carprofen (BioDeep_00001867986)
Main id: BioDeep_00000002532
代谢物信息卡片
carprofen
化学式: C15H12ClNO2 (273.0557)
中文名称: 卡洛芬
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1=CC2=C(C=C1)C3=C(N2)C=CC(=C3)Cl)C(=O)O
InChI: InChI=1S/C15H12ClNO2/c1-8(15(18)19)9-2-4-11-12-7-10(16)3-5-13(12)17-14(11)6-9/h2-8,17H,1H3,(H,18,19)
描述信息
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
D003879 - Dermatologic Agents
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:364453
- KEGG: C18364
- KEGGdrug: D03410
- KEGGdrug: D70911
- PubChem: 2581
- DrugBank: DB00821
- ChEMBL: CHEMBL1316
- CAS: 53716-49-7
- CAS: 52263-47-5
- PubChem: 124489038
- medchemexpress: HY-B1227
- KNApSAcK: 364453
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Busra Aslan Akyol, Cengiz Gokbulut. The effect of intravenous lipid emulsion (ILE) on the pharmacokinetic/toxicokinetic dispositions of ivermectin and carprofen in rabbits.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Sep; ?(?):. doi:
10.1007/s00210-023-02738-5. [PMID: 37768375] - Miranda Buseman, April E Blong, Rebecca A L Walton. Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2022 Sep; 32(5):675-679. doi:
10.1111/vec.13203. [PMID: 35527394] - Florea Dumitrascu, Ana-Maria Udrea, Mino R Caira, Diana Camelia Nuta, Carmen Limban, Mariana Carmen Chifiriuc, Marcela Popa, Coralia Bleotu, Anamaria Hanganu, Denisa Dumitrescu, Speranta Avram. In Silico and Experimental Investigation of the Biological Potential of Some Recently Developed Carprofen Derivatives.
Molecules (Basel, Switzerland).
2022 Apr; 27(9):. doi:
10.3390/molecules27092722. [PMID: 35566083] - Desiree Ferrari, Sandra Lundgren, Johanna Holmberg, Anna Edner, Carl Ekstrand, Görel Nyman, Ulf Bondesson, Ragnvi Hagman. Concentration of carprofen in the milk of lactating bitches after cesarean section and during inflammatory conditions.
Theriogenology.
2022 Mar; 181(?):59-68. doi:
10.1016/j.theriogenology.2022.01.016. [PMID: 35063922] - Lon V Kendall, Alexandrea L Bailey, Benjamin Singh, Whitney McGee. Toxic Effects of High-dose Meloxicam and Carprofen on Female CD1 Mice.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2022 01; 61(1):75-80. doi:
10.30802/aalas-jaalas-21-000071. [PMID: 34920791] - Cristhian Rene Vargas Estrada, Bruna Fernanda Firmo, Daniele Belchior Vela, Marjury Cristina Maronezi, Ricardo Andrés Ramirez Uscategui, Beatriz Gasser, Marcus Antônio Rossi Feliciano, Letícia Pavan, Luiz Paulo Nogueira Aires, Gabriela Piovan Lima, Andrigo Barboza De Nardi. Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen.
Scientific reports.
2021 12; 11(1):23277. doi:
10.1038/s41598-021-02781-3. [PMID: 34857853] - A Parra-Coca, A Boix-Montañés, A C Calpena-Campmany, H Colom. In vivo pharmacokinetic evaluation of carprofen delivery from intra-articular nanoparticles in rabbits: A population modelling approach.
Research in veterinary science.
2021 Jul; 137(?):235-242. doi:
10.1016/j.rvsc.2021.05.012. [PMID: 34049110] - Erdinc Turk, Ibrahim Ozan Tekeli, Orhan Corum, Duygu Durna Corum, Fatma Ceren Kirgiz, Gul Cetin, Dilek Arslan Atessahin, Kamil Uney. Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (Coturnix coturnix japonica).
Journal of veterinary pharmacology and therapeutics.
2021 May; 44(3):388-396. doi:
10.1111/jvp.12972. [PMID: 33846990] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Maša Bošnjak, Mojca Kržan, Urša Lampreht Tratar, Jožica Dolenc, Maja Čemažar, Alenka Seliškar. Pharmacokinetics of carprofen in anaesthetized pigs: a preliminary study.
Veterinary anaesthesia and analgesia.
