nafcillin (BioDeep_00001867824)
Main id: BioDeep_00000002189
代谢物信息卡片
nafcillin
化学式: C21H22N2O5S (414.1249)
中文名称: 萘夫西林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC1=C(C2=CC=CC=C2C=C1)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
InChI: InChI=1S/C21H22N2O5S/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27)/t15-,16+,19-/m1/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CF - Beta-lactamase resistant penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:7447
- KEGG: C07250
- KEGGdrug: D08242
- PubChem: 8982
- DrugBank: DB00607
- ChEMBL: CHEMBL1443
- MeSH: Nafcillin
- CAS: 147-52-4
- MetaboLights: MTBLC7447
- PubChem: 9459
- PDB-CCD: NFN
- NIKKAJI: J10.134F
- RefMet: Nafcillin
- KNApSAcK: 7447
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lynn Chan, Noreen H Chan-Tompkins, James Como, Anthony J Guarascio. Retrospective Analysis of Adverse Drug Events Between Nafcillin Versus Cefazolin for Treatment of Methicillin-Susceptible Staphylococcus aureus Infections.
The Annals of pharmacotherapy.
2020 07; 54(7):662-668. doi:
10.1177/1060028019897267. [PMID: 31888347] - Tristan T Timbrook, Lydia McKay, Jesse D Sutton, Emily S Spivak. Disproportionality Analysis of Safety with Nafcillin and Oxacillin with the FDA Adverse Event Reporting System (FAERS).
Antimicrobial agents and chemotherapy.
2020 02; 64(3):. doi:
10.1128/aac.01818-19. [PMID: 31844017] - Marguerite L Monogue, Jessica K Ortwine, Wenjing Wei, Khalid Eljaaly, Kavita P Bhavan. Nafcillin versus cefazolin for the treatment of methicillin-susceptible Staphylococcus aureus bacteremia.
Journal of infection and public health.
2018 Sep; 11(5):727-731. doi:
10.1016/j.jiph.2018.02.004. [PMID: 29526442] - Corey C Burrelli, Eleanor K Broadbent, Alice Margulis, Graham M Snyder, Howard S Gold, Christopher McCoy, Monica V Mahoney, Elizabeth B Hirsch. Does the Beta-Lactam Matter? Nafcillin versus Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bloodstream Infections.
Chemotherapy.
2018; 63(6):345-351. doi:
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PloS one.
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Pharmacotherapy.
2016 09; 36(9):994-1002. doi:
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10.1093/infdis/149.6.904. [PMID: 6736681] - L Swanberg, C U Tuazon. Rifampin in the treatment of serious staphylococcal infections.
The American journal of the medical sciences.
1984 May; 287(3):49-54. doi:
10.1097/00000441-198405000-00018. [PMID: 6563847] - W A Creasey, J Adamovics, R Dhruv, T B Platt, A A Sugerman. Pharmacokinetic interaction of aztreonam with other antibiotics.
Journal of clinical pharmacology.
1984 Apr; 24(4):174-80. doi:
10.1002/j.1552-4604.1984.tb01827.x. [PMID: 6539343] - G D Qureshi, T P Reinders, G J Somori, H J Evans. Warfarin resistance with nafcillin therapy.
Annals of internal medicine.
1984 Apr; 100(4):527-9. doi:
10.7326/0003-4819-100-4-527. [PMID: 6703546] - F S Lundergan, T P Lombardi, G E Neilan, C H Nightingale. Stability of tobramycin sulfate mixed with oxacillin sodium and nafcillin sodium in human serum.
American journal of hospital pharmacy.
1984 Jan; 41(1):144-5. doi:
10.1093/ajhp/41.1.144. [PMID: 6695930] - S W Chapman, R T Steigbigel. Staphylococcal beta-lactamase and efficacy of beta-lactam antibiotics: in vitro and in vivo evaluation.
The Journal of infectious diseases.
1983 Jun; 147(6):1078-89. doi:
10.1093/infdis/147.6.1078. [PMID: 6602190] - P T Frame, C Watanakunakorn, R L McLaurin, G Khodadad. Penetration of nafcillin, methicillin, and cefazolin into human brain tissue.
Neurosurgery.
1983 Feb; 12(2):142-7. doi:
10.1227/00006123-198302000-00002. [PMID: 6835496] - A U Gerber, C Feller-Segessenmann, W A Craig. [What does the minimal inhibitory concentration of an antibiotic hide from the clinician? Experimental examples].
Schweizerische medizinische Wochenschrift.
