Cyclamic acid (BioDeep_00000001756)
Secondary id: BioDeep_00001867635
human metabolite Endogenous blood metabolite
代谢物信息卡片
Cyclamate, calcium (2:1) salt, dihydrate
化学式: C6H13NO3S (179.0616)
中文名称: 环氨基酸, 环己基氨基磺酸
谱图信息:
最多检出来源 Homo sapiens(lipidsearch) 26.94%
分子结构信息
SMILES: C1(CCCCC1)NS(O)(=O)=O
InChI: InChI=1S/C6H13NO3S/c8-11(9,10)7-6-4-2-1-3-5-6/h6-7H,1-5H2,(H,8,9,10)
描述信息
Cyclamic acid is an artificial sweetening agent, usually employed as Na or Ca salt (cyclamate). Use suspended in some countries, including USA, because of possible weak carcinogenic activity (disputed). Cyclamic acid is a permitted in EU at levels of 250-1600 ppm in food products.Cyclamic acid is a compound with formula C6H11NHSO2OH
D000074385 - Food Ingredients > D005503 - Food Additives
D010592 - Pharmaceutic Aids > D005421 - Flavoring Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2813
同义名列表
47 个代谢物同义名
Cyclamate, calcium (2:1) salt, dihydrate; N-Cyclohexyl-sulfuric acid monoamide; Cyclohexylamine-N-sulfonic acid; Cyclohexylamide sulphuric acid; Cyclohexylamine sulfamic acid; Cyclohexylaminesulphonic acid; Cyclohexylamide sulfuric acid; Cyclohexylamidosulphuric acid; Cyclohexylaminesulfonic acid; Cyclamate calcium (2:1) salt; Cyclohexylamidosulfuric acid; N-Cyclohexylsulphamic acid; N-Cyclohexyl-sulfamic acid; N-Cyclohexylsulfamic acid; Cyclohexylaminesulphonate; Cyclohexanesulphamic acid; Cyclohexylsulphamic acid; Cyclohexylaminesulfonate; Cyclohexylamide sulphate; Cyclamic acid, ban, usan; Cyclohexanesulfamic acid; Cyclohexyl-sulfamic acid; Cyclohexylamide sulfate; Cyclohexylsulfamic acid; Cyclamate, sodium salt; Cyclohexylsulphamate; Cyclamate, potassium; Cyclohexylsulfamate; Potassium cyclamate; Cyclamate, calcium; Cyclamate, sodium; Calcium cyclamate; Sodium cyclamate; Sucaryl acidxine; Cyclamic acid; Hexamic acid; Sucaryl acid; Cylamic acid; Polycat 200; Cyclamates; Cyclamate; Hexamate; Cylamate; Asugryn; e952; Cyclohexylsulfamate; Cyclamic acid
数据库引用编号
40 个数据库交叉引用编号
- ChEBI: CHEBI:15964
- KEGG: C02824
- KEGGdrug: D02442
- PubChem: 7533
- HMDB: HMDB0031340
- Metlin: METLIN65844
- ChEMBL: CHEMBL1206440
- Wikipedia: Cyclamic_acid
- MeSH: Cyclamates
- foodb: FDB009257
- chemspider: 7252
- CAS: 100-88-9
- MoNA: EA281354
- MoNA: EA281302
- MoNA: EA281360
- MoNA: EA281359
- MoNA: EA281363
- MoNA: EA281301
- MoNA: EA281303
- MoNA: EA281362
- MoNA: EA281353
- MoNA: EA281304
- MoNA: EA281305
- MoNA: EA281357
- MoNA: EA281351
- MoNA: EA281308
- MoNA: EA281356
- MoNA: EA281309
- MoNA: EA281352
- MoNA: EA281364
- MoNA: EA281310
- MoNA: EA281355
- MoNA: EA281314
- MoNA: EA281358
- MoNA: EA281361
- PMhub: MS000001111
- PubChem: 5772
- NIKKAJI: J4.986G
- RefMet: Cyclamic acid
- KNApSAcK: 15964
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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The American journal of physiology.
1981 Nov; 241(5):F540-55. doi:
10.1152/ajprenal.1981.241.5.f540. [PMID: 7304748] - L S Lee. Saccharin and cyclamate inhibit binding of epidermal growth factor.
Proceedings of the National Academy of Sciences of the United States of America.
1981 Feb; 78(2):1042-6. doi:
10.1073/pnas.78.2.1042. [PMID: 6262753] - K Lindner. Non-nutritive sweetening agents.
Bibliotheca nutritio et dieta.
1980; ?(29):82-8. doi:
10.1159/000387470. [PMID: 7447919] - R Green, J H Bishop, G Giebisch. Ionic requirements of proximal tubular sodium transport. III. Selective luminal anion substitution.
The American journal of physiology.
1979 Mar; 236(3):F268-77. doi:
10.1152/ajprenal.1979.236.3.f268. [PMID: 426069] - W J Spillane, G A Benson, G McGlinchey. Metabolic studies with nonnutritive sweeteners cyclooctylsulfamate and 4-methylcyclohexylsulfamate.
