Phorbol 12-myristate 13-acetate (BioDeep_00000172941)

Main id: BioDeep_00000000580

 

human metabolite blood metabolite natural product


代谢物信息卡片


13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0²,⁶.0¹¹,¹³]pentadeca-3,8-dien-14-yl tetradecanoate

化学式: C36H56O8 (616.3974976000001)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 98.21%

分子结构信息

SMILES: CCCCCCCCCCCCCC(=O)OC1C(C)C2(O)C(C=C(CO)CC3(O)C(=O)C(C)=CC32)C2C(C)(C)C12OC(C)=O
InChI: InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3

描述信息

D009676 - Noxae > D002273 - Carcinogens > D010703 - Phorbol Esters

同义名列表

17 个代谢物同义名

13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0²,⁶.0¹¹,¹³]pentadeca-3,8-dien-14-yl tetradecanoate; 13-(Acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0,.0,]pentadeca-3,8-dien-14-yl tetradecanoic acid; Tetradecanoylphorbol Acetate, 4a alpha-Isomer; Tetradecanoylphorbol Acetate, 4a alpha Isomer; 13-Acetate, 12-O-Tetradecanoyl Phorbol; Phorbol 13-Acetate, 12-O-Tetradecanoyl; 12 O Tetradecanoyl Phorbol 13 Acetate; 12-O-Tetradecanoyl Phorbol 13-Acetate; Phorbol acetic acid, myristic acid; Phorbol 12-myristate 13-acetate; 12-Myristoyl-13-acetylphorbol; Acetate, Tetradecanoylphorbol; 12 Myristoyl 13 acetylphorbol; Tetradecanoylphorbol acetate; Myristate Acetate, Phorbol; Acetate, Phorbol Myristate; Phorbol myristate acetate



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huan Wang, Yuejia Lan, Cuiping Chen, Lu Yang, Jiayi Sun, Yong Zeng, Jiasi Wu. LPS and ATP-induced Death of PMA-differentiated THP-1 Macrophages and its Validation. Journal of visualized experiments : JoVE. 2024 May; ?(207):. doi: 10.3791/66831. [PMID: 38767387]
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  • Mohamed Sofiane Merakeb, Noureddine Bribi, Riad Ferhat, Meriem Aziez, Betitera Yanat. Alkaloids Extract from Linum usitatissimum Attenuates 12-O-Tetradecanoylphorbol-13-Acetate (TPA)-induced Inflammation and Oxidative Stress in Mouse Skin. Anti-inflammatory & anti-allergy agents in medicinal chemistry. 2022 Dec; ?(?):. doi: 10.2174/1871523022666221212121621. [PMID: 36515033]
  • Pakize Neslihan Taşlı. Usage of celery root exosome as an immune suppressant; Lipidomic characterization of apium graveolens originated exosomes and its suppressive effect on PMA/ionomycin mediated CD4+ T lymphocyte activation. Journal of food biochemistry. 2022 12; 46(12):e14393. doi: 10.1111/jfbc.14393. [PMID: 36181394]
  • Ming-Shan Chen, Kung-Ssu Yang, Wen-Chun Lin, Chien-Liang Fang, Hsin-Fu Chen, Shew-Meei Sheu. Lipofundin mediates major inhibition of intravenous propofol on phorbol myristate acetate and Escherichia coli-induced neutrophil extracellular traps. Molecular biology reports. 2022 Jul; 49(7):6517-6529. doi: 10.1007/s11033-022-07482-2. [PMID: 35637315]
  • Gilda Varricchi, Luca Modestino, Remo Poto, Leonardo Cristinziano, Luca Gentile, Loredana Postiglione, Giuseppe Spadaro, Maria Rosaria Galdiero. Neutrophil extracellular traps and neutrophil-derived mediators as possible biomarkers in bronchial asthma. Clinical and experimental medicine. 2022 May; 22(2):285-300. doi: 10.1007/s10238-021-00750-8. [PMID: 34342773]
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  • Mhd Yousuf Yassouf, Xu Zhang, Zisheng Huang, Da Zhai, Reiko Sekiya, Tsuyoshi Kawabata, Tao-Sheng Li. Biphasic effect of mechanical stress on lymphocyte activation. Journal of cellular physiology. 2022 02; 237(2):1521-1531. doi: 10.1002/jcp.30623. [PMID: 34724217]
  • Daria V Grigorieva, Irina V Gorudko, Natalia A Grudinina, Oleg M Panasenko, Igor V Semak, Alexey V Sokolov, Alexander V Timoshenko. Lactoferrin modified by hypohalous acids: Partial loss in activation of human neutrophils. International journal of biological macromolecules. 2022 Jan; 195(?):30-40. doi: 10.1016/j.ijbiomac.2021.11.165. [PMID: 34863835]
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  • Alessia D'Aloia, Laura Molteni, Francesca Gullo, Elena Bresciani, Valentina Artusa, Laura Rizzi, Michela Ceriani, Ramona Meanti, Marzia Lecchi, Silvia Coco, Barbara Costa, Antonio Torsello. Palmitoylethanolamide Modulation of Microglia Activation: Characterization of Mechanisms of Action and Implication for Its Neuroprotective Effects. International journal of molecular sciences. 2021 Mar; 22(6):. doi: 10.3390/ijms22063054. [PMID: 33802689]
  • Li Xiao, Nobuhiko Miwa. Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents. Cells. 2021 03; 10(3):. doi: 10.3390/cells10030626. [PMID: 33799840]
  • Guillaume Cardin, Cyril Poupet, Muriel Bonnet, Philippe Veisseire, Isabelle Ripoche, Pierre Chalard, Anne Chauder, Etienne Saunier, Julien Priam, Stéphanie Bornes, Laurent Rios. A Mechanistic Study of the Antiaging Effect of Raw-Milk Cheese Extracts. Nutrients. 2021 Mar; 13(3):. doi: 10.3390/nu13030897. [PMID: 33802038]
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  • Hamza Saidi, Babar Murtaza, Amira Sayed Khan, Elhadj Ahmed Koceir, Aziz Hichami, Naim Akhtar Khan. DHA induces Jurkat T-cell arrest in G2/M phase of cell cycle and modulates the plasma membrane expression of TRPC3/6 channels. Biochimie. 2021 Feb; 181(?):169-175. doi: 10.1016/j.biochi.2020.12.005. [PMID: 33333171]
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  • Sukkum Ngullie Chang, Debasish Kumar Dey, Seong Taek Oh, Won Ho Kong, Kiu Hyung Cho, Ebtesam M Al-Olayan, Buyng Su Hwang, Sun Chul Kang, Jae Gyu Park. Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1α-NF-κB Crosstalk In Vitro and In Vivo. International journal of molecular sciences. 2020 Dec; 21(23):. doi: 10.3390/ijms21239261. [PMID: 33291656]
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