2021 Jan; 48(1):35-41. doi:
10.1016/j.vaa.2020.09.006. [PMID: 33303396] - T H Morris, S W Paine, P W Zahra, E C Li, S A Colgan, S L Karamatic. Pharmacokinetics of carprofen and firocoxib for medication control in racing greyhounds.
Australian veterinary journal.
2020 Dec; 98(12):578-585. doi:
10.1111/avj.13014. [PMID: 32875570] - Susan M Jones, Ann Gaier, Hiroko Enomoto, Patricia Ishii, Rachel Pilla, Josh Price, Jan Suchodolski, Joerg M Steiner, Mark G Papich, Kristen Messenger, M Katherine Tolbert. The effect of combined carprofen and omeprazole administration on gastrointestinal permeability and inflammation in dogs.
Journal of veterinary internal medicine.
2020 Sep; 34(5):1886-1893. doi:
10.1111/jvim.15897. [PMID: 32893926] - Kavitha Kongara, Nick Cave, Karin Weidgraaf, Venkata Sayoji Rao Dukkipati. Effect of non-steroidal anti-inflammatory drugs on glomerular filtration rate and urinary N-acetyl-β-D-glucosaminidase activity in cats after dental surgery.
Veterinary anaesthesia and analgesia.
2020 Sep; 47(5):631-636. doi:
10.1016/j.vaa.2020.04.014. [PMID: 32792267] - Steven C Budsberg, Stephanie A Kleine, Megan M Norton, Gabriella S Sandberg, Mark G Papich. Comparison of the effects on lameness of orally administered acetaminophen-codeine and carprofen in dogs with experimentally induced synovitis.
American journal of veterinary research.
2020 Aug; 81(8):627-634. doi:
10.2460/ajvr.81.8.627. [PMID: 32701001] - Kate S Farrell, Jamie M Burkitt-Creedon, Laura G Osborne, Erin A Gibson, Anna M Massie. Gastrointestinal obstruction secondary to activated charcoal granule impaction in a dog.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2020 Jul; 30(4):461-466. doi:
10.1111/vec.12980. [PMID: 32583603] - Aleix Gimeno, Júlia Mestres-Truyol, María José Ojeda-Montes, Guillem Macip, Bryan Saldivar-Espinoza, Adrià Cereto-Massagué, Gerard Pujadas, Santiago Garcia-Vallvé. Prediction of Novel Inhibitors of the Main Protease (M-pro) of SARS-CoV-2 through Consensus Docking and Drug Reposition.
International journal of molecular sciences.
2020 May; 21(11):. doi:
10.3390/ijms21113793. [PMID: 32471205] - Jutarat Apakupakul, Panpicha Sattasathuchana, Phongsak Chanloinapha, Naris Thengchaisri. Optimization of a rapid one-step platelet-rich plasma preparation method using syringe centrifugation with and without carprofen.
BMC veterinary research.
2020 May; 16(1):124. doi:
10.1186/s12917-020-02350-2. [PMID: 32375782] - M Locatelli, A Tartaglia, F D'Ambrosio, P Ramundo, H I Ulusoy, K G Furton, A Kabir. Biofluid sampler: A new gateway for mail-in-analysis of whole blood samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Apr; 1143(?):122055. doi:
10.1016/j.jchromb.2020.122055. [PMID: 32172173] - Meghan E Fick, Kristen M Messenger, Alessio Vigani. Efficacy of a single session in-series hemoperfusion and hemodialysis in the management of carprofen overdose in two dogs.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2020 Mar; 30(2):226-231. doi:
10.1111/vec.12931. [PMID: 32128985] - Daniel Limones-Herrero, Fabrizio Palumbo, Victoria Vendrell-Criado, Inmaculada Andreu, Emilio Lence, Concepción González-Bello, Miguel A Miranda, M Consuelo Jiménez. Investigation of metabolite-protein interactions by transient absorption spectroscopy and in silico methods.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Feb; 226(?):117652. doi:
10.1016/j.saa.2019.117652. [PMID: 31654902] - Ismael Hernández-Avalos, Alexander Valverde, José Antonio Ibancovichi-Camarillo, Pedro Sánchez-Aparicio, Sergio Recillas-Morales, Jorge Osorio-Avalos, Desiderio Rodríguez-Velázquez, Agatha Elisa Miranda-Cortés. Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and carprofen in dogs undergoing ovariohysterectomy.
PloS one.
