Phenylmethylsulfonyl fluoride (BioDeep_00001868069)

Main id: BioDeep_00000006313

 

natural product


代谢物信息卡片


Phenylmethylsulfonyl fluoride

化学式: C7H7FO2S (174.0151)
中文名称: PMSF溶液
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)CS(=O)(=O)F
InChI: InChI=1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors

同义名列表

3 个代谢物同义名

Phenylmethylsulfonyl fluoride; PMSF; Phenylmethanesulfonyl fluoride



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 CAT, CNR1, CTSG, ELANE, PLA2G12A, XDH
Peripheral membrane protein 3 ACHE, CTSG, PRTN3
Endoplasmic reticulum membrane 2 FAAH, PNPLA6
Nucleus 3 ACHE, CTSG, PLCZ1
cytosol 8 CAT, CTSG, ELANE, LIPE, PLCZ1, PNPLA6, PRTN3, XDH
phagocytic vesicle 1 ELANE
nucleoplasm 1 PLCZ1
Cell membrane 6 ACHE, CNR1, CTSG, LIPE, PRTN3, TNF
Cell projection, axon 1 CNR1
Cytoplasmic granule 2 CTSG, PRTN3
Multi-pass membrane protein 2 CNR1, FAAH
Synapse 1 ACHE
cell surface 3 ACHE, ELANE, TNF
glutamatergic synapse 2 CNR1, FAAH
Golgi apparatus 1 ACHE
growth cone 1 CNR1
neuromuscular junction 1 ACHE
neuronal cell body 1 TNF
postsynapse 1 FAAH
presynaptic membrane 1 CNR1
Cytoplasm, cytosol 2 CTSG, LIPE
Lysosome 1 CTSG
Presynapse 2 CNR1, FAAH
plasma membrane 8 ACHE, BCHE, CNR1, CTSG, F2, KNG1, PRTN3, TNF
Membrane 6 ACHE, CAT, CTSG, FAAH, LIPE, PNPLA6
axon 1 CNR1
caveola 1 LIPE
extracellular exosome 7 CAT, CPVL, CTSG, ELANE, F2, KNG1, PRTN3
endoplasmic reticulum 2 FAAH, PNPLA6
extracellular space 11 ACHE, BCHE, CTRL, CTSG, CXCL8, ELANE, F2, KNG1, PRTN3, TNF, XDH
perinuclear region of cytoplasm 2 ACHE, PLCZ1
mitochondrion 1 CAT
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 3 CAT, CTSG, PRTN3
Microsome membrane 1 FAAH
pronucleus 1 PLCZ1
Secreted 7 ACHE, BCHE, CTSG, CXCL8, F2, PLA2G12A, PRTN3
extracellular region 12 ACHE, BCHE, CAT, CTSG, CXCL8, ELANE, ELN, F2, KNG1, PLA2G12A, PRTN3, TNF
Mitochondrion outer membrane 1 CNR1
Single-pass membrane protein 1 FAAH
mitochondrial outer membrane 1 CNR1
mitochondrial matrix 1 CAT
Extracellular side 2 ACHE, PRTN3
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 ELN
actin cytoskeleton 1 CNR1
nucleolus 1 PLCZ1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 3 CNR1, PRTN3, TNF
Cytoplasm, cytoskeleton 1 FAAH
focal adhesion 1 CAT
GABA-ergic synapse 1 CNR1
extracellular matrix 1 ELN
Peroxisome 2 CAT, XDH
basement membrane 1 ACHE
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 5 CTSG, ELANE, ELN, F2, KNG1
secretory granule 2 CTSG, ELANE
phagocytic cup 1 TNF
cytoskeleton 1 FAAH
Secreted, extracellular space 1 KNG1
blood microparticle 3 BCHE, F2, KNG1
Lipid-anchor, GPI-anchor 1 ACHE
organelle membrane 1 FAAH
Endomembrane system 1 FAAH
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
cytoplasmic stress granule 1 CTSG
side of membrane 1 ACHE
plasma membrane raft 1 PRTN3
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
Golgi lumen 1 F2
endoplasmic reticulum lumen 3 BCHE, F2, KNG1
transcription repressor complex 1 ELANE
platelet alpha granule lumen 1 KNG1
specific granule lumen 1 ELANE
Single-pass type III membrane protein 1 PNPLA6
azurophil granule lumen 3 CTSG, ELANE, PRTN3
nuclear envelope lumen 1 BCHE
synaptic cleft 1 ACHE
Cytoplasmic vesicle, phagosome 1 ELANE
elastic fiber 1 ELN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
sperm head 1 PLCZ1
[Isoform H]: Cell membrane 1 ACHE
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Cory L Brooks, David A Ostrov, Nicholas C Schumann, Schuchi Kakkad, Danmeng Li, Karla Peña, Brady Paul Williams, Nathan E Goldfarb. 2.1 Å crystal structure of the Mycobacterium tuberculosis serine hydrolase, Hip1, in its anhydro-form (Anhydrohip1). Biochemical and biophysical research communications. 2022 11; 630(?):57-63. doi: 10.1016/j.bbrc.2022.09.021. [PMID: 36148729]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Alejandro A Puchol Tarazona, Daniel Maresch, Annette Grill, Janet Bakalarz, Juan A Torres Acosta, Alexandra Castilho, Herta Steinkellner, Lukas Mach. Identification of two subtilisin-like serine proteases engaged in the degradation of recombinant proteins in Nicotiana benthamiana. FEBS letters. 2021 02; 595(3):379-388. doi: 10.1002/1873-3468.14014. [PMID: 33263189]
