3,3-DIMETHOXYBENZIDINE (BioDeep_00001868120)

Main id: BioDeep_00000003586

 


代谢物信息卡片


3,3-Dimethoxybiphenyl-4,4-diamine

化学式: C14H16N2O2 (244.1212)
中文名称: 3,3-二甲氧基联苯胺, 3,3'-二甲氧基联苯胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=CC(=C1)C2=CC(=C(C=C2)N)OC)N
InChI: InChI=1S/C14H16N2O2/c1-17-13-7-9(3-5-11(13)15)10-4-6-12(16)14(8-10)18-2/h3-8H,15-16H2,1-2H3



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, AOC3, CAT, DAO, G6PD
Peripheral membrane protein 6 ACHE, ALAS2, AOC1, DAO, G6PD, HSD17B6
Nucleus 6 ACHE, ALB, FLI1, GATA1, KDR, MPO
cytosol 8 ALB, CAT, DAO, FLI1, G6PD, GSR, MB, TNNT2
nuclear body 1 FLI1
centrosome 1 ALB
nucleoplasm 3 FLI1, GATA1, MPO
Cell membrane 5 ACHE, AOC1, AOC3, DAO, KDR
Early endosome membrane 1 HSD17B6
Synapse 1 ACHE
cell junction 1 KDR
cell surface 3 ACHE, AOC3, EPO
Golgi apparatus 4 ACHE, ALB, AOC3, KDR
lysosomal membrane 1 CP
mitochondrial inner membrane 1 ALAS2
neuromuscular junction 1 ACHE
Cytoplasm, cytosol 2 DAO, G6PD
Lysosome 1 MPO
endosome 1 KDR
plasma membrane 6 ACHE, AOC1, AOC3, CP, DAO, KDR
presynaptic active zone 1 DAO
Membrane 4 ACHE, AOC3, CAT, G6PD
extracellular exosome 12 ALB, AOC1, CAT, CP, DAO, EPO, G6PD, GSR, HP, LYZ, MB, MPO
Lumenal side 1 HSD17B6
endoplasmic reticulum 4 ALB, AOC3, HSD17B6, KDR
extracellular space 9 ACHE, ALB, AOC1, CP, DAO, EPO, HP, LYZ, MPO
perinuclear region of cytoplasm 1 ACHE
bicellular tight junction 2 AOC1, DAO
mitochondrion 3 ALAS2, CAT, GSR
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 4 CAT, G6PD, HSD17B6, MPO
Microsome membrane 1 HSD17B6
Secreted 6 ACHE, ALB, CP, DAO, EPO, HP
extracellular region 11 ACHE, ALB, AOC1, CAT, CP, DAO, EPO, HP, KDR, LYZ, MPO
cytoplasmic side of plasma membrane 1 G6PD
[Isoform 2]: Secreted 1 KDR
mitochondrial matrix 3 ALAS2, CAT, GSR
Extracellular side 3 ACHE, AOC1, DAO
anchoring junction 2 ALB, KDR
transcription regulator complex 1 GATA1
centriolar satellite 1 G6PD
external side of plasma membrane 2 GSR, KDR
sarcoplasm 1 MB
Early endosome 2 AOC3, KDR
Single-pass type II membrane protein 1 AOC3
Mitochondrion inner membrane 1 ALAS2
Membrane raft 1 KDR
focal adhesion 1 CAT
Peroxisome 3 AOC1, CAT, DAO
basement membrane 1 ACHE
Peroxisome matrix 2 CAT, DAO
peroxisomal matrix 2 CAT, DAO
peroxisomal membrane 1 CAT
secretory granule 1 MPO
sarcomere 1 TNNT2
receptor complex 1 KDR
ciliary basal body 1 ALB
chromatin 2 FLI1, GATA1
cell projection 1 DAO
centriole 1 ALB
Secreted, extracellular space 2 AOC1, DAO
spindle pole 1 ALB
blood microparticle 3 ALB, CP, HP
Lipid-anchor, GPI-anchor 1 ACHE
sorting endosome 1 KDR
microvillus 1 AOC3
cell body 1 EPO
side of membrane 1 ACHE
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, EPO
endoplasmic reticulum lumen 2 ALB, CP
transcription repressor complex 1 GATA1
platelet alpha granule lumen 1 ALB
specific granule lumen 4 AOC1, DAO, HP, LYZ
tertiary granule lumen 2 HP, LYZ
azurophil granule lumen 2 LYZ, MPO
phagocytic vesicle lumen 1 MPO
synaptic cleft 1 ACHE
protein-DNA complex 1 GATA1
endocytic vesicle lumen 1 HP
haptoglobin-hemoglobin complex 1 HP
Cytoplasm, sarcoplasm 1 MB
cardiac myofibril 1 TNNT2
troponin complex 1 TNNT2
catalase complex 1 CAT
cardiac Troponin complex 1 TNNT2
[Isoform H]: Cell membrane 1 ACHE
