lomefloxacin (BioDeep_00001868189)
Main id: BioDeep_00000002814
代谢物信息卡片
lomefloxacin
化学式: C17H19F2N3O3 (351.1394)
中文名称: 洛美沙星
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O
InChI: InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25)
描述信息
A fluoroquinolone antibiotic, used (generally as the hydrochloride salt) to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AE - Fluoroquinolones
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:116278
- KEGG: C07078
- KEGGdrug: D02318
- PubChem: 3948
- DrugBank: DB00978
- ChEMBL: CHEMBL561
- CAS: 98079-51-7
- MetaboLights: MTBLC116278
- PubChem: 9289
- NIKKAJI: J135.046C
- KNApSAcK: 116278
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tamer Z Attia, Mahmoud A Omar, Deena A M Nour El-Deen, Asmaa Mohamed Abbas, Abobakr A Mohamed. A novel spectrofluorimetric method for determination of lomefloxacin adopting on zinc(II) chelation strategy: Application in human plasma.
Luminescence : the journal of biological and chemical luminescence.
2022 Feb; 37(2):255-262. doi:
10.1002/bio.4168. [PMID: 34806313] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Kamal Ahmed El-Shazly, Amera Abd El-Latif, Walied Abdo, Ahmed El-Morsey, Magdy Ibrahim Abd El-Aziz, Heba El-Mogazy. The anticoccidial activity of the fluoroquinolone lomefloxacin against experimental Eimeria tenella infection in broiler chickens.
Parasitology research.
2020 Jun; 119(6):1955-1968. doi:
10.1007/s00436-020-06692-6. [PMID: 32399722] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Sima Beigoli, Atena Sharifi Rad, Azam Askari, Reza Assaran Darban, Jamshidkhan Chamani. Isothermal titration calorimetry and stopped flow circular dichroism investigations of the interaction between lomefloxacin and human serum albumin in the presence of amino acids.
Journal of biomolecular structure & dynamics.
2019 Jun; 37(9):2265-2282. doi:
10.1080/07391102.2018.1491421. [PMID: 30047851] - Shereen A Boltia, Aya T Soudi, Eman S Elzanfaly, Hala E Zaazaa. Analytical Eco-Scale for Assessing the Greenness of a Developed Potentiometric Method for Lomefloxacin Hydrochloride Determination in its Different Dosage Forms, Plasma, and Dissolution Medium.
Journal of AOAC International.
2019 May; 102(3):794-800. doi:
10.5740/jaoacint.18-0217. [PMID: 30446018] - Ren San, Weidong Yue, Surong Hasi. Effects of CYP1A enzyme specific inhibitor on pharmacokinetics of para-acetaminophen in Bactrian camel.
Journal of veterinary science.
2019 May; 20(3):e12. doi:
10.4142/jvs.2019.20.e12. [PMID: 31161735] - Tianlie Luo, Jingwen Chen, Xuehua Li, Shuying Zhang, Hongye Yao, Willie J G M Peijnenburg. Effects of lomefloxacin on survival, growth and reproduction of Daphnia magna under simulated sunlight radiation.
Ecotoxicology and environmental safety.
2018 Dec; 166(?):63-70. doi:
10.1016/j.ecoenv.2018.09.067. [PMID: 30248562] - Mengmeng Gao, Lili Li, Suxiang Lu, Qiang Liu, Hua He. Silver nanoparticles for the visual detection of lomefloxacin in the presence of cystine.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Dec; 205(?):72-78. doi:
10.1016/j.saa.2018.05.072. [PMID: 30007902] - Lei Sha, Xiaoyan Tang, Dengyong Liu, Yongping Xu, Y U Ding, Feng Ding. Detection and Quantitation of Lomefloxacin and Pefloxacin Residues in the Organ Tissues and Eggs of Laying Hens.
Journal of food protection.
2018 05; 81(5):810-814. doi:
10.4315/0362-028x.jfp-17-422. [PMID: 29637810] - Neng Jiang, Qichun Huang, Jing Liu, Ningsheng Liang, Qing Li, Qinghua Li, Sai-Sai Xie. Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2018 Feb; 146(?):287-298. doi:
10.1016/j.ejmech.2018.01.055. [PMID: 29407958] - Jin-Shuai Lan, Tong Zhang, Yun Liu, Jing Yang, Sai-Sai Xie, Jing Liu, Ze-Yang Miao, Yue Ding. Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.
European journal of medicinal chemistry.
