Paeoniflorin (BioDeep_00000182045)

   

human metabolite blood metabolite


代谢物信息卡片


(6-Hydroxy-8-methyl-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-9,10-dioxatetracyclo[4.3.1.0²,⁵.0³,⁸]decan-2-yl)methyl benzoic acid

化学式: C23H28O11 (480.16315380000003)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CC3(C4CC1(C4(C(O2)O3)COC(=O)C5=CC=CC=C5)OC6C(C(C(C(O6)CO)O)O)O)O
InChI: InChI=1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • X F Hong, L Li, Z X Yang, J Yan. [Paeoniflorin improves myocardial injury via inhibition of Src/VE-cadherin pathway in septic rats]. Zhonghua nei ke za zhi. 2022 Jun; 61(6):652-658. doi: 10.3760/cma.j.cn112138-20210811-00545. [PMID: 35673745]
  • Jingjing Wu, Dongmei Zhang, Linlin Hu, Xiaowei Zheng, Caihong Chen. Paeoniflorin alleviates NG-nitro-L-arginine methyl ester (L-NAME)-induced gestational hypertension and upregulates silent information regulator 2 related enzyme 1 (SIRT1) to reduce H2O2-induced endothelial cell damage. Bioengineered. 2022 02; 13(2):2248-2258. doi: 10.1080/21655979.2021.2024325. [PMID: 35030965]
  • Li-Li Liu, Xie-Xie Chen, Yu-Ting Yin, Hui-Fa Ouyang, Yong-Mei Guan, Wei-Feng Zhu, Li-Hua Chen. [Pharmacokinetic behavior and brain tissue distribution of paeoniflorin combined with normal and toxic doses of strychnine in rats after percutaneous administration]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Feb; 47(4):1064-1072. doi: 10.19540/j.cnki.cjcmm.20211102.202. [PMID: 35285207]
  • Yanyan Hu, Wei Yang. Paeoniflorin Can Improve Acute Lung Injury Caused by Severe Acute Pancreatitis through Nrf2/ARE Pathway. Computational and mathematical methods in medicine. 2022; 2022(?):5712219. doi: 10.1155/2022/5712219. [PMID: 35586665]
  • Ting Zhang, Sheng Guo, Yang Niu, Kaidi Huang, Fanshu Bu, Hui Ren, Yiying Zhang, Erxin Shang, Jin-Ao Duan, Dawei Qian. The influence of essential oils from ZhaLi NuSi Prescription on the pharmacokinetics of its non-volatile components in normal rats. Biomedical chromatography : BMC. 2022 Jan; 36(1):e5257. doi: 10.1002/bmc.5257. [PMID: 34611921]
  • Sicong Li, Xuting Li, Dingsheng Yuan, Bin Wang, Rui Yang, Min Zhang, Jinliang Li, Fuqiang Zeng. Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Sep; 51(9):961-967. doi: 10.1080/00498254.2017.1404659. [PMID: 29160125]
  • Feng Jiao, Kevin Varghese, Shaoxun Wang, Yedan Liu, Hongwei Yu, George W Booz, Richard J Roman, Ruen Liu, Fan Fan. Recent Insights Into the Protective Mechanisms of Paeoniflorin in Neurological, Cardiovascular, and Renal Diseases. Journal of cardiovascular pharmacology. 2021 06; 77(6):728-734. doi: 10.1097/fjc.0000000000001021. [PMID: 34001724]
  • Ting Wang, Xu Zhou, Ge Kuang, Rong Jiang, Xinyi Guo, Shengwang Wu, Jingyuan Wan, Liangjun Yin. Paeoniflorin modulates oxidative stress, inflammation and hepatic stellate cells activation to alleviate CCl4-induced hepatic fibrosis by upregulation of heme oxygenase-1 in mice. The Journal of pharmacy and pharmacology. 2021 Mar; 73(3):338-346. doi: 10.1093/jpp/rgaa042. [PMID: 33793876]
  • Chun-Ling Liang, Weihui Lu, Feifei Qiu, Dan Li, Huazhen Liu, Fang Zheng, Qunfang Zhang, Yuchao Chen, Chuanjian Lu, Bin Li, Zhenhua Dai. Paeoniflorin ameliorates murine lupus nephritis by increasing CD4+Foxp3+ Treg cells via enhancing mTNFα-TNFR2 pathway. Biochemical pharmacology. 2021 03; 185(?):114434. doi: 10.1016/j.bcp.2021.114434. [PMID: 33513343]
