amifostine (BioDeep_00001867785)
Main id: BioDeep_00000003434
代谢物信息卡片
amifostine
化学式: C5H15N2O3PS (214.05409699999998)
中文名称: 氨磷汀
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CN)CNCCSP(=O)(O)O
InChI: InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10)
描述信息
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AF - Detoxifying agents for antineoplastic treatment
C26170 - Protective Agent > C2459 - Chemoprotective Agent > C2080 - Cytoprotective Agent
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action[1][2][3][4].
同义名列表
2 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:2636
- KEGG: C06819
- PubChem: 2141
- DrugBank: DB01143
- ChEMBL: CHEMBL1006
- MeSH: Amifostine
- CAS: 20537-88-6
- PubChem: 9037
- NIKKAJI: J23.675F
- RefMet: Amifostine
- medchemexpress: HY-B0639
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sunmin Park, Suhyun Kim, Soonil Koun, Hae-Chul Park, Won Sup Yoon, Chai Hong Rim. Radioprotective effect of mistletoe extract on intestinal toxicity: in vivo study using adult zebrafish.
International journal of radiation biology.
2022 Nov; ?(?):1-8. doi:
10.1080/09553002.2023.2142982. [PMID: 36318746] - Lu Wang, Yu Cao, Xiaoyi Zhang, Chang Liu, Jia Yin, Liangju Kuang, Weiwei He, Daoben Hua. Reactive oxygen species-responsive nanodrug of natural crocin-i with prolonged circulation for effective radioprotection.
Colloids and surfaces. B, Biointerfaces.
2022 May; 213(?):112441. doi:
10.1016/j.colsurfb.2022.112441. [PMID: 35272253] - Alexandra Crook, Aline De Lima Leite, Thomas Payne, Fatema Bhinderwala, Jade Woods, Vijay K Singh, Robert Powers. Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine.
Scientific reports.
2021 07; 11(1):14004. doi:
10.1038/s41598-021-93401-7. [PMID: 34234212] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Junling Zhang, Kui Li, Qianru Zhang, Zhimei Zhu, Gongchao Huang, Hongqi Tian. Polycysteine as a new type of radio-protector ameliorated tissue injury through inhibiting ferroptosis in mice.
Cell death & disease.
2021 02; 12(2):195. doi:
10.1038/s41419-021-03479-0. [PMID: 33602915] - Saad A Alkahtani. Silver nanoparticles conjugated MnFe-based Prussian blue analogue for voltammetric and impedimetric bioaptasensing of amifostine (ethyol).
Mikrochimica acta.
2020 09; 187(10):576. doi:
10.1007/s00604-020-04557-4. [PMID: 32975672] - Ching-Bin Ke, Te-Ling Lu, Jian-Lian Chen. Fluorometric determination of amifostine and alkaline phosphatase on amphiprotic molecularly imprinted silica crosslinked with binary functional silanes and carbon dots.
Biosensors & bioelectronics.
2020 Mar; 151(?):111965. doi:
10.1016/j.bios.2019.111965. [PMID: 31868611] - Liang Zhang, Bo Huang, Haiyang Tang, Xingchen Ye, Yang Yao, Ping Gong, Hua Tang. Amifostine inhibited the differentiation of RAW264.7 cells into osteoclasts by reducing the production of ROS under 2 Gy radiation.
Journal of cellular biochemistry.
2020 01; 121(1):497-507. doi:
10.1002/jcb.29247. [PMID: 31267572] - Till Markowiak, Nadine Kerner, Reiner Neu, Tobias Potzger, Christian Großer, Florian Zeman, Hans-Stefan Hofmann, Michael Ried. Adequate nephroprotection reduces renal complications after hyperthermic intrathoracic chemotherapy.
Journal of surgical oncology.
2019 Dec; 120(7):1220-1226. doi:
10.1002/jso.25726. [PMID: 31602673] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Chai Hong Rim, Soonil Koun, Hae-Chul Park, Suk Lee, Chul Yong Kim. Radioprotective effects of mistletoe extract in zebrafish embryos in vivo.
International journal of radiation biology.
2019 08; 95(8):1150-1159. doi:
10.1080/09553002.2019.1590661. [PMID: 30836032] - Gulgun Cakmak Arslan, Feride Severcan. The effects of radioprotectant and potential antioxidant agent amifostine on the structure and dynamics of DPPC and DPPG liposomes.