2017 Jun; 133(?):184-196. doi:
10.1016/j.ejmech.2017.02.045. [PMID: 28388521] - Yutaka Yonezawa, Taishi Miyashita, Hiroko Ashizawa, Kazuto Hashimoto, Hiroaki Nejishima, Haruko Ogawa. Evaluation of a general toxicity study incorporating phototoxicity assessments in Sprague-Dawley rats.
The Journal of toxicological sciences.
2017; 42(2):145-157. doi:
10.2131/jts.42.145. [PMID: 28321041] - Urszula K Komarnicka, Radosław Starosta, Agnieszka Kyzioł, Michał Płotek, Małgorzata Puchalska, Małgorzata Jeżowska-Bojczuk. New copper(I) complexes bearing lomefloxacin motif: Spectroscopic properties, in vitro cytotoxicity and interactions with DNA and human serum albumin.
Journal of inorganic biochemistry.
2016 12; 165(?):25-35. doi:
10.1016/j.jinorgbio.2016.09.015. [PMID: 27764707] - Xiao-hu Dai, Yong-gang Xue, Hua-jie Liu, Ling-ling Dai, Han Yan, Ning Li. [Development of Determination Method of Fluoroquinolone Antibiotics in Sludge Based on Solid Phase Extraction and HPLC-Fluorescence Detection Analysis].
Huan jing ke xue= Huanjing kexue.
2016 Apr; 37(4):1553-61. doi:
". [PMID: 27548982] - Mitra Amoli-Diva, Kamyar Pourghazi, Somayeh Hajjaran. Dispersive micro-solid phase extraction using magnetic nanoparticle modified multi-walled carbon nanotubes coupled with surfactant-enhanced spectrofluorimetry for sensitive determination of lomefloxacin and ofloxacin from biological samples.
Materials science & engineering. C, Materials for biological applications.
2016 Mar; 60(?):30-36. doi:
10.1016/j.msec.2015.11.013. [PMID: 26706503] - Sonia Soldevila, M Consuelo Cuquerella, Francisco Bosca. Understanding of the photoallergic properties of fluoroquinolones: photoreactivity of lomefloxacin with amino acids and albumin.
Chemical research in toxicology.
2014 Apr; 27(4):514-23. doi:
10.1021/tx400377s. [PMID: 24528107] - Ornella Di Pietro, Elisabet Viayna, Esther Vicente-García, Manuela Bartolini, Rosario Ramón, Jordi Juárez-Jiménez, M Victòria Clos, Belén Pérez, Vincenza Andrisano, F Javier Luque, Rodolfo Lavilla, Diego Muñoz-Torrero. 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.
European journal of medicinal chemistry.
2014 Feb; 73(?):141-52. doi:
10.1016/j.ejmech.2013.12.008. [PMID: 24389509] - Zohreh Sattar, Mohammad Reza Saberi, Jamshidkhan Chamani. Determination of LMF binding site on a HSA-PPIX complex in the presence of human holo transferrin from the viewpoint of drug loading on proteins.
PloS one.
2014; 9(1):e84045. doi:
10.1371/journal.pone.0084045. [PMID: 24392106] - Zohreh Sattar, Hediye Iranfar, Ahmad Asoodeh, Mohammad Reza Saberi, Mahboobeh Mazhari, Jamshidkhan Chamani. Interaction between holo transferrin and HSA-PPIX complex in the presence of lomefloxacin: an evaluation of PPIX aggregation in protein-protein interactions.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2012 Nov; 97(?):1089-100. doi:
10.1016/j.saa.2012.07.034. [PMID: 22925987] - Iram Shaifali, Uma Gupta, Syed Esam Mahmood, Jawed Ahmed. Antibiotic susceptibility patterns of urinary pathogens in female outpatients.
North American journal of medical sciences.
2012 Apr; 4(4):163-9. doi:
10.4103/1947-2714.94940. [PMID: 22536558] - Huan Yu, Yanfei Tao, Dongmei Chen, Yuanhu Pan, Zhenli Liu, Yulian Wang, Lingli Huang, Menghong Dai, Dapeng Peng, Xu Wang, Zonghui Yuan. Simultaneous determination of fluoroquinolones in foods of animal origin by a high performance liquid chromatography and a liquid chromatography tandem mass spectrometry with accelerated solvent extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Feb; 885-886(?):150-9. doi:
10.1016/j.jchromb.2011.12.016. [PMID: 22230742] - Jian Yi, Meng Meng, Zhong-qiu Liu, Jin-fang Zhi, Yuan-yang Zhang, Jing Xu, Ya-bin Wang, Jin-ting Liu, Ri-mo Xi. Development of an electrochemical immunoassay for detection of gatifloxacin in swine urine.