  • Zhao-Lin Ji, Shuai Peng, Li-Li Chen, Yang Liu, Chun Yan, Feng Zhu. Identification and characterization of a serine protease from Bacillus licheniformis W10: A potential antifungal agent. International journal of biological macromolecules. 2020 Feb; 145(?):594-603. doi: 10.1016/j.ijbiomac.2019.12.216. [PMID: 31891703]
  • María Del Pilar Caro, Nicholas Holton, Gabriela Conti, Andrea Laura Venturuzzi, Martin Gustavo Martínez-Zamora, Cyril Zipfel, Sebastian Asurmendi, Juan Carlos Díaz-Ricci. The fungal subtilase AsES elicits a PTI-like defence response in Arabidopsis thaliana plants independently of its enzymatic activity. Molecular plant pathology. 2020 02; 21(2):147-159. doi: 10.1111/mpp.12881. [PMID: 31769595]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Wei Sun, Stacy Ho, Xiaojun Rick Fang, Thomas O'Shea, Hanlan Liu. Simultaneous determination of triamcinolone hexacetonide and triamcinolone acetonide in rabbit plasma using a highly sensitive and selective UPLC-MS/MS method. Journal of pharmaceutical and biomedical analysis. 2018 May; 153(?):267-273. doi: 10.1016/j.jpba.2018.02.052. [PMID: 29550043]
  • Myrna Sabanero López, Lérida L Flores Villavicencio, Karla Soto Arredondo, Gloria Barbosa Sabanero, Julio César Villagómez-Castro, Gustavo Cruz Jiménez, Gerardo Sandoval Bernal, Haydee Torres Guerrero. Proteases of Sporothrix schenckii: Cytopathological effects on a host-cell model. Revista iberoamericana de micologia. 2018 Jan; 35(1):32-38. doi: 10.1016/j.riam.2017.05.003. [PMID: 29221633]
  • Jarogniew J Luszczki, Pawel Patrzylas, Miroslaw Zagaja, Marta Andres-Mach, Katarzyna Zaluska, Maria W Kondrat-Wrobel, Monika Szpringer, Jaroslaw Chmielewski, Magdalena Florek-Luszczki. Effects of arachidonyl-2'-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice. PloS one. 2017; 12(8):e0183873. doi: 10.1371/journal.pone.0183873. [PMID: 28859122]
  • Murugesan Chandrasekaran, Raman Chandrasekar, Se-Chul Chun, Muthukrishnan Sathiyabama. Isolation, characterization and molecular three-dimensional structural predictions of metalloprotease from a phytopathogenic fungus, Alternaria solani (Ell. and Mart.) Sor. Journal of bioscience and bioengineering. 2016 Aug; 122(2):131-9. doi: 10.1016/j.jbiosc.2015.12.021. [PMID: 26924427]
  • Satoru Inagaki, Ryuta Kimizuka, Eitoyo Kokubu, Atsushi Saito, Kazuyuki Ishihara. Treponema denticola invasion into human gingival epithelial cells. Microbial pathogenesis. 2016 May; 94(?):104-11. doi: 10.1016/j.micpath.2016.01.010. [PMID: 26806000]
  • Satomi Miwa, Achim Treumann, Amy Bell, Giulio Vistoli, Glyn Nelson, Sam Hay, Thomas von Zglinicki. Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays. Free radical biology & medicine. 2016 Jan; 90(?):173-83. doi: 10.1016/j.freeradbiomed.2015.11.011. [PMID: 26577176]
  • Xiaolin Wang, Xiao Gu, Huahua Song, Qingxiang Song, Xiaoling Gao, Yang Lu, Hongzhuan Chen. Phenylmethanesulfonyl fluoride pretreatment stabilizes plasma lipidome in lipidomic and metabolomic analysis. Analytica chimica acta. 2015 Sep; 893(?):77-83. doi: 10.1016/j.aca.2015.08.049. [PMID: 26398425]
  • Norio Kamemura, Miwa Takashima, Hideaki Morita, Kenji Matsumoto, Hirohisa Saito, Hiroshi Kido. Measurement of allergen-specific secretory IgA in stool of neonates, infants and toddlers by protection against degradation of immunoglobulins and allergens. The journal of medical investigation : JMI. 2015; 62(3-4):137-44. doi: 10.2152/jmi.62.137. [PMID: 26399337]
  • Long Yuan, Yunlin Fu, Duxi Zhang, Yuan-Qing Xia, Qianping Peng, Anne-Françoise Aubry, Mark E Arnold. Use of a carboxylesterase inhibitor of phenylmethanesulfonyl fluoride to stabilize epothilone D in rat plasma for a validated UHPLC-MS/MS assay. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Oct; 969(?):60-8. doi: 10.1016/j.jchromb.2014.08.006. [PMID: 25151331]
  • Long Yuan, Wenying Jian, Duxi Zhang, Anne-Françoise Aubry, Mark E Arnold. Application of a stabilizer cocktail of N-ethylmaleimide and phenylmethanesulfonyl fluoride to concurrently stabilize the disulfide and ester containing compounds in a plasma LC-MS/MS assay. Journal of pharmaceutical and biomedical analysis. 2014 Jan; 88(?):552-61. doi: 10.1016/j.jpba.2013.10.014. [PMID: 24211707]