Biochimica et biophysica acta. Biomembranes.
2019 06; 1861(6):1240-1251. doi:
10.1016/j.bbamem.2019.04.009. [PMID: 31028720] - Pamela Sinha, Kantha D Arunachalam, Sathesh Kumar Annamalai. Radio-protective dosimetry of Pangasius sutchi as a biomarker, against gamma radiation dosages perceived by genotoxic assays.
Ecotoxicology and environmental safety.
2018 Nov; 164(?):629-640. doi:
10.1016/j.ecoenv.2018.08.071. [PMID: 30165340] - Filiz Mercantepe, Tolga Mercantepe, Atilla Topcu, Adnan Yılmaz, Levent Tumkaya. Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury.
Naunyn-Schmiedeberg's archives of pharmacology.
2018 09; 391(9):915-931. doi:
10.1007/s00210-018-1514-4. [PMID: 29860655] - Vesna Jaćević, Viktorija Dragojević-Simić, Željka Tatomirović, Silva Dobrić, Dubravko Bokonjić, Aleksandra Kovačević, Eugenie Nepovimova, Martin Vališ, Kamil Kuča. The Efficacy of Amifostine against Multiple-Dose Doxorubicin-Induced Toxicity in Rats.
International journal of molecular sciences.
2018 Aug; 19(8):. doi:
10.3390/ijms19082370. [PMID: 30103540] - Kavitha Ranganathan, Eric Simon, Jeremy Lynn, Alicia Snider, Yu Zhang, Noah Nelson, Alexis Donneys, Jose Rodriguez, Lauren Buchman, Dawn Reyna, Elke Lipka, Steven R Buchman. Novel Formulation Strategy to Improve the Feasibility of Amifostine Administration.
Pharmaceutical research.
2018 Mar; 35(5):99. doi:
10.1007/s11095-018-2386-5. [PMID: 29556791] - Michael I Koukourakis, Alexandra Giatromanolaki, Konstantina Fylaktakidou, Maria Kouroupi, Efthimios Sivridis, Christos E Zois, Dimitra Kalamida, Achilleas Mitrakas, Stamatia Pouliliou, Ilias V Karagounis, Konstantinos Simopoulos, David J P Ferguson, Adrian L Harris. Amifostine Protects Mouse Liver Against Radiation-induced Autophagy Blockage.
Anticancer research.
2018 01; 38(1):227-238. doi:
10.21873/anticanres.12212. [PMID: 29277777] - Philip Riley, Anne-Marie Glenny, Fang Hua, Helen V Worthington. Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy.
The Cochrane database of systematic reviews.
2017 07; 7(?):CD012744. doi:
10.1002/14651858.cd012744. [PMID: 28759701] - Gulgun Cakmak, Mete Severcan, Faruk Zorlu, Feride Severcan. Structural and functional damages of whole body ionizing radiation on rat brain homogenate membranes and protective effect of amifostine.
International journal of radiation biology.
2016 12; 92(12):837-848. doi:
10.1080/09553002.2016.1230237. [PMID: 27585945] - Sukru Tas, Faruk Ozkul, Muhammet Kasim Arik, Asli Kiraz, Ahmet Vural. The effect of amifostine on bacterial translocation after radiation ınduced acute enteritis.
Acta cirurgica brasileira.
2016 Mar; 31(3):156-60. doi:
10.1590/s0102-865020160030000002. [PMID: 27050785] - N Bouhadjari, W Gabato, D Calabrese, S Msika, H Keita. Hyperthermic intraperitoneal chemotherapy with cisplatin: Amifostine prevents acute severe renal impairment.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
2016 Feb; 42(2):219-23. doi:
10.1016/j.ejso.2015.07.016. [PMID: 26278017] - G M Kannan, Pravin Kumar, A S B Bhaskar, U Pathak, Deo Kumar, D P Nagar, S C Pant, K Ganesan. Prophylactic efficacy of S-2(2-aminoethylamino)ethyl phenyl sulfide (DRDE-07) against sulfur mustard induced lung toxicity in mice.
Drug and chemical toxicology.
2016; 39(2):182-9. doi:
10.3109/01480545.2015.1070169. [PMID: 26247826] - Dejan Gođevac, Jovana Stanković, Miroslav Novaković, Boban Anđelković, Zora Dajić-Stevanović, Milica Petrović, Miroslava Stanković. Phenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activity.