[Isoform 4]: Mitochondrion inner membrane 1 ALAS2
striated muscle thin filament 1 TNNT2
ciliary transition fiber 1 ALB


文献列表

  • Vani Nagaraja, M Kiran Kumar, Nagendrappa Giddappa. Spectrophotometric determination of gold(III) in forensic and pharmaceutical samples and results complemented with ICP AES and EDXRF analysis. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2017 Feb; 173(?):407-417. doi: 10.1016/j.saa.2016.09.045. [PMID: 27701047]
  • Veda P Pandey, Upendra N Dwivedi. A ripening associated peroxidase from papaya having a role in defense and lignification: heterologous expression and in-silico and in-vitro experimental validation. Gene. 2015 Jan; 555(2):438-47. doi: 10.1016/j.gene.2014.11.013. [PMID: 25447898]
  • Mariacristina Siotto, Patrizio Pasqualetti, Massimo Marano, Rosanna Squitti. Automation of o-dianisidine assay for ceruloplasmin activity analyses: usefulness of investigation in Wilson's disease and in hepatic encephalopathy. Journal of neural transmission (Vienna, Austria : 1996). 2014 Oct; 121(10):1281-6. doi: 10.1007/s00702-014-1196-0. [PMID: 24663495]
  • D V Grigorieva, I V Gorudko, A V Sokolov, O V Kosmachevskaya, A F Topunov, I V Buko, E E Konstantinova, S N Cherenkevich, O M Panasenko. Measurement of plasma hemoglobin peroxidase activity. Bulletin of experimental biology and medicine. 2013 May; 155(1):118-21. doi: 10.1007/s10517-013-2095-3. [PMID: 23667888]
  • Harun Alp, Sefer Varol, Muhammet Murat Celik, Murat Altas, Osman Evliyaoglu, Orhan Tokgoz, Mehmet Halis Tanrıverdi, Ertugrul Uzar. Protective effects of beta glucan and gliclazide on brain tissue and sciatic nerve of diabetic rats induced by streptozosin. Experimental diabetes research. 2012; 2012(?):230342. doi: 10.1155/2012/230342. [PMID: 22291696]
  • Nazaret Hidalgo Cuadrado, Galina G Zhadan, Manuel G Roig, Valery L Shnyrov. Suicide inactivation of peroxidase from Chamaerops excelsa palm tree leaves. International journal of biological macromolecules. 2011 Dec; 49(5):1078-82. doi: 10.1016/j.ijbiomac.2011.09.001. [PMID: 21925205]
  • In-Seok Jang, Mi-Young Park, Il-Woo Shin, Ju-Tae Sohn, Heon-Keun Lee, Young-Kyun Chung. Ethyl pyruvate has anti-inflammatory and delayed myocardial protective effects after regional ischemia/reperfusion injury. Yonsei medical journal. 2010 Nov; 51(6):838-44. doi: 10.3349/ymj.2010.51.6.838. [PMID: 20879048]
  • Uta Merle, Christoph Eisenbach, Karl Heinz Weiss, Sabine Tuma, Wolfgang Stremmel. Serum ceruloplasmin oxidase activity is a sensitive and highly specific diagnostic marker for Wilson's disease. Journal of hepatology. 2009 Nov; 51(5):925-30. doi: 10.1016/j.jhep.2009.06.022. [PMID: 19720421]
  • I V Gorudko, O S Cherkalina, A V Sokolov, M O Pulina, E T Zakharova, V B Vasil'ev, S N Cherenkevich, O M Panasenko. [New approaches to the measurement of the concentration and peroxidase activity of myeloperoxidase in human blood plasma]. Bioorganicheskaia khimiia. 2009 Sep; 35(5):629-39. doi: 10.1134/s1068162009050057. [PMID: 19915640]
  • A V Chasov, F V Minibayeva. Effect of exogenous phenols on superoxide production by extracellular peroxidase from wheat seedling roots. Biochemistry. Biokhimiia. 2009 Jul; 74(7):766-74. doi: 10.1134/s0006297909070098. [PMID: 19747097]
