Sho-saiko-to (BioDeep_00000017308)

Main id: BioDeep_00000356621

 

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


2-[3,5-Dihydroxy-2-[[2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracos-15-en-10-yl]oxy]-6-methyloxan-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol

化学式: C42H68O13 (780.4659678)
中文名称: 柴胡皂苷A, 柴胡皂甙D, 柴胡皂苷D
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C)CC[C@]2(CO3)[C@H](O)C[C@@]4(C)[C@]([C@]5([H])C=C[C@]43[C@]2([H])C1)(C)CC[C@@]([C@]5(C)CC6)([H])[C@@](CO)(C)[C@H]6O[C@@](O[C@H](C)[C@@H]7O)([H])[C@H](O)[C@H]7O[C@@]8([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8
InChI: InChI=1S/C42H68O13/c1-21-28(46)33(55-34-31(49)30(48)29(47)22(18-43)53-34)32(50)35(52-21)54-27-10-11-37(4)23(38(27,5)19-44)8-12-39(6)24(37)9-13-42-25-16-36(2,3)14-15-41(25,20-51-42)26(45)17-40(39,42)7/h9,13,21-35,43-50H,8,10-12,14-20H2,1-7H3

描述信息

2-[3,5-Dihydroxy-2-[[2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracos-15-en-10-yl]oxy]-6-methyloxan-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol is a natural product found in Clinopodium vulgare, Bupleurum angustissimum, and other organisms with data available.
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D000893 - Anti-Inflammatory Agents
D000970 - Antineoplastic Agents
D018501 - Antirheumatic Agents
Saikosaponin A is an active component of Bupleurum chinensis, up-regulates LXRα expression, with potent anti-inflammatory activity[1].
Saikosaponin A is an active component of Bupleurum chinensis, up-regulates LXRα expression, with potent anti-inflammatory activity[1].
Saikosaponin A is an active component of Bupleurum chinensis, up-regulates LXRα expression, with potent anti-inflammatory activity[1].
Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.
Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.

同义名列表

14 个代谢物同义名

2-[3,5-Dihydroxy-2-[[2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracos-15-en-10-yl]oxy]-6-methyloxan-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol; Saikosaponin D from Bupleurum falcatnum; saikosaponin B3; saikosaponin B1; saikosaponin B2; saikosaponin B4; saikosaponin D; Saikosaponin A; saikosaponin L; saikosaponin K; saikosaponin C; saikosaponin B; saikosaponins; Saikosaponin



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rui Zhang, Xiangchuan Li, Jixu Qu, Doudou Zhang, Linxu Cao, Xuemei Qin, Zhenyu Li. Intercropping with maize and sorghum-induced saikosaponin accumulation in Bupleurum chinense DC. by liquid chromatography-mass spectrometry-based metabolomics. Journal of mass spectrometry : JMS. 2024 Jun; 59(6):e5035. doi: 10.1002/jms.5035. [PMID: 38726730]
  • Mingxia Xie, Hongping Long, Sainan Tian, Zhengqing Zhu, Pan Meng, Ke Du, Yajing Wang, Dongwei Guo, Hanqing Wang, Qinghua Peng. Saikosaponin F ameliorates depression-associated dry eye disease by inhibiting TRIM8-induced TAK1 ubiquitination. International immunopharmacology. 2024 Mar; 130(?):111749. doi: 10.1016/j.intimp.2024.111749. [PMID: 38430804]
  • Y Xiong, X Liang, X Liang, W Li, Y Qian, W Xie. [Saikosaponin a alleviates pentylenetetrazol-induced acute epileptic seizures in mouse models of depression by suppressing microglia activation-mediated inflammation]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2024 Mar; 44(3):515-522. doi: 10.12122/j.issn.1673-4254.2024.03.13. [PMID: 38597443]
  • Shen Chen, Ke Wang, Hongzhan Wang, Yang Gao, Kexin Nie, Xinyue Jiang, Hao Su, Yueheng Tang, Fuer Lu, Hui Dong, Zhi Wang. The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical applications. Pharmacological research. 2024 Mar; 201(?):107090. doi: 10.1016/j.phrs.2024.107090. [PMID: 38309381]
  • Yupeng Cheng, Yuanzhen Liu, Xinhong Li, Guangjie Liu, Zhongmeng Li, Bo Liu, Ning Gao. Transcriptome analysis of the mechanism of endophytic fungus CHS3 promoting saikosaponin d synthesis in Bupleurum scorzonerifolium Willd. suspension cells. Fitoterapia. 2024 Mar; 173(?):105778. doi: 10.1016/j.fitote.2023.105778. [PMID: 38128620]
  • Tiantian Gao, Tao Wang, Lili Wu, Yue Tong, Jinlong Tian, Keke Zhao, Hanqing Wang. Saikosaponin-d alleviates depression by promoting NLRP3 ubiquitination and inhibiting inflammasome activation. International immunopharmacology. 2024 Jan; 127(?):111324. doi: 10.1016/j.intimp.2023.111324. [PMID: 38070467]
