Tirofiban (BioDeep_00001868184)
Main id: BioDeep_00000006640
代谢物信息卡片
Tirofiban
化学式: C22H36N2O5S (440.23448060000004)
中文名称: 替罗非班
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCS(=O)(=O)NC(CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O
InChI: InChI=1S/C22H36N2O5S/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26)/t21-/m0/s1
描述信息
B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AC - Platelet aggregation inhibitors excl. heparin
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents
D050299 - Fibrin Modulating Agents
D002317 - Cardiovascular Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:9605
- KEGG: C07965
- KEGGdrug: D08607
- PubChem: 60947
- DrugBank: DB00775
- ChEMBL: CHEMBL916
- MeSH: Tirofiban
- CAS: 144494-65-5
- PubChem: 10166
- PDB-CCD: AGG
- NIKKAJI: J523.557J
- RefMet: Tirofiban
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jun Zhang, Xin Huang, Guoqing Wang, Xianjun Wang, Tao Zhang, Dong Wang, Lifeng Qi, Jiye Liang, Bing Li, Jianfeng Chu, Kai Li, Lili Sun, Yun Song, Wei Zhao, Meimei Zheng, Yao Meng, Hao Yin, Wei Wang, Ju Han. Efficacy and Safety of Tirofiban Before Stenting for Symptomatic Intracranial Atherosclerotic Stenosis: A Randomized Clinical Trial.
Neurology.
2024 Apr; 102(7):e209217. doi:
10.1212/wnl.0000000000209217. [PMID: 38489544] - Hongfei Sang, Zhihua Cao, Jie Du, Thanh N Nguyen, Jeffrey L Saver, An Mao, Raul G Nogueira, Zhaojun Tao, Simin Zhou, Qin Han, Dong Sun, Bo Lei, Shudong Liu, Guoyong Zeng, Congguo Yin, Dongjing Xie, Weidong Luo, Zhenglong Jin, Zhongming Qiu. Intravenous Tirofiban Versus Alteplase Before Endovascular Treatment in Acute Ischemic Stroke: A Pooled Analysis of the DEVT and RESCUE BT Trials.
Stroke.
2024 Apr; 55(4):856-865. doi:
10.1161/strokeaha.123.044562. [PMID: 38362756] - Haiyan Xie, Ying Chen, Wukun Ge, Xiuping Xu, Chengjiang Liu, Zhiyong Lan, Yina Yang. Does Endovascular Thrombectomy(ET) plus tirofiban benefit stroke patients: A systematic review and meta-analysis.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2024 Jan; 33(1):107494. doi:
10.1016/j.jstrokecerebrovasdis.2023.107494. [PMID: 38035642] - Wenjie Zi, Jiaxing Song, Weilin Kong, Jiacheng Huang, Changwei Guo, Wencheng He, Yinquan Yu, Bo Zhang, Wanjie Geng, Xiaolin Tan, Yaoyu Tian, Zongtao Liu, Minghua Cao, Daoyou Cheng, Bo Li, Wenguo Huang, Junsheng Liu, Pengfei Wang, Zhou Yu, Hao Liang, Shuang Yang, Mingshan Tang, Wenhua Liu, Xianjun Huang, Shugai Liu, Yufeng Tang, Youlin Wu, Li Yao, Zhu Shi, Pengcheng He, Haojin Zhao, Zhuo Chen, Jun Luo, Yue Wan, Qiang Shi, Maorong Wang, De Yang, Xianglin Chen, Fang Huang, Jinlin Mu, Hao Li, Zhimin Li, Jingbang Zheng, Shunli Xie, Tieying Cai, Yuqi Peng, Weihua Xie, Zhongming Qiu, Chang Liu, Chengsong Yue, Linyu Li, Yan Tian, Dahong Yang, Jian Miao, Jie Yang, Jinrong Hu, Raul G Nogueira, Duolao Wang, Jeffrey L Saver, Fengli Li, Qingwu Yang. Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion.