  • H Tayefi-Nasrabadi, Gh Moghaddam, Z Rajabi. Effect of zinc ion on peroxidase activity of serum in cow. Pakistan journal of biological sciences : PJBS. 2008 Nov; 11(22):2589-93. doi: 10.3923/pjbs.2008.2589.2593. [PMID: 19260338]
  • Chao Wang, Song He Zhang, Pei Fang Wang, Jun Hou, Wei Li, Wen Jing Zhang. Metabolic adaptations to ammonia-induced oxidative stress in leaves of the submerged macrophyte Vallisneria natans (Lour.) Hara. Aquatic toxicology (Amsterdam, Netherlands). 2008 Apr; 87(2):88-98. doi: 10.1016/j.aquatox.2008.01.009. [PMID: 18304660]
  • Elena García-Martín, Pedro Ayuso, Carmen Martínez, José A G Agúndez. Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individuals. Clinical biochemistry. 2007 Nov; 40(16-17):1339-41. doi: 10.1016/j.clinbiochem.2007.07.019. [PMID: 17826755]
  • Patrudu Makena, King-Thom Chung. Evidence that 4-aminobiphenyl, benzidine, and benzidine congeners produce genotoxicity through reactive oxygen species. Environmental and molecular mutagenesis. 2007 Jun; 48(5):404-13. doi: 10.1002/em.20288. [PMID: 17370336]
  • Dmitri M Hushpulian, Andrew A Poloznikov, Pavel A Savitski, Alexandra M Rozhkova, Tatyana A Chubar, Victoria A Fechina, Marina A Orlova, Vladimir I Tishkov, Irina G Gazaryan, L Mark Lagrimini. Glutamic acid-141: a heme 'bodyguard' in anionic tobacco peroxidase. Biological chemistry. 2007 Apr; 388(4):373-80. doi: 10.1515/bc.2007.050. [PMID: 17391058]
  • Ezzatollah Keyhani, Lila Ghamsari, Jacqueline Keyhani, Mahnaz Hadizadeh. Antioxidant enzymes during hypoxia-anoxia signaling events in Crocus sativus L. corm. Annals of the New York Academy of Sciences. 2006 Dec; 1091(?):65-75. doi: 10.1196/annals.1378.055. [PMID: 17341603]
  • Ananda Mookerjee, Jayati Mookerjee Basu, Surajit Majumder, Shilpak Chatterjee, Gouri S Panda, Pranabananda Dutta, Smarajit Pal, Pratima Mukherjee, Thomas Efferth, Syamal Roy, Soumitra K Choudhuri. A novel copper complex induces ROS generation in doxorubicin resistant Ehrlich ascitis carcinoma cells and increases activity of antioxidant enzymes in vital organs in vivo. BMC cancer. 2006 Nov; 6(?):267. doi: 10.1186/1471-2407-6-267. [PMID: 17107616]
  • Ozcan Erel. A novel automated method to measure total antioxidant response against potent free radical reactions. Clinical biochemistry. 2004 Feb; 37(2):112-9. doi: 10.1016/j.clinbiochem.2003.10.014. [PMID: 14725941]
  • Eda Imren-Eryilmaz, Huriye Kuzu-Karsilayan, Ayse Ogan. Spectrophotometric determination of leukocytes in urine. Journal of clinical laboratory analysis. 2004; 18(4):251-4. doi: 10.1002/jcla.20032. [PMID: 15202119]
  • William H Waugh. Simplified method to assay total plasma peroxidase activity and ferriheme products in sickle cell anemia, with initial results in assessing clinical severity in a trial with citrulline therapy. Journal of pediatric hematology/oncology. 2003 Oct; 25(10):831-4. doi: 10.1097/00043426-200310000-00021. [PMID: 14528113]
  • V G Artiukhov, O V Basharina, A Iu Iskusnykh. [Effect of temperature on structure and functional properties of horseradish peroxidase]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). 2003 May; 75(3):45-9. doi: ". [PMID: 14577150]