  • Xuan-Jing Shen, Jian-Qing Zhang, Ya-Ling An, Lin Yang, Xiao-Lan Li, Yun-Shu Hu, Fei Sha, Chang-Liang Yao, Qi-Rui Bi, Hua Qu, De-An Guo. MATLAB language assisted data acquisition and processing in liquid chromatography Orbitrap mass spectrometry: Application to the identification and differentiation of Radix Bupleuri from its adulterants. Journal of chromatography. A. 2024 Jan; 1714(?):464544. doi: 10.1016/j.chroma.2023.464544. [PMID: 38142618]
  • Min-Seong Lee, Ji-Won Noh, Byung-Cheol Lee. Effects of Saikosaponin-A on Insulin Resistance in Obesity: Computational and Animal Experimental Study. Chemical & pharmaceutical bulletin. 2024; 72(4):365-373. doi: 10.1248/cpb.c23-00782. [PMID: 38569867]
  • Jie Tang, Lixiang Wang, Mengge Shi, Shuaixia Feng, Tong Zhang, Han Han. Study on the mechanism of Shuganzhi Tablet against nonalcoholic fatty liver disease and lipid regulation effects of its main substances in vitro. Journal of ethnopharmacology. 2023 Nov; 316(?):116780. doi: 10.1016/j.jep.2023.116780. [PMID: 37311504]
  • Xinmei Wang, Shanshan Li, Jiayu Yu, Wenlin Wang, Zhuoqi Du, Shuchun Gao, Yin Ma, Ruixin Tang, Ting Liu, Shiping Ma, Qiang Fu, Xueyang Deng. Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress. Journal of ethnopharmacology. 2023 Nov; 316(?):116729. doi: 10.1016/j.jep.2023.116729. [PMID: 37277081]
  • Yue Tong, Ge Zhao, Ruonan Shuang, Hanqing Wang, Nan Zeng. Saikosaponin a activates tet1/dll3/notch1 signalling and promotes hippocampal neurogenesis to improve depression-like behavior in mice. Journal of ethnopharmacology. 2023 Oct; 319(Pt 3):117289. doi: 10.1016/j.jep.2023.117289. [PMID: 37844745]
  • Jia Feng, Hui Ma, Yanrui Yue, Lijun Wang, Keyang Hao, Yanan Zhang, Jinghe Li, Yujun Xiang, Yuna Min. Saikosaponin a ameliorates diet-induced fatty liver via regulating intestinal microbiota and bile acid profile in laying hens. Poultry science. 2023 Sep; 102(12):103155. doi: 10.1016/j.psj.2023.103155. [PMID: 37871490]
  • Xinsheng Xu, Lihua Cui, Lanqiu Zhang, Lei Yang, Yuzhen Zhuo, Caixia Li. Saikosaponin d modulates the polarization of tumor-associated macrophages by deactivating the PI3K/AKT/mTOR pathway in murine models of pancreatic cancer. International immunopharmacology. 2023 Sep; 122(?):110579. doi: 10.1016/j.intimp.2023.110579. [PMID: 37433245]
  • Chao Wang, Ruijuan Zhang, Xu Chen, Mengyun Yuan, Jian Wu, Qingmin Sun, Chunrun Miao, Yali Jing. The potential effect and mechanism of Saikosaponin A against gastric cancer. BMC complementary medicine and therapies. 2023 Aug; 23(1):295. doi: 10.1186/s12906-023-04108-3. [PMID: 37608281]
  • Shijie Bi, Yanan Liu, Tianyi Lv, Yue Ren, Kaiyang Liu, Chaoqun Liu, Yanling Zhang. Preliminary exploration of method for screening efficacy markers compatibility in TCM prescriptions based on Q-markers: Anti-inflammatory activity of Dachaihu decoction as an example. Journal of ethnopharmacology. 2023 Aug; 312(?):116539. doi: 10.1016/j.jep.2023.116539. [PMID: 37088240]
  • Zhenhuan Wang, Lu Tian, Yusheng Xiao, Mengya Zhao, Yanyan Chang, Yujiang Zhou, Shuying Liu, Huanxi Zhao, Yang Xiu. Quantitative and Differential Analysis between Bupleurum chinense DC. and Bupleurum scorzonerifolium Willd. Using HPLC-MS and GC-MS Coupled with Multivariate Statistical Analysis. Molecules (Basel, Switzerland). 2023 Jul; 28(15):. doi: 10.3390/molecules28155630. [PMID: 37570602]
  • Hui He, Jiaqi Guo, Yunxiang Hu, Han Zhang, Xinyang Li, Jian Zhang, Shi Jin. Saikosaponin D reverses epinephrine- and norepinephrine-induced gemcitabine resistance in intrahepatic cholangiocarcinoma by downregulating ADRB2/glycolysis signaling. Acta biochimica et biophysica Sinica. 2023 Jul; ?(?):. doi: 10.3724/abbs.2023040. [PMID: 37489008]
  • Tong-Tong Tang, Li Jiang, Qian Zhong, Zhi-Jing Ni, Kiran Thakur, Mohammad Rizwan Khan, Zhao-Jun Wei. Saikosaponin D exerts cytotoxicity on human endometrial cancer ishikawa cells by inducing apoptosis and inhibiting metastasis through MAPK pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Jul; 177(?):113815. doi: 10.1016/j.fct.2023.113815. [PMID: 37209937]