The New England journal of medicine.
2023 Jun; 388(22):2025-2036. doi:
10.1056/nejmoa2214299. [PMID: 37256974] - Chong Liu, Lu Yin, Yinqin Hu, Zhizhen Shi, Qiaoyan Zhu, Qian Xiao, Guoyi Li, Jiwei Cheng, Yangbo Hou. Analysis of risk factors for the efficacy of tirofiban in the treatment of acute ischemic stroke.
Neurological research.
2023 Jun; 45(6):538-543. doi:
10.1080/01616412.2022.2164447. [PMID: 36599001] - Hongfei Sang, Jiacheng Huang, Bingwu Jiang, Qifeng Guo, Thanh N Nguyen, Mohamad Abdalkader, Qin Han, Simin Zhou, Zhaojun Tao, An Mao, Zhizhong Yan, Jie Du, Ying Jin, Chuming Huang, Tianzhu Liu, Wenlong Zhao, Gangfeng Gu, Li Wang, Shugai Liu, Shiwei Luo, Jie Pu, Jinrong Hu, Jie Yang, Fengli Li, Wenjie Zi, Xiaogang Hu, Zhongming Qiu. Association between intravenous tirofiban and intracranial hemorrhage in acute large vessel occlusion stroke: insight from the RESCUE BT randomized placebo-controlled trial.
Journal of neurology.
2023 Jan; ?(?):. doi:
10.1007/s00415-023-11579-4. [PMID: 36697890] - Zhongming Qiu, Fengli Li, Hongfei Sang, Weidong Luo, Shuai Liu, Wenhua Liu, Zhangbao Guo, Huagang Li, Dong Sun, Wenguo Huang, Min Zhang, Min Zhang, Weipeng Dai, Peiyang Zhou, Wei Deng, Zhiming Zhou, Xianjun Huang, Bo Lei, Jinglun Li, Zhengzhou Yuan, Bo Song, Jian Miao, Shudong Liu, Zhenglong Jin, Guoyong Zeng, Hongliang Zeng, Junjie Yuan, Changming Wen, Yang Yu, Guangxiong Yuan, Junxiong Wu, Chen Long, Jun Luo, Zhenxuan Tian, Chong Zheng, Zhizhou Hu, Shouchun Wang, Tao Wang, Li Qi, Rongzong Li, Yue Wan, Yingbing Ke, Youlin Wu, Xiurong Zhu, Weilin Kong, Jiacheng Huang, Daizhou Peng, Mingze Chang, Hanming Ge, Zhonghua Shi, Zhizhong Yan, Jie Du, Ying Jin, Dongsheng Ju, Chuming Huang, Yifan Hong, Tianzhu Liu, Wenlong Zhao, Jian Wang, Bo Zheng, Li Wang, Shugai Liu, Xiaojun Luo, Shiwei Luo, Xinwei Xu, Jinrong Hu, Jie Pu, Shengli Chen, Yaxuan Sun, Shunfu Jiang, Liping Wei, Xinmin Fu, Yongjie Bai, Shunyu Yang, Wei Hu, Guling Zhang, Chengde Pan, Shuai Zhang, Yan Wang, Wenfeng Cao, Shiquan Yang, Jun Zhang, Fuqiang Guo, Hongbin Wen, Jinhua Zhang, Jiaxing Song, Chengsong Yue, Linyu Li, Deping Wu, Yan Tian, Jie Yang, Mengjie Lu, Jeffrey L Saver, Raul G Nogueira, Wenjie Zi, Qingwu Yang. Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke: The RESCUE BT Randomized Clinical Trial.
JAMA.
2022 08; 328(6):543-553. doi:
10.1001/jama.2022.12584. [PMID: 35943471] - Wei Tian, Taimin Zhang, Yan Gao, Zhangchao Yang, Hua Yang. Efficacy and safety assessment of urokinase plus tirofiban in acute cerebral infarction patients without clear criminal vessels.
