N-Hydroxy-2-acetamidofluorene (BioDeep_00001868495)
Main id: BioDeep_00000005359
代谢物信息卡片
N-Hydroxy-2-acetamidofluorene
化学式: C15H13NO2 (239.0946)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)N(C1=CC2=C(C=C1)C3=CC=CC=C3C2)O
InChI: InChI=1S/C15H13NO2/c1-10(17)16(18)13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9,18H,8H2,1H3
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:17931
- KEGG: C03954
- PubChem: 5896
- ChEMBL: CHEMBL284464
- MeSH: Hydroxyacetylaminofluorene
- CAS: 53-95-2
- PubChem: 6675
- 3DMET: B00656
- NIKKAJI: J1.912G
分类词条
相关代谢途径
Reactome(4)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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PPAR research.
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Xenobiotica; the fate of foreign compounds in biological systems.
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Chemical research in toxicology.
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Chemical research in toxicology.
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Biochemical pharmacology.
1990 Oct; 40(8):1885-92. doi:
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Biochemical pharmacology.
1989 Nov; 38(22):3987-94. doi:
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Biochemical pharmacology.
1987 Aug; 36(16):2605-8. doi:
10.1016/0006-2952(87)90538-7. [PMID: 3606659] - K Tatsumi, S Kitamura. N-hydroxy-2-acetylaminofluorene as effective inhibitor of aldehyde oxidase.
Biochemical and biophysical research communications.
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10.1016/0006-291x(86)90281-0. [PMID: 3741414] - S Yokoyama, M Satoh, B Lombardi. Bile ductular cells and the phenotypic heterogeneity of the population of hepatic non-parenchymal epithelial cells induced in rats by chemical carcinogens.
Carcinogenesis.
1986 Jul; 7(7):1215-9. doi:
10.1093/carcin/7.7.1215. [PMID: 2424628] - T J Flammang, F F Kadlubar. Acetyl coenzyme A-dependent metabolic activation of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl and several carcinogenic N-hydroxy arylamines in relation to tissue and species differences, other acyl donors, and arylhydroxamic acid-dependent acyltransferases.
Carcinogenesis.
1986 Jun; 7(6):919-26. doi:
10.1093/carcin/7.6.919. [PMID: 3708755] - V T Vu, P H Grantham, P P Roller, W D Hankins, P J Wirth, S S Thorgeirsson. Formation of DNA adducts from N-acetoxy-2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene in rat hemopoietic tissues in vivo.
Cancer research.
1986 Jan; 46(1):233-8. doi:
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Cancer research.
1985 Mar; 45(3):1132-9. doi:
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Biochemical pharmacology.
1983 Sep; 32(18):2721-7. doi:
10.1016/0006-2952(83)90082-5. [PMID: 6626243] - N M El-Torkey, E K Weisburger. Influence of disulfiram on mutagenicity of the urinary metabolites of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene in the Salmonella test system.
Mutation research.
1983 Jul; 118(1-2):1-6. doi:
10.1016/0165-1218(83)90110-6. [PMID: 6346083] - C Y Wang, E M Linsmaier-Bednar, C D Garner. Inhibition of 4-nitroquinoline 1-oxide induced unscheduled DNA synthesis in primary cultures of rat urothelial cells by dicumarol and pyrophosphate.
Chemico-biological interactions.
1982 Oct; 42(1):79-84. doi:
10.1016/0009-2797(82)90143-0. [PMID: 6185243] - F A Beland, K L Dooley, C D Jackson. Persistence of DNA adducts in rat liver and kidney after multiple doses of the carcinogen N-hydroxy-2-acetylaminofluorene.
Cancer research.
1982 Apr; 42(4):1348-54. doi:
. [PMID: 6949639] - J H Meerman, F A Beland, B Ketterer, S K Srai, A P Bruins, G J Mulder. Identification of glutathione conjugates formed from N-hydroxy-2-acetylaminofluorene in the rat.
Chemico-biological interactions.