Journal of Zhejiang University. Science. B.
2012 Feb; 13(2):118-25. doi:
10.1631/jzus.b1100073. [PMID: 22302425] - Ai Jia, Yi Wan, Yang Xiao, Jianying Hu. Occurrence and fate of quinolone and fluoroquinolone antibiotics in a municipal sewage treatment plant.
Water research.
2012 Feb; 46(2):387-94. doi:
10.1016/j.watres.2011.10.055. [PMID: 22118907] - Xuelan Chen, Hengyi Xu, Weihua Lai, Yuan Chen, Xiaohui Yang, Yonghua Xiong. A sensitive chromatographic strip test for the rapid detection of enrofloxacin in chicken muscle.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2012; 29(3):383-91. doi:
10.1080/19440049.2011.641509. [PMID: 22243423] - N A Nozdrachev, A I Neĭmark, B A Neĭmark. [Administration of vitaprost plus for prevention of infectious-inflammatory complications of transurethral prostatic resection in patients with prostatic adenoma].
Urologiia (Moscow, Russia : 1999).
2011 Jul; ?(4):55, 57-60. doi:
NULL. [PMID: 22066244] - Joana Sousa, Gilberto Alves, Ana Fortuna, Angelina Pena, Celeste Lino, Amílcar Falcão. Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma.
Biomedical chromatography : BMC.
2011 May; 25(5):535-41. doi:
10.1002/bmc.1480. [PMID: 20641047] - JamshidKhan Chamani, Hanif Vahedian-Movahed, Mohammad Reza Saberi. Lomefloxacin promotes the interaction between human serum albumin and transferrin: a mechanistic insight into the emergence of antibiotic's side effects.
Journal of pharmaceutical and biomedical analysis.
2011 Apr; 55(1):114-24. doi:
10.1016/j.jpba.2010.12.029. [PMID: 21273024] - H Vahedian-Movahed, M R Saberi, J Chamani. Comparison of binding interactions of lomefloxacin to serum albumin and serum transferrin by resonance light scattering and fluorescence quenching methods.
Journal of biomolecular structure & dynamics.
2011 Feb; 28(4):483-502. doi:
10.1080/07391102.2011.10508590. [PMID: 21142219] - Seiji Hori. [Safety profile of antimicrobial agents].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2011; 131(10):1423-8. doi:
10.1248/yakushi.131.1423. [PMID: 21963968] - M I Davidov. [Treatment of prostatic adenoma with concomitant chronic bacterial prostatitis].
Urologiia (Moscow, Russia : 1999).
2011 Jan; ?(1):21-8. doi:
. [PMID: 21500490] - Shou-fu Wang, Hui-jian Zhang, Jian-sheng Li, Jin-li Qin, Su-yun Li, Hai-bin Yu, Feng Wang, Ya Li, Si-hua Liu. [Effects of Chinese herbal medicine Dusuqing Granule on toll-like receptor 4 signaling in multiple organ injury induced by bacterial pneumonia in aged rats].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2011 Jan; 9(1):84-90. doi:
10.3736/jcim20110114. [PMID: 21227038] - Maluta S Mufamadi, Viness Pillay, Yahya E Choonara, Lisa C Du Toit, Girish Modi, Dinesh Naidoo, Valence M K Ndesendo. A review on composite liposomal technologies for specialized drug delivery.
Journal of drug delivery.
2011; 2011(?):939851. doi:
10.1155/2011/939851. [PMID: 21490759] - Shuyu Xie, Luyan Zhu, Zhao Dong, Yan Wang, Xiaofang Wang, WenZhong Zhou. Preparation and evaluation of ofloxacin-loaded palmitic acid solid lipid nanoparticles.
International journal of nanomedicine.
2011; 6(?):547-55. doi:
10.2147/ijn.s17083. [PMID: 21468357] - Gyan P Mishra, Mahuya Bagui, Viral Tamboli, Ashim K Mitra. Recent applications of liposomes in ophthalmic drug delivery.
Journal of drug delivery.
2011; 2011(?):863734. doi:
10.1155/2011/863734. [PMID: 21490757] - Ayman Goudah, Sherifa Hasabelnaby. Disposition kinetics of levofloxacin in sheep after intravenous and intramuscular administration.
Veterinary medicine international.