Pakistan journal of pharmaceutical sciences.
2022 May; 35(3(Special)):878-883. doi:
. [PMID: 35791582] - N Du, L-X Wang, Y-L Liu, X-L Yin, J-S Zhao, L Yang. Effect of tirofiban in treating patients with progressive ischemic stroke.
European review for medical and pharmacological sciences.
2022 03; 26(6):2098-2105. doi:
10.26355/eurrev_202203_28357. [PMID: 35363359] - Rui Peng, Feng Li. The Clinical Efficacy of Tirofiban Combined with Ticagrelor and Aspirin in Treating Acute Myocardial Infarction by Percutaneous Coronary Intervention and Its Effect on Patients' Cardiac Function.
Journal of healthcare engineering.
2022; 2022(?):4708572. doi:
10.1155/2022/4708572. [PMID: 35186231] - Fang Li, Shuhui Wang, Lei Wang, Feng Liu, Zhen Meng, Jia Liu. The Effects of Ticagrelor Combined with Tirofiban on Coagulation Function, Serum Myocardial Injury Markers, and Inflammatory Factor Levels in Patients with Acute Myocardial Infarction after Percutaneous Coronary Intervention.
Computational and mathematical methods in medicine.
2022; 2022(?):4217270. doi:
10.1155/2022/4217270. [PMID: 35529262] - Li Deng, Hai-Zhen Jia, Mao-Chun Li, Wei Zhu. Comparison of the effect of ticagrelor combined with tirofiban versus clopidogrel combined with tirofiban on inflammation response and prognosis of patients with unstable angina pectoris in long term follow-up.
The Kaohsiung journal of medical sciences.
2021 Nov; 37(11):1010-1015. doi:
10.1002/kjm2.12421. [PMID: 34338425] - Wenbo Zhao, Jiali Xu, Sijie Li, Guiyou Liu, Longfei Wu, Chuanhui Li, Chuanjie Wu, Changhong Ren, Jian Chen, Jiangang Duan, Ruixian Wang, Haiqing Song, Qingfeng Ma, Xunming Ji. Low-dose tirofiban is associated with reduced in-hospital mortality in cardioembolic stroke patients treated with endovascular thrombectomy.
Journal of the neurological sciences.
2021 Aug; 427(?):117539. doi:
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BMC neurology.
2021 Jan; 21(1):4. doi:
10.1186/s12883-020-02033-3. [PMID: 33397310] - Maoling Xu, Cun Zhang, Xiuzhen Yu, Lele Zhu, Hong Tan, Cong Wang, Lingshi Zhao, Zhihua Zhao. Application effect of tirofiban on percutaneous coronary intervention in patients with acute coronary syndrome and its postoperative effect on C-X-C motif chemokine ligand 16 level and myocardial perfusion.
Pakistan journal of pharmaceutical sciences.
2021 Jan; 34(1(Special)):465-472. doi:
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The Pan African medical journal.
2021; 38(?):9. doi:
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2020 Oct; 80(?):112-120. doi:
10.1016/j.jocn.2020.07.040. [PMID: 33099332] - Maurizio Viecca, Dejan Radovanovic, Giovanni Battista Forleo, Pierachille Santus. Enhanced platelet inhibition treatment improves hypoxemia in patients with severe Covid-19 and hypercoagulability. A case control, proof of concept study.
Pharmacological research.
2020 08; 158(?):104950. doi:
10.1016/j.phrs.2020.104950. [PMID: 32450344] - Nicola Corcione, Martino Pepe, Paolo Ferraro, Alberto Morello, Sirio Conte, Raffaella Avellino, Elena Cavarretta, Eugenio Carulli, Giuseppe Biondi-Zoccai, Arturo Giordano. Impact of Tirofiban on Serum Troponin Changes in Patients Undergoing Carotid Artery Stenting: A Propensity Matched Analysis.
