Cefoxitin (BioDeep_00001868004)

Main id: BioDeep_00000006369

 


代谢物信息卡片


Cefoxitin

化学式: C16H17N3O7S2 (427.0507892)
中文名称: 头孢西丁
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1(C2N(C1=O)C(=C(CS2)COC(=O)N)C(=O)O)NC(=O)CC3=CC=CS3
InChI: InChI=1S/C16H17N3O7S2/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22)/t14-,16+/m1/s1

描述信息

A semisynthetic cephamycin antibiotic which, in addition to the methoxy group at the 7alpha position, has 2-thienylacetamido and carbamoyloxymethyl side-groups. It is resistant to beta-lactamase.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DC - Second-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002513 - Cephamycins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

1 个代谢物同义名

Cefoxitin



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Md Sekendar Ali, Hyun-Ju Song, Bo-Youn Moon, Su-Jeong Kim, Hee Young Kang, Dong Chan Moon, Yeon-Hee Lee, Dong-Hyeon Kwon, Soon-Seek Yoon, Suk-Kyung Lim. Antibiotic Resistance Profiles and Molecular Characteristics of blaCMY-2-Carrying Salmonella enterica Serovar Albany Isolated from Chickens During 2013-2020 in South Korea. Foodborne pathogens and disease. 2023 Sep; ?(?):. doi: 10.1089/fpd.2023.0034. [PMID: 37699238]
  • Priscila Martins-Silva, Camila de Paula Dias, Lucas Cecílio Vilar, Silvana de Queiroz Silva, Ciro César Rossi, Marcia Giambiagi-deMarval. Dispersion and persistence of antimicrobial resistance genes among Staphylococcus spp. and Mammaliicoccus spp. isolated along a swine manure treatment plant. Environmental science and pollution research international. 2022 Dec; ?(?):. doi: 10.1007/s11356-022-24725-8. [PMID: 36515883]
  • Kyung-Hyo Do, Kwang Won Seo, Jae-Won Byun, Wan-Kyu Lee. Relationship between virulence factors and antimicrobial resistance genes of pathogenic Escherichia coli from diarrheic weaned piglets. Research in veterinary science. 2022 Dec; 150(?):137-143. doi: 10.1016/j.rvsc.2022.05.007. [PMID: 35830753]
  • Sultana Solaiman, Eric Handy, Taylor Brinks, Kasey Goon, Chris Bollinger, Amy R Sapkota, Manan Sharma, Shirley A Micallef. Extended Spectrum β-Lactamase Activity and Cephalosporin Resistance in Escherichia coli from U.S. Mid-Atlantic Surface and Reclaimed Water. Applied and environmental microbiology. 2022 08; 88(15):e0083722. doi: 10.1128/aem.00837-22. [PMID: 35862684]
  • Jun-Lan Liu, Tian-Ming Li, Ni Zhong, Xing Wang, Jie Jiang, Wen-Xia Zhang, Rong Tang, Yin-Juan Guo, Yun Liu, Jiang Hu, Li-Hua He, Jin Tang, Wen-Juan Wu, Min Li. Current status of oxacillin-susceptible mecA-positive Staphylococcus aureus infection in Shanghai, China: A multicenter study. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. 2021 Dec; 54(6):1070-1077. doi: 10.1016/j.jmii.2020.07.021. [PMID: 32819837]
  • Kyung Mi Kim, Sung-Hoon Kim, Ho-Yong Yun, Jiwon Jung, Ji-Yeon Bang, Eun-Kyung Lee, Byung-Moon Choi, Gyu-Jeong Noh. Development of a new pharmacokinetic model for target-concentration controlled infusion of cefoxitin as a prophylactic antibiotic in colorectal surgical patients. British journal of clinical pharmacology. 2021 12; 87(12):4648-4657. doi: 10.1111/bcp.14883. [PMID: 33929765]
  • Dan Wang, Anthony J Emanuel, Ron R Neyens, Eugene Bakharev, Nikolina Babic. Cefoxitin-Serum Creatinine Interference in a Patient With Nontuberculous Mycobacteria Ventriculomeningitis. Journal of pharmacy practice. 2021 Aug; 34(4):658-661. doi: 10.1177/0897190020921613. [PMID: 32351174]
