EFLORNITHINE (BioDeep_00001868055)
Main id: BioDeep_00000003457
代谢物信息卡片
2-(Difluoromethyl)-DL-ornithine
化学式: C6H12F2N2O2 (182.0867)
中文名称: DL-α-二氟甲基鸟氨酸 盐酸盐 水合物, 依氟鸟氨酸盐酸盐, 依氟鸟氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CC(C(F)F)(C(=O)O)N)CN
InChI: InChI=1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)
描述信息
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01C - Agents against leishmaniasis and trypanosomiasis
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D004791 - Enzyme Inhibitors > D065108 - Ornithine Decarboxylase Inhibitors
C471 - Enzyme Inhibitor > C2088 - Ornithine Decarboxylase Inhibitor
D000970 - Antineoplastic Agents
D - Dermatologicals
同义名列表
3 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:41948
- KEGG: C07997
- KEGGdrug: D07883
- PubChem: 3009
- DrugBank: DB06243
- ChEMBL: CHEMBL830
- MeSH: Eflornithine
- CAS: 70052-12-9
- CAS: 70050-56-5
- CAS: 67037-37-0
- PubChem: 10198
- NIKKAJI: J290.818B
- KNApSAcK: 41948
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chad R Schultz, Matthew A Swanson, Thomas C Dowling, André S Bachmann. Probenecid increases renal retention and antitumor activity of DFMO in neuroblastoma.
Cancer chemotherapy and pharmacology.
2021 10; 88(4):607-617. doi:
10.1007/s00280-021-04309-y. [PMID: 34129075] - Mohamed A Abdel-Lateef, Albandary Almahri. Micellar sensitized Resonance Rayleigh Scattering and spectrofluorometric methods based on isoindole formation for determination of Eflornithine in cream and biological samples.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Sep; 258(?):119806. doi:
10.1016/j.saa.2021.119806. [PMID: 33933938] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ognjen Perišić. Recognition of Potential COVID-19 Drug Treatments through the Study of Existing Protein-Drug and Protein-Protein Structures: An Analysis of Kinetically Active Residues.
Biomolecules.
2020 09; 10(9):. doi:
10.3390/biom10091346. [PMID: 32967116] - Cyril Fersing, Clotilde Boudot, Caroline Castera-Ducros, Emilie Pinault, Sébastien Hutter, Romain Paoli-Lombardo, Nicolas Primas, Julien Pedron, Line Seguy, Sandra Bourgeade-Delmas, Alix Sournia-Saquet, Jean-Luc Stigliani, Jean-Yves Brossas, Luc Paris, Alexis Valentin, Susan Wyllie, Alan H Fairlamb, Élisa Boutet-Robinet, Sophie Corvaisier, Marc Since, Aurélie Malzert-Fréon, Alexandre Destere, Dominique Mazier, Pascal Rathelot, Bertrand Courtioux, Nadine Azas, Pierre Verhaeghe, Patrice Vanelle. 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.
European journal of medicinal chemistry.
2020 Sep; 202(?):112558. doi:
10.1016/j.ejmech.2020.112558. [PMID: 32652409] - Chad R Schultz, Martin C H Gruhlke, Alan J Slusarenko, André S Bachmann. Allicin, a Potent New Ornithine Decarboxylase Inhibitor in Neuroblastoma Cells.
Journal of natural products.
2020 08; 83(8):2518-2527. doi:
10.1021/acs.jnatprod.0c00613. [PMID: 32786875] - Gaber El-Saber Batiha, Amany Magdy Beshbishy, Oluyomi Stephen Adeyemi, Eman Nadwa, Eman Rashwan, Naoaki Yokoyama, Ikuo Igarashi. Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria.
PloS one.
2020; 15(2):e0228996. doi:
10.1371/journal.pone.0228996. [PMID: 32053698] - Mitchell B Diccianni, Katarzyna Kempińska, Jon A Gangoti, Alice L Yu, Linda S Sorkin. Anti-GD2 induced allodynia in rats can be reduced by pretreatment with DFMO.
PloS one.
2020; 15(7):e0236115. doi:
10.1371/journal.pone.0236115. [PMID: 32697811] - Sihyung Yang, Yao Chen, Mei Feng, Larry Rodriguez, Judy Qiju Wu, Michael Zhuo Wang. Improving Eflornithine Oral Bioavailability and Brain Uptake by Modulating Intercellular Junctions With an E-cadherin Peptide.
Journal of pharmaceutical sciences.