Journal of natural products.
2015 Sep; 78(9):2198-204. doi:
10.1021/acs.jnatprod.5b00273. [PMID: 26290401] - Chia-Hung Chen, Min-Liang Kuo, Jen-Ling Wang, Wei-Chuan Liao, Li-Ching Chang, Leong-Perng Chan, Johnson Lin. CCM-AMI, a Polyethylene Glycol Micelle with Amifostine, as an Acute Radiation Syndrome Protectant in C57BL/6 Mice.
Health physics.
2015 Sep; 109(3):242-8. doi:
10.1097/hp.0000000000000326. [PMID: 26222219] - Shuqi Jiang, Xianrong Shen, Yuming Liu, Ying He, Dingwen Jiang, Wei Chen. Radioprotective effects of Sipunculus nudus L. polysaccharide combined with WR-2721, rhIL-11 and rhG-CSF on radiation-injured mice.
Journal of radiation research.
2015 May; 56(3):515-22. doi:
10.1093/jrr/rrv009. [PMID: 25852150] - Ayse Arducoglu Merter, Burhan Mayir, Okan Erdogan, Taner Colak. Protective effects of amifostine on ischemia-reperfusion injury of rat kidneys.
Indian journal of pharmacology.
2015 Mar; 47(2):185-9. doi:
10.4103/0253-7613.153427. [PMID: 25878379] - Yifu Sun, Han Wu, Guoqing Zhao, Ying Shi. Binding of amifostine to human serum albumin: a biophysical study.
Luminescence : the journal of biological and chemical luminescence.
2015 Feb; 30(1):79-85. doi:
10.1002/bio.2693. [PMID: 24962599] - P J Shaw, C E Nath, H M Lazarus. Not too little, not too much-just right! (Better ways to give high dose melphalan).
Bone marrow transplantation.
2014 Dec; 49(12):1457-65. doi:
10.1038/bmt.2014.186. [PMID: 25133893] - Eng-Yen Huang, Feng-Sheng Wang, Yu-Min Chen, Yi-Fan Chen, Chung-Chi Wang, I-Hui Lin, Yu-Jie Huang, Kuender D Yang. Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation.
Oncotarget.
2014 Oct; 5(20):9756-69. doi:
10.18632/oncotarget.2386. [PMID: 25230151] - Sami Akbulut, Hulya Elbe, Cengiz Eris, Zumrut Dogan, Gulten Toprak, Emrah Otan, Erman Erdemli, Yusuf Turkoz. Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats.
World journal of gastroenterology.
2014 Aug; 20(29):10158-65. doi:
10.3748/wjg.v20.i29.10158. [PMID: 25110444] - Z Chang, H L Wang, H Du. Protective effect of Ginkgo flavonoids, amifostine, and leuprorelin against platinum-induced ovarian impairment in rats.
Genetics and molecular research : GMR.
2014 Jul; 13(3):5276-84. doi:
10.4238/2014.july.24.6. [PMID: 25078583] - Gogsen Onalan, Cagri Gulumser, Barıs Mulayim, Atilla Dagdeviren, Hulusi Zeyneloglu. Effects of amifostine on endometriosis, comparison with N-acetyl cysteine, and leuprolide as a new treatment alternative: a randomized controlled trial.
Archives of gynecology and obstetrics.
2014 Jan; 289(1):193-200. doi:
10.1007/s00404-013-2963-0. [PMID: 23880890] - Abdol-Mohammad Kajbafzadeh, Nastaran Sabetkish, Shabnam Sabetkish, Niloufar Javan-Farazmand, Sara Harsini, Seyyed-Mohammad Tavangar. The ameliorative effect of various antioxidants on Adriamycin-induced fetal renal abnormalities.
Journal of pediatric urology.
2013 Dec; 9(6 Pt B):1084-92. doi:
10.1016/j.jpurol.2013.03.010. [PMID: 23665376] - Shekhar D Sawale, Pratul D Ambhore, Pallavi P Pawar, Uma Pathak, Utsab Deb, Ravindra M Satpute. Ameliorating effect of S-2(ω-aminoalkylamino) alkylaryl sulfide (DRDE-07) on sulfur mustard analogue, 2-chloroethyl ethyl sulfide-induced oxidative stress and inflammation.