  • Man You, Junmin Fu, Xingzhi Lv, Lan Wang, Hongwei Wang, Ruifang Li. Saikosaponin b2 inhibits tumor angiogenesis in liver cancer via down‑regulation of VEGF/ERK/HIF‑1α signaling. Oncology reports. 2023 07; 50(1):. doi: 10.3892/or.2023.8573. [PMID: 37232376]
  • Tian Lan, Wen Wang, Xi-Xi Zeng, Yu-Hua Tong, Zhu-Jun Mao, Si-Wei Wang. Saikosaponin A triggers cell ferroptosis in hepatocellular carcinoma by inducing endoplasmic reticulum stress-stimulated ATF3 expression. Biochemical and biophysical research communications. 2023 Jun; 674(?):10-18. doi: 10.1016/j.bbrc.2023.06.086. [PMID: 37393639]
  • Yingchao Zhu, Yu Lai. Pharmacological properties and derivatives of saikosaponins-a review of recent studies. The Journal of pharmacy and pharmacology. 2023 Jun; ?(?):. doi: 10.1093/jpp/rgad052. [PMID: 37307427]
  • Rong Yang, Linhua Liu, Dansheng Jiang, Lei Liu, Huili Yang, Hongling Xu, Meirong Qin, Ping Wang, Jiangyong Gu, Yufeng Xing. Identification of Potential TMPRSS2 Inhibitors for COVID-19 Treatment in Chinese Medicine by Computational Approaches and Surface Plasmon Resonance Technology. Journal of chemical information and modeling. 2023 May; ?(?):. doi: 10.1021/acs.jcim.2c01643. [PMID: 37155923]
  • Zijun Bai, Tiantian Gao, Rui Zhang, Youyuan Lu, Jinlong Tian, Tao Wang, Keke Zhao, Hanqing Wang. Inhibition of IL-6 methylation by Saikosaponin C regulates neuroinflammation to alleviate depression. International immunopharmacology. 2023 May; 118(?):110043. doi: 10.1016/j.intimp.2023.110043. [PMID: 36965369]
  • Yiqing Peng, Alam Nafee-Ul, Mingzhi Liu, Qiuling He, Zongsuo Liang. Assessment of Genetic Diversity in Bupleurum spp. Basing Agronomic Traits, Medicinal Components and ISSR Markers. Genes. 2023 04; 14(4):. doi: 10.3390/genes14040951. [PMID: 37107709]
  • Qi Zheng, Xiaojiaoyang Li, Nana Huang, Fanghong Li, Junde Ge, Daijie Wang, Rong Sun, Runping Liu. Saikosaponins ameliorate hyperlipidemia in rats by enhancing hepatic lipid and cholesterol metabolism. Journal of ethnopharmacology. 2023 Apr; 305(?):116110. doi: 10.1016/j.jep.2022.116110. [PMID: 36581162]
  • Ye-Feng Wang, Rui-Xia Ma, Bin Zou, Jia Li, Yao Yao, Juan Li. Endoplasmic reticulum stress regulates autophagic response that is involved in Saikosaponin a-induced liver cell damage. Toxicology in vitro : an international journal published in association with BIBRA. 2023 Apr; 88(?):105534. doi: 10.1016/j.tiv.2022.105534. [PMID: 36539104]
  • Wen-Xue Wang, Xiao-Wei DU, Bing-Yan Hou, Hong-Ru Zhu, Dan Yu. [Correlations between appearance traits and internal quality of Bupleurum scorzonerifolium roots based on theory of 'quality evaluation through morphological identification']. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Apr; 48(7):1815-1823. doi: 10.19540/j.cnki.cjcmm.20230115.102. [PMID: 37282956]
  • Minna Huang, Yan Yan, Zihao Deng, Lingli Zhou, Meiling She, Yajun Yang, Meng Zhang, Dongtao Wang. Saikosaponin A and D attenuate skeletal muscle atrophy in chronic kidney disease by reducing oxidative stress through activation of PI3K/AKT/Nrf2 pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154766. doi: 10.1016/j.phymed.2023.154766. [PMID: 37002971]
  • Qingwei Xiang, Yu Liu, Li Chen. Saikosaponin d (SSD) alleviates diabetic peripheral neuropathy by regulating the AQP1/RhoA/ROCK signaling in streptozotocin-induced diabetic rats. Acta diabetologica. 2023 Mar; ?(?):. doi: 10.1007/s00592-023-02060-9. [PMID: 36920548]
  • Lin-Lin Chen, Liu-Yuan Xia, Jun-Ping Zhang, Yan Wang, Jian-Yu Chen, Cheng Guo, Wei-Heng Xu. Saikosaponin D alleviates cancer cachexia by directly inhibiting STAT3. Phytotherapy research : PTR. 2023 Mar; 37(3):809-819. doi: 10.1002/ptr.7676. [PMID: 36447385]
  • Jiling Feng, Zhichao Xi, Xue Jiang, Yang Li, Wan Najbah Nik Nabil, Mengfan Liu, Zejia Song, Xiaoqiong Chen, Hua Zhou, Qihan Dong, Hongxi Xu. Saikosaponin A enhances Docetaxel efficacy by selectively inducing death of dormant prostate cancer cells through excessive autophagy. Cancer letters. 2023 Feb; 554(?):216011. doi: 10.1016/j.canlet.2022.216011. [PMID: 36442771]