  • Jonathan Negrel, Francine Javelle, Dominique Morandi. Detection of a plant enzyme exhibiting chlorogenate-dependant caffeoyltransferase activity in methanolic extracts of arbuscular mycorrhizal tomato roots. Plant physiology and biochemistry : PPB. 2013 May; 66(?):77-83. doi: 10.1016/j.plaphy.2013.02.009. [PMID: 23500709]
  • Marta Andres-Mach, Dorota Zolkowska, Beata Barcicka-Klosowska, Agnieszka Haratym-Maj, Magdalena Florek-Luszczki, Jarogniew J Luszczki. Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. Progress in neuro-psychopharmacology & biological psychiatry. 2012 Dec; 39(2):301-9. doi: 10.1016/j.pnpbp.2012.07.001. [PMID: 22789660]
  • Katia Gindro, Valentine Berger, Sophie Godard, Francine Voinesco, Sylvain Schnee, Olivier Viret, Virginia Alonso-Villaverde. Protease inhibitors decrease the resistance of Vitaceae to Plasmopara viticola. Plant physiology and biochemistry : PPB. 2012 Nov; 60(?):74-80. doi: 10.1016/j.plaphy.2012.07.028. [PMID: 22906813]
  • Meghan Johnston, Shachi R Bhatt, Surina Sikka, Richard W Mercier, Jay M West, Alexandros Makriyannis, S John Gatley, Richard I Duclos. Assay and inhibition of diacylglycerol lipase activity. Bioorganic & medicinal chemistry letters. 2012 Jul; 22(14):4585-92. doi: 10.1016/j.bmcl.2012.05.101. [PMID: 22738638]
  • Jaruwan Siritapetawee, Kanjana Thumanu, Punchapat Sojikul, Sompong Thammasirirak. A novel serine protease with human fibrino(geno)lytic activities from Artocarpus heterophyllus latex. Biochimica et biophysica acta. 2012 Jul; 1824(7):907-12. doi: 10.1016/j.bbapap.2012.05.002. [PMID: 22579962]
  • Srinivasan Rengachari, Gustavo A Bezerra, Lina Riegler-Berket, Christian C Gruber, Christian Sturm, Ulrike Taschler, Andras Boeszoermenyi, Ingrid Dreveny, Robert Zimmermann, Karl Gruber, Monika Oberer. The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes. Biochimica et biophysica acta. 2012 Jul; 1821(7):1012-21. doi: 10.1016/j.bbalip.2012.04.006. [PMID: 22561231]
  • Naiyu Zheng, Eliza N Fung, Adela Buzescu, Mark E Arnold, Jianing Zeng. Esterase inhibitors as ester-containing drug stabilizers and their hydrolytic products: potential contributors to the matrix effects on bioanalysis by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2012 Jun; 26(11):1291-304. doi: 10.1002/rcm.6230. [PMID: 22555922]
  • Hui-Kyoung Sun, Yun Mi Lee, Kum Hyun Han, Han-Seong Kim, Seon-Ho Ahn, Sang-Youb Han. Phosphodiesterase inhibitor improves renal tubulointerstitial hypoxia of the diabetic rat kidney. The Korean journal of internal medicine. 2012 Jun; 27(2):163-70. doi: 10.3904/kjim.2012.27.2.163. [PMID: 22707888]
  • Jan Dimberg, Karin Ström, Sture Löfgren, Niklas Zar, Mikael Lindh, Andreas Matussek. DNA promoter methylation status and protein expression of interleukin-8 in human colorectal adenocarcinomas. International journal of colorectal disease. 2012 Jun; 27(6):709-14. doi: 10.1007/s00384-011-1367-5. [PMID: 22108905]
  • Nobuo N Noda, Takafumi Kobayashi, Wakana Adachi, Yuko Fujioka, Yoshinori Ohsumi, Fuyuhiko Inagaki. Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy. The Journal of biological chemistry. 2012 May; 287(20):16256-66. doi: 10.1074/jbc.m112.348250. [PMID: 22437838]
  • Jean Charles Isner, Thomas Nühse, Frans J M Maathuis. The cyclic nucleotide cGMP is involved in plant hormone signalling and alters phosphorylation of Arabidopsis thaliana root proteins. Journal of experimental botany. 2012 May; 63(8):3199-205. doi: 10.1093/jxb/ers045. [PMID: 22345640]
  • Yu Cheng Zhu, Sandy West, Fanny X Liu, Yueping He. Interaction of proteinase inhibitors with Cry1Ac toxicity and the presence of 15 chymotrypsin cDNAs in the midgut of the tobacco budworm, Heliothis virescens (F.) (Lepidoptera: Noctuidae). Pest management science. 2012 May; 68(5):692-701. doi: 10.1002/ps.2315. [PMID: 22228503]
  • Alison H Kingston-Smith, Teri E Davies, Joan Edwards, Alan Gay, Luis A J Mur. Evidence of a role for foliar salicylic acid in regulating the rate of post-ingestive protein breakdown in ruminants and contributing to landscape pollution. Journal of experimental botany. 2012 May; 63(8):3243-55. doi: 10.1093/jxb/ers048. [PMID: 22378947]
  • Sudhakar Pandurangan, Agnieszka Pajak, Stephen J Molnar, Elroy R Cober, Sangeeta Dhaubhadel, Cinta Hernández-Sebastià, Werner M Kaiser, Randall L Nelson, Steven C Huber, Frédéric Marsolais. Relationship between asparagine metabolism and protein concentration in soybean seed. Journal of experimental botany. 2012 May; 63(8):3173-84. doi: 10.1093/jxb/ers039. [PMID: 22357599]