Toxicology mechanisms and methods.
2013 Nov; 23(9):702-10. doi:
10.3109/15376516.2013.843109. [PMID: 24024669] - Vesna S Kuntić, Miroslava B Stanković, Zorica B Vujić, Jasmina S Brborić, Snežana M Uskoković-Marković. Radioprotectors - the evergreen topic.
Chemistry & biodiversity.
2013 Oct; 10(10):1791-803. doi:
10.1002/cbdv.201300054. [PMID: 24130023] - Viktorija Dragojević-Simić, Silva Dobrić, Vesna Jaćević, Dubravko Bokonjić, Ivica Milosavljević, Aleksandra Kovacević, Dragan Mikić. Efficacy of amifostine in protection against doxorubicin-induced acute cardiotoxic effects in rats.
Vojnosanitetski pregled.
2013 Jan; 70(1):38-45. doi:
10.2298/vsp110905041d. [PMID: 23401928] - Wenlong Lv, Mei Zhang, Zhenhuan Zhang, Luqiang Huang, Shanmin Yang, Liangjie Yin, Jinsheng Hong, Deping Han, Chun Chen, Sadasivan Vidyasagar, Paul Okunieff, Lurong Zhang. Amifostine acts upon mitochondria to stimulate growth of bone marrow and regulate cytokines.
Advances in experimental medicine and biology.
2013; 789(?):195-201. doi:
10.1007/978-1-4614-7411-1_27. [PMID: 23852495] - Yasemin Savranlar, Mehmet Fatih Sönmez. Letter to the editor regarding the article by Uzunoglu et al.
Medical oncology (Northwood, London, England).
2012 Sep; 29(3):2220. doi:
10.1007/s12032-011-0052-4. [PMID: 21874566] - Rusen Cosar, Vuslat Yurut-Caloglu, Sevgi Eskiocak, Alaattin Ozen, Semsi Altaner, Kamuran Ibis, Nesrin Turan, Bengu Denizli, Cem Uzal, Mert Saynak, Sule Parlar, Murat Caloglu, Burcu Uregen, Zafer Kocak. Radiation-induced chronic oxidative renal damage can be reduced by amifostine.
Medical oncology (Northwood, London, England).
2012 Jun; 29(2):768-75. doi:
10.1007/s12032-011-9870-7. [PMID: 21347716] - Marleen Melis, Roelf Valkema, Eric P Krenning, Marion de Jong. Reduction of renal uptake of radiolabeled octreotate by amifostine coadministration.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2012 May; 53(5):749-53. doi:
10.2967/jnumed.111.098665. [PMID: 22496587] - Gulgun Cakmak, Lisa M Miller, Faruk Zorlu, Feride Severcan. Amifostine, a radioprotectant agent, protects rat brain tissue lipids against ionizing radiation induced damage: an FTIR microspectroscopic imaging study.
Archives of biochemistry and biophysics.
2012 Apr; 520(2):67-73. doi:
10.1016/j.abb.2012.02.012. [PMID: 22402174] - Firoz N Momin, Bharatesh R Kalai, Tabassum S Shikalgar, Nilofar S Naikwade. Cardioprotective effect of methanolic extract of Ixora coccinea Linn. leaves on doxorubicin-induced cardiac toxicity in rats.
Indian journal of pharmacology.
2012 Mar; 44(2):178-83. doi:
10.4103/0253-7613.93844. [PMID: 22529471] - Kazunori Anzai, Nobuhiko Ban, Toshihiko Ozawa, Shinji Tokonami. Fukushima Daiichi Nuclear Power Plant accident: facts, environmental contamination, possible biological effects, and countermeasures.
Journal of clinical biochemistry and nutrition.
2012 Jan; 50(1):2-8. doi:
10.3164/jcbn.d-11-00021. [PMID: 22247595] - Jini Joseph, Sudheesh Narayana Panicker, Kainoor Krishnankutty Janardhanan. Protective effect of polysaccharide-protein complex from a polypore mushroom, Phellinus rimosus against radiation-induced oxidative stress.
Redox report : communications in free radical research.
2012; 17(1):22-7. doi:
10.1179/1351000211y.0000000018. [PMID: 22340512] - Emin Ozbek. Induction of oxidative stress in kidney.