1983 Jan; 113(2):34-7. doi:
NULL. [PMID: 6402813] - D M Lichtenwalner, B Suh, B Lorber, M R Rudnick, W A Craig. Correction of drug binding defects in uremia in vitro by anion exchange resin treatment.
Biochemical pharmacology.
1982 Nov; 31(21):3483-7. doi:
10.1016/0006-2952(82)90630-x. [PMID: 7150368] - E S Waller, M A Sharanevych, G J Yakatan. The effect of probenecid on nafcillin disposition.
Journal of clinical pharmacology.
1982 Oct; 22(10):482-9. doi:
10.1002/j.1552-4604.1982.tb02639.x. [PMID: 7174857] - F W Teare, R H Kwan, M Spino, S M MacLeod. High-pressure liquid chromatographic assay of cloxacillin in serum and urine.
Journal of pharmaceutical sciences.
1982 Aug; 71(8):938-41. doi:
10.1002/jps.2600710826. [PMID: 7120103] - J W Bass, F W Bruhn, W T Merritt, D E Suttle, J H Jirka, R B Mesrobian, J T Berkenbaugh. Comparison of oral penicillinase-resistant penicillins: contrasts between agents and assays.
Southern medical journal.
1982 Apr; 75(4):408-10. doi:
10.1097/00007611-198204000-00008. [PMID: 7041278] - S L Kaplan, E O Mason, R D Feigin. Clindamycin versus nafcillin or methicillin in the treatment of Staphylococcus aureus osteomyelitis in children.
Southern medical journal.
1982 Feb; 75(2):138-42. doi:
10.1097/00007611-198202000-00005. [PMID: 7036354] - D N Carney, R H Parker, B E Fossieck. Staphylococcal bacteremia in cancer patients: intravenous and oral antimicrobial therapy.
Southern medical journal.
1982 Feb; 75(2):143-6. doi:
10.1097/00007611-198202000-00006. [PMID: 7036355] - R G Washburn, D T Durack. Efficacy of ampicillin plus a beta-lactamase inhibitor (CP-45,899) in experimental endocarditis due to Staphylococcus aureus.
The Journal of infectious diseases.
1981 Sep; 144(3):237-43. doi:
10.1093/infdis/144.3.237. [PMID: 6268715] - J Felice-Johnson, J M Nappi. Nafcillin interference with quantitative protein urinalysis.
American journal of hospital pharmacy.
1981 Sep; 38(9):1360-1. doi:
10.1093/ajhp/38.9.1360. [PMID: 7282724] - R Yogev, W E Schultz, S B Rosenman. Penetrance of nafcillin into human ventricular fluid: correlation with ventricular pleocytosis and glucose levels.
Antimicrobial agents and chemotherapy.
1981 Apr; 19(4):545-8. doi:
10.1128/aac.19.4.545. [PMID: 7247377] - M R Glick, M B Kleiman, W R Moorehead, T O Oei, S P Andreoli. Nafcillin may cause a subtle pseudoproteinuria.
Clinical chemistry.
1981 Mar; 27(3):506-7. doi:
10.1093/clinchem/27.3.506. [PMID: 7471409] - A C Novick. The value of intraoperative antibiotics in preventing renal transplant wound infections.
The Journal of urology.
1981 Feb; 125(2):151-2. doi:
10.1016/s0022-5347(17)54942-3. [PMID: 7009886] - W Kitzing, J D Nelson, E Mohs. Comparative toxicities of methicillin and nafcillin.
American journal of diseases of children (1960).
1981 Jan; 135(1):52-5. doi:
10.1001/archpedi.1981.02130250040013. [PMID: 7006381] - J Carrizosa, W D Kobasa, D Kaye. Comparison of ceforanide, cefazolin, methicillin, and nafcillin in Staphylococcus aureus endocarditis therapy in rabbits.
Antimicrobial agents and chemotherapy.
1980 Oct; 18(4):562-5. doi:
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Antimicrobial agents and chemotherapy.
1980 Apr; 17(4):691-4. doi:
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Therapeutic drug monitoring.
1980; 2(4):417-22. doi:
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Archives of internal medicine.
1979 Oct; 139(10):1094-8. doi:
10.1001/archinte.139.10.1094. [PMID: 258599] - J A Mohr, R M Clark, T C Waack, R Whang. Nafcillin-associated hypokalemia.
JAMA.
1979 Aug; 242(6):544. doi:
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Antimicrobial agents and chemotherapy.
1979 Aug; 16(2):210-3. doi:
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