  • Ruonan Chen, Chenlin Shen, Qingqing Xu, Yaru Liu, Bo Li, Cheng Huang, Taotao Ma, Xiaoming Meng, Maomao Wu, Jun Li. The permeability characteristics and interaction of main components from Si-Ni-San in a MDCK epithelial cell monolayer model. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Feb; 51(2):239-248. doi: 10.1080/00498254.2017.1359433. [PMID: 28745128]
  • Xia Luo, Xiaojing Wang, Shaowei Huang, Bo Xu, Shuang Luo, Yanyang Li, Qing Wang, Yanping Chen, Xiangliang Deng, Lingyun Liu, Lian Zhou. Paeoniflorin ameliorates experimental colitis by inhibiting gram-positive bacteria-dependent MDP-NOD2 pathway. International immunopharmacology. 2021 Jan; 90(?):107224. doi: 10.1016/j.intimp.2020.107224. [PMID: 33302036]
  • Qilin Fan, Xiaojing Guan, Yuanlong Hou, Yali Liu, Wei Wei, Xiaoying Cai, Youying Zhang, Guangji Wang, Xiao Zheng, Haiping Hao. Paeoniflorin modulates gut microbial production of indole-3-lactate and epithelial autophagy to alleviate colitis in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Dec; 79(?):153345. doi: 10.1016/j.phymed.2020.153345. [PMID: 33002829]
  • Yongjing Zhang, Shiling Hu, Shuai Ge, Jue Wang, Langchong He. Paeoniflorin inhibits IgE-mediated allergic reactions by suppressing the degranulation of mast cells though binding with FcϵRI alpha subunits. European journal of pharmacology. 2020 Nov; 886(?):173415. doi: 10.1016/j.ejphar.2020.173415. [PMID: 32771669]
  • Yulong Gu, Xianglan Piao, Dan Zhu. Simultaneous determination of calycosin, prim-O-glucosylcimifugin, and paeoniflorin in rat plasma by HPLC-MS/MS: application in the pharmacokinetic analysis of HQCF. The Journal of international medical research. 2020 Nov; 48(11):300060520972902. doi: 10.1177/0300060520972902. [PMID: 33213240]
  • R Q Yao, C Ren, L X Wang, N Dong, Y Wu, Y M Yao. [Influence of Xuebijing injection and its component paeoniflorin on immune function and survival rate of septic rats]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2020 Aug; 36(8):658-664. doi: 10.3760/cma.j.cn501120-20200430-00246. [PMID: 32829604]
  • Xiaojing Wang, Xia Luo, Zhongzheng Zhao, Shuang Luo, Jinyan Chen, Lian Zhou. [Paeoniflorin attenuates dextran sulfate sodium-induced ulcerative colitis in mice by inhibiting TLR5 expression and T cell activation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2020 Aug; 36(8):673-679. doi: . [PMID: 32958122]
  • Yong-Liang Zhu, Shuang-Long Li, Jun-Li Jin, Jia-Ao Fang, Xiang-Die Wang, Ling-Yun Chen, Xiang-Jun Qiu. Simultaneous determination of six components of Danzhi Xiaoyao Pill in beagle plasma by HPLC-MS/MS and a study of pharmacokinetic of paeoniflorin and geniposide after single-dose administration. Journal of pharmaceutical and biomedical analysis. 2020 Jul; 186(?):113269. doi: 10.1016/j.jpba.2020.113269. [PMID: 32247162]
  • Xiaoqian Huang, Liying Ren, Lianbing Hou, Hua Fan, Chengliang Wang, Chunxia Wang, Yuhao Li. Paeoniflorin ameliorates antipsychotic-induced hyperprolactinemia in rats by attenuating impairment of the dopamine D2 receptor and TGF-β1 signaling pathways in the hypothalamus and pituitary. Journal of ethnopharmacology. 2020 Jul; 257(?):112862. doi: 10.1016/j.jep.2020.112862. [PMID: 32294507]