International journal of nephrology.
2012; 2012(?):465897. doi:
10.1155/2012/465897. [PMID: 22577546] - Meenakshi Sharma, Rakesh Sehgal, Sukhbir Kaur. Evaluation of nephroprotective and immunomodulatory activities of antioxidants in combination with cisplatin against murine visceral leishmaniasis.
PLoS neglected tropical diseases.
2012; 6(5):e1629. doi:
10.1371/journal.pntd.0001629. [PMID: 22563510] - Yuan Hu, Jing-Jing Cao, Ping Liu, Dai-Hong Guo, Ya-Ping Wang, Jian Yin, Ying Zhu, Khalid Rahman. Protective role of tea polyphenols in combination against radiation-induced haematopoietic and biochemical alterations in mice.
Phytotherapy research : PTR.
2011 Dec; 25(12):1761-9. doi:
10.1002/ptr.3483. [PMID: 21452375] - Lebana J Joseph, Uma S Bhartiya, Yogita S Raut, Rohini W Hawaldar, Yogendra Nayak, Yogita P Pawar, Nirmala A Jambhekar, M G R Rajan. Radioprotective effect of Ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure.
Cancer biotherapy & radiopharmaceuticals.
2011 Dec; 26(6):737-43. doi:
10.1089/cbr.2011.1014. [PMID: 22087607] - Sernaz Uzunoglu, Hakan Karagol, Fulya Ozpuyan, Rusen Cosar, Irfan Cicin, Vuslat Yurutcaloglu, Bengü Denizli, Özgür Tanriverdi, Necdet Sut, Zafer Kocak. Protective effect of L-carnitine versus amifostine against cisplatin-induced nephrotoxicity in rats.
Medical oncology (Northwood, London, England).
2011 Dec; 28 Suppl 1(?):S690-6. doi:
10.1007/s12032-010-9746-2. [PMID: 21140244] - M Alcaraz, D Armero, Y Martínez-Beneyto, J Castillo, O Benavente-García, H Fernandez, M Alcaraz-Saura, M Canteras. Chemical genoprotection: reducing biological damage to as low as reasonably achievable levels.
Dento maxillo facial radiology.
2011 Jul; 40(5):310-4. doi:
10.1259/dmfr/95408354. [PMID: 21697157] - Wieslawa Kosinska, Michael Khmelnitsky, Jung Hyun Kim, Zhong-Lin Zhao, Joseph B Guttenplan. Effects of potential dietary inhibitors of endogenous DNA damage on mutagenesis and lipid peroxidation in lacZ mice.
Environmental and molecular mutagenesis.
2011 Jul; 52(6):502-9. doi:
10.1002/em.20648. [PMID: 21538553] - Melpo Christofidou-Solomidou, Sonia Tyagi, Kay-See Tan, Sarah Hagan, Ralph Pietrofesa, Floyd Dukes, Evguenia Arguiri, Daniel F Heitjan, Charalambos C Solomides, Keith A Cengel. Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice.
BMC cancer.
2011 Jun; 11(?):269. doi:
10.1186/1471-2407-11-269. [PMID: 21702963] - Michael I Koukourakis, Dimitra Pitsiava, Alexandra Giatromanolaki, Georgia Kambouromiti, Efthimios Sivridis, George Kartalis. Amifostine-related fever-rash during fractionated radiotherapy: diagnostic and predictive role of C-reactive protein.
American journal of clinical oncology.
2011 Jun; 34(3):281-5. doi:
10.1097/coc.0b013e3181dea7bd. [PMID: 20838325] - Gulgun Cakmak, Faruk Zorlu, Mete Severcan, Feride Severcan. Screening of protective effect of amifostine on radiation-induced structural and functional variations in rat liver microsomal membranes by FT-IR spectroscopy.
Analytical chemistry.
2011 Apr; 83(7):2438-44. doi:
10.1021/ac102043p. [PMID: 21410135] - Ling Zhang, Yinxin Yang, Lingyan Yu, Yi Wang, Li Liu, Xiaohui Fan. Cardioprotective effects of Glycyrrhiza uralensis extract against doxorubicin-induced toxicity.
International journal of toxicology.