  • A Padiglia, R Medda, G Pazzaglia, A Rescigno, E Cruciani, G Floris. Fractionation and characterization of two forms of peroxidase from Oryza sativa. Preparative biochemistry. 1995 Feb; 25(1-2):11-9. doi: 10.1080/10826069508010104. [PMID: 7603969]
  • M Chopra, H Beswick, M Clapperton, H J Dargie, W E Smith, J McMurray. Antioxidant effects of angiotensin-converting enzyme (ACE) inhibitors: free radical and oxidant scavenging are sulfhydryl dependent, but lipid peroxidation is inhibited by both sulfhydryl- and nonsulfhydryl-containing ACE inhibitors. Journal of cardiovascular pharmacology. 1992 Mar; 19(3):330-40. doi: 10.1097/00005344-199203000-00005. [PMID: 1378110]
  • T G Semak, V P Kurchenko, A T Pikulev. [Status of the antioxidant system and lipid peroxidation in rat liver after poisoning animals with aminobiphenyl]. Biokhimiia (Moscow, Russia). 1991 Oct; 56(10):1806-11. doi: . [PMID: 1777520]
  • A B Bridges, N A Scott, J J Belch. Probucol, a superoxide free radical scavenger in vitro. Atherosclerosis. 1991 Aug; 89(2-3):263-5. doi: 10.1016/0021-9150(91)90068-e. [PMID: 1793454]
  • D Nowak, G Piasecka. The main serum protease inhibitors; alpha-1-proteinase inhibitor and alpha-2-macroglobulin inhibit H2O2 release from human polymorphonuclear leukocytes stimulated with phorbol myristate acetate. Archivum immunologiae et therapiae experimentalis. 1991; 39(1-2):51-60. doi: . [PMID: 1725105]
  • D L Morgan, C W Jameson, J H Mennear, B M Ulland, J K Lemen. Thirteen-week toxicity studies of 3,3'-dimethoxybenzidene and C.I. Direct Blue 15 in the Fischer 344 rat. Toxicology. 1989 Dec; 59(3):297-309. doi: 10.1016/0300-483x(89)90199-6. [PMID: 2631298]
  • M Libon, L Angenot. [Toxic substances sought in sneezing powders]. Journal de pharmacie de Belgique. 1984 Jul; 39(4):233-7. doi: ". [PMID: 6512667]
  • R M Rodgers, C Garvie-Gould, K F Scott, D F Milam, R K Lynn. Metabolism, distribution, and excretion of the carcinogenic aromatic amine, 3,3'-dimethoxybenzidine in the rat. Formation of mutagenic urinary and biliary metabolites. Drug metabolism and disposition: the biological fate of chemicals. 1983 Jul; 11(4):293-300. doi: . [PMID: 6137333]
  • R M Aloisi, J C Dowd. An ELISA method for detecting unexpected antibodies. The American journal of medical technology. 1981 Nov; 47(11):913-8. doi: NULL. [PMID: 7032295]
  • R K Lynn, D W Donielson, A M Ilias, J M Kennish, K Wong, H B Matthews. Metabolism of bisazobiphenyl dyes derived from benzidine, 3,3'-dimethylbenzidine or 3,3'-dimethoxybenzidine to carcinogenic aromatic amines in the dog and rat. Toxicology and applied pharmacology. 1980 Nov; 56(2):248-58. doi: 10.1016/0041-008x(80)90296-3. [PMID: 7466824]
  • J Kaplan, M Nielsen. Pinocytic activity of rabbit alveolar macrophages in vitro. Journal of the Reticuloendothelial Society. 1978 Dec; 24(6):673-85. doi: NULL. [PMID: 87515]
  • J A Hathaway, J A Thomasino, R J Sayers, P A Rothouse, R Anderson. Urinary cytologic examinations of laboratory workers. Useful medical surveillance tool or clinician's nightmare?. Journal of occupational medicine. : official publication of the Industrial Medical Association. 1978 Jul; 20(7):482-7. doi: 10.1097/00043764-197807000-00010. [PMID: 671126]