  • Donghui Peng, Yuchan Chen, Yanping Sun, Zhihong Zhang, Na Cui, Wensen Zhang, Ying Qi, Yuanning Zeng, Bin Hu, Bingyou Yang, Qiuhong Wang, Haixue Kuang. Saikosaponin A and Its Epimers Alleviate LPS-Induced Acute Lung Injury in Mice. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28030967. [PMID: 36770631]
  • Yuchan Li, Jun Zhao, Hua Chen, Yanping Mao, Yuping Yang, Liang Feng, Chuanxin Mo, Lin Huang, Dabin Hou, Ma Yu. Transcriptome Level Reveals the Triterpenoid Saponin Biosynthesis Pathway of Bupleurum falcatum L. Genes. 2022 11; 13(12):. doi: 10.3390/genes13122237. [PMID: 36553505]
  • Yupeng Cheng, Guangjie Liu, Zhongmeng Li, Yongqiang Zhou, Ning Gao. Screening saikosaponin d (SSd)-producing endophytic fungi from Bupleurum scorzonerifolium Willd. World journal of microbiology & biotechnology. 2022 Oct; 38(12):242. doi: 10.1007/s11274-022-03434-x. [PMID: 36280622]
  • Xiao Li, Ruihong Hou, Xuemei Qin, Yanfei Wu, Xingkang Wu, Junsheng Tian, Xiaoxia Gao, Guanhua Du, Yuzhi Zhou. Synergistic neuroprotective effect of saikosaponin A and albiflorin on corticosterone-induced apoptosis in PC12 cells via regulation of metabolic disorders and neuroinflammation. Molecular biology reports. 2022 Sep; 49(9):8801-8813. doi: 10.1007/s11033-022-07730-5. [PMID: 36002654]
  • Li-Li Li, Qi Huang, Jia-Jia Qi, Min Yao, Dai-Yin Peng. [Simultaneous determination and pharmacokinetic study of five compounds from total extract of Clinopodium chinense in abnormal uterine bleeding rat plasma by UPLC-MS/MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(18):5071-5078. doi: 10.19540/j.cnki.cjcmm.20220421.702. [PMID: 36164917]
  • Paola Maccioni, Giancarlo Colombo, Irene Lorrai, Jung Hwan Lee, Pisey Pel, Young-Won Chin, Hak Cheol Kwon. Suppressing effect of a saikosaponin-enriched extract of Bupleurum falcatum on alcohol and chocolate self-administration in rats. Natural product research. 2022 Sep; 36(17):4502-4505. doi: 10.1080/14786419.2021.1986816. [PMID: 34652253]
  • Linlin Yang, Lu Qiao, Xiuhong Su, Baoyu Ji, Chengming Dong. Drought Stress Stimulates the Terpenoid Backbone and Triterpenoid Biosynthesis Pathway to Promote the Synthesis of Saikosaponin in Bupleurum chinense DC. Roots. Molecules (Basel, Switzerland). 2022 Aug; 27(17):. doi: 10.3390/molecules27175470. [PMID: 36080237]
  • Yiqing Gu, Shuni Duan, Mingning Ding, Qi Zheng, Guifang Fan, Xiaojiaoyang Li, Yijie Li, Chuanyang Liu, Rong Sun, Runping Liu. Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Aug; 103(?):154219. doi: 10.1016/j.phymed.2022.154219. [PMID: 35691075]
  • Wenjing Han, Jiao Xu, Hefang Wan, Lei Zhou, Bin Wu, Jianping Gao, Xinwei Guo, Chun Sui, Jianhe Wei. Overexpression of BcERF3 increases the biosynthesis of saikosaponins in Bupleurum chinense. FEBS open bio. 2022 07; 12(7):1344-1352. doi: 10.1002/2211-5463.13412. [PMID: 35429231]
  • Jia Luo, Juan Wang, Jun Yang, Wenjing Huang, Junqiu Liu, Wenfu Tan, Hong Xin. Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway. Journal of natural medicines. 2022 Jun; 76(3):584-593. doi: 10.1007/s11418-022-01603-8. [PMID: 35171398]
  • Yu-Heng Zhong, Shan Jiang, Wei-Min Qu, Wen Zhang, Zhi-Li Huang, Chang-Rui Chen. Saikosaponin a promotes sleep by decreasing neuronal activities in the lateral hypothalamus. Journal of sleep research. 2022 04; 31(2):e13484. doi: 10.1111/jsr.13484. [PMID: 34510626]
  • Jikun Du, Daibo Song, Yuanhua Li, Jierong Liu, Xiaoman Huang, Baohong Li, Li Li. Saikosaponin-D Mitigates Oxidation in SH-SY5Y Cells Stimulated by Glutamate Through Activation of Nrf2 Pathway: Involvement of PI3K. Neurotoxicity research. 2022 Feb; 40(1):230-240. doi: 10.1007/s12640-021-00438-7. [PMID: 34994954]
  • Peng Du, Jianbin Xu, Yanfei Jiang, Jing Zhao, Chaoqun Gao, Yudie Fang, Xiaorong Yang, Yan-Ping Yang, Jin-An Zhang. Saikosaponin-d Attenuates Hashimoto's Thyroiditis by Regulating Macrophage Polarization. Journal of immunology research. 2022; 2022(?):7455494. doi: 10.1155/2022/7455494. [PMID: 36398316]
  • Yiwei Zhang, Lizhen Lin, Yushu Wang, Zhenzhen Liu, Wenxin Xia, Hong Sui, Xueyan Fu. Saikosaponin B4 Suppression Cancer Progression by Inhibiting SW480 and SW620 Cells Proliferation via the PI3K/AKT/mTOR Pathway in Colon Cancer. Current cancer drug targets. 2022; 22(11):889-903. doi: 10.2174/1568009622666220627160834. [PMID: 35762543]