2011 Mar; 30(2):181-9. doi:
10.1177/1091581810393033. [PMID: 21378374] - Banasri Hazra, Subhalakshmi Ghosh, Amit Kumar, B N Pandey. The prospective role of plant products in radiotherapy of cancer: a current overview.
Frontiers in pharmacology.
2011; 2(?):94. doi:
10.3389/fphar.2011.00094. [PMID: 22291649] - Mehmet Kanter, Yeter Topcu-Tarladacalisir, Cem Uzal. Role of amifostine on acute and late radiation nephrotoxicity: a histopathological study.
In vivo (Athens, Greece).
2011 Jan; 25(1):77-85. doi:
NULL. [PMID: 21282738] - Pankaj Chaudhary, Sandeep Kumar Shukla, Rakesh Kumar Sharma. REC-2006-A Fractionated Extract of Podophyllum hexandrum Protects Cellular DNA from Radiation-Induced Damage by Reducing the Initial Damage and Enhancing Its Repair In Vivo.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):473953. doi:
10.1093/ecam/nep212. [PMID: 20008078] - Mohammed Koussai Chok, Marc Conti, Abdelhamid Almolki, Sophie Ferlicot, Sylvain Loric, Antoine Dürrbach, Gérard Benoît, Stéphane Droupy, Pascal Eschwège. Renoprotective potency of amifostine in rat renal ischaemia-reperfusion.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2010 Dec; 25(12):3845-51. doi:
10.1093/ndt/gfq314. [PMID: 20525975] - Ronald P Miller, Raghu K Tadagavadi, Ganesan Ramesh, William Brian Reeves. Mechanisms of Cisplatin nephrotoxicity.
Toxins.
2010 11; 2(11):2490-518. doi:
10.3390/toxins2112490. [PMID: 22069563] - Sabry M Attia, Saleh A Al-Bakheet, Nouf M Al-Rasheed. Proanthocyanidins produce significant attenuation of doxorubicin-induced mutagenicity via suppression of oxidative stress.
Oxidative medicine and cellular longevity.
2010 Nov; 3(6):404-13. doi:
10.4161/oxim.3.6.14418. [PMID: 21311213] - Jorge L F Pinto, Fernando L A Fonseca, Sarah R Marsicano, Pamela O Delgado, Aleksandra V L Sant'anna, Patrícia G Coelho, Patríca Maeda, Auro Del Giglio. Systemic chemotherapy-induced microsatellite instability in the mononuclear cell fraction of women with breast cancer can be reproduced in vitro and abrogated by amifostine.
The Journal of pharmacy and pharmacology.
2010 07; 62(7):931-4. doi:
10.1211/jpp.62.07.0015. [PMID: 20636882] - Edgar J Rolleman, Marleen Melis, Roelf Valkema, Otto C Boerman, Eric P Krenning, Marion de Jong. Kidney protection during peptide receptor radionuclide therapy with somatostatin analogues.
European journal of nuclear medicine and molecular imaging.
2010 May; 37(5):1018-31. doi:
10.1007/s00259-009-1282-y. [PMID: 19915842] - Amichay Meirovitz, Michal Kuten, Salem Billan, Roxolyana Abdah-Bortnyak, Anat Sharon, Tamar Peretz, Mordechai Sela, Moshe Schaffer, Vivian Barak. Cytokines levels, severity of acute mucositis and the need of PEG tube installation during chemo-radiation for head and neck cancer--a prospective pilot study.
Radiation oncology (London, England).
2010 Feb; 5(?):16. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2010 Feb; 16(3):1049-57. doi:
10.1158/1078-0432.ccr-09-1997. [PMID: 20103669] - Savita Verma, Manju Lata Gupta, Ajaswrata Dutta, Sanghmitra Sankhwar, Sandeep Kumar Shukla, Swaran J S Flora. Modulation of ionizing radiation induced oxidative imbalance by semi-fractionated extract of Piper betle: an in vitro and in vivo assessment.
Oxidative medicine and cellular longevity.
2010 Jan; 3(1):44-52. doi:
10.4161/oxim.3.1.10349. [PMID: 20716927] - Robert Haddad, Stephen Sonis, Marshall Posner, Lori Wirth, Rosemary Costello, Patricia Braschayko, Aaron Allen, Anand Mahadevan, Jayme Flynn, Elaine Burke, Yi Li, Roy B Tishler. Randomized phase 2 study of concomitant chemoradiotherapy using weekly carboplatin/paclitaxel with or without daily subcutaneous amifostine in patients with locally advanced head and neck cancer.