2020; 15(2):e0223697. doi:
10.1371/journal.pone.0223697. [PMID: 32059002] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Veena Krishnan, David Booker, Gabrielle Cunningham, Jeevan Kumar Jadapalli, Vasundhara Kain, Amanda B Pullen, Ganesh V Halade. Pretreatment of carprofen impaired initiation of inflammatory- and overlapping resolution response and promoted cardiorenal syndrome in heart failure.
Life sciences.
2019 Feb; 218(?):224-232. doi:
10.1016/j.lfs.2018.12.048. [PMID: 30597172] - Evgeniy Salnikov, Binia Drung, Gabin Fabre, Anna Itkin, Michal Otyepka, Norbert A Dencher, Boris Schmidt, Thomas Hauß, Patrick Trouillas, Burkhard Bechinger. Lipid bilayer position and orientation of novel carprofens, modulators of γ-secretase in Alzheimer's disease.
Biochimica et biophysica acta. Biomembranes.
2018 11; 1860(11):2224-2233. doi:
10.1016/j.bbamem.2018.09.003. [PMID: 30409518] - M Leiberich, R Krebber, M Hewetson, J Marais, V Naidoo. A study of the pharmacokinetics and thromboxane inhibitory activity of a single intramuscular dose of carprofen as a means to establish its potential use as an analgesic drug in white rhinoceros.
Journal of veterinary pharmacology and therapeutics.
2018 Aug; 41(4):605-613. doi:
10.1111/jvp.12508. [PMID: 29691872] - Astrid B Kjaergaard, Jennifer L Davis, Mark J Acierno. Treatment of carprofen overdose with therapeutic plasma exchange in a dog.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2018 Jul; 28(4):356-360. doi:
10.1111/vec.12729. [PMID: 29898245] - V Naidoo, M A Taggart, N Duncan, K Wolter, J Chipangura, R E Green, T H Galligan. The use of toxicokinetics and exposure studies to show that carprofen in cattle tissue could lead to secondary toxicity and death in wild vultures.
Chemosphere.
2018 Jan; 190(?):80-89. doi:
10.1016/j.chemosphere.2017.08.167. [PMID: 28985539] - Vanessa L Oliver, Stephanie Athavale, Katherine E Simon, Lon V Kendall, Jean A Nemzek, Jennifer L Lofgren. Evaluation of Pain Assessment Techniques and Analgesia Efficacy in a Female Guinea Pig (Cavia porcellus) Model of Surgical Pain.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2017 Jul; 56(4):425-435. doi:
NULL. [PMID: 28724492] - Andrea Barbarossa, Julie Rambaldi, Massimo Giunti, Anna Zaghini, Marco Cunto, Daniele Zambelli, Simond Valgimigli, Francesco Santoro, Noemi Romagnoli. Pharmacokinetics of buprenorphine following constant rate infusion for postoperative analgesia in dogs undergoing ovariectomy.
Veterinary anaesthesia and analgesia.
2017 May; 44(3):435-443. doi:
10.1016/j.vaa.2016.05.010. [PMID: 28416162] - I Schulze, E M Poos, H Meyer, A K List, S B R Kaestner, J Rehage. Effects of preoperative carprofen on cardio-respiratory, hormonal and metabolic stress response in calves during umbilical surgery under isoflurane inhalation anaesthesia.
Veterinary journal (London, England : 1997).
2016 Oct; 216(?):18-24. doi:
10.1016/j.tvjl.2016.06.009. [PMID: 27687921] - Thanikul Srithunyarat, Odd V Höglund, Ragnvi Hagman, Ulf Olsson, Mats Stridsberg, Anne-Sofie Lagerstedt, Ann Pettersson. Catestatin, vasostatin, cortisol, temperature, heart rate, respiratory rate, scores of the short form of the Glasgow composite measure pain scale and visual analog scale for stress and pain behavior in dogs before and after ovariohysterectomy.
BMC research notes.
2016 Aug; 9(?):381. doi:
10.1186/s13104-016-2193-1. [PMID: 27484122] - Mingjie Tang, Yanjie Guo, Youshui Gao, Chao Tang, Xiaoqian Dang, Zubin Zhou, Yuqiang Sun, Kunzheng Wang. Albumin's Influence on Carprofen Enantiomers-Hymecromone Interaction.
Chirality.
