mecamylamine (BioDeep_00001867896)

Main id: BioDeep_00000003466

 

PANOMIX_OTCML-2023


代谢物信息卡片


methyl(2,3,3-trimethyltrinorbornan-2-yl)amine

化学式: C11H21N (167.1673906)
中文名称: 异莰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C2CCC(C2)C1(C)NC)C
InChI: InChI=1S/C11H21N/c1-10(2)8-5-6-9(7-8)11(10,3)12-4/h8-9,12H,5-7H2,1-4H3

描述信息

C - Cardiovascular system > C02 - Antihypertensives > C02B - Antiadrenergic agents, ganglion-blocking > C02BB - Secondary and tertiary amines
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D005730 - Ganglionic Blockers
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents

同义名列表

2 个代谢物同义名

methyl(2,3,3-trimethyltrinorbornan-2-yl)amine; mecamylamine



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xing-Yuan Li, Jia-Qi Liu, Yan Wang, Yan Chen, Wen-Hui Hu, Yan-Xia Lv, Yan Wu, Jing Lv, Jun-Ming Tang, Deying Kong. VNS improves VSMC metabolism and arteriogenesis in infarcted hearts through m/n-AChR-Akt-SDF-1α in adult male rats. Journal of molecular histology. 2024 Feb; 55(1):51-67. doi: 10.1007/s10735-023-10171-4. [PMID: 38165566]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
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  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Giulia Donvito, Fabiana Piscitelli, Pretal Muldoon, Asti Jackson, Rosa Maria Vitale, Enrico D'Aniello, Catia Giordano, Bogna M Ignatowska-Jankowska, Mohammed A Mustafa, Francesca Guida, Gavin N Petrie, Linda Parker, Reem Smoum, Laura Sim-Selley, Sabatino Maione, Aron H Lichtman, M Imad Damaj, Vincenzo Di Marzo, Raphael Mechoulam. N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice. Neuropharmacology. 2019 04; 148(?):320-331. doi: 10.1016/j.neuropharm.2018.03.020. [PMID: 29567093]
  • Lance R McMahon. Green tobacco sickness: mecamylamine, varenicline, and nicotine vaccine as clinical research tools and potential therapeutics. Expert review of clinical pharmacology. 2019 Mar; 12(3):189-195. doi: 10.1080/17512433.2019.1570844. [PMID: 30650314]
  • Begum Aydin, Gokcen Guvenc, Burcin Altinbas, Nasir Niaz, Murat Yalcin. Modulation of nesfatin-1-induced cardiovascular effects by the central cholinergic system. Neuropeptides. 2018 Aug; 70(?):9-15. doi: 10.1016/j.npep.2018.05.001. [PMID: 29751997]
  • Helen Keyworth, Polymnia Georgiou, Panos Zanos, André Veloso Rueda, Ying Chen, Ian Kitchen, Rosana Camarini, Mark Cropley, Alexis Bailey. Wheel running during chronic nicotine exposure is protective against mecamylamine-precipitated withdrawal and up-regulates hippocampal α7 nACh receptors in mice. British journal of pharmacology. 2018 06; 175(11):1928-1943. doi: 10.1111/bph.14068. [PMID: 29266170]
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  • Ricardo Alvarez-Jimenez, Anne Catrien Baakman, Jasper Stevens, Sebastiaan C Goulooze, Ellen P Hart, Robert Rissmann, Joop Ma van Gerven, Geert Jan Groeneveld. Pharmacokinetics and pharmacodynamics of oral mecamylamine - development of a nicotinic acetylcholine receptor antagonist cognitive challenge test using modelling and simulation. Journal of psychopharmacology (Oxford, England). 2017 02; 31(2):192-203. doi: 10.1177/0269881116681417. [PMID: 27927703]
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  • Sofie Alverlind, Stéphane Barassin, Per Dalén, Yan Li, Steven Toler, Hans Eriksson, Raj Tummala. Clinical pharmacokinetics of the nicotinic channel modulator dexmecamylamine (TC-5214) in subjects with various degrees of renal impairment. Clinical drug investigation. 2014 Jul; 34(7):457-65. doi: 10.1007/s40261-014-0195-0. [PMID: 24760402]
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  • Eric J Belin de Chantemèle, Mohammed Irfan Ali, James D Mintz, William E Rainey, Michel L Tremblay, David J Fulton, David W Stepp. Increasing peripheral insulin sensitivity by protein tyrosine phosphatase 1B deletion improves control of blood pressure in obesity. Hypertension (Dallas, Tex. : 1979). 2012 Nov; 60(5):1273-9. doi: 10.1161/hypertensionaha.112.196295. [PMID: 23045458]
  • Mariana Martins Gomes Pinheiro, Fábio Boylan, Patrícia Dias Fernandes. Antinociceptive effect of the Orbignya speciosa Mart. (Babassu) leaves: evidence for the involvement of apigenin. Life sciences. 2012 Sep; 91(9-10):293-300. doi: 10.1016/j.lfs.2012.06.013. [PMID: 22749864]
  • Mohammad Nasehi, Shahrbano Sharifi, Mohammad Reza Zarrindast. Involvement of the cholinergic system of CA1 on harmane-induced amnesia in the step-down passive avoidance test. Journal of psychopharmacology (Oxford, England). 2012 Aug; 26(8):1151-61. doi: 10.1177/0269881111421972. [PMID: 21965190]
  • Karl B Scheidweiler, Diaa M Shakleya, Marilyn A Huestis. Simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine, norcotinine and mecamylamine in human urine by liquid chromatography-tandem mass spectrometry. Clinica chimica acta; international journal of clinical chemistry. 2012 Jun; 413(11-12):978-84. doi: 10.1016/j.cca.2012.02.017. [PMID: 22394455]
  • Zishen Zhang, Xiaoguang Bai, Kejun Du, Yi Huang, Wenyong Wang, Yiling Zhao, Yuping Pei, Jinglan Mu, Han Han, Sheng Hu, Shuzhi Li, Hailong Dong, Yan Lu, Lichao Hou, Lize Xiong. Activation of cholinergic anti-inflammatory pathway contributes to the protective effects of 100\% oxygen inhalation on zymosan-induced generalized inflammation in mice. The Journal of surgical research. 2012 May; 174(2):e75-83. doi: 10.1016/j.jss.2011.10.037. [PMID: 22261596]
  • Laura Calvillo, Emilio Vanoli, Elisa Andreoli, Alessandra Besana, Elisabetta Omodeo, Massimiliano Gnecchi, Pietro Zerbi, Gianluca Vago, Giuseppe Busca, Peter J Schwartz. Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusion. Journal of cardiovascular pharmacology. 2011 Nov; 58(5):500-7. doi: 10.1097/fjc.0b013e31822b7204. [PMID: 21765369]
  • Nimisha Sood, Debasish Hota, Ashok Kumar Sahai, Amitava Chakrabarti. Nicotine reversal of anticonvulsant action of topiramate in kainic acid-induced seizure model in mice. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2011 Nov; 13(11):1084-91. doi: 10.1093/ntr/ntr138. [PMID: 21799193]
  • Jianhua Liu, Li-Fang Yu, J Brek Eaton, Barbara Caldarone, Katie Cavino, Christina Ruiz, Matthew Terry, Allison Fedolak, Daguang Wang, Afshin Ghavami, David A Lowe, Dani Brunner, Ronald J Lukas, Alan P Kozikowski. Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depression. Journal of medicinal chemistry. 2011 Oct; 54(20):7280-8. doi: 10.1021/jm200855b. [PMID: 21905669]
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