  • Joerg Fettke, Lydia Leifels, Henrike Brust, Karoline Herbst, Martin Steup. Two carbon fluxes to reserve starch in potato (Solanum tuberosum L.) tuber cells are closely interconnected but differently modulated by temperature. Journal of experimental botany. 2012 May; 63(8):3011-29. doi: 10.1093/jxb/ers014. [PMID: 22378944]
  • Azza Al-Tawashi, Sung Yun Jung, Dou Liu, Bing Su, Jun Qin. Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity. The Journal of biological chemistry. 2012 Apr; 287(18):14644-58. doi: 10.1074/jbc.m111.261875. [PMID: 22375002]
  • Emanuela Esposito, Barbara Rinaldi, Emanuela Mazzon, Maria Donniacuo, Daniela Impellizzeri, Irene Paterniti, Annalisa Capuano, Placido Bramanti, Salvatore Cuzzocrea. Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α. Journal of neuroinflammation. 2012 Apr; 9(?):81. doi: 10.1186/1742-2094-9-81. [PMID: 22537532]
  • Mustafa Yavuz Selcuk, Bilge Aygen, Ayhan Dogukan, Zeynep Tuzcu, Fatih Akdemir, James R Komorowski, Mustafa Atalay, Kazim Sahin. Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-κB pathway in high-fat diet fed and Streptozotocin-induced diabetic rats. Nutrition & metabolism. 2012 Apr; 9(?):30. doi: 10.1186/1743-7075-9-30. [PMID: 22483164]
  • Gon-Sup Kim, Hyoung Joon Park, Jong-Hwa Woo, Mi-Kyeong Kim, Phil-Ok Koh, Wongi Min, Yeoung-Gyu Ko, Chung-Hei Kim, Chung-Kil Won, Jae-Hyeon Cho. Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells. BMC complementary and alternative medicine. 2012 Apr; 12(?):31. doi: 10.1186/1472-6882-12-31. [PMID: 22471389]
  • Xuan Yao, Wei Xiong, Tiantian Ye, Yan Wu. Overexpression of the aspartic protease ASPG1 gene confers drought avoidance in Arabidopsis. Journal of experimental botany. 2012 Apr; 63(7):2579-93. doi: 10.1093/jxb/err433. [PMID: 22268147]
  • Eun Young Kim, Joon Seok Choi, Ko Eun Lee, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Suhn Hee Kim, Jong Un Lee, Soo Wan Kim. Altered regulation of renal Acid base transporters in response to ammonium chloride loading in rats. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. 2012 Apr; 16(2):91-5. doi: 10.4196/kjpp.2012.16.2.91. [PMID: 22563253]
  • Cheul Ho Park, Jae Woo Kim. Effect of advanced glycation end products on oxidative stress and senescence of trabecular meshwork cells. Korean journal of ophthalmology : KJO. 2012 Apr; 26(2):123-31. doi: 10.3341/kjo.2012.26.2.123. [PMID: 22511839]
  • Myung Hee Nam, Sun Mi Huh, Kyung Mi Kim, Woong June Park, Jong Bok Seo, Kun Cho, Dool Yi Kim, Beom Gi Kim, In Sun Yoon. Comparative proteomic analysis of early salt stress-responsive proteins in roots of SnRK2 transgenic rice. Proteome science. 2012 Mar; 10(?):25. doi: 10.1186/1477-5956-10-25. [PMID: 22462395]
  • You-Chang Oh, Won-Kyung Cho, Jin Hui Oh, Ga Young Im, Yun Hee Jeong, Min Cheol Yang, Jin Yeul Ma. Fermentation by Lactobacillus enhances anti-inflammatory effect of Oyaksungisan on LPS-stimulated RAW 264.7 mouse macrophage cells. BMC complementary and alternative medicine. 2012 Mar; 12(?):17. doi: 10.1186/1472-6882-12-17. [PMID: 22405334]
  • Tae Myoung Kim, Sang-Kyung Shin, Tae-Wang Kim, So-Young Youm, Dae Joong Kim, Byeongwoo Ahn. Elm tree bark extract inhibits HepG2 hepatic cancer cell growth via pro-apoptotic activity. Journal of veterinary science. 2012 Mar; 13(1):7-13. doi: 10.4142/jvs.2012.13.1.7. [PMID: 22437530]
  • Axel Tiessen, Annika Nerlich, Benjamin Faix, Christine Hümmer, Simon Fox, Kay Trafford, Hans Weber, Winfriede Weschke, Peter Geigenberger. Subcellular analysis of starch metabolism in developing barley seeds using a non-aqueous fractionation method. Journal of experimental botany. 2012 Mar; 63(5):2071-87. doi: 10.1093/jxb/err408. [PMID: 22200665]
  • Patricia Gangoiti, Caterina Bernacchioni, Chiara Donati, Francesca Cencetti, Alberto Ouro, Antonio Gómez-Muñoz, Paola Bruni. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts. Biochimie. 2012 Mar; 94(3):597-607. doi: 10.1016/j.biochi.2011.09.009. [PMID: 21945811]