2010 Nov; 2010(?):727231. doi:
10.4061/2010/727231. [PMID: 21052556] - M G Chesnokova, A I Novikov, Iu A Novikov, V N Kabanov, T D Solov'eva. [Characteristics of microbiological diagnosis of chronic bacterial prostatitis].
Urologiia (Moscow, Russia : 1999).
2010 Nov; ?(6):47-50. doi:
. [PMID: 21427995] - Christos Chatzikyrkou, Iyas Hamwi, Christian Clajus, Jan Becker, Carsten Hafer, Jan T Kielstein. Biopsy proven acute interstitial nephritis after treatment with moxifloxacin.
BMC nephrology.
2010 Aug; 11(?):19. doi:
10.1186/1471-2369-11-19. [PMID: 20731847] - Emirhan Nemutlu, Sedef Kir, Hakan Eroglu, Doruk Katlan, Aykut Ozek, Özgür Özyüncü, Ozgür Oyüncü, M Sinan Beksaç. Comparison of pharmacokinetic profiles of moxifloxacin in Caesarean versus non-pregnant sectioned women by fully validated HPLC with fluorescence detection.
Combinatorial chemistry & high throughput screening.
2010 Jul; 13(6):502-9. doi:
10.2174/138620710791516003. [PMID: 20426751] - Shuowen Wang, Jun Wen, Lijun Cui, Xiurong Zhang, Hua Wei, Rui Xie, Bo Feng, Yutian Wu, Guorong Fan. Optimization and validation of a high performance liquid chromatography method for rapid determination of sinafloxacin, a novel fluoroquinolone in rat plasma using a fused-core C(18)-silica column.
Journal of pharmaceutical and biomedical analysis.
2010 Mar; 51(4):889-93. doi:
10.1016/j.jpba.2009.09.046. [PMID: 19896316] - A Samie, R L Guerrant, L Barrett, P O Bessong, E O Igumbor, C L Obi. Prevalence of intestinal parasitic and bacterial pathogens in diarrhoeal and non-diarroeal human stools from Vhembe district, South Africa.
Journal of health, population, and nutrition.
2009 Dec; 27(6):739-45. doi:
10.3329/jhpn.v27i6.4325. [PMID: 20099757] - Maria Rambla-Alegre, Josep Esteve-Romero, Samuel Carda-Broch. Validation of a MLC method with fluorescence detection for the determination of quinolones in urine samples by direct injection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Dec; 877(31):3975-81. doi:
10.1016/j.jchromb.2009.10.007. [PMID: 19854116] - Xiaofan Sui, Jin Sun, Haiyan Li, Yongjun Wang, Jianfang Liu, Xiaohong Liu, Wenping Zhang, Lijiang Chen, Zhonggui He. Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
European journal of medicinal chemistry.
2009 Nov; 44(11):4455-60. doi:
10.1016/j.ejmech.2009.06.004. [PMID: 19586686] - Vivyanne S Falcão-Silva, Davi A Silva, Maria de Fátima V Souza, José P Siqueira-Junior. Modulation of drug resistance in Staphylococcus aureus by a kaempferol glycoside from Herissantia tiubae (Malvaceae).
Phytotherapy research : PTR.
2009 Oct; 23(10):1367-70. doi:
10.1002/ptr.2695. [PMID: 19224523] - Sevgi Tatar Ulu. Highly sensitive spectrofluorimetric determination of lomefloxacin in spiked human plasma, urine and pharmaceutical preparations.
European journal of medicinal chemistry.
2009 Sep; 44(9):3402-5. doi:
10.1016/j.ejmech.2009.02.019. [PMID: 19359067] - Hanwen Sun, Peiyun Chen, Fei Wang, Haifang Wen. Investigation on enhanced chemiluminescence reaction systems with bis(hydrogenperiodato) argentate(III) complex anion for fluoroquinolones synthetic antibiotics.
Talanta.
2009 Jul; 79(2):134-40. doi:
10.1016/j.talanta.2009.03.008. [PMID: 19559854] - Qingfa Tang, Tongtong Yang, Xiaomei Tan, Jiabo Luo. Simultaneous determination of fluoroquinolone antibiotic residues in milk sample by solid-phase extraction-liquid chromatography-tandem mass spectrometry.
Journal of agricultural and food chemistry.
2009 Jun; 57(11):4535-9. doi:
10.1021/jf900513b. [PMID: 19432448] - N A Lopatkin, A A Kamalov, E B Mazo, A S Kozdoba, S V Popov, E A Efremov, S D Dorofeev, Ia I Mel'nik, D A Okhobotov. [Vitaprost plus in the treatment of chronic bacterial prostatitis].