2019 12; 108(12):3870-3878. doi:
10.1016/j.xphs.2019.09.015. [PMID: 31545969] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Nadine Schäfer, Prashanth Reddy Rikkala, Maike Veyhl-Wichmann, Thorsten Keller, Christian Ferdinand Jurowich, Dietmar Geiger, Hermann Koepsell. A Modified Tripeptide Motif of RS1 (RSC1A1) Down-Regulates Exocytotic Pathways of Human Na+-d-glucose Cotransporters SGLT1, SGLT2, and Glucose Sensor SGLT3 in the Presence of Glucose.
Molecular pharmacology.
2019 01; 95(1):82-96. doi:
10.1124/mol.118.113514. [PMID: 30355744] - Yoshinori Asakawa, Agnieszka Ludwiczuk. Chemical Constituents of Bryophytes: Structures and Biological Activity.
Journal of natural products.
2018 03; 81(3):641-660. doi:
10.1021/acs.jnatprod.6b01046. [PMID: 29019405] - Juan P Macedo, Rachel B Currier, Corina Wirdnam, David Horn, Sam Alsford, Doris Rentsch. Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2017 10; 31(10):4649-4660. doi:
10.1096/fj.201700311r. [PMID: 28679527] - N Estiarte, A Crespo-Sempere, S Marín, V Sanchis, A J Ramos. Exploring polyamine metabolism of Alternaria alternata to target new substances to control the fungal infection.
Food microbiology.
2017 Aug; 65(?):193-204. doi:
10.1016/j.fm.2017.02.001. [PMID: 28400003] - Sanofar Abdeen, Nilshad Salim, Najiba Mammadova, Corey M Summers, Karen Goldsmith-Pestana, Diane McMahon-Pratt, Peter G Schultz, Arthur L Horwich, Eli Chapman, Steven M Johnson. Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness.
Bioorganic & medicinal chemistry letters.
2016 11; 26(21):5247-5253. doi:
10.1016/j.bmcl.2016.09.051. [PMID: 27720295] - Chakravarthi Chintalapati, Thorsten Keller, Thomas D Mueller, Valentin Gorboulev, Nadine Schäfer, Ilona Zilkowski, Maike Veyhl-Wichmann, Dietmar Geiger, Jürgen Groll, Hermann Koepsell. Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase.
Molecular pharmacology.
2016 Nov; 90(5):508-521. doi:
10.1124/mol.116.104521. [PMID: 27555600] - S D Ivanov, V G Bespalov, A L Semenov, E G Kovan'ko, V A Aleksandrov. Toxicogenomic Effects in Rat Blood Leukocytes and Chemoprophylaxis of Radiation-Induced Carcinogenesis.
Bulletin of experimental biology and medicine.
2016 Mar; 160(5):705-8. doi:
10.1007/s10517-016-3255-z. [PMID: 27021083] - Yo-Hsian Tsai, Kuan-Lian Lin, Yuan-Pin Huang, Yi-Chiang Hsu, Chung-Hwan Chen, Yuhsin Chen, Min-Hua Sie, Gwo-Jaw Wang, Mon-Juan Lee. Suppression of ornithine decarboxylase promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
FEBS letters.
2015 Jul; 589(16):2058-65. doi:
10.1016/j.febslet.2015.06.023. [PMID: 26140984] - Courtney R Giordano, Robin Roberts, Kendra A Krentz, David Bissig, Deepa Talreja, Ashok Kumar, Stanley R Terlecky, Bruce A Berkowitz. Catalase therapy corrects oxidative stress-induced pathophysiology in incipient diabetic retinopathy.
Investigative ophthalmology & visual science.
2015 May; 56(5):3095-102. doi:
10.1167/iovs.14-16194. [PMID: 25813998] - R Jansson-Löfmark, K Na-Bangchang, S Björkman, F Doua, M Ashton. Enantiospecific reassessment of the pharmacokinetics and pharmacodynamics of oral eflornithine against late-stage Trypanosoma brucei gambiense sleeping sickness.
Antimicrobial agents and chemotherapy.
2015 Feb; 59(2):1299-307. doi:
10.1128/aac.04101-14. [PMID: 25512417] - Subhashree Subramanyam, Nagesh Sardesai, Subhash C Minocha, Cheng Zheng, Richard H Shukle, Christie E Williams. Hessian fly larval feeding triggers enhanced polyamine levels in susceptible but not resistant wheat.
BMC plant biology.
