GS-Rd (BioDeep_00001867459)

Main id: BioDeep_00000000031

 

PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


.BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,12.BETA.)-20-(.BETA.-D-GLUCOPYRANOSYLOXY)-12-HYDROXYDAMMAR-24-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-

化学式: C48H82O18 (946.5501)
中文名称: 人参皂甙 Rd, 人参皂苷 Rd, 人参皂甙Rd, 人参皂苷Rd
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)[C@@H](O)[C@H](O)[C@@H](CO)O2)C(C)(C)[C@]2([H])CC[C@@]3(C)[C@]4(C)CC[C@@]([C@](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)(C)CC/C=C(\C)/C)([H])[C@@]4([H])[C@H](O)C[C@]3([H])[C@@]12C
InChI: InChI=1S/C48H82O18/c1-22(2)10-9-14-48(8,66-42-39(60)36(57)33(54)26(20-50)62-42)23-11-16-47(7)31(23)24(52)18-29-45(5)15-13-30(44(3,4)28(45)12-17-46(29,47)6)64-43-40(37(58)34(55)27(21-51)63-43)65-41-38(59)35(56)32(53)25(19-49)61-41/h10,23-43,49-60H,9,11-21H2,1-8H3/t23-,24+,25+,26+,27+,28-,29+,30-,31-,32+,33+,34+,35-,36-,37-,38+,39+,40+,41-,42-,43-,45-,46+,47+,48-/m0/s1

描述信息

Ginsenoside Rd is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is (20S)-ginsenoside Rg3 in which the hydroxy group at position 20 has been converted to its beta-D-glucopyranoside. It has a role as a vulnerary, a neuroprotective agent, an apoptosis inducer, an anti-inflammatory drug, an immunosuppressive agent and a plant metabolite. It is a ginsenoside, a beta-D-glucoside and a tetracyclic triterpenoid. It is functionally related to a (20S)-ginsenoside Rg3.
Ginsenoside Rd is a natural product found in Panax vietnamensis, Gynostemma pentaphyllum, and other organisms with data available.
See also: American Ginseng (part of); Panax notoginseng root (part of).
A ginsenoside found in Panax ginseng and Panax japonicus var. major that is (20S)-ginsenoside Rg3 in which the hydroxy group at position 20 has been converted to its beta-D-glucopyranoside.
Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.
Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

同义名列表

25 个代谢物同义名

.BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,12.BETA.)-20-(.BETA.-D-GLUCOPYRANOSYLOXY)-12-HYDROXYDAMMAR-24-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-; (3beta,12beta,20S)-20-[(beta-D-glucopyranosyl)oxy]-3-[(beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranosyl)oxy]dammar-24-en-12-ol; (3beta,12beta,20S)-20-((beta-D-glucopyranosyl)oxy)-3-((beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranosyl)oxy)dammar-24-en-12-ol; beta-D-Glucopyranoside, (3-beta,12-beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-; beta-D-Glucopyranoside, (3beta,12beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-; 2-O-beta-D-Glucopyranosyl-(3beta,12beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammara-24-en-3-yl-beta-D-glucopyranoside; (3beta,12beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; 20-(beta-D-glucopyranosyloxy)-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; b-D-Glucopyranoside,(3b,12b)-20-(b-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl2-O-b-D-glucopyranosyl-; 3-O-(beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranosyl)-20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol; GINSENOSIDE RD (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]; GINSENOSIDE RD (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG); RLDVZILFNVRJTL-IWFVLDDISA-N; GINSENOSIDE RD [INCI]; Chikusetsusaponin FK7; (20S)-ginsenoside Rd; Sanchinoside Rd; Gypenoside VIII; Ginsenoside Rd; ginsenoside-Rd; Panaxoside Rd; Ginsenoside; (GS)-Rd; GS-Rd; G-Rd