Urologiia (Moscow, Russia : 1999).
2009 May; ?(3):54-61. doi:
NULL. [PMID: 19670818] - Constance Chollet, Alessandro Baliani, Pui Ee Wong, Michael P Barrett, Ian H Gilbert. Targeted delivery of compounds to Trypanosoma brucei using the melamine motif.
Bioorganic & medicinal chemistry.
2009 Mar; 17(6):2512-23. doi:
10.1016/j.bmc.2009.01.058. [PMID: 19250832] - Jahye Kim, Hisakazu Ohtani, Masayuki Tsujimoto, Yasufumi Sawada. Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.
Drug metabolism and pharmacokinetics.
2009; 24(2):167-74. doi:
10.2133/dmpk.24.167. [PMID: 19430173] - Ritu Aggarwal, Uma Chaudhary, Rama Sikka. Detection of Extended Spectrum β-lactamase Production Among Uropathogens.
Journal of laboratory physicians.
2009 Jan; 1(1):7-10. doi:
10.4103/0974-2727.44423. [PMID: 21938241] - Tao Ding, Dongxu Shen, Jinzhong Xu, Bin Wu, Huilan Chen, Chongyu Shen, Weijian Shen, Zengyun Zhao, Hongzhen Lian. [Simultaneous determination of 19 quinolone residues in honey using high performance liquid chromatography-tandem mass spectrometry].
Se pu = Chinese journal of chromatography.
2009 Jan; 27(1):34-8. doi:
". [PMID: 19449537] - Sabry M Attia. Abatement by naringin of lomefloxacin-induced genomic instability in mice.
Mutagenesis.
2008 Nov; 23(6):515-21. doi:
10.1093/mutage/gen045. [PMID: 18755759] - Lingli Zhang, Jun Wen, Yaju Pan, Zhen Li, Guorong Fan, Yutian Wu. Determination of ulifloxacin, the active metabolite of prulifloxacin, in human plasma by a 96-well format solid-phase extraction and capillary zone electrophoresis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Sep; 872(1-2):172-6. doi:
10.1016/j.jchromb.2008.07.033. [PMID: 18706872] - Hirotaka Ando, Shigeru Izawa, Wataru Hori, Ippei Nakagawa. Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling.
Theoretical biology & medical modelling.
2008 Aug; 5(?):19. doi:
10.1186/1742-4682-5-19. [PMID: 18687151] - Jian Wang, Zhongfang Liu, Jiangtao Liu, Shaopu Liu, Wei Shen. Study on the interaction between fluoroquinolones and erythrosine by absorption, fluorescence and resonance Rayleigh scattering spectra and their application.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2008 Mar; 69(3):956-63. doi:
10.1016/j.saa.2007.05.057. [PMID: 17618827] - Ashwini Kumar, Ashok Kumar Malik, Dhananjay Kumar Tewary, Baldev Singh. Gradient HPLC of antibiotics in urine, ground water, chicken muscle, hospital wastewater, and pharmaceutical samples using C-18 and RP-amide columns.
Journal of separation science.
2008 Feb; 31(2):294-300. doi:
10.1002/jssc.200700373. [PMID: 18183552] - Nóra Kaszás, Marianna Budai, Lívia Budai, Pál Gróf, Andreas Zimmer, Imre Klebovich. [Methods to increase the encapsulation efficiency for liposomal drugs].
Acta pharmaceutica Hungarica.
2008; 78(2):69-74. doi:
". [PMID: 18807386] - Shoulian Wei, Jiesheng Lin, Haifang Li, Jin-Ming Lin. Separation of seven fluoroquinolones by microemulsion electrokinetic chromatography and application to ciprofloxacin, lomefloxacin determination in urine.
Journal of chromatography. A.
2007 Sep; 1163(1-2):333-6. doi:
10.1016/j.chroma.2007.06.052. [PMID: 17658537] - N T Abdel Ghani, M A El-Ries, M A El-Shall. Validated polarographic methods for the determination of certain antibacterial drugs.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2007 Sep; 23(9):1053-8. doi:
10.2116/analsci.23.1053. [PMID: 17878577] - Florentina Cañada-Cañada, Anunciación Espinosa-Mansilla, Arsenio Muñoz de la Peña. Separation of fifteen quinolones by high performance liquid chromatography: application to pharmaceuticals and ofloxacin determination in urine.
Journal of separation science.