Cancer.
2009 Oct; 115(19):4514-23. doi:
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Journal of cardiothoracic surgery.
2009 Sep; 4(?):50. doi:
10.1186/1749-8090-4-50. [PMID: 19758462] - Borbala Daroczi, Gabor Kari, Qing Ren, Adam P Dicker, Ulrich Rodeck. Nuclear factor kappaB inhibitors alleviate and the proteasome inhibitor PS-341 exacerbates radiation toxicity in zebrafish embryos.
Molecular cancer therapeutics.
2009 Sep; 8(9):2625-34. doi:
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Biosensors & bioelectronics.
2009 Aug; 24(12):3587-93. doi:
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The Journal of thoracic and cardiovascular surgery.
2009 Aug; 138(2):405-11. doi:
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Journal of hematology & oncology.
2009 Jul; 2(?):32. doi:
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International journal of radiation biology.
2009 Jul; 85(7):539-73. doi:
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Shock (Augusta, Ga.).
2009 Jun; 31(6):607-14. doi:
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Clinical and experimental pharmacology & physiology.
2009 May; 36(5-6):523-30. doi:
10.1111/j.1440-1681.2008.05103.x. [PMID: 19673935] - S Ortega-Gutiérrez, M López-Vicente, F Lostalé, L Fuentes-Broto, E Martínez-Ballarín, J J García. Protective effect of melatonin against mitomycin C-induced genotoxic damage in peripheral blood of rats.
Journal of biomedicine & biotechnology.
2009; 2009(?):791432. doi:
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Environmental health perspectives.
2008 Dec; 116(12):1689-93. doi:
10.1289/ehp.11438. [PMID: 19079721] - Sevil Kilciksiz, Can Demirel, Nurten Erdal, Serkan Gürgül, Lulufer Tamer, Lokman Ayaz, Yasemin Ors. The effect of N-acetylcysteine on biomarkers for radiation-induced oxidative damage in a rat model.
Acta medica Okayama.
2008 Dec; 62(6):403-9. doi:
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Current gastroenterology reports.
2008 Oct; 10(5):507-13. doi:
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International journal of radiation oncology, biology, physics.
2008 Oct; 72(2):553-61. doi:
10.1016/j.ijrobp.2008.06.1497. [PMID: 18793957] - Thulasi G Pillai, Cherupally Krishnan Krishnan Nair, K K Janardhanan. Polysaccharides isolated from Ganoderma lucidum occurring in Southern parts of India, protects radiation induced damages both in vitro and in vivo.
Environmental toxicology and pharmacology.
2008 Jul; 26(1):80-5. doi:
10.1016/j.etap.2008.02.004. [PMID: 21783892] - Mine Kaldir, Rusen Cosar-Alas, Tevfik Fikret Cermik, Vuslat Yurut-Caloglu, Mert Saynak, Semsi Altaner, Murat Caloglu, Zafer Kocak, Fusun Tokatli, Mevlüt Türe, Sule Parlar, Cem Uzal. Amifostine use in radiation-induced kidney damage. Preclinical evaluation with scintigraphic and histopathologic parameters.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].
2008 Jul; 184(7):370-5. doi:
10.1007/s00066-008-1777-7. [PMID: 19016036] - Zeinab Yaseen, Christian Michoudet, Gabriel Baverel, Laurence Dubourg. In vivo mesna and amifostine do not prevent chloroacetaldehyde nephrotoxicity in vitro.
Pediatric nephrology (Berlin, Germany).
2008 Apr; 23(4):611-8. doi:
10.1007/s00467-007-0689-6. [PMID: 18204866] - M Fevzi Ozkaynak, Indira Sahdev, Thomas G Gross, John E Levine, Alexandra C Cheerva, Michael K Richards, Marta K Rozans, Peter J Shaw, Richard P Kadota. A pilot study of addition of amifostine to melphalan, carboplatin, etoposide, and cyclophosphamide with autologous hematopoietic stem cell transplantation in pediatric solid tumors-A pediatric blood and marrow transplant consortium study.
Journal of pediatric hematology/oncology.
2008 Mar; 30(3):204-9. doi:
10.1097/mph.0b013e318162bd0c. [PMID: 18376282] - Jinsong Zhang, Xufang Wang, Hongjuan Lu. Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase.