  • Piao Zhou, Wei Shi, Xiao-Yan He, Quan-Yu Du, Fei Wang, Jing Guo. Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics. Pharmaceutical biology. 2021 Dec; 59(1):1480-1489. doi: 10.1080/13880209.2021.1992448. [PMID: 34714209]
  • Yirong Chen, Renye Que, Na Zhang, Liubing Lin, Mengen Zhou, Yong Li. Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling. Molecular biology reports. 2021 Dec; 48(12):7853-7863. doi: 10.1007/s11033-021-06807-x. [PMID: 34714484]
  • Yilian He, Hua Chen, Jun Zhao, Yuxia Yang, Bin Yang, Liang Feng, Yiguan Zhang, Ping Wei, Dabin Hou, Junning Zhao, Ma Yu. Transcriptome and metabolome analysis to reveal major genes of saikosaponin biosynthesis in Bupleurum chinense. BMC genomics. 2021 Nov; 22(1):839. doi: 10.1186/s12864-021-08144-6. [PMID: 34798822]
  • Meina Gao, Hui Li, Chenghao Ye, Kaixian Chen, Hualiang Jiang, Kunqian Yu. Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study. Biomolecules. 2021 10; 11(11):. doi: 10.3390/biom11111586. [PMID: 34827585]
  • Sung Ho Lim, Ho Seon Lee, Hyo-Kyung Han, Chang-Ik Choi. Saikosaponin A and D Inhibit Adipogenesis via the AMPK and MAPK Signaling Pathways in 3T3-L1 Adipocytes. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111409. [PMID: 34768840]
  • Geng-Ruei Chang, Wei-Li Lin, Tzu-Chun Lin, Huei-Jyuan Liao, Yu-Wen Lu. The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111383. [PMID: 34768813]
  • Hua Zhao, Xiaohui Wang, Yuli Zhang, Xiaowan Huang, Yaling Jiang, Huan Ma, Li An, Xujin Wu, Qiang Wang. Quantitative 1H NMR for the Direct Quantification of Saikosaponins in Bupleurum chinense DC. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2021 Oct; 37(10):1413-1418. doi: 10.2116/analsci.20p462. [PMID: 33775977]
  • Liubing Lin, Mengen Zhou, Renye Que, Yirong Chen, Xiaolin Liu, Kehui Zhang, Zhe Shi, Yong Li. Saikosaponin-d protects against liver fibrosis by regulating the estrogen receptor-β/NLRP3 inflammasome pathway. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2021 10; 99(5):666-674. doi: 10.1139/bcb-2020-0561. [PMID: 33974808]
  • Tao Yao, Lei Zhang, Ye Fu, Lina Yao, Chengjie Zhou, Guozhong Chen. Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition. Molecular and cellular biology. 2021 09; 41(10):e0033221. doi: 10.1128/mcb.00332-21. [PMID: 34309413]
  • Rupesh Chikhale, Saurabh K Sinha, Manish Wanjari, Nilambari S Gurav, Muniappan Ayyanar, Satyendra Prasad, Pukar Khanal, Yadu Nandan Dey, Rajesh B Patil, Shailendra S Gurav. Computational assessment of saikosaponins as adjuvant treatment for COVID-19: molecular docking, dynamics, and network pharmacology analysis. Molecular diversity. 2021 Aug; 25(3):1889-1904. doi: 10.1007/s11030-021-10183-w. [PMID: 33492566]
  • Jie Tang, Mengge Shi, Yan Xu, Zhengcai Ju, Huida Guan, Jun Lin, Gan Li, Han Han, Tong Zhang. Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Aug; 1179(?):122827. doi: 10.1016/j.jchromb.2021.122827. [PMID: 34147874]
  • Saurabh K Sinha, Anshul Shakya, Satyendra K Prasad, Shashikant Singh, Nilambari S Gurav, Rupali S Prasad, Shailendra S Gurav. An in-silico evaluation of different Saikosaponins for their potency against SARS-CoV-2 using NSP15 and fusion spike glycoprotein as targets. Journal of biomolecular structure & dynamics. 2021 Jun; 39(9):3244-3255. doi: 10.1080/07391102.2020.1762741. [PMID: 32345124]
  • Tingting Sun, Jiaoyang Luo, Yuanyuan Xu, Xinqi Sun, Shihai Yang, Meihua Yang. Ultra-high performance supercritical fluid chromatography method for separation and quantitation of saikosaponins in herbal medicine. Journal of pharmaceutical and biomedical analysis. 2021 May; 199(?):114039. doi: 10.1016/j.jpba.2021.114039. [PMID: 33839642]
  • An-Rong Wang, Lian-Fang Mi, Zhi-Lei Zhang, Ming-Zhe Hu, Ze-Yu Zhao, Bin Liu, Yan-Bin Li, Shu Zheng. Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway. Behavioural brain research. 2021 04; 403(?):113138. doi: 10.1016/j.bbr.2021.113138. [PMID: 33493495]