2016 Mar; 28(3):226-9. doi:
10.1002/chir.22562. [PMID: 26708612] - M L Stock, L A Barth, N K Van Engen, S T Millman, R Gehring, C Wang, E A Voris, L W Wulf, Léa Labeur, W H Hsu, J F Coetzee. Impact of carprofen administration on stress and nociception responses of calves to cautery dehorning.
Journal of animal science.
2016 Feb; 94(2):542-55. doi:
10.2527/jas.2015-9510. [PMID: 27065124] - K M Messenger, J A Wofford, M G Papich. Carprofen pharmacokinetics in plasma and in control and inflamed canine tissue fluid using in vivo ultrafiltration.
Journal of veterinary pharmacology and therapeutics.
2016 Feb; 39(1):32-9. doi:
10.1111/jvp.12233. [PMID: 25958925] - Travis L Seymour, Sean C Adams, Stephen A Felt, Katechan Jampachaisri, David C Yeomans, Cholawat Pacharinsak. Postoperative Analgesia Due to Sustained-Release Buprenorphine, Sustained-Release Meloxicam, and Carprofen Gel in a Model of Incisional Pain in Rats (Rattus norvegicus).
Journal of the American Association for Laboratory Animal Science : JAALAS.
2016; 55(3):300-5. doi:
. [PMID: 27177563] - Amy M Koenigshof, Matthew W Beal, Robert H Poppenga, L Ari Jutkowitz. Effect of sorbitol, single, and multidose activated charcoal administration on carprofen absorption following experimental overdose in dogs.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2015 Sep; 25(5):606-10. doi:
10.1111/vec.12305. [PMID: 25891141] - D Marini, J Pippia, I G Colditz, G Hinch, J C Petherick, C Lee. Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep.
Australian veterinary journal.
2015 Aug; 93(8):265-70. doi:
10.1111/avj.12351. [PMID: 26220318] - M Vailati Riboni, S Meier, N V Priest, C R Burke, J K Kay, S McDougall, M D Mitchell, C G Walker, M Crookenden, A Heiser, J R Roche, J J Loor. Adipose and liver gene expression profiles in response to treatment with a nonsteroidal antiinflammatory drug after calving in grazing dairy cows.
Journal of dairy science.
2015 May; 98(5):3079-85. doi:
10.3168/jds.2014-8579. [PMID: 25771063] - K S Kalchofner Guerrero, A Schwarz, R Wuhrmann, S Feldmann, S Hartnack, R Bettschart-Wolfensberger. Comparison of a new metamizole formulation and carprofen for extended post-operative analgesia in dogs undergoing ovariohysterectomy.
Veterinary journal (London, England : 1997).
2015 Apr; 204(1):99-104. doi:
10.1016/j.tvjl.2015.01.028. [PMID: 25744803] - Zhong-Ze Fang, Haina Wang, Yun-Feng Cao, Dong-Xue Sun, Li-Xuan Wang, Mo Hong, Ting Huang, Jian-Xing Chen, Jia Zeng. Enantioselective inhibition of carprofen towards UDP-glucuronosyltransferase (UGT) 2B7.
Chirality.
2015 Mar; 27(3):189-93. doi:
10.1002/chir.22412. [PMID: 25502512] - Tamsyn Fourie, Duncan Cromarty, Neil Duncan, Kerri Wolter, Vinny Naidoo. The Safety and Pharmacokinetics of Carprofen, Flunixin and Phenylbutazone in the Cape Vulture (Gyps coprotheres) following Oral Exposure.
PloS one.
2015; 10(10):e0141419. doi:
10.1371/journal.pone.0141419. [PMID: 26512724] - Michèle Sidler, Nathalie Fouché, Ingmar Meth, Friedrich von Hahn, Brigitte von Rechenberg, Peter W Kronen. Preliminary study on carprofen concentration measurements after transcutaneous treatment with Vetdrop® in a microfracture joint defect model in sheep.
BMC veterinary research.
2014 Dec; 10(?):268. doi:
10.1186/s12917-014-0268-6. [PMID: 25488522] - Lisa Y Pang, Sally A Argyle, Ayako Kamida, Katherine O'Neill Morrison, David J Argyle. The long-acting COX-2 inhibitor mavacoxib (Trocoxil™) has anti-proliferative and pro-apoptotic effects on canine cancer cell lines and cancer stem cells in vitro.
BMC veterinary research.