2015 Jan; 15(?):3. doi:
10.1186/s12870-014-0396-y. [PMID: 25592131] - Giselle L Saulnier Sholler, Eugene W Gerner, Genevieve Bergendahl, Robert B MacArthur, Alyssa VanderWerff, Takamaru Ashikaga, Jeffrey P Bond, William Ferguson, William Roberts, Randal K Wada, Don Eslin, Jacqueline M Kraveka, Joel Kaplan, Deanna Mitchell, Nehal S Parikh, Kathleen Neville, Leonard Sender, Timothy Higgins, Masao Kawakita, Kyoko Hiramatsu, Shun-Suke Moriya, André S Bachmann. A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma.
PloS one.
2015; 10(5):e0127246. doi:
10.1371/journal.pone.0127246. [PMID: 26018967] - Christoph Mathieu, Amaia González Salgado, Corina Wirdnam, Stefan Meier, Marianne Suter Grotemeyer, Ehud Inbar, Pascal Mäser, Dan Zilberstein, Erwin Sigel, Peter Bütikofer, Doris Rentsch. Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids.
The Biochemical journal.
2014 Oct; 463(1):9-18. doi:
10.1042/bj20140719. [PMID: 24988048] - Sudhakar Manda, Shabana I Khan, Surendra K Jain, Shabber Mohammed, Babu L Tekwani, Ikhlas A Khan, Ram A Vishwakarma, Sandip B Bharate. Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines.
Bioorganic & medicinal chemistry letters.
2014 Aug; 24(15):3247-50. doi:
10.1016/j.bmcl.2014.06.030. [PMID: 24980054] - Yutaka Aoyagi, Koji Fujiwara, Akira Yamazaki, Naoko Sugawara, Reiko Yano, Haruhiko Fukaya, Yukio Hitotsuyanagi, Koichi Takeya, Aki Ishiyama, Masato Iwatsuki, Kazuhiko Otoguro, Haruki Yamada, Satoshi Ōmura. Semisynthesis of salviandulin E analogues and their antitrypanosomal activity.
Bioorganic & medicinal chemistry letters.
2014 Jan; 24(2):442-6. doi:
10.1016/j.bmcl.2013.12.052. [PMID: 24388808] - Bénédicte Desforges, Patrick A Curmi, Ouissame Bounedjah, Samir Nakib, Loic Hamon, Jean-Pascal De Bandt, David Pastré. An intercellular polyamine transfer via gap junctions regulates proliferation and response to stress in epithelial cells.
Molecular biology of the cell.
2013 May; 24(10):1529-43. doi:
10.1091/mbc.e12-10-0729. [PMID: 23515223] - Carl-Christer Johansson, Peter Gennemark, Per Artursson, Angela Äbelö, Michael Ashton, Rasmus Jansson-Löfmark. Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat.
Journal of pharmacokinetics and pharmacodynamics.
2013 Feb; 40(1):117-28. doi:
10.1007/s10928-012-9293-x. [PMID: 23307171] - Yi He, Xian Zhang, Xing Zeng, Yu Huang, Jian-An Wei, Ling Han, Cai-Xia Li, Guo-Wei Zhang. HuR-mediated posttranscriptional regulation of p21 is involved in the effect of Glycyrrhiza uralensis licorice aqueous extract on polyamine-depleted intestinal crypt cells proliferation.
The Journal of nutritional biochemistry.
2012 Oct; 23(10):1285-93. doi:
10.1016/j.jnutbio.2011.07.009. [PMID: 22217517] - Peng Wen, Jing-Jing Sui, Ru-Liu Li, Shi-Qing Zhao, Wen-Biao Lu, Wei-Wen Chen. [Effect of polysaccharides from Radix Glycyrrhizae on migration and polyamines contents of IEC-6 cell].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2012 Jul; 35(7):1112-6. doi:
". [PMID: 23252278] - Kazuhiko Otoguro, Masato Iwatsuki, Aki Ishiyama, Miyuki Namatame, Aki Nishihara-Tsukashima, Hiroaki Kiyohara, Toshihiro Hashimoto, Yoshinori Asakawa, Satoshi Omura, Haruki Yamada. In vitro antitrypanosomal activity of some phenolic compounds from propolis and lactones from Fijian Kawa (Piper methysticum).
Journal of natural medicines.
2012 Jul; 66(3):558-61. doi:
10.1007/s11418-011-0613-z. [PMID: 22116743] - Kazuhiko Otoguro, Aki Ishiyama, Masato Iwatsuki, Miyuki Namatame, Aki Nishihara-Tukashima, Hiroaki Kiyohara, Toshihiro Hashimoto, Yoshinori Asakawa, Satoshi Omura, Haruki Yamada. In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma brucei.
Journal of natural medicines.