  • Yijia Xu, Yue Yu, Qi Wang, Wenwen Li, Suli Zhang, Xiaoyuan Liao, Yanfeng Liu, Yang Su, Mingyi Zhao, Jinghai Zhang. Active components of Bupleurum chinense and Angelica biserrata showed analgesic effects in formalin induced pain by acting on Nav1.7. Journal of ethnopharmacology. 2021 Apr; 269(?):113736. doi: 10.1016/j.jep.2020.113736. [PMID: 33359917]
  • Xiao Yu, Jielu Pan, Nan Shen, Haiyan Zhang, Lu Zou, Hongyu Miao, Lianjun Xing. Development of Saikosaponin D Liposome Nanocarrier with Increased Hepatoprotective Effect Against Alcoholic Hepatitis Mice. Journal of biomedical nanotechnology. 2021 Apr; 17(4):627-639. doi: 10.1166/jbn.2021.3054. [PMID: 35057889]
  • Yanyan Song, Haowen Sun, Siyuan Gao, Ke Tang, Yao Zhao, Guanghong Xie, Hang Gao. Saikosaponin a attenuates lead-induced kidney injury through activating Nrf2 signaling pathway. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2021 Apr; 242(?):108945. doi: 10.1016/j.cbpc.2020.108945. [PMID: 33278595]
  • Ruonan Chen, Chenlin Shen, Qingqing Xu, Yaru Liu, Bo Li, Cheng Huang, Taotao Ma, Xiaoming Meng, Maomao Wu, Jun Li. The permeability characteristics and interaction of main components from Si-Ni-San in a MDCK epithelial cell monolayer model. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Feb; 51(2):239-248. doi: 10.1080/00498254.2017.1359433. [PMID: 28745128]
  • Xiaotian Qi, Jing Liu, Xiaoyu Li, Mengyue Fan, Nana Huang, Rong Sun. Saikosaponin a contributed to CCIN treatment by promoting neutrophil bactericidal activity via activation CBL-dependent ERK pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Feb; 82(?):153444. doi: 10.1016/j.phymed.2020.153444. [PMID: 33421903]
  • Chun Sui, Wen-Jing Han, Chu-Ran Zhu, Jian-He Wei. Recent Progress in Saikosaponin Biosynthesis in Bupleurum. Current pharmaceutical biotechnology. 2021; 22(3):329-340. doi: 10.2174/1389201021999200918101248. [PMID: 32957882]
  • Tan Cheng, Muying Ying. Antitumor Effect of Saikosaponin A on Human Neuroblastoma Cells. BioMed research international. 2021; 2021(?):5845554. doi: 10.1155/2021/5845554. [PMID: 34513994]
  • Xiaotian Qi, Mengyue Fan, Nana Huang, Xinyu Zhang, Jing Liu, Xiaoyu Li, Rong Sun. Saikosaponin d contributed to cancer chemotherapy induced neutropenia therapy by promoting neutrophil differentiation via activation CBL-dependent ERK pathway. Pharmacological research. 2020 10; 160(?):105149. doi: 10.1016/j.phrs.2020.105149. [PMID: 32822868]
  • Meng Liu, Guanfei Zhang, Saima Naqvi, Fan Zhang, Tong Kang, Qiqi Duan, Ziyang Wang, Shengxiang Xiao, Yan Zheng. Cytotoxicity of Saikosaponin A targets HEKa cell through apoptosis induction by ROS accumulation and inflammation suppression via NF-κB pathway. International immunopharmacology. 2020 Sep; 86(?):106751. doi: 10.1016/j.intimp.2020.106751. [PMID: 32634696]
  • Lin-Lin Yang, Li Yang, Xiao Yang, Tao Zhang, Yi-Ming Lan, Yu Zhao, Mei Han, Li-Min Yang. Drought stress induces biosynthesis of flavonoids in leaves and saikosaponins in roots of Bupleurum chinense DC. Phytochemistry. 2020 Sep; 177(?):112434. doi: 10.1016/j.phytochem.2020.112434. [PMID: 32544729]
  • Lihua Cui, Caixia Li, Yuzhen Zhuo, Lei Yang, Naiqiang Cui, Yuhong Li, Shukun Zhang. Saikosaponin A inhibits the activation of pancreatic stellate cells by suppressing autophagy and the NLRP3 inflammasome via the AMPK/mTOR pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Aug; 128(?):110216. doi: 10.1016/j.biopha.2020.110216. [PMID: 32497863]
  • Junsong Jiang, Yanfeng Meng, Songfeng Hu, Benson O A Botchway, Yong Zhang, Xuehong Liu. Saikosaponin D: A potential therapeutic drug for osteoarthritis. Journal of tissue engineering and regenerative medicine. 2020 08; 14(8):1175-1184. doi: 10.1002/term.3090. [PMID: 32592611]
  • Eshak I Bahbah, Ahmed Negida, Mohamed Salah Nabet. Purposing Saikosaponins for the treatment of COVID-19. Medical hypotheses. 2020 07; 140(?):109782. doi: 10.1016/j.mehy.2020.109782. [PMID: 32353743]
  • Puze Li, Minna Wu, Wancheng Xiong, Jinsong Li, Yunying An, Jie Ren, Yingguang Xie, Hongfei Xue, Dong Yan, Min Li, Genshen Zhong. Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis by suppressing NF-κB activation and modulating the gut microbiota in mice. International immunopharmacology. 2020 Apr; 81(?):106288. doi: 10.1016/j.intimp.2020.106288. [PMID: 32062075]