2014 Sep; 10(?):184. doi:
10.1186/s12917-014-0184-9. [PMID: 25190452] - Gerald A Hish, Jose A Diaz, Angela E Hawley, Daniel D Myers, Patrick A Lester. Effects of analgesic use on inflammation and hematology in a murine model of venous thrombosis.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2014 Sep; 53(5):485-93. doi:
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Journal of the American Association for Laboratory Animal Science : JAALAS.
2014 Sep; 53(5):478-84. doi:
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Veterinary clinical pathology.
2014 Sep; 43(3):463-4. doi:
10.1111/vcp.12158. [PMID: 24931400] - S Meier, N V Priest, C R Burke, J K Kay, S McDougall, M D Mitchell, C G Walker, A Heiser, J J Loor, J R Roche. Treatment with a nonsteroidal antiinflammatory drug after calving did not improve milk production, health, or reproduction parameters in pasture-grazed dairy cows.
Journal of dairy science.
2014 May; 97(5):2932-43. doi:
10.3168/jds.2013-7838. [PMID: 24630655] - Magdalena Szweda, Józef Szarek, Krystyna Dublan, Tomasz Męcik-Kronenberg, Zdzisław Kiełbowicz, Marcin Bigoszewski. Effect of mucoprotective plant-derived therapies on damage to colonic mucosa caused by carprofen and robenacoxib administered to healthy dogs for 21 days.
The veterinary quarterly.
2014; 34(4):185-93. doi:
10.1080/01652176.2014.968939. [PMID: 25330194] - Cavit Kum, Huseyin Voyvoda, Selim Sekkin, Umit Karademir, Tugrul Tarimcilar. Effects of carprofen and meloxicam on C-reactive protein, ceruloplasmin, and fibrinogen concentrations in dogs undergoing ovariohysterectomy.
American journal of veterinary research.
2013 Oct; 74(10):1267-73. doi:
10.2460/ajvr.74.10.1267. [PMID: 24066910] - Rae G Hutchins, Kristen M Messenger, Shelly L Vaden. Suspected carprofen toxicosis caused by coprophagia in a dog.
Journal of the American Veterinary Medical Association.
2013 Sep; 243(5):709-11. doi:
10.2460/javma.243.5.709. [PMID: 23971852] - Joelle C Ingrao, Ron Johnson, Elizabeth Tor, Yu Gu, Marcus Litman, Patricia V Turner. Aqueous stability and oral pharmacokinetics of meloxicam and carprofen in male C57BL/6 mice.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2013 Sep; 52(5):553-9. doi:
NULL. [PMID: 24041210] - C Brentnall, Z Cheng, Q A McKellar, P Lees. Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves.
Journal of veterinary pharmacology and therapeutics.
2013 Aug; 36(4):320-8. doi:
10.1111/jvp.12000. [PMID: 22913421] - A Torres, J Chagas E Silva, P Diniz, L Lopes-da-Costa. Evaluation of treatments with hCG and carprofen at embryo transfer in a demi-embryo and recipient virgin heifer model.
Animal : an international journal of animal bioscience.
2013 Aug; 7(8):1317-22. doi:
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Journal of dairy science.
2013 Jul; 96(7):4323-32. doi:
10.3168/jds.2012-6266. [PMID: 23660148] - C Brentnall, Z Cheng, Q A McKellar, P Lees. Pharmacokinetic-pharmacodynamic integration and modelling of oxytetracycline administered alone and in combination with carprofen in calves.
Research in veterinary science.
2013 Jun; 94(3):687-94. doi:
10.1016/j.rvsc.2013.01.012. [PMID: 23415880] - Claire Brentnall, Zhangrui Cheng, Quintin A McKellar, Peter Lees. Potency and selectivity of carprofen enantiomers for inhibition of bovine cyclooxygenase in whole blood assays.
Research in veterinary science.
2012 Dec; 93(3):1387-92. doi:
10.1016/j.rvsc.2012.05.002. [PMID: 22703724] - C Brentnall, Z Cheng, Q A McKellar, P Lees. Pharmacodynamics of oxytetracycline administered alone and in combination with carprofen in calves.
The Veterinary record.
2012 Sep; 171(11):273. doi:
10.1136/vr.100935. [PMID: 22843613] - Kathryn K Surdyk, Dawn L Sloan, Scott A Brown. Renal effects of carprofen and etodolac in euvolemic and volume-depleted dogs.
American journal of veterinary research.