  • Birgit Pudelski, Annette Schock, Stefan Hoth, Ruslana Radchuk, Hans Weber, Jörg Hofmann, Uwe Sonnewald, Jürgen Soll, Katrin Philippar. The plastid outer envelope protein OEP16 affects metabolic fluxes during ABA-controlled seed development and germination. Journal of experimental botany. 2012 Mar; 63(5):1919-36. doi: 10.1093/jxb/err375. [PMID: 22155670]
  • Yang Zhou, Hong Wang, Ruili Yang, Hui Huang, Yuanming Sun, Yudong Shen, Hongtao Lei, Hong Gao. Effects of Litchi chinensis fruit isolates on prostaglandin E(2) and nitric oxide production in J774 murine macrophage cells. BMC complementary and alternative medicine. 2012 Mar; 12(?):12. doi: 10.1186/1472-6882-12-12. [PMID: 22380404]
  • Anisuzzaman, M Khyrul Islam, M Abdul Alim, Takeharu Miyoshi, Takeshi Hatta, Kayoko Yamaji, Yasunobu Matsumoto, Kozo Fujisaki, Naotoshi Tsuji. Longistatin is an unconventional serine protease and induces protective immunity against tick infestation. Molecular and biochemical parasitology. 2012 Mar; 182(1-2):45-53. doi: 10.1016/j.molbiopara.2011.12.002. [PMID: 22206819]
  • Se-Hwan Joo, Tae-Wuk Kim, Seung-Hyun Son, Woo Sung Lee, Takao Yokota, Seong-Ki Kim. Biosynthesis of a cholesterol-derived brassinosteroid, 28-norcastasterone, in Arabidopsis thaliana. Journal of experimental botany. 2012 Mar; 63(5):1823-33. doi: 10.1093/jxb/err354. [PMID: 22170941]
  • Qingshan Wang, Hui Zhou, Huiming Gao, Shih-Heng Chen, Chun-Hsien Chu, Belinda Wilson, Jau-Shyong Hong. Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase. Journal of neuroinflammation. 2012 Feb; 9(?):32. doi: 10.1186/1742-2094-9-32. [PMID: 22340895]
  • Henriette Cordes, Ulla Riber, Tim K Jensen, Gregers Jungersen. Cell-mediated and humoral immune responses in pigs following primary and challenge-exposure to Lawsonia intracellularis. Veterinary research. 2012 Feb; 43(?):9. doi: 10.1186/1297-9716-43-9. [PMID: 22316065]
  • Madeleen Bosma, Ronnie Minnaard, Lauren M Sparks, Gert Schaart, Mario Losen, Marc H de Baets, Hans Duimel, Sander Kersten, Perry E Bickel, Patrick Schrauwen, Matthijs K C Hesselink. The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. Histochemistry and cell biology. 2012 Feb; 137(2):205-16. doi: 10.1007/s00418-011-0888-x. [PMID: 22127648]
  • Junqi Wang, Yu Chung Tse, Giselbert Hinz, David G Robinson, Liwen Jiang. Storage globulins pass through the Golgi apparatus and multivesicular bodies in the absence of dense vesicle formation during early stages of cotyledon development in mung bean. Journal of experimental botany. 2012 Feb; 63(3):1367-80. doi: 10.1093/jxb/err366. [PMID: 22143915]
  • Adriana Arita, Jingping Niu, Qingshan Qu, Najuan Zhao, Ye Ruan, Arthur Nadas, Yana Chervona, Fen Wu, Hong Sun, Richard B Hayes, Max Costa. Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel. Environmental health perspectives. 2012 Feb; 120(2):198-203. doi: 10.1289/ehp.1104140. [PMID: 22024396]
  • Jing-Yi Lin, Venugopal Mendu, Judit Pogany, Jun Qin, Peter D Nagy. The TPR domain in the host Cyp40-like cyclophilin binds to the viral replication protein and inhibits the assembly of the tombusviral replicase. PLoS pathogens. 2012 Feb; 8(2):e1002491. doi: 10.1371/journal.ppat.1002491. [PMID: 22346747]
  • Sonia Giacometti, Claudia Adriana Marrano, Maria Cristina Bonza, Laura Luoni, Margherita Limonta, Maria Ida De Michelis. Phosphorylation of serine residues in the N-terminus modulates the activity of ACA8, a plasma membrane Ca2+-ATPase of Arabidopsis thaliana. Journal of experimental botany. 2012 Feb; 63(3):1215-24. doi: 10.1093/jxb/err346. [PMID: 22090438]
  • Fushan Liu, Zaheer Ahmed, Elizabeth A Lee, Elizabeth Donner, Qiang Liu, Regina Ahmed, Matthew K Morell, Michael J Emes, Ian J Tetlow. Allelic variants of the amylose extender mutation of maize demonstrate phenotypic variation in starch structure resulting from modified protein-protein interactions. Journal of experimental botany. 2012 Feb; 63(3):1167-83. doi: 10.1093/jxb/err341. [PMID: 22121198]
  • Qiang Wang, Feng Wang, Xin Li, Qianzi Yang, Xuying Li, Ning Xu, Yi Huang, Qiaomei Zhang, Xingchun Gou, Shaoyang Chen, Lize Xiong. Electroacupuncture pretreatment attenuates cerebral ischemic injury through α7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats. Journal of neuroinflammation. 2012 Jan; 9(?):24. doi: 10.1186/1742-2094-9-24. [PMID: 22277256]