2012 Apr; 66(2):377-82. doi:
10.1007/s11418-011-0587-x. [PMID: 21922219] - G Xie, T Nie, G G Mackenzie, Y Sun, L Huang, N Ouyang, N Alston, C Zhu, O T Murray, P P Constantinides, L Kopelovich, B Rigas. The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine.
British journal of pharmacology.
2012 Apr; 165(7):2152-66. doi:
10.1111/j.1476-5381.2011.01705.x. [PMID: 21955327] - David Bode, Dean A Seehusen, Drew Baird. Hirsutism in women.
American family physician.
2012 Feb; 85(4):373-80. doi:
. [PMID: 22335316] - Sam Alsford, Sabine Eckert, Nicola Baker, Lucy Glover, Alejandro Sanchez-Flores, Ka Fai Leung, Daniel J Turner, Mark C Field, Matthew Berriman, David Horn. High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Nature.
2012 Jan; 482(7384):232-6. doi:
10.1038/nature10771. [PMID: 22278056] - Neeraj Gupta, Hu Zhang, Ping Liu. Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats.
Pharmacology, biochemistry, and behavior.
2012 Jan; 100(3):464-73. doi:
10.1016/j.pbb.2011.10.011. [PMID: 22024160] - Ewa Maciaszczyk-Dziubinska, Donata Wawrzycka, Robert Wysocki. Arsenic and antimony transporters in eukaryotes.
International journal of molecular sciences.
2012; 13(3):3527-3548. doi:
10.3390/ijms13033527. [PMID: 22489166] - Paul F Seke Etet, M Fawzi Mahomoodally. New insights in staging and chemotherapy of African trypanosomiasis and possible contribution of medicinal plants.
TheScientificWorldJournal.
2012; 2012(?):343652. doi:
10.1100/2012/343652. [PMID: 22593674] - V G Bespalov, V A Aleksandrov, A L Semenov, E G Kovan'ko, S D Ivanov. [Comparative effects of difluoromethylornithine and tincture of Siberian ginseng root on radiation carcinogenesis and life span in rats].
Advances in gerontology = Uspekhi gerontologii.
2012; 25(2):293-300. doi:
". [PMID: 23130522] - Kazuhiko Otoguro, Masato Iwatsuki, Aki Ishiyama, Miyuki Namatame, Aki Nishihara-Tukashima, Hiroaki Kiyohara, Toshihiro Hashimoto, Yoshinori Asakawa, Satoshi Omura, Haruki Yamada. In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei.
Phytochemistry.
2011 Nov; 72(16):2024-30. doi:
10.1016/j.phytochem.2011.07.015. [PMID: 21843897] - Michael P Barrett, Isabel M Vincent, Richard J S Burchmore, Anne J N Kazibwe, Enock Matovu. Drug resistance in human African trypanosomiasis.
Future microbiology.
2011 Sep; 6(9):1037-47. doi:
10.2217/fmb.11.88. [PMID: 21958143] - Rehana Rehman, Muhammad Aslam, Muhammad Saleh Soomro. Reversal of difluoromethylornithine effects by the administration of putrescine in rats.
JPMA. The Journal of the Pakistan Medical Association.
2011 Aug; 61(8):752-5. doi:
NULL. [PMID: 22355995] - Robert T Jacobs, Bakela Nare, Stephen A Wring, Matthew D Orr, Daitao Chen, Jessica M Sligar, Matthew X Jenks, Robert A Noe, Tana S Bowling, Luke T Mercer, Cindy Rewerts, Eric Gaukel, Jennifer Owens, Robin Parham, Ryan Randolph, Beth Beaudet, Cyrus J Bacchi, Nigel Yarlett, Jacob J Plattner, Yvonne Freund, Charles Ding, Tsutomu Akama, Y-K Zhang, Reto Brun, Marcel Kaiser, Ivan Scandale, Robert Don. SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.
PLoS neglected tropical diseases.
2011 Jun; 5(6):e1151. doi:
10.1371/journal.pntd.0001151. [PMID: 21738803] - Can Hu, Ru-Liu Li, Wen-Biao Lu, Yan-Qun Yang, Jing Wang, Wei-Wen Chen. Studies on cell migration model in intestinal epithelial restitution for pharmacological research.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2011 May; 34(5):738-46. doi:
NULL. [PMID: 21954562] - Theunis T Cloete, Carl C Johansson, David D N'Da, Suman Kumar Vodnala, Martin E Rottenberg, Jaco C Breytenbach, Michael Ashton. Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma.
Arzneimittel-Forschung.
