TETRACHLOROETHYLENE (BioDeep_00001867652)

Main id: BioDeep_00000006345

 

Industrial Pollutants


代谢物信息卡片


TETRACHLOROETHYLENE

化学式: C2Cl4 (163.8754)
中文名称: 四氯乙烯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(=C(Cl)Cl)(Cl)Cl
InChI: InChI=1S/C2Cl4/c3-1(4)2(5)6

描述信息

D009676 - Noxae > D002273 - Carcinogens
D004785 - Environmental Pollutants
D012997 - Solvents

同义名列表

3 个代谢物同义名

TETRACHLOROETHYLENE; Tetrachloroethene; Tetrachloroethylene



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALB, AXIN2, CASP3, CAT, CYP2B6, CYP2E1, HPGDS, SDR9C7, TBX20
Peripheral membrane protein 2 CYP2B6, CYP2E1
Endoplasmic reticulum membrane 3 CYP2B6, CYP2E1, KTN1
Nucleus 6 ALB, AXIN2, CASP3, PPARGC1B, TBX20, TCEA1
cytosol 9 ALB, AXIN2, B2M, CASP3, CAT, CBL, GPT, HPGDS, PPARGC1B
centrosome 2 ALB, AXIN2
nucleoplasm 5 ATP2B1, CASP3, HPGDS, PPARGC1B, TCEA1
Cell membrane 2 ATP2B1, B2M
Early endosome membrane 1 B2M
Multi-pass membrane protein 1 ATP2B1
Synapse 1 ATP2B1
cell surface 1 B2M
glutamatergic synapse 2 ATP2B1, CASP3
Golgi apparatus 3 ALB, B2M, CBL
Golgi membrane 1 B2M
growth cone 1 CBL
lysosomal membrane 1 B2M
mitochondrial inner membrane 1 CYP2E1
neuronal cell body 1 CASP3
presynaptic membrane 1 ATP2B1
plasma membrane 7 ATP2B1, AXIN2, B2M, BCHE, CBL, IGHE, KTN1
synaptic vesicle membrane 1 ATP2B1
Membrane 4 ATP2B1, B2M, CAT, KTN1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 5 ALB, ATP2B1, B2M, CAT, GPT
endoplasmic reticulum 3 ALB, B2M, KTN1
extracellular space 6 ALB, B2M, BCHE, IFNG, IGHE, IL4
perinuclear region of cytoplasm 1 CBL
mitochondrion 2 CAT, PPARGC1B
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 6 ATP2B1, CAT, CYP2B6, CYP2E1, HPGDS, SDR9C7
Microsome membrane 2 CYP2B6, CYP2E1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 IGHE
Secreted 5 ALB, B2M, BCHE, IFNG, IL4
extracellular region 7 ALB, B2M, BCHE, CAT, IFNG, IGHE, IL4
Single-pass membrane protein 1 KTN1
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
Cell projection, cilium 1 CBL
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 B2M
beta-catenin destruction complex 1 AXIN2
nucleolus 1 TCEA1
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 1 CBL
focal adhesion 3 B2M, CAT, CBL
flotillin complex 1 CBL
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
lateral plasma membrane 1 ATP2B1
ciliary basal body 1 ALB
cilium 1 CBL
chromatin 1 TBX20
mediator complex 1 PPARGC1B
IgE immunoglobulin complex 1 IGHE
Late endosome membrane 1 B2M
cell projection 1 ATP2B1
phagocytic vesicle membrane 1 B2M
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, BCHE
Basolateral cell membrane 1 ATP2B1
[Isoform 2]: Cell membrane 1 IGHE
Recycling endosome membrane 1 B2M
Presynaptic cell membrane 1 ATP2B1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
HFE-transferrin receptor complex 1 B2M
endoplasmic reticulum lumen 4 ALB, B2M, BCHE, KTN1
transcription factor TFIID complex 1 TCEA1
platelet alpha granule lumen 1 ALB
specific granule lumen 1 B2M
tertiary granule lumen 1 B2M
immunological synapse 1 ATP2B1
ER to Golgi transport vesicle membrane 1 B2M
nuclear envelope lumen 1 BCHE
death-inducing signaling complex 1 CASP3
MHC class I peptide loading complex 1 B2M
[Isoform 3]: Cell membrane 1 IGHE
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
MHC class I protein complex 1 B2M
MHC class II protein complex 1 B2M
catalase complex 1 CAT
photoreceptor ribbon synapse 1 ATP2B1
ciliary transition fiber 1 ALB
early endosome lumen 1 B2M