  • Andria P Medina, Jialing Lin, Paul H Weigel. Hyaluronan synthase mediates dye translocation across liposomal membranes. BMC biochemistry. 2012 Jan; 13(?):2. doi: 10.1186/1471-2091-13-2. [PMID: 22276637]
  • Maja B Hoegg, Stephen M Robbins, James D McGhee. Characterization of the C. elegans erlin homologue. BMC cell biology. 2012 Jan; 13(?):2. doi: 10.1186/1471-2121-13-2. [PMID: 22269071]
  • Djédoux Maxime Angaman, Rocco Petrizzo, Francesc Hernández-Gras, Carmen Romero-Segura, Irene Pateraki, Montserrat Busquets, Albert Boronat. Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts. Plant methods. 2012 Jan; 8(1):1. doi: 10.1186/1746-4811-8-1. [PMID: 22243738]
  • Sophie Doublier, Dimas C Belisario, Manuela Polimeni, Laura Annaratone, Chiara Riganti, Elena Allia, Dario Ghigo, Amalia Bosia, Anna Sapino. HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast. BMC cancer. 2012 Jan; 12(?):4. doi: 10.1186/1471-2407-12-4. [PMID: 22217342]
  • Naveen Sharma, Carlos M Castorena, Gregory D Cartee. Tissue-specific responses of IGF-1/insulin and mTOR signaling in calorie restricted rats. PloS one. 2012; 7(6):e38835. doi: 10.1371/journal.pone.0038835. [PMID: 22701721]
  • Hua Sun, Linghong Yu, Huailing Wei, Gengtao Liu. A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model. Journal of biomedicine & biotechnology. 2012; 2012(?):584728. doi: 10.1155/2012/584728. [PMID: 22500097]
  • Chi-Ling Fu, Justin I Odegaard, De'Broski R Herbert, Michael H Hsieh. A novel mouse model of Schistosoma haematobium egg-induced immunopathology. PLoS pathogens. 2012; 8(3):e1002605. doi: 10.1371/journal.ppat.1002605. [PMID: 22479181]
  • Weiwei Huang, Tiantian He, Chengsen Chai, Yuan Yang, Yahong Zheng, Pei Zhou, Xiaoxia Qiao, Bin Zhang, Zengzhen Liu, Junru Wang, Changhong Shi, Liping Lei, Kun Gao, Hewei Li, Sue Zhong, Libo Yao, Meng-Er Huang, Ming Lei. Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression. PloS one. 2012; 7(5):e37693. doi: 10.1371/journal.pone.0037693. [PMID: 22666381]
  • Casper Søgaard, Anne Stenbæk, Sophie Bernard, Masood Hadi, Azeddine Driouich, Henrik Vibe Scheller, Yumiko Sakuragi. GO-PROMTO illuminates protein membrane topologies of glycan biosynthetic enzymes in the Golgi apparatus of living tissues. PloS one. 2012; 7(2):e31324. doi: 10.1371/journal.pone.0031324. [PMID: 22363620]
  • Maria Luisa Sirico, Bruna Guida, Alfredo Procino, Andrea Pota, Maurizio Sodo, Giuseppe Grandaliano, Simona Simone, Giovanni Pertosa, Eleonora Riccio, Bruno Memoli. Human mature adipocytes express albumin and this expression is not regulated by inflammation. Mediators of inflammation. 2012; 2012(?):236796. doi: 10.1155/2012/236796. [PMID: 22675238]
  • Angelina E Altshuler, Alexander H Penn, Jessica A Yang, Ga-Ram Kim, Geert W Schmid-Schönbein. Protease activity increases in plasma, peritoneal fluid, and vital organs after hemorrhagic shock in rats. PloS one. 2012; 7(3):e32672. doi: 10.1371/journal.pone.0032672. [PMID: 22479334]
  • Amanda Bernardes, Fernanda A H Batista, Mario de Oliveira Neto, Ana Carolina M Figueira, Paul Webb, Daniel Saidemberg, Mario S Palma, Igor Polikarpov. Low-resolution molecular models reveal the oligomeric state of the PPAR and the conformational organization of its domains in solution. PloS one. 2012; 7(2):e31852. doi: 10.1371/journal.pone.0031852. [PMID: 22363753]
  • René Anour, Olena Andrukhova, Eva Ritter, Ute Zeitz, Reinhold G Erben. Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo. PloS one. 2012; 7(2):e31376. doi: 10.1371/journal.pone.0031376. [PMID: 22319626]
  • Mohammad Moneruzzaman Khandaker, Amru Nasrulhaq Boyce, Normaniza Osman, Abm Sharif Hossain. Physiochemical and phytochemical properties of wax apple (Syzygium samarangense [Blume] Merrill & L. M. Perry var. Jambu Madu) as affected by growth regulator application. TheScientificWorldJournal. 2012; 2012(?):728613. doi: 10.1100/2012/728613. [PMID: 22701370]
  • Teresa Morera-Herreras, Cristina Miguelez, Asier Aristieta, José Ángel Ruiz-Ortega, Luisa Ugedo. Endocannabinoid modulation of dopaminergic motor circuits. Frontiers in pharmacology. 2012; 3(?):110. doi: 10.3389/fphar.2012.00110. [PMID: 22701427]