Cancer letters.
2008 Feb; 260(1-2):127-36. doi:
10.1016/j.canlet.2007.10.023. [PMID: 18039557] - Li Liu, Run Shi, Qiang Shi, Yiyu Cheng, Yang Huo. Protective effect of saponins from Panax notoginseng against doxorubicin-induced cardiotoxicity in mice.
Planta medica.
2008 Feb; 74(3):203-9. doi:
10.1055/s-2008-1034303. [PMID: 18260050] - Ze Tian, Jianyong Si, Qi Chang, Liang Zhou, Shilin Chen, Peigen Xiao, Erxi Wu. Antitumor activity and mechanisms of action of total glycosides from aerial part of Cimicifuga dahurica targeted against hepatoma.
BMC cancer.
2007 Dec; 7(?):237. doi:
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Experimental biology and medicine (Maywood, N.J.).
2007 Dec; 232(11):1414-24. doi:
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Drug discovery today.
2007 Oct; 12(19-20):794-805. doi:
10.1016/j.drudis.2007.07.017. [PMID: 17933679] - Sergio Gallegos-Castorena, Armando Martínez-Avalos, Alejandro Mohar-Betancourt, Guadalupe Guerrero-Avendaño, Martha Zapata-Tarrés, Aurora Medina-Sansón. Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin.
Pediatric hematology and oncology.
2007 Sep; 24(6):403-8. doi:
10.1080/08880010701451244. [PMID: 17710657] - F Forrer, E Rolleman, N Schramm, E P Krenning, M de Jong. Is it possible to predict renal function in small animals using a multi-pinhole SPECT system.
European journal of nuclear medicine and molecular imaging.
2007 Jul; 34(7):1127-8. doi:
10.1007/s00259-007-0445-y. [PMID: 17497105] - Sanja Trajković, Silva Dobrić, Vesna Jaćević, Viktorija Dragojević-Simić, Zoran Milovanović, Aleksandar Dordević. Tissue-protective effects of fullerenol C60(OH)24 and amifostine in irradiated rats.
Colloids and surfaces. B, Biointerfaces.
2007 Jul; 58(1):39-43. doi:
10.1016/j.colsurfb.2007.01.005. [PMID: 17317115] - Kang Yu, Kai-Yan Yang, Xing-Zhou Ren, Yi Chen, Xin-Hua Liu. Amifostine protects bone marrow from benzene-induced hematotoxicity in mice.
International journal of toxicology.
2007 Jul; 26(4):315-23. doi:
10.1080/10915810701489697. [PMID: 17661222] - Edgar J Rolleman, Flavio Forrer, Bert Bernard, Magda Bijster, Marcel Vermeij, Roelf Valkema, Eric P Krenning, Marion de Jong. Amifostine protects rat kidneys during peptide receptor radionuclide therapy with [177Lu-DOTA0,Tyr3]octreotate.
European journal of nuclear medicine and molecular imaging.
2007 May; 34(5):763-771. doi:
10.1007/s00259-006-0291-3. [PMID: 17146655] - James Springate, Mary Taub. Ifosfamide toxicity in cultured proximal renal tubule cells.
Pediatric nephrology (Berlin, Germany).
2007 Mar; 22(3):358-65. doi:
10.1007/s00467-006-0328-7. [PMID: 17072651] - Brandon K Wills, Steven Aks, Gerry E Maloney, James Rhee, Rhonda Brand, Marin Sekosan. The effect of amifostine, a cytoprotective agent, on paraquat toxicity in mice.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2007 Mar; 3(1):1-6. doi:
10.1007/bf03161031. [PMID: 18072151] - Seyed Jalal Hosseinimehr, Mohammad Azadbakht, Seyedeh Maryam Mousavi, Aziz Mahmoudzadeh, Shahram Akhlaghpoor. Radioprotective effects of hawthorn fruit extract against gamma irradiation in mouse bone marrow cells.
Journal of radiation research.
2007 Jan; 48(1):63-8. doi:
10.1269/jrr.06032. [PMID: 17185880] - Badreldin H Ali, Mansour S Al Moundhri. Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2006 Aug; 44(8):1173-83. doi:
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International journal of radiation biology.
2006 May; 82(5):323-9. doi:
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