  • Arisa Takeuchi, Kaori Koga, Yohei Tokita, Takashi Matsumoto, Erina Satake, Ayumi Taguchi, Tomoko Makabe, Mariko Miyashita, Masashi Takamura, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Osamu Wada-Hiraike, Tomoyuki Fujii, Yutaka Osuga. The effects of tokishakuyakusan, a traditional Japanese medicine (kampo), ferulic acid and paeoniflorin, on human endometriotic stromal cells and peritoneal macrophages. Journal of reproductive immunology. 2020 06; 139(?):103104. doi: 10.1016/j.jri.2020.103104. [PMID: 32172005]
  • Heyun Zhu, Jiao Guan, Hui Zhang, Sheng Chang, Liming Wang, Jianyi Shi, Bo Feng, Jingkai Gu. Simultaneous determination of ferulic acid, paeoniflorin, and albiflorin in rat plasma by ultra-high performance liquid chromatography with tandem mass spectrometry: Application to a pharmacokinetic study of Danggui-Shaoyao-San. Journal of separation science. 2020 Jun; 43(11):2053-2060. doi: 10.1002/jssc.201900846. [PMID: 32112520]
  • Yushan Fang, Liang-Cai Wu, Kanglong Ma, Guopeng Pan, Shangqi Yang, Yanghan Zheng, Yanchang Li. Paeoniflorin alleviates lipopolysaccharide-induced disseminated intravascular coagulation by inhibiting inflammation and coagulation activation. Drug development research. 2020 06; 81(4):517-525. doi: 10.1002/ddr.21647. [PMID: 32065451]
  • Fei Fei, Li-Xiang Aa, Qi Qi, Run-Bin Sun, Cai-Xia Yan, Ji-Ye Aa, Guang-Ji Wang. Paeoniflorin inhibits Th1 and Th17 cells in gut-associated lymphoid tissues to produce anti-arthritis activities. Inflammopharmacology. 2019 Dec; 27(6):1193-1203. doi: 10.1007/s10787-019-00615-3. [PMID: 31309485]
  • Lvkeng Luo, Shuling Wu, Xiaoxiao Zhu, Weiwei Su. The profiling and identification of the absorbed constituents and metabolites of Naoshuantong capsule in mice biofluids and brain by ultra- fast liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Oct; 1129(?):121791. doi: 10.1016/j.jchromb.2019.121791. [PMID: 31610480]
  • Mingya Ding, Wenfang Ma, Xiaoyan Wang, Shujing Chen, Shuhan Zou, Jinna Wei, Yuqiao Yang, Jin Li, Xuejing Yang, Hui Wang, Yuhong Li, Qilong Wang, Haoping Mao, Xiu-Mei Gao, Yan-Xu Chang. A network pharmacology integrated pharmacokinetics strategy for uncovering pharmacological mechanism of compounds absorbed into the blood of Dan-Lou tablet on coronary heart disease. Journal of ethnopharmacology. 2019 Oct; 242(?):112055. doi: 10.1016/j.jep.2019.112055. [PMID: 31276751]
  • Mingyi Zhao, Peng Zhou, Jun Yu, Asenso James, Feng Xiao, Chun Wang, Wei Wei. The tissue distribution and excretion study of paeoniflorin-6'-O-benzene sulfonate (CP-25) in rats. Inflammopharmacology. 2019 Oct; 27(5):969-974. doi: 10.1007/s10787-018-0463-3. [PMID: 29524003]
  • Weilan Yu, Dingsheng Wen, Dake Cai, Juntao Zheng, Haining Gan, Fulin Jiang, Xiaolin Liu, Biaochang Lao, Weibang Yu, Yanping Guan, Guoping Zhong. Simultaneous determination of curcumin, tetrahydrocurcumin, quercetin, and paeoniflorin by UHPLC-MS/MS in rat plasma and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2019 Aug; 172(?):58-66. doi: 10.1016/j.jpba.2019.04.033. [PMID: 31029801]
  • Jun-Jin Liu, Yao Cheng, Yun-Yun Shao, Zhuang-Peng Chang, Yi-Ting Guo, Xiao-Juan Feng, Ding Xu, Jing-Ping Zhang, Yan Song, Rui-Gang Hou. Comparative pharmacokinetics and metabolites study of seven major bioactive components of Shaoyao-Gancao decoction in normal and polycystic ovary syndrome rats by ultra high pressure liquid chromatography with tandem mass spectrometry. Journal of separation science. 2019 Aug; 42(15):2534-2549. doi: 10.1002/jssc.201900002. [PMID: 31144455]