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 BCL2, BDNF, CASP3, CAT, MAPK14, MAPK8, NLRP3, PIK3CA, PRKAA2, PTGS2, RB1, STAT3, STMN4, VEGFA
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 11 BCL2, CASP3, MAPK14, MAPK8, MPO, NLRP3, PRKAA2, RB1, RBL2, STAT3, VEGFA
cytosol 11 BCL2, CASP3, CAT, MAPK14, MAPK8, NLRP3, PIK3CA, PRKAA2, RB1, RBL2, STAT3
dendrite 2 BDNF, PRKAA2
nucleoplasm 8 CASP3, MAPK14, MAPK8, MPO, PRKAA2, RB1, RBL2, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 1 TNF
lamellipodium 1 PIK3CA
Cell projection, axon 1 STMN4
Cell projection, growth cone 1 STMN4
Golgi apparatus membrane 1 NLRP3
Synapse 1 MAPK8
cell surface 2 TNF, VEGFA
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 3 PRKAA2, STMN4, VEGFA
Golgi membrane 2 INS, NLRP3
growth cone 1 STMN4
neuronal cell body 3 CASP3, PRKAA2, TNF
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 NLRP3
Lysosome 1 MPO
plasma membrane 3 PIK3CA, STAT3, TNF
Membrane 6 BCL2, BDNF, CAT, NLRP3, PRKAA2, VEGFA
axon 3 BDNF, MAPK8, PRKAA2
caveola 1 PTGS2
extracellular exosome 3 CAT, MPO, RBL2
endoplasmic reticulum 4 BCL2, NLRP3, PTGS2, VEGFA
extracellular space 7 BDNF, IL10, IL6, INS, MPO, TNF, VEGFA
perinuclear region of cytoplasm 2 BDNF, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CAT, MAPK14, NLRP3
protein-containing complex 3 BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 2 CAT, MPO
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Secreted 6 BDNF, IL10, IL6, INS, NLRP3, VEGFA
extracellular region 10 BDNF, CAT, IL10, IL6, INS, MAPK14, MPO, NLRP3, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
transcription regulator complex 2 RBL2, STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 1 RBL2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
spindle 1 RB1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
PML body 1 RB1
secretory granule 2 MPO, VEGFA
nuclear speck 2 MAPK14, PRKAA2
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 PTGS2, STMN4
chromatin 3 RB1, RBL2, STAT3
phagocytic cup 1 TNF
Chromosome 1 RBL2
spindle pole 1 MAPK14
Endomembrane system 1 NLRP3
endosome lumen 1 INS
microtubule organizing center 1 NLRP3
cytoplasmic stress granule 1 PRKAA2
myelin sheath 1 BCL2
azurophil granule 1 MPO
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BDNF, IL6, INS, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
SWI/SNF complex 1 RB1
phagocytic vesicle lumen 1 MPO
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yuanping Wang, Jiading Zheng, Xieyang Xiao, Cailing Feng, Yinghong Li, Hui Su, Ding Yuan, Qinghai Wang, Peihong Huang, Lili Jin. Ginsenoside Rd Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Inflammation and Apoptosis through PI3K/Akt Signaling Pathway. The American journal of Chinese medicine. 2024; 52(2):433-451. doi: 10.1142/s0192415x24500186. [PMID: 38577825]
  • Zekun Cui, Lifei Gu, Tao Liu, Yining Liu, Boyang Yu, Junping Kou, Fang Li, Kun Yang. Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca2+ pathways. European journal of pharmacology. 2023 Sep; 957(?):176044. doi: 10.1016/j.ejphar.2023.176044. [PMID: 37660968]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Shiyao Wan, ZeKun Cui, Lingling Wu, Fan Zhang, Tao Liu, Jingui Hu, Jiangwei Tian, Boyang Yu, Fuming Liu, Junping Kou, Fang Li. Ginsenoside Rd promotes omentin secretion in adipose through TBK1-AMPK to improve mitochondrial biogenesis via WNT5A/Ca2+ pathways in heart failure. Redox biology. 2023 04; 60(?):102610. doi: 10.1016/j.redox.2023.102610. [PMID: 36652744]