Annals of vascular surgery.
2020 Apr; 64(?):151-156.e2. doi:
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Journal of medicinal chemistry.
2019 08; 62(16):7417-7430. doi:
10.1021/acs.jmedchem.9b00360. [PMID: 31306009] - Ming Yang, Xiaochuan Huo, Zhongrong Miao, Yongjun Wang. Platelet Glycoprotein IIb/IIIa Receptor Inhibitor Tirofiban in Acute Ischemic Stroke.
Drugs.
2019 Apr; 79(5):515-529. doi:
10.1007/s40265-019-01078-0. [PMID: 30838514] - Rajiv A Kabadi, Ilya M Danelich, John W Entwistle, Gregary D Marhefka, Gordon Reeves, Andrew J Boyle, Ataul M Qureshi. Use of Cangrelor as a Bridge to Left Ventricular Assist Device Implantation in a Patient with a Recent Drug-Eluting Stent Who Developed Acute Tirofiban-Related Thrombocytopenia.
Pharmacotherapy.
2019 04; 39(4):521-525. doi:
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2019 03; 12(1):26. doi:
10.1186/s13045-019-0709-6. [PMID: 30845955] - Shih-Tai Chang, Ya-Ting Yang, Chi-Ming Chu, Kuo-Li Pan, Jen-Te Hsu, Ju-Feng Hsiao, Yu-Sheng Lin, Chang-Min Chung. Protein kinases are involved in the cardioprotective effects activated by platelet glycoprotein IIb/IIIa inhibitor tirofiban at reperfusion in rats in vivo.
European journal of pharmacology.
2018 Aug; 832(?):33-38. doi:
10.1016/j.ejphar.2018.05.014. [PMID: 29778748] - Elizabeth A Walker, William E Dager. Bridging with Tirofiban during Oral Antiplatelet Interruption: A Single-Center Case Series Analysis Including Patients on Hemodialysis.
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2017 Aug; 37(8):888-892. doi:
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Drug design, development and therapy.
2017; 11(?):3299-3307. doi:
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2016 Feb; 5(1):33-42. doi:
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European journal of pharmacology.
2015 Aug; 761(?):144-52. doi:
10.1016/j.ejphar.2015.05.009. [PMID: 25981297] - Shih-Tai Chang, Chang-Min Chung, Chi-Ming Chu, Teng-Yao Yang, Kuo-Li Pan, Jen-Te Hsu, Ju-Feng Hsiao. Platelet Glycoprotein IIb/IIIa Inhibitor Tirofiban Ameliorates Cardiac Reperfusion Injury.
International heart journal.
2015 May; 56(3):335-40. doi:
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Chinese medical journal.
2013 Aug; 126(16):3079-86. doi:
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International journal of cardiology.
2013 May; 165(3):437-43. doi:
10.1016/j.ijcard.2011.08.082. [PMID: 21940058] - Duane B Lakings, Michael C Janzen, David J Schneider. Pharmacokinetic modeling of the high-dose bolus regimen of tirofiban in patients with severe renal impairment.
Coronary artery disease.
2012 May; 23(3):208-14. doi:
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PloS one.
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Biomaterials.
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International journal of cardiology.
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Heart and vessels.
2011 Mar; 26(2):131-7. doi:
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Korean circulation journal.
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Biomarkers in medicine.
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PloS one.
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2010 Jan; 16(1):38-41. doi:
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Ultrasonic imaging.
2009 Oct; 31(4):235-46. doi:
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Clinical cardiology.
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Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2009 Apr; 20(3):197-206. doi:
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The American heart hospital journal.
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Critical care (London, England).
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The American journal of cardiology.
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American journal of respiratory and critical care medicine.
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Life sciences.
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BMC cardiovascular disorders.
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The journal of extra-corporeal technology.
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Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.
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