  • Yang Liu, Jiakai Han, Zhenyu Zhou, Dandan Li. Paeoniflorin protects pancreatic β cells from STZ-induced damage through inhibition of the p38 MAPK and JNK signaling pathways. European journal of pharmacology. 2019 Jun; 853(?):18-24. doi: 10.1016/j.ejphar.2019.03.025. [PMID: 30880178]
  • Jiao Guan, Liming Wang, Jia Jin, Sheng Chang, Xiao Xiao, Bo Feng, Heyun Zhu. Simultaneous determination of calycosin-7-O-β-D-glucoside, cinnamic acid, paeoniflorin and albiflorin in rat plasma by UHPLC-MS/MS and its application to a pharmacokinetic study of Huangqi Guizhi Wuwu Decoction. Journal of pharmaceutical and biomedical analysis. 2019 Jun; 170(?):1-7. doi: 10.1016/j.jpba.2019.03.022. [PMID: 30897430]
  • Feifei Nong, Zhongxiang Zhao, Xia Luo, Chang Liu, Hui Li, Qi Liu, Bin Wen, Lian Zhou. Evaluation of the influence of mirabilite on the absorption and pharmacokinetics of the ingredients in Dahuang-mudan decoction by a validated UPLC/QTOF-MS/MS method. Biomedical chromatography : BMC. 2019 Mar; 33(3):e4423. doi: 10.1002/bmc.4423. [PMID: 30381826]
  • Jinwei Gao, Jinbo Yu, Panpan Xu, Jinmei Chen, Guanghui Gao, Binglong Li, Lixin Sun. Established UPLC-MS/MS procedure for multicomponent quantitative analysis in rat plasma: A contrastive pharmacokinetics study of Qiangshen tablet in normal and kidney yang deficiency syndrome models. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Feb; 1106-1107(?):35-42. doi: 10.1016/j.jchromb.2018.12.031. [PMID: 30639948]
  • Naglaa Fathy Abd El-Aal, Eman Hassan Abdelbary. Paeoniflorin in experimental BALB/c mansoniasis: A novel anti-angiogenic therapy. Experimental parasitology. 2019 Feb; 197(?):85-92. doi: 10.1016/j.exppara.2018.11.002. [PMID: 30414842]
  • Tianjun Xie, Ke Li, Xia Gong, Rong Jiang, Wenya Huang, Xiahong Chen, Hongtao Tie, Qin Zhou, Shengwang Wu, Jingyuan Wan, Bin Wang. Paeoniflorin protects against liver ischemia/reperfusion injury in mice via inhibiting HMGB1-TLR4 signaling pathway. Phytotherapy research : PTR. 2018 Nov; 32(11):2247-2255. doi: 10.1002/ptr.6161. [PMID: 30047580]
  • Hong-Bo Xiao, Lin Liang, Zhi-Feng Luo, Zhi-Liang Sun. Paeoniflorin regulates GALNT2-ANGPTL3-LPL pathway to attenuate dyslipidemia in mice. European journal of pharmacology. 2018 Oct; 836(?):122-128. doi: 10.1016/j.ejphar.2018.08.006. [PMID: 30096295]
  • Seung-Hyun Jeong, Ji-Hun Jang, Seong-Ho Ham, Seung-Jeong Yang, Hea-Young Cho, Yong-Bok Lee. Simultaneous UPLC-MS/MS determination of four components of Socheongryong-tang tablet in human plasma: Application to pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Sep; 1095(?):214-225. doi: 10.1016/j.jchromb.2018.07.043. [PMID: 30081350]
  • Yu-Cheng Li, Jing-Yi Qiao, Bao-Ying Wang, Ming Bai, Ji-Duo Shen, Yong-Xian Cheng. Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways. Nutrients. 2018 Aug; 10(8):. doi: 10.3390/nu10081024. [PMID: 30081580]
  • Zhi-Kun Qiu, Jia-Li He, Xu Liu, Jia Zeng, Wei Xiao, Qing-Hong Fan, Xiao-Meng Chai, Wei-Hai Ye, Ji-Sheng Chen. Anxiolytic-like effects of paeoniflorin in an animal model of post traumatic stress disorder. Metabolic brain disease. 2018 08; 33(4):1175-1185. doi: 10.1007/s11011-018-0216-4. [PMID: 29633071]