  • Li Shao, Li Wang, Yong-Yan Shi, Wei Zhang, Li-Wen Tan, Jian-Bo Wan, Wei-Hua Huang. Biotransformation of the saponins in Panax notoginseng leaves mediated by gut microbiota from insomniac patients. Journal of separation science. 2023 Jan; ?(?):e2200803. doi: 10.1002/jssc.202200803. [PMID: 36661243]
  • Yuangeng Li, Ping Yu, Wenwen Fu, Shuo Wang, Wenjun Zhao, Yue Ma, Yi Wu, Heming Cui, Xiaofeng Yu, Li Fu, Huali Xu, Dayun Sui. Ginsenoside Rd Inhibited Ferroptosis to Alleviate CCl4-Induced Acute Liver Injury in Mice via cGAS/STING Pathway. The American journal of Chinese medicine. 2023; 51(1):91-105. doi: 10.1142/s0192415x23500064. [PMID: 36437551]
  • Lili Niu, Xiangyu Qin, Litao Wang, Na Guo, Hongyan Cao, Hanghang Li, Chunjian Zhao, Huimei Wang, Yujie Fu. Upgrading the accumulation of ginsenoside Rd in Panax notoginseng by a novel glycosidase-producing endophytic fungus G11-7. Folia microbiologica. 2022 Dec; ?(?):. doi: 10.1007/s12223-022-01020-0. [PMID: 36571675]
  • Hui Zhang, Hongxi Zhu, Xiuyuan Luo, Yuanzhen Deng, Wei Zhang, Shubo Li, Jingjuan Liang, Zongwen Pang. Enzymatic biotransformation of Rb3 from the leaves of Panax notoginseng to ginsenoside rd by a recombinant β-xylosidase from Thermoascus aurantiacus. World journal of microbiology & biotechnology. 2022 Nov; 39(1):21. doi: 10.1007/s11274-022-03472-5. [PMID: 36422714]
  • Yu-Ying Chen, Qiu-Ping Liu, Pei An, Min Jia, Xin Luan, Jian-Yuan Tang, Hong Zhang. Ginsenoside Rd: A promising natural neuroprotective agent. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jan; 95(?):153883. doi: 10.1016/j.phymed.2021.153883. [PMID: 34952508]
  • Ai-Fang Zhou, Ke Zhu, Pei-Min Pu, Zhuo-Yao Li, Ya-Yun Zhang, Bing Shu, Xue-Jun Cui, Min Yao, Yong-Jun Wang. Neuroprotective Effect and Possible Mechanisms of Ginsenoside-Rd for Cerebral Ischemia/Reperfusion Damage in Experimental Animal: A Meta-Analysis and Systematic Review. Oxidative medicine and cellular longevity. 2022; 2022(?):7650438. doi: 10.1155/2022/7650438. [PMID: 36092162]
  • Tingyao Zhao, Xinting Wang, Qian Liu, Tianshu Yang, Huiyan Qu, Hua Zhou. Ginsenoside Rd Promotes Cardiac Repair After Myocardial Infarction by Modulating Monocytes/Macrophages Subsets Conversion. Drug design, development and therapy. 2022; 16(?):2767-2782. doi: 10.2147/dddt.s377624. [PMID: 36033133]
  • Xinxiu Yang, Meng Gao, Mengqi Miao, Cuihua Jiang, Dongjian Zhang, Zhiqi Yin, Yicheng Ni, Jing Chen, Jian Zhang. Combining combretastatin A4 phosphate with ginsenoside Rd synergistically inhibited hepatocellular carcinoma by reducing HIF-1α via PI3K/AKT/mTOR signalling pathway. The Journal of pharmacy and pharmacology. 2021 Mar; 73(2):263-271. doi: 10.1093/jpp/rgaa006. [PMID: 33793802]
  • Eunsoo Jung, Mi-Kyung Pyo, Junghyun Kim. Pectin-Lyase-Modified Ginseng Extract and Ginsenoside Rd Inhibits High Glucose-Induced ROS Production in Mesangial Cells and Prevents Renal Dysfunction in db/db Mice. Molecules (Basel, Switzerland). 2021 Jan; 26(2):. doi: 10.3390/molecules26020367. [PMID: 33445772]