2011; 61(5):317-25. doi:
10.1055/s-0031-1296205. [PMID: 21755816] - R Jansson-Löfmark, S Römsing, E Albers, M Ashton. Determination of eflornithine enantiomers in plasma by precolumn derivatization with o-phthalaldehyde-N-acetyl-L-cysteine and liquid chromatography with UV detection.
Biomedical chromatography : BMC.
2010 Jul; 24(7):768-73. doi:
10.1002/bmc.1361. [PMID: 20020417] - Susanna Vuohelainen, Eija Pirinen, Marc Cerrada-Gimenez, Tuomo A Keinänen, Anne Uimari, Marko Pietilä, Alex R Khomutov, Juhani Jänne, Leena Alhonen. Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.
Journal of cellular and molecular medicine.
2010 Jun; 14(6B):1683-92. doi:
10.1111/j.1582-4934.2009.00808.x. [PMID: 19538475] - Kevin J Helena, David D N'Da, Carl C Johansson, Jaco C Breytenbach, Michael Ashton. Effects of oral administration of synthesized delta-amides of eflornithine in the rat.
Arzneimittel-Forschung.
2010; 60(11):682-8. doi:
10.1055/s-0031-1296347. [PMID: 21175041] - Mohammad R Namazi, Amir Feily. Green tea extract: a novel addition to the antihirsutism armamentarium?.
Journal of alternative and complementary medicine (New York, N.Y.).
2009 Jul; 15(7):700-1. doi:
10.1089/acm.2009.0019. [PMID: 19534609] - Rehana Rehman, Rakhshaan Khan, Muhammad Saleh Soomro, Muhammad Aslam. Effect of difluoromethylornithine on thyroid function in rats.
Journal of Ayub Medical College, Abbottabad : JAMC.
2009 Apr; 21(2):87-9. doi:
. [PMID: 20524478] - Nitin Telang, Meena Katdare. Novel cell culture model for prevention of carcinogenic risk in familial adenomatous polyposis syndrome.
Oncology reports.
2009 Apr; 21(4):1017-21. doi:
10.3892/or_00000318. [PMID: 19288003] - Constance Chollet, Alessandro Baliani, Pui Ee Wong, Michael P Barrett, Ian H Gilbert. Targeted delivery of compounds to Trypanosoma brucei using the melamine motif.
Bioorganic & medicinal chemistry.
2009 Mar; 17(6):2512-23. doi:
10.1016/j.bmc.2009.01.058. [PMID: 19250832] - Xiao-Ba Wu, Jing Wang, Ji-Hong Liu, Xiu-Xin Deng. Involvement of polyamine biosynthesis in somatic embryogenesis of Valencia sweet orange (Citrus sinensis) induced by glycerol.
Journal of plant physiology.
2009 Jan; 166(1):52-62. doi:
10.1016/j.jplph.2008.02.005. [PMID: 18448195] - L Venkatachalam, N Bhagyalakshmi. Spermine-induced morphogenesis and effect of partial immersion system on the shoot cultures of banana.
Applied biochemistry and biotechnology.
2008 Dec; 151(2-3):502-11. doi:
10.1007/s12010-008-8226-z. [PMID: 18543117] - Carlos López-García, Andrés Joaquín López-Contreras, Asunción Cremades, Maria Teresa Castells, Faustino Marín, Fernanda Schreiber, Rafael Peñafiel. Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice.
Endocrinology.
2008 Oct; 149(10):5012-23. doi:
10.1210/en.2008-0084. [PMID: 18583422] - Cynthia M Miracle, Timo Rieg, Hadi Mansoury, Volker Vallon, Scott C Thomson. Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt.
American journal of physiology. Renal physiology.
2008 Oct; 295(4):F995-F1002. doi:
10.1152/ajprenal.00491.2007. [PMID: 18562630] - Marshall W Anderson, Colleen Goodin, Yu Zhang, Sangmi Kim, Richard D Estensen, Timothy S Wiedmann, Padmini Sekar, C Ralph Buncher, Jane C Khoury, Joel R Garbow, Ming You, Jay W Tichelaar. Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice.
Carcinogenesis.
2008 Aug; 29(8):1594-600. doi:
10.1093/carcin/bgn129. [PMID: 18515278] - R Jansson, M Malm, C Roth, M Ashton. Enantioselective and nonlinear intestinal absorption of eflornithine in the rat.
Antimicrobial agents and chemotherapy.
2008 Aug; 52(8):2842-8. doi:
10.1128/aac.00050-08. [PMID: 18519728] - Claudio Muscari, Francesca Bonafé, Marco Carboni, Marco Govoni, Ivana Stanic, Chiara Gamberini, Francesca Ricci, Pier Luigi Tazzari, Claudio Marcello Caldarera, Carlo Guarnieri. Difluoromethylornithine stimulates early cardiac commitment of mesenchymal stem cells in a model of mixed culture with cardiomyocytes.