  • Xinwen Lv, Yongbing Zhang, Hujin Zhang. Neuroprotective effect of Trichosanthes kirilowii cassia twig on cerebral ischemia-reperfusion injury in rats. Pakistan journal of pharmaceutical sciences. 2018 Jul; 31(4(Special)):1643-1647. doi: . [PMID: 30203753]
  • Xue Kong, Dongni Leng, Guanzhao Liang, Hailin Zheng, Qiong Wang, Yongnian Shen, Guixia Lu, Huailiang Zhang, Dongmei Shi, Weida Liu. Paeoniflorin augments systemic Candida albicans infection through inhibiting Th1 and Th17 cell expression in a mouse model. International immunopharmacology. 2018 Jul; 60(?):76-83. doi: 10.1016/j.intimp.2018.03.001. [PMID: 29705532]
  • Ziqiang Li, Jia Liu, Yazhuo Li, Xi Du, Yanfen Li, Ruihua Wang, Chunxiao Lv, Xin He, Baohe Wang, Yuhong Huang, Deqin Zhang. Identify super quality markers from prototype-based pharmacokinetic markers of Tangzhiqing tablet (TZQ) based on in vitro dissolution/ permeation and in vivo absorption correlations. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jun; 45(?):59-67. doi: 10.1016/j.phymed.2018.04.001. [PMID: 29685365]
  • Yu-Tian Zhang, Mei-Feng Xiao, Qiong Liao, Wen-Long Liu, Kai-Wen Deng, Yi-Qun Zhou, Yu Tang, Fu-Yuan He, Yan-Tao Yang. Application of TQSM polypharmacokinetics and its similarity approach to ascertain Q-marker by analyses of transitivity in vivo of five candidates in Buyanghuanwu injection. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jun; 45(?):18-25. doi: 10.1016/j.phymed.2018.03.012. [PMID: 29555366]
  • Jianhui Yang, Yu Ren, Zhong-Guan Lou, Xue Wan, Guo-Bin Weng, Dong Cen. Paeoniflorin inhibits the growth of bladder carcinoma via deactivation of STAT3. Acta pharmaceutica (Zagreb, Croatia). 2018 Jun; 68(2):211-222. doi: 10.2478/acph-2018-0013. [PMID: 29702481]
  • Shanshan Sun, Lijun Zhu, Yanxi Hu, Yufeng Liu. Studies on the metabolism of paeoniflorin in human intestinal microflora by high performance liquid chromatography/electrospray ionization/Fourier transform ion cyclotron resonance mass spectrometry and quadrupole time-of-flight mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 May; 1085(?):63-71. doi: 10.1016/j.jchromb.2018.03.042. [PMID: 29631252]
  • Ziqiang Li, Jia Liu, Deqin Zhang, Xi Du, Lifeng Han, Chunxiao Lv, Yanfen Li, Ruihua Wang, Baohe Wang, Yuhong Huang. Nuciferine and paeoniflorin can be quality markers of Tangzhiqing tablet, a Chinese traditional patent medicine, based on the qualitative, quantitative and dose-exposure-response analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 May; 44(?):155-163. doi: 10.1016/j.phymed.2018.02.006. [PMID: 29519686]
  • Xinyu Li, Yan Wang, Kun Wang, Yonggui Wu. Renal protective effect of Paeoniflorin by inhibition of JAK2/STAT3 signaling pathway in diabetic mice. Bioscience trends. 2018 May; 12(2):168-176. doi: 10.5582/bst.2018.01009. [PMID: 29669962]
  • Chang-Hao Xie, Zhi-Jun Li, Lin-Jie Chen, Ping Zhao, Jia-Jia Zhang, Shan-Wang Bai, Tong Shen, Wen-Xin He, Yuan-Yuan Wang. [The Study of Protective Effect of Paeoniflorin on Lung Injury in MRL/lpr Mice]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2018 May; 49(3):394-398. doi: . [PMID: 30014641]
  • Yanmao Wang, Yu Zhu, Shengdi Lu, Chengfang Hu, Wanrun Zhong, Yimin Chai. Beneficial effects of paeoniflorin on osteoporosis induced by high-carbohydrate, high-fat diet-associated hyperlipidemia in vivo. Biochemical and biophysical research communications. 2018 04; 498(4):981-987. doi: 10.1016/j.bbrc.2018.03.093. [PMID: 29550473]