  • Benoît Pilmis, Assaf Mizrahi, Céline Mory, Alban Le Monnier, Najoua El Helali. How to optimize administration of cefoxitin for the treatment of extended spectrum producing Enterobacteriaceae-related infection?. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2021 Jul; 40(7):1393-1397. doi: 10.1007/s10096-021-04165-x. [PMID: 33502648]
  • Thibaut Belveyre, Julien Scala-Bertola, Mathieu Esposito, Amandine Luc, Jeffrey Lipman, Emmanuel Novy. Influence of the Obesity Phenotype on the Adequacy of Antibiotic Prophylaxis with Cefoxitin for Obese Patients Undergoing Bariatric Surgery: Lessons Learnt and Future Considerations. European journal of drug metabolism and pharmacokinetics. 2021 Jul; 46(4):479-485. doi: 10.1007/s13318-021-00688-y. [PMID: 33959888]
  • Wafaa Jamal, Fatima Bibi Khodakhast, Ameerah AlAzmi, Jόzsef Sόki, Ghayda AlHashem, Vincent O Rotimi. Prevalence and antimicrobial susceptibility of enterotoxigenic extra-intestinal Bacteroides fragilis among 13-year collection of isolates in Kuwait. BMC microbiology. 2020 01; 20(1):14. doi: 10.1186/s12866-020-1703-4. [PMID: 31941446]
  • Feng Yang, Shidong Zhang, Xiaofei Shang, Xurong Wang, Ling Wang, Yan Sun. Short communication: N-Acetylcysteine-mediated augmentation of β-lactam antibacterial activity against methicillin-resistant Staphylococcus aureus isolated from bovine mastitis cases. Journal of dairy science. 2019 Aug; 102(8):6920-6922. doi: 10.3168/jds.2019-16389. [PMID: 31178194]
  • Shachi Mehta, Vincent Aranzana-Climent, Blandine Rammaert, Nicolas Grégoire, Sandrine Marchand, William Couet, Julien M Buyck. Preclinical Pharmacokinetic and Pharmacodynamic Data To Support Cefoxitin Nebulization for the Treatment of Mycobacterium abscessus. Antimicrobial agents and chemotherapy. 2019 07; 63(7):. doi: 10.1128/aac.02651-18. [PMID: 31061149]
  • Zaccaria Ricci, Simona Benegni, Jeffrey J Cies, Eleonora Marinari, Roberta Haiberger, Cristiana Garisto, Sara Cairoli, Luca Di Chiara, Bianca Goffredo. Cefoxitin Prophylaxis During Pediatric Cardiac Surgery: Retrospective Exploration of Postoperative Trough Levels. The Pediatric infectious disease journal. 2019 05; 38(5):484-489. doi: 10.1097/inf.0000000000002179. [PMID: 30169486]
  • Annet E Heuvelink, Maaike A Gonggrijp, Rianne G J Buter, Carlijn C Ter Bogt-Kappert, Gerdien van Schaik, Annet G J Velthuis, Theo J G M Lam. Prevalence of extended-spectrum and AmpC β-lactamase-producing Escherichia coli in Dutch dairy herds. Veterinary microbiology. 2019 May; 232(?):58-64. doi: 10.1016/j.vetmic.2019.04.005. [PMID: 31030845]
  • Evaggelos Kiriazopoulos, Sabina Zaharaki, Ariadni Vonaparti, Panagiota Vourna, Eirini Panteri-Petratou, Dimitra Gennimata, Kara Lombardo, Irene Panderi. Quantification of three beta-lactam antibiotics in breast milk and human plasma by hydrophilic interaction liquid chromatography/positive-ion electrospray ionization mass spectrometry. Drug testing and analysis. 2017 Jul; 9(7):1062-1072. doi: 10.1002/dta.2104. [PMID: 27714984]
  • Yodit Ayele, Fanta Desissa Gutema, Bedaso Mamo Edao, Robel Girma, Takele Beyene Tufa, Tariku Jibat Beyene, Fanos Tadesse, Mesula Geloye, Ashenafi Feyisa Beyi. Assessment of Staphylococcus aureus along milk value chain and its public health importance in Sebeta, central Oromia, Ethiopia. BMC microbiology. 2017 06; 17(1):141. doi: 10.1186/s12866-017-1048-9. [PMID: 28655298]