2012 Sep; 73(9):1485-90. doi:
10.2460/ajvr.73.9.1485. [PMID: 22924732] - Kathleen B Mullins, John M Thomason, Kari V Lunsford, Lesya M Pinchuk, Vernon C Langston, Robert W Wills, Ronald M McLaughlin, Andrew J Mackin. Effects of carprofen, meloxicam and deracoxib on platelet function in dogs.
Veterinary anaesthesia and analgesia.
2012 Mar; 39(2):206-17. doi:
10.1111/j.1467-2995.2011.00684.x. [PMID: 22248445] - Bryan E Essien, Michael Kotiw. Anti-inflammatory activity of hyperimmune plasma in a lipopolysaccharide-mediated rat air pouch model of inflammation.
Inflammation.
2012 Feb; 35(1):58-64. doi:
10.1007/s10753-010-9289-x. [PMID: 21213030] - Tawina J Zollinger, John P Hoover, Mark E Payton, Chris A Schiller. Clinicopathologic, gross necropsy, and histologic findings after intramuscular injection of carprofen in a pigeon (Columba livia) model.
Journal of avian medicine and surgery.
2011 Sep; 25(3):173-84. doi:
10.1647/2010-023.1. [PMID: 22216717] - Stephan Neumann, Pelle Stolt, Gabriele Braun, Klaus Hellmann, Erich Reinhart. Effectiveness of the homeopathic preparation Zeel compared with carprofen in dogs with osteoarthritis.
Journal of the American Animal Hospital Association.
2011 Jan; 47(1):12-20. doi:
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American journal of veterinary research.
2010 Oct; 71(10):1246-52. doi:
10.2460/ajvr.71.10.1246. [PMID: 20919914] - Shauna L Blois, Dana G Allen, R Darren Wood, Peter D Conlon. Effects of aspirin, carprofen, deracoxib, and meloxicam on platelet function and systemic prostaglandin concentrations in healthy dogs.
American journal of veterinary research.
2010 Mar; 71(3):349-58. doi:
10.2460/ajvr.71.3.349. [PMID: 20187838] - D R Paull, C Lee, I G Colditz, A D Fisher. Effects of a topical anaesthetic formulation and systemic carprofen, given singly or in combination, on the cortisol and behavioural responses of Merino lambs to castration.
Australian veterinary journal.
2009 Jun; 87(6):230-7. doi:
10.1111/j.1751-0813.2009.00429.x. [PMID: 19489780] - P V M Steagall, F Q Moutinho, F B Mantovani, D Passarelli, A Thomassian. Evaluation of the adverse effects of subcutaneous carprofen over six days in healthy cats.
Research in veterinary science.
2009 Feb; 86(1):115-20. doi:
10.1016/j.rvsc.2008.04.002. [PMID: 18504052] - M G Hawkins, I T Taylor, A L Craigmill, L A Tell. Enantioselective pharmacokinetics of racemic carprofen in New Zealand white rabbits.
Journal of veterinary pharmacology and therapeutics.
2008 Oct; 31(5):423-30. doi:
10.1111/j.1365-2885.2008.00975.x. [PMID: 19000261] - George Stilwell, Miguel S Lima, Donald M Broom. Effects of nonsteroidal anti-inflammatory drugs on long-term pain in calves castrated by use of an external clamping technique following epidural anesthesia.
American journal of veterinary research.
2008 Jun; 69(6):744-50. doi:
10.2460/ajvr.69.6.744. [PMID: 18518654] - Dóra Halmay, Tibor Gaál, Róbert Kocsis. Influencing factors of ADP-induced, epinephrine-induced and ristomycin-induced platelet aggregation in dogs.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2008 Jan; 19(1):14-22. doi:
10.1097/mbc.0b013e3282e38e41. [PMID: 18180610] - Hannes M Bergmann, Ingo Nolte, Sabine Kramer. Comparison of analgesic efficacy of preoperative or postoperative carprofen with or without preincisional mepivacaine epidural anesthesia in canine pelvic or femoral fracture repair.
Veterinary surgery : VS.
2007 Oct; 36(7):623-32. doi:
10.1111/j.1532-950x.2007.00314.x. [PMID: 17894588] - Melanie Craven, Marge L Chandler, Jörg M Steiner, Ashkan Farhadi, Elizabeth Welsh, Kathryn Pratschke, Darren J Shaw, David A Williams. Acute effects of carprofen and meloxicam on canine gastrointestinal permeability and mucosal absorptive capacity.