  • Bin Chao, Shijing Huang, Juhua Pan, Ying Zhang, Yanyun Wang. Saikosaponin d downregulates microRNA-155 and upregulates FGF2 to improve depression-like behaviors in rats induced by unpredictable chronic mild stress by negatively regulating NF-κB. Brain research bulletin. 2020 04; 157(?):69-76. doi: 10.1016/j.brainresbull.2020.01.008. [PMID: 31926302]
  • Jing Su, Yi-Wei Pan, Si-Qi Wang, Xue-Zhen Li, Fang Huang, Shi-Ping Ma. Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation. International immunopharmacology. 2020 Mar; 80(?):106181. doi: 10.1016/j.intimp.2019.106181. [PMID: 31926446]
  • Dadui Ren, Jia Luo, Yingxue Li, Jing Zhang, Jiahong Yang, Junqiu Liu, Xuemei Zhang, Nengneng Cheng, Hong Xin. Saikosaponin B2 attenuates kidney fibrosis via inhibiting the Hedgehog Pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Feb; 67(?):153163. doi: 10.1016/j.phymed.2019.153163. [PMID: 31901891]
  • Jing Li, Jinfeng Han, Juan Lv, Shiji Wang, Lai Qu, Yanfang Jiang. Saikosaponin A-Induced Gut Microbiota Changes Attenuate Severe Acute Pancreatitis through the Activation of Keap1/Nrf2-ARE Antioxidant Signaling. Oxidative medicine and cellular longevity. 2020; 2020(?):9217219. doi: 10.1155/2020/9217219. [PMID: 33204401]
  • Chia-Yu Lin, Jen-Ai Lee, Po-Yeh Lin, Shih-Chun Hua, Pei-Yun Tsai, Bi-Li Chen, Chia-En Lin, Tzong-Huei Lee, Shih-Ming Chen. Utilizing methylglyoxal and D-lactate in urine to evaluate saikosaponin C treatment in mice with accelerated nephrotoxic serum nephritis. PloS one. 2020; 15(10):e0241053. doi: 10.1371/journal.pone.0241053. [PMID: 33104740]
  • Hongfang Li, Yunyan Tang, Yang Wang, Weipeng Wei, Chengchen Yin, Fushang Tang. Effects of Saikosaponin D on CYP1A2 and CYP2D6 in HepaRG Cells. Drug design, development and therapy. 2020; 14(?):5251-5258. doi: 10.2147/dddt.s268358. [PMID: 33273809]
  • Yirong Chen, Renye Que, Liubing Lin, Yanting Shen, Jinkai Liu, Yong Li. Inhibition of oxidative stress and NLRP3 inflammasome by Saikosaponin-d alleviates acute liver injury in carbon tetrachloride-induced hepatitis in mice. International journal of immunopathology and pharmacology. 2020 Jan; 34(?):2058738420950593. doi: 10.1177/2058738420950593. [PMID: 32816567]
  • Ruijia Fu, Jingjing Liu, Yunwen Xue, Zunjian Zhang, Rui Song. Effects of Animal Strain, Dose, and Cotreatment with Saikosaponin b2 on the Pharmacokinetics of Saikosaponin a in Rats. European journal of drug metabolism and pharmacokinetics. 2019 Dec; 44(6):827-836. doi: 10.1007/s13318-019-00569-5. [PMID: 31317503]
  • Wu Shuai-Cheng, Chu Xiu-Ling, Su Jian-Qing, Wu Zong-Mei, Yu Zhen-Jiang, Li Lian-Tao. Saikosaponin A protects chickens against pullorum disease via modulation of cholesterol. Poultry science. 2019 Sep; 98(9):3539-3547. doi: 10.3382/ps/pez197. [PMID: 30995307]
  • Linlin Yang, Yu Zhao, Qi Zhang, Lin Cheng, Mei Han, Yueying Ren, Limin Yang. Effects of drought-re-watering-drought on the photosynthesis physiology and secondary metabolite production of Bupleurum chinense DC. Plant cell reports. 2019 Sep; 38(9):1181-1197. doi: 10.1007/s00299-019-02436-8. [PMID: 31165250]
  • Lixing Xu, Jing Su, Liting Guo, Siqi Wang, Xueyang Deng, Shiping Ma. Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression. Neuropharmacology. 2019 09; 155(?):150-161. doi: 10.1016/j.neuropharm.2019.05.027. [PMID: 31145906]
  • Ya Zhao, Limin Feng, Lijuan Liu, Ruizhi Zhao. Saikosaponin b2 enhances the hepatotargeting effect of anticancer drugs through inhibition of multidrug resistance-associated drug transporters. Life sciences. 2019 Aug; 231(?):116557. doi: 10.1016/j.lfs.2019.116557. [PMID: 31194994]
  • Jingjing Liu, Yunwen Xue, Jianbo Sun, Ruijia Fu, Siqi Ren, Zunjian Zhang, Rui Song. Pharmacokinetics and oral bioavailability studies of three saikogenins in rats using a validated UFLC-MS/MS method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Aug; 1124(?):265-272. doi: 10.1016/j.jchromb.2019.06.020. [PMID: 31252254]
  • Yunwen Xue, Jingjing Liu, Ruijia Fu, Lei Gao, Xuping Yang, Zunjian Zhang, Rui Song. In vitro studies on the metabolism of saikogenins and the detection of their metabolites in authentic biosamples. Journal of pharmaceutical and biomedical analysis. 2019 Aug; 172(?):295-301. doi: 10.1016/j.jpba.2019.04.051. [PMID: 31079023]