  • S A Zelenitsky, C Lawson, D Calic, R E Ariano, J A Roberts, J Lipman, G G Zhanel. Integrated pharmacokinetic-pharmacodynamic modelling to evaluate antimicrobial prophylaxis in abdominal surgery. The Journal of antimicrobial chemotherapy. 2016 10; 71(10):2902-8. doi: 10.1093/jac/dkw247. [PMID: 27402005]
  • Pierre Moine, Scott W Mueller, Jonathan A Schoen, Kevin B Rothchild, Douglas N Fish. Pharmacokinetic and Pharmacodynamic Evaluation of a Weight-Based Dosing Regimen of Cefoxitin for Perioperative Surgical Prophylaxis in Obese and Morbidly Obese Patients. Antimicrobial agents and chemotherapy. 2016 10; 60(10):5885-93. doi: 10.1128/aac.00585-16. [PMID: 27458209]
  • B Ghosh, M Mukherjee. Emergence of co-production of plasmid-mediated AmpC beta-lactamase and ESBL in cefoxitin-resistant uropathogenic Escherichia coli. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2016 Sep; 35(9):1449-54. doi: 10.1007/s10096-016-2683-z. [PMID: 27250633]
  • Gaixia Li, Bao-Sheng Liu, Qiuju Zhang, Rong Han. Investigation on the effect of fluorescence quenching of bovine serum albumin by cefoxitin sodium using fluorescence spectroscopy and synchronous fluorescence spectroscopy. Luminescence : the journal of biological and chemical luminescence. 2016 Aug; 31(5):1054-62. doi: 10.1002/bio.3071. [PMID: 26678839]
  • Seth T Housman, Mary Anne Banevicius, Lucinda M Lamb, David P Nicolau. Isolation and quantitation of Clostridium difficile in aqueous and fecal matter using two types of selective media. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. 2016 Jun; 49(3):445-7. doi: 10.1016/j.jmii.2015.05.012. [PMID: 26198865]
  • Darlan Augusto Costa Rocha, Juliana Coutinho Campos, Lilian Ferri Passadore, Suely Carlos Ferreira Sampaio, Antonio Carlos Nicodemo, Jorge Luiz Mello Sampaio. Frequency of Plasmid-Mediated AmpC β-Lactamases in Escherichia coli Isolates from Urine Samples in São Paulo, Brazil. Microbial drug resistance (Larchmont, N.Y.). 2016 Jun; 22(4):321-7. doi: 10.1089/mdr.2015.0190. [PMID: 26670152]
  • Luigi Brunetti, Leonid Kagan, Glenn Forrester, Lauren M Aleksunes, Hongxia Lin, Steven Buyske, Ronald G Nahass. Cefoxitin Plasma and Subcutaneous Adipose Tissue Concentration in Patients Undergoing Sleeve Gastrectomy. Clinical therapeutics. 2016 Jan; 38(1):204-10. doi: 10.1016/j.clinthera.2015.11.009. [PMID: 26686826]
  • Arianna Pompilio, Serena De Nicola, Valentina Crocetta, Simone Guarnieri, Vincenzo Savini, Edoardo Carretto, Giovanni Di Bonaventura. New insights in Staphylococcus pseudintermedius pathogenicity: antibiotic-resistant biofilm formation by a human wound-associated strain. BMC microbiology. 2015 May; 15(?):109. doi: 10.1186/s12866-015-0449-x. [PMID: 25994406]
  • E I Vingopoulou, V I Siarkou, G Batzias, F Kaltsogianni, E Sianou, I Tzavaras, A Koutinas, M N Saridomichelakis, D Sofianou, E Tzelepi, V Miriagou. Emergence and maintenance of multidrug-resistant Escherichia coli of canine origin harbouring a blaCMY-2-IncI1/ST65 plasmid and topoisomerase mutations. The Journal of antimicrobial chemotherapy. 2014 Aug; 69(8):2076-80. doi: 10.1093/jac/dku090. [PMID: 24722836]
  • Feixia Duan, Xiaohong Li, Suping Cai, Guang Xin, Yanyan Wang, Dan Du, Shiliang He, Baozhan Huang, Xiurong Guo, Hang Zhao, Rui Zhang, Limei Ma, Yan Liu, Qigen Du, Zeliang Wei, Zhihua Xing, Yong Liang, Xiaohua Wu, Chengzhong Fan, Chengjie Ji, Dequan Zeng, Qianming Chen, Yang He, Xuyang Liu, Wen Huang. Haloemodin as novel antibacterial agent inhibiting DNA gyrase and bacterial topoisomerase I. Journal of medicinal chemistry. 2014 May; 57(9):3707-14. doi: 10.1021/jm401685f. [PMID: 24588790]
