6-(4-Chlorophenyl)imidazo[2,1-B][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (BioDeep_00000177534)

   

human metabolite blood metabolite


代谢物信息卡片


{[6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylidene}[(3,4-dichlorophenyl)methoxy]amine

化学式: C19H12Cl3N3OS (434.9767)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 90%

分子结构信息

SMILES: ClC1=CC=C(C=C1)C1=C(C=NOCC2=CC(Cl)=C(Cl)C=C2)N2C=CSC2=N1
InChI: InChI=1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AHR, CTNNB1, CYP2B6, CYP2C8, CYP3A4, CYP4A11, HPGDS, HSD17B4, NR1I3
Peripheral membrane protein 2 CYP2B6, CYP4A11
Endoplasmic reticulum membrane 8 CYB5A, CYB5R1, CYP17A1, CYP2B6, CYP2C8, CYP3A4, CYP4A11, RDH12
Nucleus 7 AHR, CTNNB1, GABPA, NR1H4, NR1I2, NR1I3, PPARA
cytosol 7 AHR, CTNNB1, CYB5A, CYB5R1, HPGDS, HSD17B4, NR1I3
nuclear body 1 NR1I2
centrosome 1 CTNNB1
nucleoplasm 8 AHR, CTNNB1, GABPA, HPGDS, NR1H4, NR1I2, NR1I3, PPARA
RNA polymerase II transcription regulator complex 1 NR1H4
Cell membrane 1 CTNNB1
lamellipodium 1 CTNNB1
Early endosome membrane 1 WNT3A
Multi-pass membrane protein 2 HCAR1, HCAR3
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 2 CTNNB1, HCAR3
cell surface 1 WNT3A
glutamatergic synapse 2 CTNNB1, WNT3A
neuronal cell body 1 CYP17A1
presynaptic membrane 1 CTNNB1
Presynapse 1 WNT3A
plasma membrane 6 CTNNB1, CYB5R1, CYP2C8, HCAR1, HCAR3, WNT3A
Membrane 8 CTNNB1, CYB5A, CYB5R1, CYP3A4, CYP4A11, HCAR1, HCAR3, HSD17B4
apical plasma membrane 1 CYP4A11
axon 1 CYP17A1
basolateral plasma membrane 1 CTNNB1
extracellular exosome 3 CTNNB1, CYB5R1, WNT3A
endoplasmic reticulum 1 CYP17A1
extracellular space 1 WNT3A
perinuclear region of cytoplasm 1 CTNNB1
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 1 CYB5R1
protein-containing complex 2 AHR, CTNNB1
intracellular membrane-bounded organelle 7 CYB5A, CYP2B6, CYP2C8, CYP3A4, CYP4A11, HPGDS, HSD17B4
Microsome membrane 4 CYP17A1, CYP2B6, CYP3A4, CYP4A11
Secreted 1 WNT3A
extracellular region 1 WNT3A
Single-pass membrane protein 1 CYB5R1
mitochondrial outer membrane 1 CYB5A
transcription regulator complex 3 AHR, CTNNB1, NR1I2
photoreceptor inner segment 1 RDH12
Secreted, extracellular space, extracellular matrix 1 WNT3A
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
Wnt signalosome 1 CTNNB1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
Cytoplasm, cytoskeleton 2 CTNNB1, NR1I3
focal adhesion 1 CTNNB1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Peroxisome 1 HSD17B4
peroxisomal matrix 1 HSD17B4
peroxisomal membrane 1 HSD17B4
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
receptor complex 1 NR1H4
chromatin 6 AHR, GABPA, NR1H4, NR1I2, NR1I3, PPARA
cell periphery 1 CTNNB1
cytoskeleton 1 NR1I3
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
[Isoform 3]: Nucleus 1 NR1H4
spindle pole 1 CTNNB1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
Endomembrane system 1 CTNNB1
aryl hydrocarbon receptor complex 1 AHR
euchromatin 2 CTNNB1, NR1H4
intermediate filament cytoskeleton 1 NR1I2
Golgi lumen 1 WNT3A
endoplasmic reticulum lumen 1 WNT3A
Photoreceptor inner segment membrane 1 RDH12
endocytic vesicle membrane 1 WNT3A
beta-catenin-TCF complex 1 CTNNB1
presynaptic active zone cytoplasmic component 1 CTNNB1
[Isoform 2]: Nucleus 1 NR1H4
[Isoform 1]: Nucleus 1 NR1H4
protein-DNA complex 1 CTNNB1
catenin complex 1 CTNNB1
platelet alpha granule membrane 1 CYB5R1
Wnt-Frizzled-LRP5/6 complex 1 WNT3A
[Isoform 4]: Nucleus 1 NR1H4
beta-catenin-TCF7L2 complex 1 CTNNB1
nuclear aryl hydrocarbon receptor complex 1 AHR
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
cytosolic aryl hydrocarbon receptor complex 1 AHR


文献列表

  • Wenwei Lin, Monicah Bwayi, Jing Wu, Yongtao Li, Sergio C Chai, Andrew D Huber, Taosheng Chen. CITCO Directly Binds to and Activates Human Pregnane X Receptor. Molecular pharmacology. 2020 03; 97(3):180-190. doi: 10.1124/mol.119.118513. [PMID: 31882411]
  • Elizabeth M Laurenzana, Tao Chen, Malavika Kannuswamy, Brian E Sell, Stephen C Strom, Yong Li, Curtis J Omiecinski. The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3). Molecular pharmacology. 2012 Nov; 82(5):918-28. doi: 10.1124/mol.112.080721. [PMID: 22896671]
  • Aik Jiang Lau, Guixiang Yang, Thomas K H Chang. Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: functional analysis of the SV23, SV24, and SV25 splice variants. The Journal of pharmacology and experimental therapeutics. 2011 Nov; 339(2):704-15. doi: 10.1124/jpet.111.186130. [PMID: 21862659]
  • Cyril Breuker, Amélie Moreau, Laila Lakhal, Viola Tamasi, Yannick Parmentier, Urs Meyer, Patrick Maurel, Serge Lumbroso, Marie-José Vilarem, Jean-Marc Pascussi. Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3). Endocrinology. 2010 Apr; 151(4):1653-61. doi: 10.1210/en.2009-1435. [PMID: 20185760]
  • Hisashi Masuyama, Hideki Nakatsukasa, Yuji Hiramatsu. Effect of oncostatin M on uridine diphosphate-5'-glucuronosyltransferase 1A1 through cross talk with constitutive androstane receptor. Molecular endocrinology (Baltimore, Md.). 2010 Apr; 24(4):745-53. doi: 10.1210/me.2009-0478. [PMID: 20197307]