1982 Mar; 39(2):149-68. doi:
10.1016/0009-2797(82)90118-1. [PMID: 7060226] - B P Moore, R M Hicks, M A Knowles, S Redgrave. Metabolism and binding of benzo(a)pyrene and 2-acetylaminofluorene by short-term organ cultures of human and rat bladder.
Cancer research.
1982 Feb; 42(2):642-8. doi:
. [PMID: 6275985] - P Rio, S Bazgar, M Leng. Detection of N-hydroxy-2-acetylaminofluorene-DNA adducts in rat liver measured by radioimmunoassay.
Carcinogenesis.
1982; 3(2):225-7. doi:
10.1093/carcin/3.2.225. [PMID: 6978201] - T V Reddy, E K Weisburger, S S Thorgeirsson. Mutagenic activation of N-2-fluorenylacetamide and N-hydroxy-N-2-fluorenylacetamide in subcellular fractions from X/Gf mice.
Journal of the National Cancer Institute.
1980 Jun; 64(6):1563-9. doi:
10.1093/jnci/64.6.1563. [PMID: 6929392] - J E Steward, R A Floyd. The deacetylation of N-hydroxy-2-acetylaminofluorene by rat liver microsomes and carboxyl esterase.
Cancer biochemistry biophysics.
1980; 5(1):47-53. doi:
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Cancer treatment reports.
1979 Sep; 63(9-10):1663-7. doi:
. [PMID: 91435] - C E Castro, I C Felkner, S P Yang. Dietary lipid-dependent activation of the carcinogen N-2-fluorenylacetamide in rats as monitored by Salmonella typhimurium.
Cancer research.
1978 Sep; 38(9):2836-41. doi:
NULL. [PMID: 354780] - H A Schut, P J Wirth, S S Thorgeirsson. Mutagenic activation of N-hydroxy-2-acetylaminofluorene in the Salmonella test system: the role of deacetylation by liver and kidney fractions from mouse and rat.
Molecular pharmacology.
1978 Jul; 14(4):682-92. doi:
NULL. [PMID: 683178] - L A Poirier, P H Grantham, A E Rogers. The effects of a marginally lipotrope-deficient diet on the hepatic levels of S-adenosylmethionine and on the urinary metabolites of 2-acetylaminofluorene in rats.
Cancer research.
1977 Mar; 37(3):744-8. doi:
. [PMID: 65217] - M L Hopp, M Matsumoto, C Lee, R Oyasu. Absorption and protein binding of N-2-fluorenylacetamide and its metabolites in the bladder of rabbit.
Journal of the National Cancer Institute.
1977 Feb; 58(2):281-5. doi:
10.1093/jnci/58.2.281. [PMID: 833876] - R A Floyd, L M Soong, R N Walker, M Stuart. Lipid hydroperoxide activation of N-hydroxy-N-acetylaminofluorene via a free radical route.
Cancer research.
1976 Aug; 36(8):2761-7. doi:
". [PMID: 1277186] - L C Mohan, P H Grantham, E K Weisburger, J H Weisburger, J B Idoine. Mechanisms of the inhibitory action of p-hydroxyacetanilide on carcinogenesis by N-2-fluorenylacetamide or N-hydroxy-N-2-fluorenylacetamide.
Journal of the National Cancer Institute.
1976 Apr; 56(4):763-8. doi:
10.1093/jnci/56.4.763. [PMID: 815562] - C W Olive, C M King. Evidence for a second arylhydroxamic acid acyltransferase species in the small intestine of the rat.
Chemico-biological interactions.
1975 Dec; 11(6):599-604. doi:
10.1016/0009-2797(75)90034-4. [PMID: 1201619] - M Nozaki. [Combined use of bucolome and pyrazolone derivatives (1). Pharmacological activities and blood concentration].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1975 Sep; 71(6):609-29. doi:
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Japanese journal of medical science & biology.
1975 Jun; 28(3):165-77. doi:
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The Journal of pharmacology and experimental therapeutics.
1975 Mar; 192(3):592-604. doi:
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