N-Nitrosopyrrolidine (BioDeep_00001867909)

Main id: BioDeep_00000002975

 

natural product


代谢物信息卡片


N-Nitrosopyrrolidine

化学式: C4H8N2O (100.0637)
中文名称: 1-亚硝基吡咯烷, n-亚硝基吡咯烷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCN(C1)N=O
InChI: InChI=1S/C4H8N2O/c7-5-6-3-1-2-4-6/h1-4H2

描述信息

同义名列表

4 个代谢物同义名

N-Nitrosopyrrolidine; NPYR; N-Nitrosopyrrolidine; N-Nitrosopyrrolidine



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AOC3, CYP1A1, CYP2A6, CYP2C8, CYP2D6, CYP2E1, CYP3A4, HPGDS
Peripheral membrane protein 3 CYP1A1, CYP1B1, CYP2E1
Endoplasmic reticulum membrane 9 CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C8, CYP2D6, CYP2E1, CYP3A4, CYP3A5
cytosol 1 HPGDS
nucleoplasm 1 HPGDS
Cell membrane 2 AOC3, NPY1R
Multi-pass membrane protein 2 NPY1R, SLC45A2
cell surface 1 AOC3
Golgi apparatus 2 AOC3, NPY
Golgi membrane 1 INS
mitochondrial inner membrane 2 CYP1A1, CYP2E1
sarcolemma 1 SYNM
Presynapse 1 NPY5R
plasma membrane 5 AOC3, CYP2C8, NPY1R, NPY2R, NPY5R
Membrane 9 AOC3, CYP1B1, CYP2A6, CYP2D6, CYP3A4, CYP3A5, NPIPA1, NPY1R, SLC45A2
endoplasmic reticulum 2 AOC3, CYP2D6
extracellular space 2 INS, NPY
adherens junction 1 SYNM
mitochondrion 3 CYP1A1, CYP1B1, CYP2D6
intracellular membrane-bounded organelle 10 CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C8, CYP2D6, CYP2E1, CYP3A4, CYP3A5, HPGDS
Microsome membrane 7 CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP2E1, CYP3A4, CYP3A5
Secreted 3 INS, NPY, PRB1
extracellular region 3 INS, NPY, PRB1
Single-pass membrane protein 1 CYP2D6
Nucleus membrane 1 NPIPA1
nuclear membrane 1 NPIPA1
Melanosome membrane 1 SLC45A2
Early endosome 1 AOC3
Single-pass type II membrane protein 1 AOC3
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
GABA-ergic synapse 2 NPY, NPY5R
intermediate filament 1 SYNM
neuron projection 2 NPY1R, NPY5R
cilium 1 NPY2R
non-motile cilium 1 NPY2R
Nucleus, nuclear pore complex 1 NPIPA1
nuclear pore 1 NPIPA1
endosome lumen 1 INS
microvillus 1 AOC3
intermediate filament cytoskeleton 1 SYNM
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 NPY
costamere 1 SYNM
neurofilament cytoskeleton 1 SYNM
cytoplasmic microtubule 1 CYP2A6
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY


文献列表

  • James A Hodgson, Tiffany H Seyler, Lanqing Wang. Long-Term Stability of Volatile Nitrosamines in Human Urine. Journal of analytical toxicology. 2016 Jul; 40(6):414-8. doi: 10.1093/jat/bkw038. [PMID: 27274026]
  • Tiffany H Seyler, Jenny G Kim, James A Hodgson, Elizabeth A Cowan, Benjamin C Blount, Lanqing Wang. Quantitation of urinary volatile nitrosamines from exposure to tobacco smoke. Journal of analytical toxicology. 2013 May; 37(4):195-202. doi: 10.1093/jat/bkt020. [PMID: 23508653]
  • Kenjiro Tatematsu, Akihiro Koide, Keiichirou Morimura, Shoji Fukushima, Yukio Mori. The enhancing effect of ethanol on the mutagenic activation of N-nitrosomethylbenzylamine by cytochrome P450 2A in the rat oesophagus. Mutagenesis. 2013 Mar; 28(2):161-9. doi: 10.1093/mutage/ges066. [PMID: 23325793]
  • Jehan A Khan, Jalaluddin A Jalal, C Ioanndes, Said S Moselhy. Evaluation of the in vitro antimutagenic effect of Doash tea aqueous extracts. Toxicology and industrial health. 2012 Aug; 28(7):593-604. doi: 10.1177/0748233711416952. [PMID: 21996713]
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  • Ana Paula M Loureiro, Wenbing Zhang, Fekadu Kassie, Siyi Zhang, Peter W Villalta, Mingyao Wang, Stephen S Hecht. Mass spectrometric analysis of a cyclic 7,8-butanoguanine adduct of N-nitrosopyrrolidine: comparison to other N-nitrosopyrrolidine adducts in rat hepatic DNA. Chemical research in toxicology. 2009 Oct; 22(10):1728-35. doi: 10.1021/tx900238t. [PMID: 19761253]
  • Hitoshi Kodamatani, Shigeo Yamazaki, Keiitsu Saito, Abena Amponsaa-Karikari, Naoya Kishikawa, Naotaka Kuroda, Takashi Tomiyasu, Yu Komatsu. Highly sensitive method for determination of N-nitrosamines using high-performance liquid chromatography with online UV irradiation and luminol chemiluminescence detection. Journal of chromatography. A. 2009 Jan; 1216(1):92-8. doi: 10.1016/j.chroma.2008.11.025. [PMID: 19062029]
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  • . Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. International journal of toxicology. 2007; 26 Suppl 1(?):3-106. doi: 10.1080/10915810601163939. [PMID: 17365137]
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  • Oscar A Bizzozero, Gisela DeJesus, Tamara A Howard. Exposure of rat optic nerves to nitric oxide causes protein S-nitrosation and myelin decompaction. Neurochemical research. 2004 Sep; 29(9):1675-85. doi: 10.1023/b:nere.0000035802.27087.16. [PMID: 15453262]
  • Kun Lin, Wenying Shen, Zhongying Shen, Yongning Wu, Shihhsin Lu. Dietary exposure and urinary excretion of total N-nitroso compounds, nitrosamino acids and volatile nitrosamine in inhabitants of high- and low-risk areas for esophageal cancer in southern China. International journal of cancer. 2002 Nov; 102(3):207-11. doi: 10.1002/ijc.10698. [PMID: 12397637]
  • M Wang, S S Hecht. A cyclic N7,C-8 guanine adduct of N-nitrosopyrrolidine (NPYR): formation in nucleic acids and excretion in the urine of NPYR-treated rats. Chemical research in toxicology. 1997 Jul; 10(7):772-8. doi: 10.1021/tx960193x. [PMID: 9250411]
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  • A R Tricker, M J Perkins, R C Massey, D J McWeeny. N-Nitrosopyrrolidine formation in bacon. Food additives and contaminants. 1985 Oct; 2(4):247-52. doi: 10.1080/02652038509373552. [PMID: 4065391]
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