文献列表

  • Asghar Ghahri, Mohammad Hossien Dehghan, Pouria Seydi, Sara Mashayekhi, Yasaman Naderi, Enayatollah Seydi. The perchloroethylene-induced toxicity in dry cleaning workers lymphocytes through induction of oxidative stress. Journal of biochemical and molecular toxicology. 2022 Apr; 36(4):e23000. doi: 10.1002/jbt.23000. [PMID: 35156261]
  • Chimeddulam Dalaijamts, Joseph A Cichocki, Yu-Syuan Luo, Ivan Rusyn, Weihsueh A Chiu. Quantitative Characterization of Population-Wide Tissue- and Metabolite-Specific Variability in Perchloroethylene Toxicokinetics in Male Mice. Toxicological sciences : an official journal of the Society of Toxicology. 2021 08; 182(2):168-182. doi: 10.1093/toxsci/kfab057. [PMID: 33988684]
  • Alberto Modenese, Tiziana Concetta Gioia, Andrea Chiesi, Carlotta Abbacchini, Lucia Borsari, Davide Ferrari, Fabrizio De Pasquale, Renato Di Rico, Raffaella Ricci, Antonella Sala, Ennio Gianaroli, Guerrino Predieri, Sara Verri, Fabriziomaria Gobba. Evaluation of Occupational Exposure to Perchlorethylene in a Group of Italian Dry Cleaners Using Noninvasive Exposure Indices. International journal of environmental research and public health. 2019 08; 16(16):. doi: 10.3390/ijerph16162832. [PMID: 31398862]
  • Yu-Syuan Luo, Joseph A Cichocki, Nan-Hung Hsieh, Lauren Lewis, Fred A Wright, David W Threadgill, Weihsueh A Chiu, Ivan Rusyn. Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene. Environmental health perspectives. 2019 06; 127(6):67011. doi: 10.1289/ehp5105. [PMID: 31246107]
  • Catherine L Callahan, Patricia A Stewart, Aaron Blair, Mark P Purdue. Extended Mortality Follow-up of a Cohort of Dry Cleaners. Epidemiology (Cambridge, Mass.). 2019 03; 30(2):285-290. doi: 10.1097/ede.0000000000000951. [PMID: 30721169]
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  • Toshio Kawai, Haruhiko Sakurai, Masayuki Ikeda. Further examination of log Pow-based procedures to estimate biological occupational exposure limits. Journal of occupational health. 2018 Nov; 60(6):453-457. doi: 10.1539/joh.2018-0046-oa. [PMID: 30058609]
  • Yu-Syuan Luo, Nan-Hung Hsieh, Valerie Y Soldatow, Weihsueh A Chiu, Ivan Rusyn. Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains. Toxicology. 2018 11; 409(?):33-43. doi: 10.1016/j.tox.2018.07.012. [PMID: 30053492]
  • Greg C Randall. Electric Field Deformation of Protein-Coated Droplets in Thin Channels. Langmuir : the ACS journal of surfaces and colloids. 2018 08; 34(34):10028-10039. doi: 10.1021/acs.langmuir.8b01713. [PMID: 30060664]
  • Yu-Syuan Luo, Shinji Furuya, Valerie Y Soldatov, Oksana Kosyk, Hong Sik Yoo, Hisataka Fukushima, Lauren Lewis, Yasuhiro Iwata, Ivan Rusyn. Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice. Toxicological sciences : an official journal of the Society of Toxicology. 2018 08; 164(2):489-500. doi: 10.1093/toxsci/kfy099. [PMID: 29897530]
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  • Joseph A Cichocki, Shinji Furuya, Yu-Syuan Luo, Yasuhiro Iwata, Kranti Konganti, Weihsueh A Chiu, David W Threadgill, Igor P Pogribny, Ivan Rusyn. Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice. Toxicological sciences : an official journal of the Society of Toxicology. 2017 09; 159(1):102-113. doi: 10.1093/toxsci/kfx120. [PMID: 28903486]
  • Joseph A Cichocki, Shinji Furuya, Abhishek Venkatratnam, Thomas J McDonald, Anthony H Knap, Terry Wade, Stephen Sweet, Weihsueh A Chiu, David W Threadgill, Ivan Rusyn. Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population. Environmental health perspectives. 2017 05; 125(5):057006. doi: 10.1289/ehp788. [PMID: 28572074]
  • Joseph A Cichocki, Shinji Furuya, Kranti Konganti, Yu-Syuan Luo, Thomas J McDonald, Yasuhiro Iwata, Weihsueh A Chiu, David W Threadgill, Igor P Pogribny, Ivan Rusyn. Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice. The Journal of pharmacology and experimental therapeutics. 2017 04; 361(1):17-28. doi: 10.1124/jpet.116.238790. [PMID: 28148637]