2007 Jun; 30(9):1242-9. doi:
10.1002/jssc.200600536. [PMID: 17623463] - Lun Wang, Ping Yang, Yongxin Li, Hongqi Chen, Maoguo Li, Fabao Luo. A flow injection chemiluminescence method for the determination of fluoroquinolone derivative using the reaction of luminol and hydrogen peroxide catalyzed by gold nanoparticles.
Talanta.
2007 May; 72(3):1066-72. doi:
10.1016/j.talanta.2006.12.050. [PMID: 19071726] - Jian-Quan Lu, Fen Jin, Ting-Quan Sun, Xing-Wang Zhou. Multi-spectroscopic study on interaction of bovine serum albumin with lomefloxacin-copper(II) complex.
International journal of biological macromolecules.
2007 Mar; 40(4):299-304. doi:
10.1016/j.ijbiomac.2006.08.010. [PMID: 17030362] - Shiwang Liu, Li-Wei Zhang, Xin-Xiang Zhang. Interaction between fluoroquinolones and bovine serum albumin studied by affinity capillary electrophoresis.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2006 Dec; 22(12):1515-8. doi:
10.2116/analsci.22.1515. [PMID: 17159308] - Anne-Catherine Huet, Caroline Charlier, Sheryl A Tittlemier, Gurmit Singh, Samuel Benrejeb, Philippe Delahaut. Simultaneous determination of (fluoro)quinolone antibiotics in kidney, marine products, eggs, and muscle by enzyme-linked immunosorbent assay (ELISA).
Journal of agricultural and food chemistry.
2006 Apr; 54(8):2822-7. doi:
10.1021/jf052445i. [PMID: 16608195] - Seiji Hori, Junko Kizu, Masahiro Kawamura. Effect of fluoroquinolones on plasma glucose levels in fasted and glucose-loaded mice.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2006 Apr; 12(2):109-11. doi:
10.1007/s10156-006-0429-z. [PMID: 16648952] - Hua He, Hai-ying Ye, Li Dai, Qing-cai Jiao, Pham-huy Chuong. [Study on the interaction of lomefloxacin terbium complex and bovine serum albumin by fluorescence spectra].
Guang pu xue yu guang pu fen xi = Guang pu.
2006 Mar; 26(3):480-3. doi:
NULL. [PMID: 16830760] - R S Ray, N Agrawal, R B Misra, M Farooq, R K Hans. Radiation-induced in vitro phototoxic potential of some fluoroquinolones.
Drug and chemical toxicology.
2006 Jan; 29(1):25-38. doi:
10.1080/01480540500408572. [PMID: 16455588] - Hiroyuki Sasabe, Yukio Kato, Takashi Suzuki, Minoru Itose, Gohachiro Miyamoto, Yuichi Sugiyama. Carrier-mediated uptake of grepafloxacin, a fluoroquinolone antibiotic, by the isolated rat lung cells.
Drug metabolism and pharmacokinetics.
2005 Dec; 20(6):491-5. doi:
10.2133/dmpk.20.491. [PMID: 16415534] - M A El Ries, A A Wassel, N T Abdel Ghani, M A El-Shall. Electrochemical adsorptive behavior of some fluoroquinolones at carbon paste electrode.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2005 Oct; 21(10):1249-54. doi:
10.2116/analsci.21.1249. [PMID: 16270589] - Richard A Brain, David J Johnson, Sean M Richards, Hans Sanderson, Paul K Sibley, Keith R Solomon. Effects of 25 pharmaceutical compounds to Lemna gibba using a seven-day static-renewal test.
Environmental toxicology and chemistry.
2004 Feb; 23(2):371-82. doi:
10.1897/02-576. [PMID: 14982384] - Michael E El-Kommos, Gamal A Saleh, Samia M El-Gizawi, Mohamed A Abou-Elwafa. Spectrofluorometric determination of certain quinolone antibacterials using metal chelation.
Talanta.
2003 Jul; 60(5):1033-50. doi:
10.1016/s0039-9140(03)00171-1. [PMID: 18969129] - Roberto Leone, Mauro Venegoni, Domenico Motola, Ugo Moretti, Valentina Piazzetta, Alfredo Cocci, Domenico Resi, Federico Mozzo, Giampaolo Velo, Liliana Burzilleri, Nicola Montanaro, Anita Conforti. Adverse drug reactions related to the use of fluoroquinolone antimicrobials: an analysis of spontaneous reports and fluoroquinolone consumption data from three italian regions.
Drug safety.