Journal of cellular biochemistry.
2008 Mar; 103(4):1046-52. doi:
10.1002/jcb.21683. [PMID: 18240140] - Andrés Gárriz, María E Gonzalez, María Marina, Oscar A Ruiz, Fernando L Pieckenstain. Polyamine metabolism during sclerotial development of Sclerotinia sclerotiorum.
Mycological research.
2008 Mar; 112(Pt 3):414-22. doi:
10.1016/j.mycres.2007.10.016. [PMID: 18308526] - Mervi T Hyvönen, Tuomo A Keinänen, Marc Cerrada-Gimenez, Riitta Sinervirta, Nikolay Grigorenko, Alex R Khomutov, Jouko Vepsäläinen, Leena Alhonen, Juhani Jänne. Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.
The Journal of biological chemistry.
2007 Nov; 282(48):34700-6. doi:
10.1074/jbc.m704282200. [PMID: 17901051] - Jeongmi Lee, Anthony J Michael, Dariusz Martynowski, Elizabeth J Goldsmith, Margaret A Phillips. Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases.
The Journal of biological chemistry.
2007 Sep; 282(37):27115-27125. doi:
10.1074/jbc.m704066200. [PMID: 17626020] - J Satriano. Kidney growth, hypertrophy and the unifying mechanism of diabetic complications.
Amino acids.
2007 Aug; 33(2):331-9. doi:
10.1007/s00726-007-0529-9. [PMID: 17443269] - Takeshi Kumazawa, Takaki Hiwasa, Masaki Takiguchi, Osamu Suzuki, Keizo Sato. Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts.
International journal of molecular medicine.
2007 May; 19(5):765-70. doi:
10.3892/ijmm.19.5.765. [PMID: 17390081] - Carmen M Bastida, Asunción Cremades, Maria T Castells, Andrés J López-Contreras, Carlos López-García, Jesús Sánchez-Mas, Rafael Peñafiel. Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels.
American journal of physiology. Endocrinology and metabolism.
2007 Apr; 292(4):E1010-7. doi:
10.1152/ajpendo.00316.2006. [PMID: 17148758] - M Malm, Y Bergqvist. Determination of eflornithine enantiomers in plasma, by solid-phase extraction and liquid chromatography with evaporative light-scattering detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Feb; 846(1-2):98-104. doi:
10.1016/j.jchromb.2006.08.030. [PMID: 16996325] - Ildikó Loikkanen, Yanfeng Lin, Antti Railo, Antti Pajunen, Seppo Vainio. Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes.
Differentiation; research in biological diversity.
2005 Jul; 73(6):303-12. doi:
10.1111/j.1432-0436.2005.00036.x. [PMID: 16138831] - Neil Ashman, Steven M Harwood, Julius Kieswich, David A Allen, Norman B Roberts, A Claudio Mendes-Ribeiro, Muhammad M Yaqoob. Albumin stimulates cell growth, l-arginine transport, and metabolism to polyamines in human proximal tubular cells.
Kidney international.
2005 May; 67(5):1878-89. doi:
10.1111/j.1523-1755.2005.00286.x. [PMID: 15840035] - Carmen M Bastida, Asunción Cremades, Maria T Castells, Andrés J López-Contreras, Carlos López-García, Francisco Tejada, Rafael Peñafiel. Influence of ovarian ornithine decarboxylase in folliculogenesis and luteinization.
Endocrinology.
2005 Feb; 146(2):666-74. doi:
10.1210/en.2004-1004. [PMID: 15514084] - Xiangmin Liao, Wei Liang, Timothy Wiedmann, Lee Wattenberg, Alan Dahl. Lung distribution of the chemopreventive agent difluoromethylornithine (DFMO) following oral and inhalation delivery.
Experimental lung research.
2004 Dec; 30(8):755-69. doi:
10.1080/01902140490517836. [PMID: 15700551] - K Na-Bangchang, F Doua, J Konsil, W Hanpitakpong, B Kamanikom, F Kuzoe. The pharmacokinetics of eflornithine (alpha-difluoromethylornithine) in patients with late-stage T.b. gambiense sleeping sickness.
European journal of clinical pharmacology.
2004 Jun; 60(4):269-78. doi:
10.1007/s00228-004-0759-7. [PMID: 15141331] - W Hart, P H Slee, H G Schipper, R P Koopmans, P A Kager. [Clinical reasoning and decision making in practice. A depressive foreign woman with symptoms of malaise].