  • Alexander V Chibalin, Judith A Heiny, Boubacar Benziane, Alexander V Prokofiev, Alexander V Vasiliev, Violetta V Kravtsova, Igor I Krivoi. Chronic nicotine modifies skeletal muscle Na,K-ATPase activity through its interaction with the nicotinic acetylcholine receptor and phospholemman. PloS one. 2012; 7(3):e33719. doi: 10.1371/journal.pone.0033719. [PMID: 22442718]
  • Bryan N Kahner, Hisashi Kato, Asoka Banno, Mark H Ginsberg, Sanford J Shattil, Feng Ye. Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3. PloS one. 2012; 7(3):e34056. doi: 10.1371/journal.pone.0034056. [PMID: 22457811]
  • Mohamad Hamshou, Els J M Van Damme, Gianni Vandenborre, Bart Ghesquière, Geert Trooskens, Kris Gevaert, Guy Smagghe. GalNAc/Gal-binding Rhizoctonia solani agglutinin has antiproliferative activity in Drosophila melanogaster S2 cells via MAPK and JAK/STAT signaling. PloS one. 2012; 7(4):e33680. doi: 10.1371/journal.pone.0033680. [PMID: 22529896]
  • Zhaojing Hao, Li Zheng, Lan Kluwe, Weida Huang. Ferritin light chain and squamous cell carcinoma antigen 1 are coreceptors for cellular attachment and entry of hepatitis B virus. International journal of nanomedicine. 2012; 7(?):827-34. doi: 10.2147/ijn.s27803. [PMID: 22359459]
  • Emma Mormeneo, Cecilia Jimenez-Mallebrera, Xavier Palomer, Valeria De Nigris, Manuel Vázquez-Carrera, Anna Orozco, Andrés Nascimento, Jaume Colomer, Carles Lerín, Anna M Gómez-Foix. PGC-1α induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells. PloS one. 2012; 7(1):e29985. doi: 10.1371/journal.pone.0029985. [PMID: 22272266]
  • Guixian Wang, Weitang Yuan, Tae-Hwan Kwon, Zhenzhen Li, Jianguo Wen, Sukru Oguzkan Topcu, Jens Christian Djurhuus, Søren Nielsen, Jørgen Frøkiær. Age-related changes in expression in renal AQPs in response to congenital, partial, unilateral ureteral obstruction in rats. Pediatric nephrology (Berlin, Germany). 2012 Jan; 27(1):83-94. doi: 10.1007/s00467-011-1878-x. [PMID: 22028046]
  • Mario D Cordero, Francisco Javier Cano-García, Elísabet Alcocer-Gómez, Manuel De Miguel, José Antonio Sánchez-Alcázar. Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvement. PloS one. 2012; 7(4):e35677. doi: 10.1371/journal.pone.0035677. [PMID: 22532869]
  • Dennys E Cintra, Eduardo R Ropelle, Juliana C Moraes, José R Pauli, Joseane Morari, Claudio T de Souza, Renato Grimaldi, Marcela Stahl, José B Carvalheira, Mario J Saad, Licio A Velloso. Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PloS one. 2012; 7(1):e30571. doi: 10.1371/journal.pone.0030571. [PMID: 22279596]
  • Sang-Hun Kang, Soo-Jin Jeong, Sun-Hee Kim, Ji-Hyun Kim, Ji Hoon Jung, Wonil Koh, Jung Hyo Kim, Dae Keun Kim, Chang-Yan Chen, Sung-Hoon Kim. Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling. PloS one. 2012; 7(4):e28706. doi: 10.1371/journal.pone.0028706. [PMID: 22493659]
  • Liang Yang, Wei Ji, Peng Gao, Yong Li, Hua Cai, Xi Bai, Qin Chen, Yanming Zhu. GsAPK, an ABA-activated and calcium-independent SnRK2-type kinase from G. soja, mediates the regulation of plant tolerance to salinity and ABA stress. PloS one. 2012; 7(3):e33838. doi: 10.1371/journal.pone.0033838. [PMID: 22439004]
  • Francisco J Ortega, José M Moreno-Navarrete, Dolores Mayas, Eva García-Santos, María Gómez-Serrano, José I Rodriguez-Hermosa, Bartomeu Ruiz, Wifredo Ricart, Francisco J Tinahones, Gema Frühbeck, Belen Peral, José M Fernández-Real. Breast cancer 1 (BrCa1) may be behind decreased lipogenesis in adipose tissue from obese subjects. PloS one. 2012; 7(5):e33233. doi: 10.1371/journal.pone.0033233. [PMID: 22666314]
  • Jeffrey C Waller, Kenneth W Ellens, Sophie Alvarez, Karen Loizeau, Stéphane Ravanel, Andrew D Hanson. Mitochondrial and plastidial COG0354 proteins have folate-dependent functions in iron-sulphur cluster metabolism. Journal of experimental botany. 2012 Jan; 63(1):403-11. doi: 10.1093/jxb/err286. [PMID: 21984653]
  • Xiaoning Chen, Kara J Margolis, Michael D Gershon, Gary J Schwartz, Ji Y Sze. Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake. PloS one. 2012; 7(3):e32511. doi: 10.1371/journal.pone.0032511. [PMID: 22412882]
  • Xin Wang, Zunji Ke, Gang Chen, Mei Xu, Kimberly A Bower, Jacqueline A Frank, Zhuo Zhang, Xianglin Shi, Jia Luo. Cdc42-dependent activation of NADPH oxidase is involved in ethanol-induced neuronal oxidative stress. PloS one. 2012; 7(5):e38075. doi: 10.1371/journal.pone.0038075. [PMID: 22662267]