  • Mark P Purdue, Patricia A Stewart, Melissa C Friesen, Joanne S Colt, Sarah J Locke, Misty J Hein, Martha A Waters, Barry I Graubard, Faith Davis, Julie Ruterbusch, Kendra Schwartz, Wong-Ho Chow, Nathaniel Rothman, Jonathan N Hofmann. Occupational exposure to chlorinated solvents and kidney cancer: a case-control study. Occupational and environmental medicine. 2017 03; 74(4):268-274. doi: 10.1136/oemed-2016-103849. [PMID: 27803178]
  • Yu-Syuan Luo, Joseph A Cichocki, Thomas J McDonald, Ivan Rusyn. Simultaneous detection of the tetrachloroethylene metabolites S-(1,2,2-trichlorovinyl) glutathione, S-(1,2,2-trichlorovinyl)-L-cysteine, and N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine in multiple mouse tissues via ultra-high performance liquid chromatography electrospray ionization tandem mass spectrometry. Journal of toxicology and environmental health. Part A. 2017; 80(9):513-524. doi: 10.1080/15287394.2017.1330585. [PMID: 28696834]
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  • Zhongbing Chen, Peter Kuschk, Heidrun Paschke, Matthias Kästner, Jochen A Müller, Heinz Köser. Treatment of a sulfate-rich groundwater contaminated with perchloroethene in a hydroponic plant root mat filter and a horizontal subsurface flow constructed wetland at pilot-scale. Chemosphere. 2014 Dec; 117(?):178-84. doi: 10.1016/j.chemosphere.2014.06.056. [PMID: 25025478]
  • Ilhan Unlu, Gulin Gokcen Kesici, Arzu Basturk, Mehmet Kos, Omer Hinc Yılmaz. A comparison of the effects of solvent and noise exposure on hearing, together and separately. Noise & health. 2014 Nov; 16(73):410-5. doi: 10.4103/1463-1741.144422. [PMID: 25387537]
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  • Kirsten M Hiortdahl, Robert C Borden. Enhanced reductive dechlorination of tetrachloroethene dense nonaqueous phase liquid with EVO and Mg(OH)2. Environmental science & technology. 2014; 48(1):624-31. doi: 10.1021/es4042379. [PMID: 24328264]
  • Darrell R Boverhof, Shannon M Krieger, Jon A Hotchkiss, Kenneth E Stebbins, Johnson Thomas, Michael R Woolhiser. Assessment of the immunotoxic potential of trichloroethylene and perchloroethylene in rats following inhalation exposure. Journal of immunotoxicology. 2013 Jul; 10(3):311-20. doi: 10.3109/1547691x.2012.735275. [PMID: 23167264]
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  • Thi Thanh Thuy Pham, Hong Heng See, Réjane Morand, Stephan Krähenbühl, Peter C Hauser. Determination of free and total valproic acid in human plasma by capillary electrophoresis with contactless conductivity detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Oct; 907(?):74-8. doi: 10.1016/j.jchromb.2012.08.037. [PMID: 22999475]
  • Zhongbing Chen, Shubiao Wu, Mareike Braeckevelt, Heidrun Paschke, Matthias Kästner, Heinz Köser, Peter Kuschk. Effect of vegetation in pilot-scale horizontal subsurface flow constructed wetlands treating sulphate rich groundwater contaminated with a low and high chlorinated hydrocarbon. Chemosphere. 2012 Oct; 89(6):724-31. doi: 10.1016/j.chemosphere.2012.06.042. [PMID: 22832338]
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  • Axel Tiessen, Annika Nerlich, Benjamin Faix, Christine Hümmer, Simon Fox, Kay Trafford, Hans Weber, Winfriede Weschke, Peter Geigenberger. Subcellular analysis of starch metabolism in developing barley seeds using a non-aqueous fractionation method. Journal of experimental botany. 2012 Mar; 63(5):2071-87. doi: 10.1093/jxb/err408. [PMID: 22200665]
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  • Teemu Hölttä, Eija Juurola, Lauri Lindfors, Albert Porcar-Castell. Cavitation induced by a surfactant leads to a transient release of water stress and subsequent 'run away' embolism in Scots pine (Pinus sylvestris) seedlings. Journal of experimental botany. 2012 Jan; 63(2):1057-67. doi: 10.1093/jxb/err349. [PMID: 22039297]
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