  • Jeon-Kyung Kim, Eun Kyu Lee, Chu Hyun Bae, Soo-Dong Park, Jae-Jung Shim, Jung-Lyoul Lee, Hye Hyun Yoo, Dong-Hyun Kim. The Impact of Gut Microbiome on the Pharmacokinetics of Ginsenosides Rd and Rg3 in Mice after Oral Administration of Red Ginseng. The American journal of Chinese medicine. 2021; 49(8):1897-1912. doi: 10.1142/s0192415x21500890. [PMID: 34961415]
  • Baobao Zhang, Xiaolong Hu, Huizhe Wang, Rong Wang, Zhongxuan Sun, Xiaomei Tan, Shumeng Liu, Hao Wang. Effects of a dammarane-type saponin, ginsenoside Rd, in nicotine-induced vascular endothelial injury. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Dec; 79(?):153325. doi: 10.1016/j.phymed.2020.153325. [PMID: 32920289]
  • Ningning Yang, Guoying Liang, Jing Lin, Sijia Zhang, Qiuchi Lin, Xuechun Ji, Haoyuan Chen, Ning Li, Shizhu Jin. Ginsenoside Rd therapy improves histological and functional recovery in a rat model of inflammatory bowel disease. Phytotherapy research : PTR. 2020 Nov; 34(11):3019-3028. doi: 10.1002/ptr.6734. [PMID: 32468636]
  • Gereltuya Renchinkhand, Soo-Hyun Cho, Young W Park, Gyu-Yong Song, Myoung Soo Nam. Biotransformation of Major Ginsenoside Rb1 to Rd by Dekkera anomala YAE-1 from Mongolian Fermented Milk (Airag). Journal of microbiology and biotechnology. 2020 Oct; 30(10):1536-1542. doi: 10.4014/jmb.2004.04022. [PMID: 32807763]
  • Min Li, Xuwen Li, Limei Zhou, Yongri Jin. Effects of total saponins from Panacis majoris Rhizoma and its degradation products on myocardial ischemia-reperfusion injury in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Oct; 130(?):110538. doi: 10.1016/j.biopha.2020.110538. [PMID: 32731133]
  • Haixia Wang, Ning Jiang, Jingwei Lv, Hong Huang, Xinmin Liu. Ginsenoside Rd reverses cognitive deficits by modulating BDNF-dependent CREB pathway in chronic restraint stress mice. Life sciences. 2020 Oct; 258(?):118107. doi: 10.1016/j.lfs.2020.118107. [PMID: 32682919]
  • Yao Cheng, Ruimei Li, Zixuan Lin, Feiyan Chen, Jianguo Dai, Zhu Zhu, Lin Chen, Yunan Zhao. Structure-activity relationship analysis of dammarane-type natural products as muscle-type creatine kinase activators. Bioorganic & medicinal chemistry letters. 2020 09; 30(17):127364. doi: 10.1016/j.bmcl.2020.127364. [PMID: 32738969]
  • Hui Xiong, Ai-Hua Zhang, Qi-Qi Zhao, Guang-Li Yan, Hui Sun, Xi-Jun Wang. Discovery of quality-marker ingredients of Panax quinquefolius driven by high-throughput chinmedomics approach. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Aug; 74(?):152928. doi: 10.1016/j.phymed.2019.152928. [PMID: 31451286]
  • Yi-Zhen Tian, Ya-Peng Liu, San-Chun Tian, Su-Yin Ge, Yong-Jie Wu, Bao-Lai Zhang. Antitumor activity of ginsenoside Rd in gastric cancer via up-regulation of Caspase-3 and Caspase-9. Die Pharmazie. 2020 04; 75(4):147-150. doi: 10.1691/ph.2020.9931. [PMID: 32295691]
  • Wenqi Jin, Rui Ma, Lu Zhai, Xiaohao Xu, Tingting Lou, Qingxia Huang, Jing Wang, Daqing Zhao, Xiangyan Li, Liwei Sun. Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells. Life sciences. 2020 Mar; 245(?):117337. doi: 10.1016/j.lfs.2020.117337. [PMID: 31972205]