Nederlands tijdschrift voor geneeskunde.
2004 Apr; 148(16):771-6. doi:
NULL. [PMID: 15129565] - Huazhang Guo, Ramesh M Ray, Leonard R Johnson. RhoA stimulates IEC-6 cell proliferation by increasing polyamine-dependent Cdk2 activity.
American journal of physiology. Gastrointestinal and liver physiology.
2003 Oct; 285(4):G704-13. doi:
10.1152/ajpgi.00044.2003. [PMID: 12816757] - W Hanpitakpong, B Kamanikom, V Banmairuroi, K Na-Bangchang. High-performance liquid chromatographic method for determination of 2-difluoromethyl-DL-ornithine in plasma and cerebrospinal fluid.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 May; 788(2):221-31. doi:
10.1016/s1570-0232(02)00438-5. [PMID: 12705962] - Tiina Pasanen, Anne Karppinen, Leena Alhonen, Juhani Jänne, Jarmo Wahlfors. Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells.
International journal of cancer.
2003 Apr; 104(3):380-8. doi:
10.1002/ijc.10942. [PMID: 12569563] - Mariano Fos, Karina Proaño, David Alabadí, Fernando Nuez, Juan Carbonell, José L García-Martínez. Polyamine metabolism is altered in unpollinated parthenocarpic pat-2 tomato ovaries.
Plant physiology.
2003 Jan; 131(1):359-66. doi:
10.1104/pp.013037. [PMID: 12529543] - Carol J Fabian, Bruce F Kimler, Deborah A Brady, Matthew S Mayo, C H Joseph Chang, John A Ferraro, Carola M Zalles, Annette L Stanton, Shahla Masood, William E Grizzle, Norman F Boyd, Dora W Arneson, Karen A Johnson. A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2002 Oct; 8(10):3105-17. doi:
. [PMID: 12374678] - Irène Hummel, Ivan Couée, Abdelhak El Amrani, Josette Martin-Tanguy, Françoise Hennion. Involvement of polyamines in root development at low temperature in the subantarctic cruciferous species Pringlea antiscorbutica.
Journal of experimental botany.
2002 Jun; 53(373):1463-73. doi:
". [PMID: 12021294] - Carmen M Bastida, Francisco Tejada, Asunción Cremades, Rafael Peñafiel. The preovulatory rise of ovarian ornithine decarboxylase is required for progesterone secretion by the corpus luteum.
Biochemical and biophysical research communications.
2002 Apr; 293(1):106-11. doi:
10.1016/s0006-291x(02)00191-2. [PMID: 12054570] - Zili Zhang, Weiwen Chen. Plating densities, alpha-difluoromethylornithine effects and time dependence on the proliferation of IEC-6 cells.
Chinese medical journal.
2002 Apr; 115(4):518-20. doi:
". [PMID: 12133287] - Dianna A Johnson, Carolyn Fields, Amy Fallon, Malinda E C Fitzgerald, Mary Jane Viar, Leonard R Johnson. Polyamine-dependent migration of retinal pigment epithelial cells.
Investigative ophthalmology & visual science.
2002 Apr; 43(4):1228-33. doi:
NULL. [PMID: 11923270] - J E Green, M A Shibata, E Shibata, R C Moon, M R Anver, G Kelloff, R Lubet. 2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice.
Cancer research.
2001 Oct; 61(20):7449-55. doi:
NULL. [PMID: 11606379] - B Malhotra, R Noveck, D Behr, M Palmisano. Percutaneous absorption and pharmacokinetics of eflornithine HCl 13.9\% cream in women with unwanted facial hair.
Journal of clinical pharmacology.
2001 Sep; 41(9):972-8. doi:
10.1177/00912700122010951. [PMID: 11549102] - G Tonon, C Kevers, T Gaspar. Changes in polyamines, auxins and peroxidase activity during in vitro rooting of Fraxinus angustifolia shoots: an auxin-independent rooting model.
Tree physiology.
2001 Jul; 21(10):655-63. doi:
10.1093/treephys/21.10.655. [PMID: 11446994] - Y N Ye, E S Liu, V Y Shin, M W Koo, Y Li, E Q Wei, H Matsui, C H Cho. A mechanistic study of proliferation induced by Angelica sinensis in a normal gastric epithelial cell line.
Biochemical pharmacology.
2001 Jun; 61(11):1439-48. doi:
10.1016/s0006-2952(01)00625-6. [PMID: 11331080] - E Matovu, J C Enyaru, D Legros, C Schmid, T Seebeck, R Kaminsky. Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda.
Tropical medicine & international health : TM & IH.
