Chulong Zhang, Xiaoming Ou, Weike Su, Jinhao Zhao, Guonian Zhu. Synthesis and antifungal activities of trichodermin derivatives as fungicides on rice. Chemistry & biodiversity. 2013 Apr; 10(4):600-11. doi: 10.1002/cbdv.201200135. [PMID: 23576346]
  • Xu-Ping Shentu, Wei-Ping Liu, Xiao-Huan Zhan, Xiao-Ping Yu, Chuan-Xi Zhang. The elicitation effect of pathogenic fungi on trichodermin production by Trichoderma brevicompactum. TheScientificWorldJournal. 2013; 2013(?):607102. doi: 10.1155/2013/607102. [PMID: 24385883]
  • Li-Wei Wang, Bai-Ge Xu, Jia-Ying Wang, Zhen-Zhu Su, Fu-Cheng Lin, Chu-Long Zhang, Christian P Kubicek. Bioactive metabolites from Phoma species, an endophytic fungus from the Chinese medicinal plant Arisaema erubescens. Applied microbiology and biotechnology. 2012 Feb; 93(3):1231-9. doi: 10.1007/s00253-011-3472-3. [PMID: 21814808]
  • Mohamed Anwar Bin-Umer, John E McLaughlin, Debaleena Basu, Susan McCormick, Nilgun E Tumer. Trichothecene mycotoxins inhibit mitochondrial translation--implication for the mechanism of toxicity. Toxins. 2011 12; 3(12):1484-501. doi: 10.3390/toxins3121484. [PMID: 22295173]
  • Petr Karlovsky. Biological detoxification of the mycotoxin deoxynivalenol and its use in genetically engineered crops and feed additives. Applied microbiology and biotechnology. 2011 Aug; 91(3):491-504. doi: 10.1007/s00253-011-3401-5. [PMID: 21691789]
  • Iwona Yike, Anne M Distler, Assem G Ziady, Dorr G Dearborn. Mycotoxin adducts on human serum albumin: biomarkers of exposure to Stachybotrys chartarum. Environmental health perspectives. 2006 Aug; 114(8):1221-6. doi: 10.1289/ehp.9064. [PMID: 16882529]
  • S N Kulikov, F K Alimova, N G Zakharova, S V Nemtsev, V P Varlamov. [Biological preparations with different mechanism of action for protecting potato against fungal diseases]. Prikladnaia biokhimiia i mikrobiologiia. 2006 Jan; 42(1):86-92. doi: . [PMID: 16521583]
  • S I Egorov, F K Alimova, N G Zakharova, I B Leshchinskaia. [Influence of Bacillus intermedius RNAse on growth-stimulating and antagonistic characteristics of Trichoderma harzianum]. Prikladnaia biokhimiia i mikrobiologiia. 1996 Sep; 32(5):554-6. doi: ". [PMID: 9011860]
  • . . . . doi: . [PMID: 22069741]