  • S Zhang, J Luo, J Xie, Z Wang, W Xiao, L Zhao. Cooperated biotransformation of ginsenoside extracts into ginsenoside 20(S)-Rg3 by three thermostable glycosidases. Journal of applied microbiology. 2020 Mar; 128(3):721-734. doi: 10.1111/jam.14513. [PMID: 31715079]
  • Fang Li, Li-Zhi Pang, Ling Zhang, Yu Zhang, Yuan-Yuan Zhang, Bo-Yang Yu, Jun-Ping Kou. YiQiFuMai powder injection ameliorates chronic heart failure through cross-talk between adipose tissue and cardiomyocytes via up-regulation of circulating adipokine omentin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Nov; 119(?):109418. doi: 10.1016/j.biopha.2019.109418. [PMID: 31505423]
  • Lan Luo, Jiazhen Kang, Weijun Zhao, Yue Qi, Shengwang Liang. Validated LC-MS/MS method for simultaneous quantification of seven components of Naodesheng in rat serum after oral administration and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):1-7. doi: 10.1016/j.jpba.2019.05.036. [PMID: 31153133]
  • Lan Luo, Jiazhen Kang, Qiong He, Yue Qi, Xingyu Chen, Shumei Wang, Shengwang Liang. A NMR-Based Metabonomics Approach to Determine Protective Effect of a Combination of Multiple Components Derived from Naodesheng on Ischemic Stroke Rats. Molecules (Basel, Switzerland). 2019 May; 24(9):. doi: 10.3390/molecules24091831. [PMID: 31086027]
  • Xiao-Nan Chen, Dan-Qi Li, Meng-di Zhao, Gang-Yan Yu, Shou-Ying Du, Yang Lu, Jie Bai, Peng-Yue Li, Ya-Li Wu, Zhi-Hao Tian, Yan-Ying Zeng. Pharmacokinetics of Panax notoginseng Saponins in Adhesive and Normal Preparation of Fufang Danshen. European journal of drug metabolism and pharmacokinetics. 2018 Apr; 43(2):215-225. doi: 10.1007/s13318-017-0433-y. [PMID: 28916980]
  • Muhammad Zubair Siddiqi, Gyu-Min Choi, Wan-Taek Im. Ciceribacter azotifigens sp. nov., a nitrogen-fixing bacterium isolated from activated sludge. International journal of systematic and evolutionary microbiology. 2018 Feb; 68(2):482-486. doi: 10.1099/ijsem.0.002438. [PMID: 29297848]
  • E González-Burgos, Carlos Fernández-Moriano, R Lozano, I Iglesias, M P Gómez-Serranillos. Ginsenosides Rd and Re co-treatments improve rotenone-induced oxidative stress and mitochondrial impairment in SH-SY5Y neuroblastoma cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Nov; 109(Pt 1):38-47. doi: 10.1016/j.fct.2017.08.013. [PMID: 28843595]
  • Eryun Zhang, Hailian Shi, Li Yang, Xiaojun Wu, Zhengtao Wang. Ginsenoside Rd regulates the Akt/mTOR/p70S6K signaling cascade and suppresses angiogenesis and breast tumor growth. Oncology reports. 2017 Jul; 38(1):359-367. doi: 10.3892/or.2017.5652. [PMID: 28534996]
  • Lu Wang, Yazheng Zhao, Ye Yang, Yuanjia Hu, Xiaohan Zou, Boyang Yu, Jin Qi. Allergens in red ginseng extract induce the release of mediators associated with anaphylactoid reactions. Journal of translational medicine. 2017 06; 15(1):148. doi: 10.1186/s12967-017-1249-x. [PMID: 28659175]
  • Shi Qiu, Wen-Zhi Yang, Chang-Liang Yao, Xiao-Jian Shi, Jing-Ya Li, Yang Lou, Ya-Nan Duan, Wan-Ying Wu, De-An Guo. Malonylginsenosides with Potential Antidiabetic Activities from the Flower Buds of Panax ginseng. Journal of natural products. 2017 04; 80(4):899-908. doi: 10.1021/acs.jnatprod.6b00789. [PMID: 28345906]
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