  • Agnès Lefort, Françoise Chau, Raphaël Lepeule, Vincent Dubée, Marie-Dominique Kitzis, Sara Dion, Bruno Fantin. Activity of fosfomycin alone or combined with cefoxitin in vitro and in vivo in a murine model of urinary tract infection due to Escherichia coli harbouring CTX-M-15-type extended-spectrum β-lactamase. International journal of antimicrobial agents. 2014 Apr; 43(4):366-9. doi: 10.1016/j.ijantimicag.2013.12.001. [PMID: 24388117]
  • F Bert, B Larroque, F Dondero, F Durand, C Paugam-Burtz, J Belghiti, R Moreau, M-H Nicolas-Chanoine. Risk factors associated with preoperative fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae in liver transplant recipients. Transplant infectious disease : an official journal of the Transplantation Society. 2014 Feb; 16(1):84-9. doi: 10.1111/tid.12169. [PMID: 24330161]
  • Fernando García-Garrote, Emilia Cercenado, Mercedes Marín, Mercedes Bal, Pilar Trincado, Juan Corredoira, Carmen Ballesteros, Julia Pita, Pilar Alonso, Ana Vindel. Methicillin-resistant Staphylococcus aureus carrying the mecC gene: emergence in Spain and report of a fatal case of bacteraemia. The Journal of antimicrobial chemotherapy. 2014 Jan; 69(1):45-50. doi: 10.1093/jac/dkt327. [PMID: 23975743]
  • Ning Liu, Ming Chen, Shu-Qiu Chen, Bin Xu, Xiao-Yun Mao. [Preventive administration of antibiotics to patients with benign prostatic hyperplasia before urodynamic examination]. Zhonghua nan ke xue = National journal of andrology. 2013 Nov; 19(11):996-8. doi: NULL. [PMID: 24341093]
  • Kerin L Tyrrell, Diane M Citron, Eliza S Leoncio, C Vreni Merriam, Ellie J C Goldstein. Evaluation of cycloserine-cefoxitin fructose agar (CCFA), CCFA with horse blood and taurocholate, and cycloserine-cefoxitin mannitol broth with taurocholate and lysozyme for recovery of Clostridium difficile isolates from fecal samples. Journal of clinical microbiology. 2013 Sep; 51(9):3094-6. doi: 10.1128/jcm.00879-13. [PMID: 23804392]
  • Dwarakanathan Ranganathan, Robert Fassett, George T John. Mycobacterium fortuitum peritonitis in a patient receiving continuous ambulatory peritoneal dialysis. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2013 Sep; 24(5):1003-4. doi: 10.4103/1319-2442.118073. [PMID: 24029271]
  • Kerry C Carson, Lusiana V Boseiwaqa, Sara K Thean, Niki F Foster, Thomas V Riley. Isolation of Clostridium difficile from faecal specimens--a comparison of chromID C. difficile agar and cycloserine-cefoxitin-fructose agar. Journal of medical microbiology. 2013 Sep; 62(Pt 9):1423-1427. doi: 10.1099/jmm.0.056515-0. [PMID: 23579394]
  • Mi Mi Oh, Ji Yun Chae, Jin Wook Kim, Jong Wook Kim, Cheol Yong Yoon, Min Gu Park, Du Geon Moon. Positive culture for extended-spectrum β-lactamase during acute prostatitis after prostate biopsy is a risk factor for progression to chronic prostatitis. Urology. 2013 Jun; 81(6):1209-12. doi: 10.1016/j.urology.2013.02.040. [PMID: 23601450]
  • Aaron T Wolman, Michael R Gionfriddo, Gregory A Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy, Adam L Vanwert. Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. Drug metabolism and disposition: the biological fate of chemicals. 2013 Apr; 41(4):791-800. doi: 10.1124/dmd.112.049569. [PMID: 23344796]
