Phorbol 12-myristate 13-acetate (BioDeep_00000172941)

Main id: BioDeep_00000000580

 

human metabolite blood metabolite natural product


代谢物信息卡片


13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0²,⁶.0¹¹,¹³]pentadeca-3,8-dien-14-yl tetradecanoate

化学式: C36H56O8 (616.3975)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 91.13%

分子结构信息

SMILES: CCCCCCCCCCCCCC(=O)OC1C(C)C2(O)C(C=C(CO)CC3(O)C(=O)C(C)=CC32)C2C(C)(C)C12OC(C)=O
InChI: InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3

描述信息

D009676 - Noxae > D002273 - Carcinogens > D010703 - Phorbol Esters

同义名列表

17 个代谢物同义名

13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0²,⁶.0¹¹,¹³]pentadeca-3,8-dien-14-yl tetradecanoate; 13-(Acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0,.0,]pentadeca-3,8-dien-14-yl tetradecanoic acid; Tetradecanoylphorbol Acetate, 4a alpha-Isomer; Tetradecanoylphorbol Acetate, 4a alpha Isomer; 13-Acetate, 12-O-Tetradecanoyl Phorbol; Phorbol 13-Acetate, 12-O-Tetradecanoyl; 12 O Tetradecanoyl Phorbol 13 Acetate; 12-O-Tetradecanoyl Phorbol 13-Acetate; Phorbol acetic acid, myristic acid; Phorbol 12-myristate 13-acetate; 12-Myristoyl-13-acetylphorbol; Acetate, Tetradecanoylphorbol; 12 Myristoyl 13 acetylphorbol; Tetradecanoylphorbol acetate; Myristate Acetate, Phorbol; Acetate, Phorbol Myristate; Phorbol myristate acetate



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 CAT, ELANE, FPR1, NFKB1, PRKX, TNK1
Peripheral membrane protein 1 TNK1
Endoplasmic reticulum membrane 1 CD4
Nucleus 5 FOS, MPO, NFKB1, PLCZ1, PRKX
cytosol 6 CAT, ELANE, FOS, NFKB1, PLCZ1, PRKCQ
phagocytic vesicle 1 ELANE
nucleoplasm 5 FOS, MPO, NFKB1, PLCZ1, PRKX
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 5 CD4, CD8A, FPR1, ITGB2, TNF
Multi-pass membrane protein 1 FPR1
cell surface 4 ELANE, ICAM1, ITGB2, TNF
Golgi membrane 1 INS
neuronal cell body 1 TNF
Lysosome 1 MPO
plasma membrane 9 CD4, CD8A, FPR1, ICAM1, IFNLR1, ITGB2, PRKCQ, TNF, TNK1
Membrane 6 CAT, FPR1, ICAM1, IFNLR1, ITGB2, TNK1
extracellular exosome 5 CAT, ELANE, ICAM1, ITGB2, MPO
endoplasmic reticulum 1 FOS
extracellular space 8 CXCL8, ELANE, ICAM1, IL2, IL4, INS, MPO, TNF
perinuclear region of cytoplasm 1 PLCZ1
mitochondrion 2 CAT, NFKB1
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 2 CAT, MPO
pronucleus 1 PLCZ1
Single-pass type I membrane protein 5 CD4, CD8A, ICAM1, IFNLR1, ITGB2
Secreted 4 CXCL8, IL2, IL4, INS
extracellular region 10 CAT, CD8A, CXCL8, ELANE, IL2, IL4, INS, MPO, NFKB1, TNF
[Isoform 2]: Secreted 1 CD8A
mitochondrial matrix 1 CAT
transcription regulator complex 1 NFKB1
centriolar satellite 1 PRKCQ
external side of plasma membrane 5 CD4, CD8A, ICAM1, ITGB2, TNF
Extracellular vesicle 1 ITGB2
nucleolus 1 PLCZ1
Early endosome 1 CD4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 4 CD4, ICAM1, ITGB2, TNF
focal adhesion 3 CAT, ICAM1, ITGB2
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 2 ELANE, ICAM1
secretory granule 2 ELANE, MPO
receptor complex 2 CD8A, ITGB2
chromatin 2 FOS, NFKB1
phagocytic cup 1 TNF
endosome lumen 1 INS
specific granule membrane 1 ITGB2
tertiary granule membrane 1 ITGB2
azurophil granule 1 MPO
plasma membrane raft 2 CD8A, ITGB2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, INS, NFKB1
secretory granule membrane 1 FPR1
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 CD4, INS
nuclear matrix 1 FOS
transcription repressor complex 1 ELANE
specific granule lumen 2 ELANE, NFKB1
transport vesicle 1 INS
azurophil granule membrane 1 FPR1
azurophil granule lumen 2 ELANE, MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 2 ICAM1, PRKCQ
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 1 CD4
phagocytic vesicle lumen 1 MPO
protein-DNA complex 1 FOS
ficolin-1-rich granule membrane 2 FPR1, ITGB2
[Isoform 1]: Cell membrane 1 CD8A
Cytoplasmic vesicle, phagosome 1 ELANE
integrin complex 1 ITGB2
transcription factor AP-1 complex 1 FOS
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 2 CD4, CD8A
catalase complex 1 CAT
sperm head 1 PLCZ1
integrin alphaL-beta2 complex 1 ITGB2
integrin alphaM-beta2 complex 1 ITGB2
integrin alphaX-beta2 complex 1 ITGB2
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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