  • Lijun Zhu, Shanshan Sun, Yanxi Hu, Yufeng Liu. Metabolic study of paeoniflorin and total paeony glucosides from Paeoniae Radix Rubra in rats by high-performance liquid chromatography coupled with sequential mass spectrometry. Biomedical chromatography : BMC. 2018 Apr; 32(4):. doi: 10.1002/bmc.4141. [PMID: 29148594]
  • Bing Yang, Shouying Du, Yang Lu, Shan Jia, Mengdi Zhao, Jie Bai, Pengyue Li, Huichao Wu. Influence of paeoniflorin and menthol on puerarin transport across MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model. The Journal of pharmacy and pharmacology. 2018 Mar; 70(3):349-360. doi: 10.1111/jphp.12853. [PMID: 29238980]
  • Guo-Wu Liang, Yi-Cun Chen, Yi Wang, Hong-Mei Wang, Xiang-Yu Pan, Pei-Hong Chen, Qing-Xia Niu. Interaction between Saikosaponin D, Paeoniflorin, and Human Serum Albumin. Molecules (Basel, Switzerland). 2018 Jan; 23(2):. doi: 10.3390/molecules23020249. [PMID: 29382045]
  • Xiujun Wu, Yang You, Gonglin Qu, Ran Ma, Mingxue Zhang. Simultaneous determination of ginsenoside Rb1, ginsenoside Rg1, paeoniflorin, albiflorin and oxypaeoniflorin in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study of wen-Yang-Huo-Xue soft capsule. Biomedical chromatography : BMC. 2017 Dec; 31(12):. doi: 10.1002/bmc.4019. [PMID: 28557007]
  • Naglaa Fathy Abd El-Aal, Rania Said Hamza, Ola Harb. Paeoniflorin targets apoptosis and ameliorates fibrosis in murine schistosomiasis mansoni: A novel insight. Experimental parasitology. 2017 Dec; 183(?):23-32. doi: 10.1016/j.exppara.2017.10.005. [PMID: 29037782]
  • Ruirui Lu, Jie Zhou, Bihao Liu, Ning Liang, Yu He, Lixia Bai, Peichun Zhang, Yanchun Zhong, Yuan Zhou, Jiuyao Zhou. Paeoniflorin ameliorates Adriamycin-induced nephrotic syndrome through the PPARγ/ANGPTL4 pathway in vivo and vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Dec; 96(?):137-147. doi: 10.1016/j.biopha.2017.09.105. [PMID: 28972886]
  • Changhao Xie, Bingbing Wu, Jin Xi, Rui Wang, Chen Zhang, Yanglei Li, Shanwang Bai, Jiajia Zhang, Tong Shen, Xiaoyan Tang, Yuanyuan Wang. [Paeoniflorin ameliorates liver injury of MRL/lpr mice through inhibition of NF-κB pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2017 Nov; 33(11):1467-1471. doi: . [PMID: 29268848]
  • Bingting Sun, Guoliang Dai, Yongtao Bai, Weidong Zhang, Lijing Zhu, Jihong Chu, Ronghua Pan, Wenzheng Ju. Determination of Paeoniflorin in Rat Plasma by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study. Journal of chromatographic science. 2017 Nov; 55(10):1006-1012. doi: 10.1093/chromsci/bmx066. [PMID: 28977364]
  • Minting Chen, Suying Wei, Chaohua Luo, Feilong Chen, Shuai Song, Qun Shen, Zhixian Mo, Fenghuan Wei. Simultaneous determination of wogonin, oroxylin a, schisandrin, paeoniflorin and emodin in rat serum by HPLC-MS/MS and application to pharmacokinetic studies. Biomedical chromatography : BMC. 2017 Oct; 31(10):. doi: 10.1002/bmc.3966. [PMID: 28236316]
  • Tingmin Zhang, Qijin Zhu, Yunxia Shao, Kun Wang, Yonggui Wu. Paeoniflorin prevents TLR2/4-mediated inflammation in type 2 diabetic nephropathy. Bioscience trends. 2017 Jul; 11(3):308-318. doi: 10.5582/bst.2017.01104. [PMID: 28626209]
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