2001 May; 6(5):407-11. doi:
10.1046/j.1365-3156.2001.00712.x. [PMID: 11348535] - P J Villano, P M Gallice, A E Nicoara, S G Honore, K Owczarczak, R G Favre, C M Briand. Polyamines secreted by cancer cells possibly account for the impairment of the human erythrocyte sodium pump activity.
Cellular and molecular biology (Noisy-le-Grand, France).
2001 Mar; 47(2):305-12. doi:
NULL. [PMID: 11355005] - E Elmore, D E Stringer, V E Steele, E W Gerner, J L Redpath. Chemoprevention by difluoromethylornithine: correlation of an in vitro human cell assay with human clinical data for biomarker modulation.
Anticancer research.
2001 Mar; 21(2A):1163-5. doi:
NULL. [PMID: 11396157] - B Tantini, F Flamigni, C Pignatti, C Stefanelli, M Fattori, A Facchini, E Giordano, C Clô, C M Caldarera. Polyamines, NO and cGMP mediate stimulation of DNA synthesis by tumor necrosis factor and lipopolysaccharide in chick embryo cardiomyocytes.
Cardiovascular research.
2001 Feb; 49(2):408-16. doi:
10.1016/s0008-6363(00)00255-8. [PMID: 11164851] - T H Hostetter. Hypertrophy and hyperfunction of the diabetic kidney.
The Journal of clinical investigation.
2001 Jan; 107(2):161-2. doi:
10.1172/jci12066. [PMID: 11160131] - J C Paz, F Sánchez-Jiménez, M A Medina. Characterization of spermine uptake by Ehrlich tumour cells in culture.
Amino acids.
2001; 21(3):271-9. doi:
10.1007/s007260170013. [PMID: 11764408] - S C Thomson, A Deng, D Bao, J Satriano, R C Blantz, V Vallon. Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes.
The Journal of clinical investigation.
2001 Jan; 107(2):217-24. doi:
10.1172/jci10963. [PMID: 11160138] - P P Carbone, J A Douglas, J Thomas, K Tutsch, M Pomplun, M Hamielec, D Pauk. Bioavailability study of oral liquid and tablet forms of alpha-difluoromethylornithine.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2000 Oct; 6(10):3850-4. doi:
NULL. [PMID: 11051229] - U R Tipnis, G Y He, S Li, G Campbell, P J Boor. Attenuation of isoproterenol-mediated myocardial injury in rat by an inhibitor of polyamine synthesis.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.
2000 Sep; 9(5):273-80. doi:
10.1016/s1054-8807(00)00038-7. [PMID: 11064274] - A B da Rocha, D R Mans, G Lenz, A K Fernandes, C de Lima, V F Monteiro, D Gonçalves, J C Moreira, A L Brunetto, R Rodnight, G Schwartsmann. Protein kinase C-mediated in vitro invasion of human glioma cells through extracellular-signal-regulated kinase and ornithine decarboxylase.
Pathobiology : journal of immunopathology, molecular and cellular biology.
2000 May; 68(3):113-23. doi:
10.1159/000055911. [PMID: 11174068] - J A Rillema, S Collins, C H Williams. Prolactin stimulation of iodide uptake and incorporation into protein is polyamine-dependent in mouse mammary gland explants.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
2000 May; 224(1):41-4. doi:
10.1046/j.1525-1373.2000.22363.x. [PMID: 10782045] - I Veress, S Haghighi, A Pulkka, A Pajunen. Changes in gene expression in response to polyamine depletion indicates selective stabilization of mRNAs.
The Biochemical journal.
2000 Feb; 346 Pt 1(?):185-91. doi:
10.1042/bj3460185. [PMID: 10657256] - H Hrselová, M Gryndler. Effect of spermine on proliferation of hyphae of Glomus fistulosum, an arbuscular mycorrhizal fungus, in maize roots.
Folia microbiologica.
2000; 45(2):167-71. doi:
10.1007/bf02817418. [PMID: 11271827] - M Ketteler, R Westenfeld, A Gawlik, E de Heer, A Distler. Acute glomerular upregulation of ornithine decarboxylase is not essential for mesangial cell proliferation and matrix expansion in anti-Thy-1-nephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2000 Jan; 15(1):16-22. doi:
10.1093/ndt/15.1.16. [PMID: 10607762] - J A O'Shaughnessy, L M Demers, S E Jones, J Arseneau, P Khandelwal, T George, R Gersh, D Mauger, A Manni. Alpha-difluoromethylornithine as treatment for metastatic breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1999 Nov; 5(11):3438-44. doi:
NULL. [PMID: 10589756]