2003; 26(2):109-20. doi:
10.2165/00002018-200326020-00004. [PMID: 12534327] - Li-Hua Nie, Hui-Chun Zhao, Xu Wang, Lin Yi, Yan Lu, Lin-Pei Jin, Hui-Min Ma. Determination of lomefloxacin by terbium sensitized chemiluminescence method.
Analytical and bioanalytical chemistry.
2002 Dec; 374(7-8):1187-90. doi:
10.1007/s00216-002-1553-y. [PMID: 12474083] - G Miolo, G Viola, D Vedaldi, F Dall'Acqua, A Fravolini, O Tabarrini, V Cecchetti. In vitro phototoxic properties of new 6-desfluoro and 6-fluoro-8-methylquinolones.
Toxicology in vitro : an international journal published in association with BIBRA.
2002 Dec; 16(6):683-93. doi:
10.1016/s0887-2333(02)00093-0. [PMID: 12423651] - Karthick Vishwanathan, Michael G Bartlett, James T Stewart. Determination of moxifloxacin in human plasma by liquid chromatography electrospray ionization tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2002 Nov; 30(4):961-8. doi:
10.1016/s0731-7085(02)00393-x. [PMID: 12408886] - Shailesh A Shah, Ishwarsinh S Rathod, Shrinivas S Savale, Dharmesh B Patel. Determination of bioequivalence of lomefloxacin tablets using urinary excretion data.
Journal of pharmaceutical and biomedical analysis.
2002 Nov; 30(4):1319-29. doi:
10.1016/s0731-7085(02)00453-3. [PMID: 12408922] - Qiuhong Li, Kohji Naora, Hidenari Hirano, Hideki Okunishi, Kikuo Iwamoto. Comparative study on salivary distribution of fluoroquinolones in rats.
Biological & pharmaceutical bulletin.
2002 Aug; 25(8):1084-9. doi:
10.1248/bpb.25.1084. [PMID: 12186414] - Mineko Nagasawa, Shozo Nakamura, Miyono Miyazaki, Yasuyuki Nojima, Hiroyoshi Hayakawa, Yasuhito Kawamura. [Phototoxicity studies of pazufloxacin mesilate, a novel parenteral quinolone antimicrobial agent--in vitro and in vivo studies].
The Japanese journal of antibiotics.
2002 Jun; 55(3):259-69. doi:
. [PMID: 12199110] - Qing-qin Xu, Li-ming Du, Jing-ping Wang. [Study on the direct determination of lomefloxacin in urine by derivative-synchronous fluorescence].
Guang pu xue yu guang pu fen xi = Guang pu.
2002 Jun; 22(3):444-5. doi:
. [PMID: 12938329] - Mehdi Shakibaei, Irmela Baumann-Wilschke, Marcus Rücker, Ralf Stahlmann. Ultrastructural characterization of murine limb buds after in vitro exposure to grepafloxacin and other fluoroquinolones.
Archives of toxicology.
2002 Jan; 75(11-12):725-33. doi:
10.1007/s00204-001-0293-7. [PMID: 11876506] - L R Baden, G Horowitz, H Jacoby, G M Eliopoulos. Quinolones and false-positive urine screening for opiates by immunoassay technology.
JAMA.
2001 Dec; 286(24):3115-9. doi:
10.1001/jama.286.24.3115. [PMID: 11754677] - A S Melani, M Pirrelli, F Sarlo, V Cantoni. Safety and effectiveness of lomefloxacin in patients with acute exacerbation of chronic bronchitis (AECB) chronically treated with oral theophyllines.
Journal of chemotherapy (Florence, Italy).
2001 Dec; 13(6):628-34. doi:
10.1179/joc.2001.13.6.628. [PMID: 11806624] - M Cazzola, M G Matera, M A Tufano, P Catalanotti, M Polverino, V Cantoni, F Fici, F Sarlo, F Rossi. Pulmonary disposition of lomefloxacin in patients with acute exacerbation of chronic obstructive pulmonary disease. A multiple-dose study.
Journal of chemotherapy (Florence, Italy).
2001 Aug; 13(4):407-12. doi:
10.1179/joc.2001.13.4.407. [PMID: 11589484] - J L Vílchez, L Araujo, A Prieto, A Navalón. Differential-pulse adsorptive stripping voltammetric determination of the antibacterial lomefloxacin.
Journal of pharmaceutical and biomedical analysis.
2001 Aug; 26(1):23-9. doi:
10.1016/s0731-7085(01)00391-0. [PMID: 11451639] - M T Maya, N J Gonçalves, N B Silva, J A Morais. Simple high-performance liquid chromatographic assay for the determination of ciprofloxacin in human plasma with ultraviolet detection.