  • Tingting Qin, Xinxin Fu, Jiayu Yu, Ruyi Zhang, Xueyang Deng, Qiang Fu, Zhanqiang Ma, Shiping Ma. Modification of GSK3β/β-catenin signaling on saikosaponins-d-induced inhibition of neural progenitor cell proliferation and adult neurogenesis. Toxicology. 2019 08; 424(?):152233. doi: 10.1016/j.tox.2019.06.004. [PMID: 31175886]
  • Qing Ma, Fang-Fang Gao, Xin He, Kai Li, Yang Gao, Xiao-Long Xu, Nan-Hui Jiang, Liang Ding, Wen-Jing Song, Yan-Qi He, Wen-Ting Pan, Lei Wei, Jing-Wei Zhang. Antitumor effects of saikosaponin b2 on breast cancer cell proliferation and migration. Molecular medicine reports. 2019 Aug; 20(2):1943-1951. doi: 10.3892/mmr.2019.10385. [PMID: 31257464]
  • Yinhong Zhu, Xiaobei Chen, Xianlin Rao, Chunhua Zheng, Xiaomou Peng. Saikosaponin a ameliorates lipopolysaccharide and d‑galactosamine-induced liver injury via activating LXRα. International immunopharmacology. 2019 Jul; 72(?):131-137. doi: 10.1016/j.intimp.2019.03.049. [PMID: 30981078]
  • Lina Liu, Jing Yan, Fei Ge, Xiangtao Xu, Jun Lu, Huilian Shi, Shuihong Li, Yue Zhao, Changzheng Zhang. Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus. Molecular medicine reports. 2019 Jul; 20(1):332-340. doi: 10.3892/mmr.2019.10232. [PMID: 31115535]
  • Man You, Rui-Fang Li, Zi-Han Gao, Yuan-Ye Li, Wei-Yi Liu, Jian-Gang Wang, Hong-Wei Wang, San-Qiang Li. [Effects of saikosaponin b_2 on inflammation and energy metabolism in mice with acute liver injury induced by LPS/GalN]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Jul; 44(14):2966-2971. doi: 10.19540/j.cnki.cjcmm.20190521.415. [PMID: 31602841]
  • Wei-Ping Lee, Keng-Li Lan, Shi-Xian Liao, Yi-Hsiang Huang, Ming-Chih Hou, Keng-Hsin Lan. Antiviral effect of saikosaponin B2 in combination with daclatasvir on NS5A resistance-associated substitutions of hepatitis C virus. Journal of the Chinese Medical Association : JCMA. 2019 May; 82(5):368-374. doi: 10.1097/jcma.0000000000000095. [PMID: 30920421]
  • Yingtong Lv, Xiaoying Hou, Qianqian Zhang, Ruiting Li, Lei Xu, Yadong Chen, Yuan Tian, Rong Sun, Zunjian Zhang, Fengguo Xu. Untargeted Metabolomics Study of the In Vitro Anti-Hepatoma Effect of Saikosaponin d in Combination with NRP-1 Knockdown. Molecules (Basel, Switzerland). 2019 Apr; 24(7):. doi: 10.3390/molecules24071423. [PMID: 30978940]
  • Li-Hua Cui, Cai-Xia Li, Yu-Zhen Zhuo, Lei Yang, Nai-Qiang Cui, Shu-Kun Zhang. Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway. Chemico-biological interactions. 2019 Feb; 300(?):18-26. doi: 10.1016/j.cbi.2019.01.005. [PMID: 30611790]
  • Jing Zheng, Juan Chen, Xiaohan Zou, Fang Zhao, Mengqi Guo, Hongbo Wang, Tian Zhang, Chunlei Zhang, Wei Feng, Isaac N Pessah, Zhengyu Cao. Saikosaponin d causes apoptotic death of cultured neocortical neurons by increasing membrane permeability and elevating intracellular Ca2+ concentration. Neurotoxicology. 2019 01; 70(?):112-121. doi: 10.1016/j.neuro.2018.11.006. [PMID: 30458186]
  • Weiwei Shi, Dechao Xu, Junhui Gu, Cheng Xue, Bo Yang, Lili Fu, Shuwei Song, Dongmei Liu, Wei Zhou, Jiayi Lv, Ke Sun, Meihan Chen, Changlin Mei. Saikosaponin-d inhibits proliferation by up-regulating autophagy via the CaMKKβ-AMPK-mTOR pathway in ADPKD cells. Molecular and cellular biochemistry. 2018 Dec; 449(1-2):219-226. doi: 10.1007/s11010-018-3358-0. [PMID: 29675630]
  • Jixia Wang, Huan Qi, Xiuli Zhang, Wei Si, Fangfang Xu, Tao Hou, Han Zhou, Anhui Wang, Guohui Li, Yanfang Liu, Ye Fang, Hai-Long Piao, Xinmiao Liang. Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Dec; 108(?):724-733. doi: 10.1016/j.biopha.2018.09.038. [PMID: 30248540]
  • Jia Zhou, Hao Cai, Sicong Tu, Yu Duan, Ke Pei, Yangyang Xu, Jing Liu, Minjie Niu, Yating Zhang, Lin Shen, Qigang Zhou. Identification and Analysis of Compound Profiles of Sinisan Based on 'Individual Herb, Herb-Pair, Herbal Formula' before and after Processing Using UHPLC-Q-TOF/MS Coupled with Multiple Statistical Strategy. Molecules (Basel, Switzerland). 2018 Nov; 23(12):. doi: 10.3390/molecules23123128. [PMID: 30501046]