  • D O Mel'nychuk, L V Skoryk, C Scholz, E V Mitsyk, M F Guly. [Effect of carbonic acid concentration in blood on content of keto-acids and redox state of nicotinamide coenzymes in rabbit tissues]. Ukrains'kyi biokhimichnyi zhurnal. 1977 Sep; 49(5):86-93. doi: NULL. [PMID: 21480]
  • T Biegański, M Z Blasinska, J Kusche. Determination of histaminase (diamine oxidase) activity by o-dianisidine test: interference of ceruloplasmin. Agents and actions. 1977 Mar; 7(1):85-92. doi: 10.1007/bf01964886. [PMID: 404858]
  • W Thefeld. [Enzymatic determination of serum uric acid by means of fully mechanized analysis systems]. Das Medizinische Laboratorium. 1977 Feb; 30(2):46-56. doi: NULL. [PMID: 834162]
  • V A Genin. [Formation of blastomogenic diphenylamino derivatives as a result of the metabolism of Direct azo dyes]. Voprosy onkologii. 1977; 23(9):50-2. doi: NULL. [PMID: 910423]
  • R E Fox, D Redstone. Sources of error in glucose determinations in neonatal blood by glucose oxidase methods, including Dextrostix. American journal of clinical pathology. 1976 Oct; 66(4):658-66. doi: 10.1093/ajcp/66.4.658. [PMID: 970367]
  • J D Boyett, H P Lehmann, M F Beeler. Automated assay of ceruloplasmin by kinetic analysis of o-dianisidine oxidation. Clinica chimica acta; international journal of clinical chemistry. 1976 Jun; 69(2):233-41. doi: 10.1016/0009-8981(76)90501-5. [PMID: 1277556]
  • J Compton, C MCClure, D P Bonderman. The use of o-dianisidine for serum haptoglobin electrophoresis using cellulose acetate. Clinical biochemistry. 1976 Apr; 9(2):104-5. doi: 10.1016/s0009-9120(76)80028-8. [PMID: 1260999]
  • K H Schosinsky, H P Lehmann, M F Beeler. Automated determination of serum ceruloplasmin activity with o-dianisidine dihydrochloride as substrate. Clinical chemistry. 1975 May; 21(6):757-9. doi: 10.1093/clinchem/21.6.757. [PMID: 1122621]
  • P Hunziker, H Keller. [A mechanized enzymic method for the determination of uric acid (author's transl)]. Zeitschrift fur klinische Chemie und klinische Biochemie. 1975 Mar; 13(3):89-96. doi: NULL. [PMID: 1189525]
  • R A Macbeth, S Bazin, J C Allain. Observations on the staining of ceruloplasmin following disc-electrophoresis utilizing polyacrylamide gels. Clinical biochemistry. 1975 Feb; 8(1):52-9. doi: 10.1016/s0009-9120(75)90603-7. [PMID: 47275]
  • J H MARYMONT, M LONDON. ANALYSES PERFORMED WITH HEAT-COAGULATED BLOOD AND SERUM. VI. DIRECT DETERMINATION OF URATE BY MEANS OF O-DIANISIDINE OXIDATION. American journal of clinical pathology. 1964 Dec; 42(?):630-3. doi: 10.1093/ajcp/42.6_ts.630. [PMID: 14239442]
  • J H MARYMONT, M LONDON. ANALYSES PERFORMED WITH HEAT-COAGULATED BLOOD AND SERUM. VI. DIRECT DETERMINATION OF URATE BY MEANS OF O-DIANISIDINE OXIDATION. Technical bulletin of the Registry of Medical Technologists. American Society of Clinical Pathologists. Registry of Medical Technologists. 1964 Nov; 34(?):184-7. doi: NULL. [PMID: 14222338]
  • P ENGELBERTZ, E BABEL. [Detection of o-tolidine and of o-dianisidine and their conversion products in urine and in parts of the organs]. Zentralblatt fur Arbeitsmedizin und Arbeitsschutz. 1954 Nov; 4(6):179-83. doi: NULL. [PMID: 14360520]