  • Zhifeng Huang, Guanghui Zhu, Chuanchuan Sun, Jingui Zhang, Yi Zhang, Youting Zhang, Chaohui Ye, Xiaojie Wang, Dariush Ilghari, Xiaokun Li. A novel solid-phase site-specific PEGylation enhances the in vitro and in vivo biostabilty of recombinant human keratinocyte growth factor 1. PloS one. 2012; 7(5):e36423. doi: 10.1371/journal.pone.0036423. [PMID: 22574160]
  • Giuseppe Procino, Lisa Mastrofrancesco, Grazia Tamma, Domenica Rita Lasorsa, Marianna Ranieri, Gilda Stringini, Francesco Emma, Maria Svelto, Giovanna Valenti. Calcium-sensing receptor and aquaporin 2 interplay in hypercalciuria-associated renal concentrating defect in humans. An in vivo and in vitro study. PloS one. 2012; 7(3):e33145. doi: 10.1371/journal.pone.0033145. [PMID: 22403735]
  • Chung-Hung Shih, Ling-Hung Lin, Hsin-Te Hsu, Kuo-Hsien Wang, Chi-Yin Lai, Chien-Ming Chen, Wun-Chang Ko. Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):472897. doi: 10.1155/2012/472897. [PMID: 22454667]
  • Siham Yasari, Denis Prud'homme, Frédérique Tesson, Marek Jankowski, Jolanta Gutkowska, Emile Levy, Jean-Marc Lavoie. Effects of exercise training on molecular markers of lipogenesis and lipid partitioning in fructose-induced liver fat accumulation. Journal of nutrition and metabolism. 2012; 2012(?):181687. doi: 10.1155/2012/181687. [PMID: 21860785]
  • Trevor Glaros, Yan Fu, Jianhua Xing, Liwu Li. Molecular mechanism underlying persistent induction of LCN2 by lipopolysaccharide in kidney fibroblasts. PloS one. 2012; 7(4):e34633. doi: 10.1371/journal.pone.0034633. [PMID: 22514649]
  • Sishuo Cao, Wentao Xu, Nan Zhang, Yan Wang, YunBo Luo, Xiaoyun He, Kunlun Huang. A mitochondria-dependent pathway mediates the apoptosis of GSE-induced yeast. PloS one. 2012; 7(3):e32943. doi: 10.1371/journal.pone.0032943. [PMID: 22403727]
  • Thing-Fong Tzeng, Hung-Jen Lu, Shorong-Shii Liou, Chia Ju Chang, I-Min Liu. Emodin, a Naturally Occurring Anthraquinone Derivative, Ameliorates Dyslipidemia by Activating AMP-Activated Protein Kinase in High-Fat-Diet-Fed Rats. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):781812. doi: 10.1155/2012/781812. [PMID: 22649478]
  • Elena A Sher, Mati Shaklai, Nurith Shaklai. Carbon monoxide promotes respiratory hemoproteins iron reduction using peroxides as electron donors. PloS one. 2012; 7(3):e33039. doi: 10.1371/journal.pone.0033039. [PMID: 22427940]
  • Sung A Jung, Miseon Choi, Sohee Kim, Rina Yu, Taesun Park. Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PPAR research. 2012; 2012(?):541204. doi: 10.1155/2012/541204. [PMID: 22675336]
  • Kenji Matsui, Kohichi Sugimoto, Jun'ichi Mano, Rika Ozawa, Junji Takabayashi. Differential metabolisms of green leaf volatiles in injured and intact parts of a wounded leaf meet distinct ecophysiological requirements. PloS one. 2012; 7(4):e36433. doi: 10.1371/journal.pone.0036433. [PMID: 22558466]
  • Xiaohua Han, Yihua Wang, Xi Liu, Ling Jiang, Yulong Ren, Feng Liu, Cheng Peng, Jingjing Li, Ximing Jin, Fuqing Wu, Jiulin Wang, Xiuping Guo, Xin Zhang, Zhijun Cheng, Jianmin Wan. The failure to express a protein disulphide isomerase-like protein results in a floury endosperm and an endoplasmic reticulum stress response in rice. Journal of experimental botany. 2012 Jan; 63(1):121-30. doi: 10.1093/jxb/err262. [PMID: 21984651]
  • Maizom Hassan, Nur Diyana Maarof, Zainon Mohd Ali, Normah Mohd Noor, Roohaida Othman, Nobuhiro Mori. Monoterpene alcohol metabolism: identification, purification, and characterization of two geraniol dehydrogenase isoenzymes from Polygonum minus leaves. Bioscience, biotechnology, and biochemistry. 2012; 76(8):1463-70. doi: 10.1271/bbb.120137. [PMID: 22878188]
  • Yucun Niu, Songtao Li, Lixin Na, Rennan Feng, Liyan Liu, Ying Li, Changhao Sun. Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK. PloS one. 2012; 7(1):e30782. doi: 10.1371/journal.pone.0030782. [PMID: 22292039]
  • Thiago Martins Batista, Lilian Midori Tomiyoshi, Ana Carolina Dias, Letícia Prates Roma, Carolina Maria Módulo, Leonardo Tannus Malki, Elísio Bueno Machado Filho, Rafael Deminice, Alceu Afonso Jordão, Daniel A Cunha, Eduardo Melani Rocha. Age-dependent changes in rat lacrimal gland anti-oxidant and vesicular related protein expression profiles. Molecular vision. 2012; 18(?):194-202. doi: ". [PMID: 22312187]