Journal of veterinary internal medicine.
2007 Sep; 21(5):917-23. doi:
10.1892/0891-6640(2007)21[917:aeocam]2.0.co;2. [PMID: 17939543] - Sarah O Allison, Lisa C Halliday, Jeffrey A French, Dmitri D Novikov, Jeffrey D Fortman. Assessment of buprenorphine, carprofen, and their combination for postoperative analgesia in olive baboons (Papio anubis).
Journal of the American Association for Laboratory Animal Science : JAALAS.
2007 May; 46(3):24-31. doi:
NULL. [PMID: 17487949] - Marja R Raekallio, Juhana M Honkavaara, Mia S Säkkinen, S Marikki Peltoniemi. Effects of urine alkalization and activated charcoal on the pharmacokinetics of orally administered carprofen in dogs.
American journal of veterinary research.
2007 Apr; 68(4):423-7. doi:
10.2460/ajvr.68.4.423. [PMID: 17397299] - Stelio P L Luna, Ana C Basílio, Paulo V M Steagall, Luciana P Machado, Flávia Q Moutinho, Regina K Takahira, Cláudia V S Brandão. Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs.
American journal of veterinary research.
2007 Mar; 68(3):258-64. doi:
10.2460/ajvr.68.3.258. [PMID: 17331014] - Benjamin M Brainard, Craig P Meredith, Mary Beth Callan, Steven C Budsberg, Francis S Shofer, Bernd Driessen, Cynthia M Otto. Changes in platelet function, hemostasis, and prostaglandin expression after treatment with nonsteroidal anti-inflammatory drugs with various cyclooxygenase selectivities in dogs.
American journal of veterinary research.
2007 Mar; 68(3):251-7. doi:
10.2460/ajvr.68.3.251. [PMID: 17331013] - D R Paull, C Lee, I G Colditz, S J Atkinson, A D Fisher. The effect of a topical anaesthetic formulation, systemic flunixin and carprofen, singly or in combination, on cortisol and behavioural responses of Merino lambs to mulesing.
Australian veterinary journal.
2007 Mar; 85(3):98-106. doi:
10.1111/j.1751-0813.2007.00115.x. [PMID: 17359309] - Virginie Lhiaubet-Vallet, Francisco Boscá, Miguel A Miranda. Stereodifferentiating drug-biomolecule interactions in the triplet excited state: studies on supramolecular carprofen/protein systems and on carprofen-tryptophan model dyads.
The journal of physical chemistry. B.
2007 Jan; 111(2):423-31. doi:
10.1021/jp066968k. [PMID: 17214494] - Jan H M Frendin, Ingrid M Boström, Naruepon Kampa, Per Eksell, Jens U Häggström, Görel C Nyman. Effects of carprofen on renal function during medetomidine-propofol-isoflurane anesthesia in dogs.
American journal of veterinary research.
2006 Dec; 67(12):1967-73. doi:
10.2460/ajvr.67.12.1967. [PMID: 17144795] - Marja R Raekallio, Anna K Hielm-Björkman, Johanna Kejonen, Hanna M Salonen, Satu M Sankari. Evaluation of adverse effects of long-term orally administered carprofen in dogs.
Journal of the American Veterinary Medical Association.
2006 Mar; 228(6):876-80. doi:
10.2460/javma.228.6.876. [PMID: 16536696] - W Y Pang, B Earley, T Sweeney, M A Crowe. Effect of carprofen administration during banding or burdizzo castration of bulls on plasma cortisol, in vitro interferon-gamma production, acute-phase proteins, feed intake, and growth.
Journal of animal science.
2006 Feb; 84(2):351-9. doi:
10.2527/2006.842351x. [PMID: 16424263] - Hannes M L Bergmann, Ingo J A Nolte, Sabine Kramer. Effects of preoperative administration of carprofen on renal function and hemostasis in dogs undergoing surgery for fracture repair.
American journal of veterinary research.
2005 Aug; 66(8):1356-63. doi:
10.2460/ajvr.2005.66.1356. [PMID: 16173478] - A Möllenhoff, I Nolte, S Kramer. Anti-nociceptive efficacy of carprofen, levomethadone and buprenorphine for pain relief in cats following major orthopaedic surgery.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine.
