Kyotorphin (BioDeep_00001868710)

Main id: BioDeep_00000005058

 

Volatile Flavor Compounds


代谢物信息卡片


Kyotorphin acetate salt

化学式: C15H23N5O4 (337.17499580000003)
中文名称: TYR-ARG
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C[C@@H](C(=O)O)NC(=O)[C@H](Cc1ccc(cc1)O)N)CNC(=N)N
InChI: InChI=1S/C15H23N5O4/c16-11(8-9-3-5-10(21)6-4-9)13(22)20-12(14(23)24)2-1-7-19-15(17)18/h3-6,11-12,21H,1-2,7-8,16H2,(H,20,22)(H,23,24)(H4,17,18,19)/t11-,12-/m0/s1

描述信息

D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D018377 - Neurotransmitter Agents > D018847 - Opioid Peptides
D018377 - Neurotransmitter Agents > D004723 - Endorphins
Kyotorphin is an endogenou neuroactive dipeptide with analgesic properties. Kyotorphin possesses anti-inflammatory and antimicrobial activity. Kyotorphin levels in cerebro-spinal fluid correlate negatively with the progression of neurodegeneration in Alzheimer's Disease patients[1].

同义名列表

3 个代谢物同义名

Kyotorphin acetate salt; Kyotorphin; Kyotorphin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tiago N Figueira, João M Freire, Catarina Cunha-Santos, Montserrat Heras, João Gonçalves, Anne Moscona, Matteo Porotto, Ana Salomé Veiga, Miguel A R B Castanho. Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance. Scientific reports. 2017 03; 7(?):45647. doi: 10.1038/srep45647. [PMID: 28358389]
  • Katia Conceição, Pedro R Magalhães, Sara R R Campos, Marco M Domingues, Vasanthakumar G Ramu, Matthias Michalek, Philippe Bertani, António M Baptista, Montserrat Heras, Eduard R Bardaji, Burkhard Bechinger, Mônica Lopes Ferreira, Miguel A R B Castanho. The anti-inflammatory action of the analgesic kyotorphin neuropeptide derivatives: insights of a lipid-mediated mechanism. Amino acids. 2016 Jan; 48(1):307-18. doi: 10.1007/s00726-015-2088-9. [PMID: 26347373]
  • Pedro R Magalhães, Miguel Machuqueiro, António M Baptista. Constant-pH Molecular Dynamics Study of Kyotorphin in an Explicit Bilayer. Biophysical journal. 2015 May; 108(9):2282-90. doi: 10.1016/j.bpj.2015.03.052. [PMID: 25954885]
  • Isa D Serrano, Vasanthakumar G Ramu, Antónia R T Pinto, João M Freire, Isaura Tavares, Montserrat Heras, Eduard R Bardaji, Miguel A R B Castanho. Correlation between membrane translocation and analgesic efficacy in kyotorphin derivatives. Biopolymers. 2015 Jan; 104(1):1-10. doi: 10.1002/bip.22580. [PMID: 25363470]
  • Marta M B Ribeiro, Henri G Franquelim, Inês M Torcato, Vasanthakumar G Ramu, Montserrat Heras, Eduard R Bardaji, Miguel A R B Castanho. Antimicrobial properties of analgesic kyotorphin peptides unraveled through atomic force microscopy. Biochemical and biophysical research communications. 2012 Apr; 420(3):676-9. doi: 10.1016/j.bbrc.2012.03.065. [PMID: 22450328]
  • Joakim E Swedberg, Jonathan M Harris. Plasmin substrate binding site cooperativity guides the design of potent peptide aldehyde inhibitors. Biochemistry. 2011 Oct; 50(39):8454-62. doi: 10.1021/bi201203y. [PMID: 21877690]
  • Marta M B Ribeiro, Antónia R T Pinto, Marco M Domingues, Isa Serrano, Montserrat Heras, Eduard R Bardaji, Isaura Tavares, Miguel A Castanho. Chemical conjugation of the neuropeptide kyotorphin and ibuprofen enhances brain targeting and analgesia. Molecular pharmaceutics. 2011 Oct; 8(5):1929-40. doi: 10.1021/mp2003016. [PMID: 21830793]
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  • Miguel Machuqueiro, Sara R R Campos, Cláudio M Soares, António M Baptista. Membrane-induced conformational changes of kyotorphin revealed by molecular dynamics simulations. The journal of physical chemistry. B. 2010 Sep; 114(35):11659-67. doi: 10.1021/jp104418g. [PMID: 20707376]
  • Ying Huang, Xiuyan Jiang, Wei Wang, Jianping Duan, Guonan Chen. Separation and determination of l-tyrosine and its metabolites by capillary zone electrophoresis with a wall-jet amperometric detection. Talanta. 2006 Dec; 70(5):1157-63. doi: 10.1016/j.talanta.2006.03.009. [PMID: 18970894]
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  • T Fujita, T Kishida, N Okada, V Ganapathy, F H Leibach, A Yamamoto. Interaction of kyotorphin and brain peptide transporter in synaptosomes prepared from rat cerebellum: implication of high affinity type H+/peptide transporter PEPT2 mediated transport system. Neuroscience letters. 1999 Aug; 271(2):117-20. doi: 10.1016/s0304-3940(99)00540-6. [PMID: 10477116]
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  • J Y Summy-Long, V Bui, S Gestl, E Koehler-Stec, H Liu, M L Terrell, M Kadekaro. Effects of central injection of kyotorphin and L-arginine on oxytocin and vasopressin release and blood pressure in conscious rats. Brain research bulletin. 1998; 45(4):395-403. doi: 10.1016/s0361-9230(97)00341-9. [PMID: 9527014]
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