  • J M Thompson, A Gündoğdu, H M Stratton, M Katouli. Antibiotic resistant Staphylococcus aureus in hospital wastewaters and sewage treatment plants with special reference to methicillin-resistant Staphylococcus aureus (MRSA). Journal of applied microbiology. 2013 Jan; 114(1):44-54. doi: 10.1111/jam.12037. [PMID: 23057695]
  • Morike Ngoe Mokube, Julius Atashili, Gregory Edie Halle-Ekane, George M Ikomey, Peter M Ndumbe. Bacteriuria amongst pregnant women in the Buea Health District, Cameroon: prevalence, predictors, antibiotic susceptibility patterns and diagnosis. PloS one. 2013; 8(8):e71086. doi: 10.1371/journal.pone.0071086. [PMID: 23976983]
  • Hong Li, De-Lei Yu, Lei Ren, Lin Zhong, Zhi-Hai Peng, Mu-Jian Teng. Analysis of Gram-positive bacterial infection in patients following liver transplantation. Chinese medical journal. 2012 Jul; 125(14):2417-21. doi: . [PMID: 22882913]
  • Salih Cesur, Hasan Irmak, Hüsniye Simşek, Nilay Cöplü, Hasan Kılıç, Uğur Arslan, Gülçin Bayramoğlu, Betil Ozhak Baysan, Zeynep Gülay, Salih Hoşoğlu, Mustafa Berktaş, Serap Gencer, Ali Pekcan Demiröz, Berrin Esen, Nihal Karabiber, Faruk Aydın, Ata Nevzat Yalçın. [Evaluation of antibiotic susceptibilities and VISA-VRSA rates among MRSA strains isolated from hospitalized patients in intensive care units of hospitals in seven provinces of Turkey]. Mikrobiyoloji bulteni. 2012 Jul; 46(3):352-8. doi: NULL. [PMID: 22951647]
  • Frédéric Bert, Béatrice Larroque, Catherine Paugam-Burtz, Federica Dondero, François Durand, Estelle Marcon, Jacques Belghiti, Richard Moreau, Marie-Hélène Nicolas-Chanoine. Pretransplant fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae and infection after liver transplant, France. Emerging infectious diseases. 2012 Jun; 18(6):908-16. doi: 10.3201/eid1806.110139. [PMID: 22607885]
  • Aurijit Sarkar, Kelcey C Anderson, Glen E Kellogg. Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. European journal of medicinal chemistry. 2012 Jun; 52(?):98-110. doi: 10.1016/j.ejmech.2012.03.008. [PMID: 22483632]
  • Y F Chen, R S Liang, X L Zhuo, X T Wu, J X Zou. Isolation and characterization of Aeromonas schubertii from diseased snakehead, Channa maculata (Lacepède). Journal of fish diseases. 2012 Jun; 35(6):421-30. doi: 10.1111/j.1365-2761.2012.01362.x. [PMID: 22524539]
  • Arantxazu Isla, Iñaki F Trocóniz, Ignacio López de Tejada, Silvia Vázquez, Andrés Canut, Jesús Muriel López, María Ángeles Solinís, Alicia Rodríguez Gascón. Population pharmacokinetics of prophylactic cefoxitin in patients undergoing colorectal surgery. European journal of clinical pharmacology. 2012 May; 68(5):735-45. doi: 10.1007/s00228-011-1206-1. [PMID: 22246211]
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  • Nadine Geser, Roger Stephan, Herbert Hächler. Occurrence and characteristics of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae in food producing animals, minced meat and raw milk. BMC veterinary research. 2012 Mar; 8(?):21. doi: 10.1186/1746-6148-8-21. [PMID: 22397509]
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  • Raphaël Lepeule, Etienne Ruppé, Patrick Le, Laurent Massias, Françoise Chau, Amandine Nucci, Agnès Lefort, Bruno Fantin. Cefoxitin as an alternative to carbapenems in a murine model of urinary tract infection due to Escherichia coli harboring CTX-M-15-type extended-spectrum β-lactamase. Antimicrobial agents and chemotherapy. 2012 Mar; 56(3):1376-81. doi: 10.1128/aac.06233-11. [PMID: 22214774]
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