2005 May; 52(4):186-98. doi:
10.1111/j.1439-0442.2005.00710.x. [PMID: 15882404] - Katja Wacker, Ingo Nolte, Sabine Kramer. [Placebo-controlled blinded study of postoperative pain therapy with carprofen and levomethadone in dogs with fractures].
Berliner und Munchener tierarztliche Wochenschrift.
2005 Mar; 118(3-4):101-12. doi:
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The Veterinary record.
2004 Nov; 155(21):667-71. doi:
10.1136/vr.155.21.667. [PMID: 15581141] - Katrina L Mealey, Nora S Matthews, Kenneth E Peck, Melissa L Burchfield, Brad S Bennett, Tex S Taylor. Pharmacokinetics of R(-) and S(+) carprofen after administration of racemic carprofen in donkeys and horses.
American journal of veterinary research.
2004 Nov; 65(11):1479-82. doi:
10.2460/ajvr.2004.65.1479. [PMID: 15566084] - Dawn E Crandell, Karol A Mathews, Doris H Dyson. Effect of meloxicam and carprofen on renal function when administered to healthy dogs prior to anesthesia and painful stimulation.
American journal of veterinary research.
2004 Oct; 65(10):1384-90. doi:
10.2460/ajvr.2004.65.1384. [PMID: 15524325] - Virginie Lhiaubet-Vallet, Zaideth Sarabia, Francisco Boscá, Miguel A Miranda. Human serum albumin-mediated stereodifferentiation in the triplet state behavior of (S)- and (R)-carprofen.
Journal of the American Chemical Society.
2004 Aug; 126(31):9538-9. doi:
10.1021/ja048518g. [PMID: 15291547] - Joel E Wilson, Naduviladath V Chandrasekharan, Kenneth D Westover, Kendra B Eager, Daniel L Simmons. Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs.
American journal of veterinary research.
2004 Jun; 65(6):810-8. doi:
10.2460/ajvr.2004.65.810. [PMID: 15198222] - Nathalie M-H Priymenko, Gary D Koritz, Jean-Pierre Ferre, Valerie M F Laroute, Pierre-Louis Toutain. Influence of feeding and analytical method on the bioequivalence of a racemic drug undergoing enantioselective enterohepatic recycling.
Journal of pharmaceutical sciences.
2004 Mar; 93(3):590-600. doi:
10.1002/jps.10581. [PMID: 14762898] - Luc R Borer, John E Peel, Wolfgang Seewald, Peter Schawalder, David E Spreng. Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis.
American journal of veterinary research.
2003 Nov; 64(11):1429-37. doi:
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Journal of veterinary pharmacology and therapeutics.
2003 Jun; 26(3):187-92. doi:
10.1046/j.1365-2885.2003.00475.x. [PMID: 12755902] - Frédéric Sauvé, Manon Paradis, Kent R Refsal, Maxim Moreau, Guy Beauchamp, Jacques Dupuis. Effects of oral administration of meloxicam, carprofen, and a nutraceutical on thyroid function in dogs with osteoarthritis.
The Canadian veterinary journal = La revue veterinaire canadienne.
2003 Jun; 44(6):474-9. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 May; 788(2):297-307. doi:
10.1016/s1570-0232(03)00035-7. [PMID: 12705970] - Hélène Greige-Georges, Thierry Buronfosse, Patrcik Netter, Jacques Magdalou, Françoise Lapicque. In vitro stereoselective covalent binding of carprofen glucuronides to human serum albumin: characterization of the mechanism.
Likars'ka sprava.
2003 Jan; ?(1):53-60. doi:
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Veterinary clinical pathology.
2003; 32(3):136-9. doi:
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Journal of veterinary pharmacology and therapeutics.
2002 Dec; 25(6):433-48. doi:
10.1046/j.1365-2885.2002.00436.x. [PMID: 12485349] - L S Slingsby, A E Waterman-Pearson. Comparison between meloxicam and carprofen for postoperative analgesia after feline ovariohysterectomy.
The Journal of small animal practice.
2002 Jul; 43(7):286-9. doi:
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The Veterinary record.
2002 Jun; 150(22):684-9. doi:
10.1136/vr.150.22.684. [PMID: 12074237] - Zhangrui Cheng, Andrea Nolan, Quintin A McKellar. Anti-inflammatory effects of carprofen, carprofen enantiomers, and N(G)-nitro-L-arginine methyl ester in sheep.
American journal of veterinary research.
2002 Jun; 63(6):782-8. doi:
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