Journal of chromatography. B, Biomedical sciences and applications.
2001 May; 755(1-2):305-9. doi:
10.1016/s0378-4347(01)00126-8. [PMID: 11393718] - A Alvarez-Lueje, C López, L J Núñez-Vergara, J A Squella. Voltammetric behavior and analytical applications of lomefloxacin, an antibacterial fluorquinolone.
Journal of AOAC International.
2001 May; 84(3):649-58. doi:
10.1093/jaoac/84.3.649. [PMID: 11417626] - S Scelzi, F Travaglini, S Nerozzi, A Dominici, R Ponchietti, A Novelli, M Rizzo. The role of lomefloxacin in the treatment of chronic prostatitis.
Journal of chemotherapy (Florence, Italy).
2001 Feb; 13(1):82-7. doi:
10.1179/joc.2001.13.1.82. [PMID: 11233805] - H de Vries, G M van Henegouwen. Photochemical decomposition of lomefloxacin in vitro and in vivo.
Journal of photochemistry and photobiology. B, Biology.
2000 Oct; 58(1):6-12. doi:
10.1016/s1011-1344(00)00103-2. [PMID: 11195854] - K Shimoda, T Ikeda, S Okawara, M Kato. Possible relationship between phototoxicity and photodegradation of sitafloxacin, a quinolone antibacterial agent, in the auricular skin of albino mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2000 Aug; 56(2):290-6. doi:
10.1093/toxsci/56.2.290. [PMID: 10910986] - K A Al-Rashood, K I Al-Khamis, Y M El-Sayed, S Al-Bella, M A Al-Yamani, S M Alam, R Dham. Bioequivalence evaluation of lomefloxacin 400 mg tablets (Lomax versus Maxaquin in healthy human volunteers.
Biopharmaceutics & drug disposition.
1999 Dec; 20(9):407-10. doi:
10.1002/1099-081x(199912)20:9<407::aid-bdd199>3.0.co;2-f. [PMID: 10951428] - A Kawada, K Hatanaka, H Gomi, I Matsuo. In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation.
Photodermatology, photoimmunology & photomedicine.
1999 Dec; 15(6):226-30. doi:
10.1111/j.1600-0781.1999.tb00094.x. [PMID: 10599972] - R Ohashi, I Tamai, H Yabuuchi, J I Nezu, A Oku, Y Sai, M Shimane, A Tsuji. Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
The Journal of pharmacology and experimental therapeutics.
1999 Nov; 291(2):778-84. doi:
. [PMID: 10525100] - H Sasabe, Y Kato, T Terasaki, A Tsuji, Y Sugiyama. Differences in the hepatobiliary transport of two quinolone antibiotics, grepafloxacin and lomefloxacin, in the rat.
Biopharmaceutics & drug disposition.
1999 Apr; 20(3):151-8. doi:
10.1002/(sici)1099-081x(199904)20:3<151::aid-bdd168>3.0.co;2-p. [PMID: 10211868] - M Zhao, S Jiang, R Wang. [The serum bactericidal activity of domestic fleroxacin and lomefloxacin].
Zhonghua nei ke za zhi.
1999 Feb; 38(2):98-100. doi:
NULL. [PMID: 11798634] - C Förster, M Rücker, M Shakibaei, I Baumann-Wilschke, J Vormann, R Stahlmann. Effects of fluoroquinolones and magnesium deficiency in murine limb bud cultures.
Archives of toxicology.
1998 Jun; 72(7):411-9. doi:
10.1007/s002040050521. [PMID: 9708880] - K G Naber, M Well, K Hollauer, D Kirchbauer, W Witte. In vitro activity of enoxacin versus ciprofloxacin, fleroxacin, lomefloxacin, ofloxacin, pefloxacin, and rufloxacin against uropathogens.
Chemotherapy.
1998 Mar; 44(2):77-84. doi:
10.1159/000007096. [PMID: 9551236] - V P Iakovlev. [Comparative pharmacokinetics of lomefloxacin and other fluoroquinolones].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic].
1998; 43(10):46-52. doi:
NULL. [PMID: 9825111] - P P Elena, A Jauch. Ocular distribution of lomefloxacin 0.3\% after a single instillation in the infected eye of pigmented rabbits.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
1997 Dec; 13(6):551-8. doi:
10.1089/jop.1997.13.551. [PMID: 9436158]