Journal of pharmaceutical sciences.
1979 Mar; 68(3):372-4. doi:
10.1002/jps.2600680333. [PMID: 423133] - A Kinawi, H Kia. [The reaction of cyclohexylsulphamic acid (Cyclamate) with nitrous acid in aqueous HCl-solution, isolated human gastric juice and urine (author's transl)].
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.
1978 Jun; 16(6):365-9. doi:
NULL. [PMID: 670904] - W J Spillane, G A Benson. Metabolic studies of the nonnutritive sweeteners cyclopentylmethylsulfamate and cyclopentylsulfamate: determination of metabolites in rat urine.
Journal of pharmaceutical sciences.
1978 Feb; 67(2):226-8. doi:
10.1002/jps.2600670225. [PMID: 621643] - R Vannier. [Replacement sweetening agents in the prevention of dental caries].
Actualites odonto-stomatologiques.
1978; ?(123):403-15. doi:
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Journal of chromatography.
1977 Jun; 136(2):318-22. doi:
10.1016/s0021-9673(00)86286-x. [PMID: 885968] - G A Benson, W J Spillane. Metabolic studies with the nonnutritive sweetener cycloheptylsulfamate.
Journal of pharmaceutical sciences.
1977 Jun; 66(6):881-3. doi:
10.1002/jps.2600660641. [PMID: 874797] - D J Marsh, C M Martin. Origin of electrical PD's in hamster thin ascending limbs of Henle's loop.
The American journal of physiology.
1977 Apr; 232(4):F348-57. doi:
10.1152/ajprenal.1977.232.4.f348. [PMID: 851193] - E Löser. [Subchronic toxicologic studies using cyclamate-Na in dogs].
Arzneimittel-Forschung.
1977; 27(1):128-131. doi:
NULL. [PMID: 576812] - G A Benson, W J Spillane. Determination of the nonnutritive sweetener sodium cyclopentylsulfamate and three of its metabolites, cyclopentylamine, cyclopentanone, and cyclopentanol, in urine of rats and rabbits.
Journal of pharmaceutical sciences.
1976 Dec; 65(12):1841-3. doi:
10.1002/jps.2600651237. [PMID: 1032676] - I F Gaunt, J Hardy, P Grasso, S D Gangolli, K R Butterworth. Long-term toxicity of cyclohexylamine hydrochloride in the rat.
Food and cosmetics toxicology.
1976 Aug; 14(4):255-67. doi:
10.1016/s0015-6264(76)80287-8. [PMID: 976884] - G Héraud, E Roux. [Recent acquisitions on sweetening agents. Applications to the diabetic diet].
Journees annuelles de diabetologie de l'Hotel-Dieu.
1976 May; ?(?):169-85. doi:
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Archives of environmental health.
1976 Jan; 31(1):51-3. doi:
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Toxicology.
1975 Jul; 4(3):315-30. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
1975 Jan; 5(1):25-31. doi:
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Human pathology.
1975 Jan; 6(1):130-2. doi:
10.1016/s0046-8177(75)80118-3. [PMID: 1110082] - B H Ershoff. Antitoxic effects of plant fiber.
The American journal of clinical nutrition.
1974 Dec; 27(12):1395-8. doi:
10.1093/ajcn/27.12.1395. [PMID: 4611191] - M H Bickel, B Burkard, E Meier-Strasser, M van den Broek-Boot. Entero-bacterial formation of cyclohexylamine in rats ingesting cyclamate.
Xenobiotica; the fate of foreign compounds in biological systems.
1974 Jul; 4(7):425-39. doi:
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Archiv fur Toxikologie.
1974 Feb; 31(3):243-63. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
1974; 282(Suppl):suppl 282:R31. doi:
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Food and cosmetics toxicology.
1973 Oct; 11(5):735-46. doi:
10.1016/0015-6264(73)90132-6. [PMID: 4768873] - B S Drasar, J S Crowther, P Goddard, G Hawksworth, M J Hill, S Peach, R E Williams, A Renwick. The relation between diet and the gut microflora in man.
The Proceedings of the Nutrition Society.
1973 Sep; 32(2):49-52. doi:
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The Journal of physiology.
1973 Apr; 230(1):51-74. doi:
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Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences.
1973; 91(0):11-8. doi:
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The Biochemical journal.
1972 Oct; 129(4):869-79. doi:
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The Biochemical journal.
1972 Oct; 129(4):881-90. doi:
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Journal of the National Cancer Institute.
1972 Sep; 49(3):751-64. doi:
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Arzneimittel-Forschung.
1972 Jul; 22(7):1174-8. doi:
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Chemical & pharmaceutical bulletin.
1972 May; 20(5):947-52. doi:
10.1248/cpb.20.947. [PMID: 5055125] - B Toth. A toxicity method with calcium cyclamate for chronic carcinogenesis experiments.
Tumori.
1972 May; 58(3):136-41. doi:
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Food and cosmetics toxicology.
1972 Apr; 10(2):237-43. doi:
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